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公开(公告)号：US06210408B1
公开(公告)日：2001-04-03
申请号：US09256977
申请日：1999-02-24
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B2017/22038 , A61B2017/22094 , A61B2018/00214 , A61B2018/00261 , A61B2018/00279 , A61B2018/00285 , A61B2018/0041 , A61B2018/00422 , A61B2018/00625 , A61B2018/1213 , A61B2018/1253 , A61B2018/1435 , A61B2018/144 , A61M25/09 , A61M25/10 , A61M2025/1047
摘要： A system for recanalizing an occluded blood vessel including a centering catheter employed to center an ablative guide wire within the blood vessel as the guide wire traverses the occlusion. The centering catheter includes a catheter body with an operative lumen through which the ablative guide wire is slidingly disposed. The centering catheter further includes a distally disposed centering mechanism that, when activated, centers the ablative guide wire within the blood vessel as it traverses the occlusion. The centering mechanism can comprise various embodiments including a single inflatable balloon or segmented inflatable balloon, which is in fluid communication with an inflation lumen. An airless preparation lumen may be disposed within the inflation lumen for ease of centering catheter preparation. The ablative guide wire includes insulation that is preferably formed of heat shrink tubing, which is stretched prior or concurrently with the heating process. The ablative guide wire includes a distal ablation tip having a non-traumatic structure and at least one discontinuous feature for creating high current densities for more efficient tissue ablation.
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公开(公告)号：US06562031B2
公开(公告)日：2003-05-13
申请号：US09814142
申请日：2001-03-20
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B2017/22038 , A61B2017/22094 , A61B2018/00214 , A61B2018/00261 , A61B2018/00279 , A61B2018/00285 , A61B2018/0041 , A61B2018/00422 , A61B2018/00625 , A61B2018/1213 , A61B2018/1253 , A61B2018/1435 , A61B2018/144 , A61M25/09 , A61M25/10 , A61M2025/1047
摘要： A system for recanalizing an occluded blood vessel including a centering catheter employed to center an ablative guide wire within the blood vessel as the guide wire traverses the occlusion. The centering catheter includes a catheter body with an operative lumen through which the ablative guide wire is slidingly disposed. The centering catheter further includes a distally disposed centering mechanism that, when activated, centers the ablative guide wire within the blood vessel as it traverses the occlusion. The centering mechanism can comprise various embodiments including a single inflatable balloon or segmented inflatable balloon, which is in fluid communication with an inflation lumen. An airless preparation lumen may be disposed within the inflation lumen for ease of centering catheter preparation. The ablative guide wire includes insulation that is preferably formed of heat shrink tubing, which is stretched prior or concurrently with the heating process. The ablative guide wire includes a distal ablation tip having a non-traumatic structure and at least one discontinuous feature for creating high current densities for more efficient tissue ablation.
摘要翻译： 包括定心导管的闭塞血管再通的系统，其用于在引导线穿过闭塞时使血管内的消融引导线居中。 定心导管包括具有操作腔的导管主体，消融导丝通过该导管本体滑动地设置。 定心导管进一步包括一个向远侧配置的定中心机构，当被激活时，该消融导丝在穿过该闭塞时在该血管内居中。 定心机构可以包括各种实施例，包括与充气腔流体连通的单个可充气球囊或分段的可充气球囊。 可以在充气腔内设置无空气制剂腔，以便于使导管制剂居中。 烧蚀导丝包括优选由热收缩管形成的绝缘体，其在加热过程之前或同时被拉伸。 烧蚀导丝包括具有非创伤性结构的远端消融尖端和用于产生高电流密度以用于更有效的组织消融的至少一个不连续特征。
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公开(公告)号：US06503227B1
公开(公告)日：2003-01-07
申请号：US09624429
申请日：2000-07-24
IPC分类号： A61B1700
CPC分类号： A61B17/320758 , A61B2017/00469 , A61B2017/22049 , A61B2017/22075
摘要： An improved guide wire brake that is particularly suited to ablative rotational atherectomy devices is disclosed. The guide wire brake ensures that a guide wire is prevented from rotating or moving axially prior to activation of a primary mover such as a turbine. In one embodiment a pressure relief valve delays the activation of the prime mover on start up, and a check valve delays the release of the guide wire brake on shut down. In a second embodiment the guide wire brake is serially connected to the prime mover such that the prime mover is not connected to the pressurized gas source until after the guide wire brake is engaged. In a third embodiment a guide wire is disposed through a flexible tube within a rigid cylinder that is serially connected to the prime mover, such that when pressurized gas is provided to the prime mover the flexible tube will collapse on the guide wire, to prevent guide wire movement. In a fourth embodiment a mechanical brake, in a single action, engages the guide wire prior to opening a flow path between the pressurized gas source and the prime mover. Methods for manually bypassing the guide wire brake are also disclosed.
摘要翻译： 公开了一种特别适用于消融性旋切体切除装置的改进的导丝线制动器。 引导线制动器确保在诸如涡轮机的初级动子的启动之前防止导丝旋转或轴向移动。 在一个实施例中，减压阀在启动时延迟原动机的启动，并且止回阀在关闭时延迟引导线制动器的释放。 在第二实施例中，引导线制动器串联连接到原动机，使得原动机不连接到加压气体源，直到在引导线制动器接合之后。 在第三实施例中，引导线通过柔性管道设置在刚性圆柱体内，该刚性圆柱体串联连接到原动机，使得当加压气体被提供给原动机时，柔性管将在引导线上塌陷，以防止引导 电线运动。 在第四实施例中，在打开加压气体源和原动机之间的流动路径之前，在一个动作中的机械制动器接合导丝。 还公开了手动绕过导丝线制动器的方法。
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公开(公告)号：USD983895S1
公开(公告)日：2023-04-18
申请号：US29841115
申请日：2022-06-02
申请人： Zihong Guo
设计人： Zihong Guo
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公开(公告)号：US09205969B2
公开(公告)日：2015-12-08
申请号：US12658579
申请日：2010-02-08
申请人： Geoffrey F. Deane , Lawrence Morgan Fowler , William Gates , Zihong Guo , Roderick A. Hyde , Edward K. Y. Jung , Jordin T. Kare , Nathan P. Myhrvold , Nathan Pegram , Nels R. Peterson , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, Jr.
发明人： Geoffrey F. Deane , Lawrence Morgan Fowler , William Gates , Zihong Guo , Roderick A. Hyde , Edward K. Y. Jung , Jordin T. Kare , Nathan P. Myhrvold , Nathan Pegram , Nels R. Peterson , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, Jr.
CPC分类号： B65D81/3802 , B65D81/3811 , B65D81/3813 , B65D81/3823 , B65D81/3825 , B65D81/3834 , B65D81/3888 , B65D81/3897 , B65D2203/10 , Y10T29/49826
摘要： A substantially thermally sealed storage container includes an outer assembly, including one or more sections of ultra efficient insulation material substantially defining at least one thermally sealed storage region, and an inner assembly, including at least one heat sink unit within the at least one thermally sealed storage region, and at least one stored material dispenser unit, wherein the at least one stored material dispenser unit includes one or more interlocks.
摘要翻译： 基本上热密封的存储容器包括外部组件，其包括基本上限定至少一个热密封存储区域的一个或多个超高效绝缘材料部分和内部组件，所述内部组件包括至少一个热密封的至少一个散热器单元 存储区域和至少一个储存材料分配器单元，其中所述至少一个储存的材料分配器单元包括一个或多个互锁。
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公开(公告)号：US08235975B2
公开(公告)日：2012-08-07
申请号：US13274192
申请日：2011-10-14
申请人： James C. Chen , Steven R. Daly , Zihong Guo , Llew Keltner , Jeffrey R. Storm
发明人： James C. Chen , Steven R. Daly , Zihong Guo , Llew Keltner , Jeffrey R. Storm
IPC分类号： A61B18/18
CPC分类号： A61N5/062 , A61B50/30 , A61N5/0601 , A61N2005/0645 , A61N2005/0652
摘要： A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.
摘要翻译： 向患者提供光动力治疗的光传输系统包括具有多个发光二极管（LED）的单次使用的集成控制模块和导管组件，以将光传送到患者体内的靶细胞。 集成光导管和控制模块与光活化药物组合使用。 所选择的操作参数可以被编程到控制模块中，或者可以在使用之前在现场进行无线可编程，以允许用户灵活地为特定患者或病症定制治疗。 防止重用的功能之一是控制模块缺少对电源进行再充电的功能，并且可能包括在触发时破坏电路或软件的停用模块。 为了在使用时防止患者干扰，控制模块还可以被配置为选择性地停用。
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公开(公告)号：US20120089207A1
公开(公告)日：2012-04-12
申请号：US13274192
申请日：2011-10-14
申请人： James C. Chen , Steven R. Daly , Zihong Guo , Llew Keltner , Jeffrey R. Storm
发明人： James C. Chen , Steven R. Daly , Zihong Guo , Llew Keltner , Jeffrey R. Storm
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61B50/30 , A61N5/0601 , A61N2005/0645 , A61N2005/0652
摘要： A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.
摘要翻译： 向患者提供光动力治疗的光传输系统包括具有多个发光二极管（LED）的单次使用的集成控制模块和导管组件，以将光传送到患者体内的靶细胞。 集成光导管和控制模块与光活化药物组合使用。 所选择的操作参数可以被编程到控制模块中，或者可以在使用之前在现场进行无线可编程，以允许用户灵活地为特定患者或病症定制治疗。 防止重用的功能之一是控制模块缺少对电源进行再充电的功能，并且可能包括在触发时破坏电路或软件的停用模块。 为了在使用时防止患者干扰，控制模块还可以被配置为选择性地停用。
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8.发明申请公开(公告)号：US20090036773A1
公开(公告)日：2009-02-05
申请号：US11831048
申请日：2007-07-31
CPC分类号： A61B8/12 , A61B8/4209 , A61B8/4272 , A61B8/4281 , A61B8/445 , A61B17/2202 , A61B17/2256 , A61B17/4241 , A61B2017/2253 , A61B2017/4216 , A61B2018/00029 , A61B2090/3782 , A61B2090/3784 , A61N7/022
摘要： A combined imaging/HIFU probe includes an imaging scan head, a HIFU transducer, and an outlet port that delivers a flow of fluid across the HIFU transducer. At least a portion of the body cavity is filled with fluid in which the probe is immersed. The fluid provides a coupling for transmission of ultrasound energy between the probe and the patient. A flow of fluid may also be used to flush obstructions from an area of tissue near the HIFU transducer. Further described herein is a cuff to help retain fluid in the body cavity, a regulator to regulate fluid flow with respect to the body cavity according to a desired fluid pressure, and a cover for the HIFU transducer that has at least one perforation defined therethrough to allow fluid to flow through the cover. Further disclosed herein are methods of deploying a combined imaging/HIFU probe in a body cavity.
摘要翻译： 组合的成像/ HIFU探头包括成像扫描头，HIFU换能器和输出流体穿过HIFU换能器的出口。 体腔的至少一部分填充有探针浸入其中的流体。 流体提供用于在探针和患者之间传输超声能量的耦合。 流体流也可用于冲洗HIFU换能器附近的组织区域的障碍物。 本文进一步描述的是用于帮助保持体腔中的流体的袖带，根据期望的流体压力调节流体相对于体腔的流体的调节器，以及用于HIFU换能器的覆盖物，其具有至少一个穿过其定义的穿孔 允许流体流过盖子。 本文进一步公开的是将组合成像/ HIFU探针部署在体腔中的方法。
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公开(公告)号：US20080033519A1
公开(公告)日：2008-02-07
申请号：US11834572
申请日：2007-08-06
申请人： Phillip Burwell , Zihong Guo , Jennifer Matson , Steven Daly , David Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , Zihong Guo , Jennifer Matson , Steven Daly , David Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
CPC分类号： A61N5/062 , A61B2018/2261 , A61N5/0601 , A61N2005/0602 , A61N2005/063 , A61N2005/0652
摘要： Light sources are incorporated into a guidewire for enabling the ability to render light therapy be added to catheters that do not have that capability. In one exemplary embodiment, a solid guidewire includes a conductive core, and light sources are added to compartments formed in a distal end of the guidewire. In another exemplary embodiment, a light source array is included in a distal end of a hollow guidewire. A plurality of openings are formed into the walls of the hollow guidewire surrounding the array, enabling light to pass through the openings. Conductors extend from the array though the hollow center of the guidewire, to a proximal end of the hollow guidewire. The hollow guidewire can be coated with a conductive material, so that the coating on the guidewire serves as a conductor.
摘要翻译： 光源被结合到导丝中，以使能够将光疗法添加到不具有该能力的导管的能力。 在一个示例性实施例中，实心导线包括导电芯，并且将光源添加到形成在导丝的远端中的隔室。 在另一示例性实施例中，光源阵列包括在中空导丝的远端中。 多个开口形成在围绕阵列的中空导丝的壁中，使得光能够穿过开口。 导体通过导丝的中空中心从阵列延伸到中空导丝的近端。 中空导丝可以用导电材料涂覆，使得导丝上的涂层用作导体。
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公开(公告)号：US20050228260A1
公开(公告)日：2005-10-13
申请号：US10799357
申请日：2004-03-12
申请人： Phillip Burwell , Zihong Guo , Jennifer Matson , Steven Daly , David Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , Zihong Guo , Jennifer Matson , Steven Daly , David Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
CPC分类号： A61N5/0601 , A61B2018/2261 , A61N5/062 , A61N2005/0602 , A61N2005/0652 , A61N2005/1003
摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
摘要翻译： 用于照射血管组织部分的光产生装置，以进行光动力疗法。 在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。 可选地提供气囊以中断可阻挡光的传播的血流，并使装置居中在血管中。 光纤可选地将来自光源的光引导到漫射元件。 光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。 线性光源元件特别适用于处理容器中组织的细长部分。 旨在用于常规气囊导管的一个实施例将光源集成到导丝中。
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