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    System and method for recruitment of candidates for clinical trials while maintaining security
    32.
    发明授权
    System and method for recruitment of candidates for clinical trials while maintaining security 有权
    在保持安全的同时招聘临床试验候选人的制度和方法

    公开(公告)号：US07483838B1

    公开(公告)日：2009-01-27

    申请号：US09556945

    申请日：2000-04-21

    Applicant: James D. Marks

    Inventor： James D. Marks

    IPC: G06Q10/00

    CPC classification number: G06Q50/24 ,  G06F19/00 ,  G06F19/3418 ,  G06Q10/10 ,  G06Q50/22 ,  G16H10/20 ,  G16H10/60

    Abstract: An on-line click wrap electronic agreement that a user must agree to prior to being registered as a volunteer and considered as a potential candidate in a clinical trial or research study. The agreement authorizes the release of the end user's medical and/or personal information to representatives of the clinical trials and research studies for which the volunteer may be considered as a potential candidate. After receiving the end user's consent to the click wrap agreement an electronic survey form is generated by a secure server and displayed at the end user's computer terminal. Responses by the end user to the survey form are kept secure as much as possible while being transmitted from the computer terminal across the network to the server and while stored and accessed only by authorized personnel at the central office.

    Abstract translation: 一个在线点击包装电子协议，用户必须在注册为志愿者之前同意，并被认为是临床试验或研究研究中的潜在候选人。 该协议授权将最终用户的医疗和/或个人信息发布给临床试验和研究研究的代表，志愿者可被视为潜在候选人。 在收到最终用户同意点击包装协议之后，电子调查表由安全服务器生成，并显示在最终用户的计算机终端。 最终用户对调查表的响应在从计算机终端通过网络传输到服务器的同时尽可能地保持安全，并且仅在中心局的授权人员存储和访问。

    Interactive system for managing questions and answers among users and experts
    33.
    发明授权
    Interactive system for managing questions and answers among users and experts 有权
    交互式系统，用于管理用户和专家之间的问题和答案

    公开(公告)号：US07472071B2

    公开(公告)日：2008-12-30

    申请号：US09447259

    申请日：1999-11-23

    Applicant: James D. Marks ,  Robert Weaver ,  Jeremy Shao

    Inventor： James D. Marks ,  Robert Weaver ,  Jeremy Shao

    IPC: G06F9/44

    CPC classification number: G06Q10/10 ,  G06Q10/06311 ,  G06Q40/08 ,  G09B7/00

    Abstract: A method, executed by a server, for providing answers on one or more topics from a set of experts on each topic to questions posed by users. Users can direct questions to one or more specific experts, who in turn can answer the questions, refer the questions to other experts, or both. The server automatically organizes and stores questions and answers in various fora. An administrator can take advantage of the design of the system to create or change a forum without having to write or change low-level code.

    Abstract translation: 由服务器执行的用于从关于每个主题的一组专家提供关于用户提出的问题的一个或多个主题的答案的方法。 用户可以向一个或多个特定专家提出问题，反过来可以回答问题，将问题转交给其他专家或两者。 服务器自动组织和存储各种论坛的问题和答案。 管理员可以利用系统的设计来创建或更改论坛，而无需编写或更改低级代码。

    ANTIBODIES DIRECTED AGAINST THE TRANSFERRIN RECEPTOR AND USES THEREOF FOR IMMUNOTHERAPY OF IRON-DEPENDENT TUMOURS
    36.
    发明申请
    ANTIBODIES DIRECTED AGAINST THE TRANSFERRIN RECEPTOR AND USES THEREOF FOR IMMUNOTHERAPY OF IRON-DEPENDENT TUMOURS 审中-公开
    针对转铁蛋白受体的抗体及其依赖于依赖于肿瘤的免疫球蛋白的用途

    公开(公告)号：US20130045206A1

    公开(公告)日：2013-02-21

    申请号：US13515551

    申请日：2010-12-16

    Applicant: Marie-Alix Poul ,  Ronan Philippe Crepin ,  James D. Marks

    Inventor： Marie-Alix Poul ,  Ronan Philippe Crepin ,  James D. Marks

    IPC: C07K16/28 ,  C12N15/63 ,  A61P37/06 ,  C12N5/10 ,  A61K39/395 ,  A61P35/00 ,  C12N15/13 ,  C12N1/21

    CPC classification number: C07K16/2881 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76

    Abstract: The present invention relates to a molecular structure characterised in that said structure includes at least one amino acid sequence selected from: SEQ. ID NO.: 1, SEQ. ID NO.: 2, SEQ. ID NO.: 3, SEQ. ID NO.: 4, SEQ. ID NO.: 5, SEQ. ID NO.: 6, SEQ. ID NO.: 7, SEQ. ID NO.: 8, SEQ. ID NO.: 9, SEQ. ID NO.: 10, SEQ. ID NO.: 11, SEQ. ID NO.: 12, SEQ. ID NO.: 13, SEQ. ID NO.: 14, SEQ. ID NO.: 15, SEQ. ID NO.: 16, SEQ. ID NO.: 17, SEQ. ID NO.: 18, SEQ. ID NO.: 19, SEQ. ID NO.: 20, SEQ. ID NO.: 21, SEQ. ID NO.: 22, SEQ. ID NO.: 23, SEQ. ID NO.: 24, SEQ. ID NO.: 25, SEQ. ID NO.: 26, SEQ. ID NO.: 27, SEQ. ID NO.: 28, SEQ. ID NO.: 29, SEQ. ID NO.: 30, SEQ. ID NO.: 31, SEQ. ID NO.: 32, SEQ. ID NO.: 33, SEQ. ID NO.: 34, SEQ. ID NO.: 35, SEQ. ID NO.: 36, said amino acid sequence corresponding to an antigen complementarity determining region (CDR) of the variable domain of the heavy chain (CDR-H) or the light chain (CDR-L) of an antibody targeting the human transferrin receptor (TfR). The present invention also relates to a pharmaceutical composition including a therapeutically effective amount of at least one molecular structure as defined in the present application, combined with a pharmaceutically acceptable carrier.

    Abstract translation: 本发明涉及分子结构，其特征在于所述结构包括至少一个选自以下的氨基酸序列：SEQ。 编号：1，SEQ。 编号：2，SEQ。 编号：3，SEQ。 编号：4，SEQ。 编号：5，SEQ。 编号：6，SEQ。 SEQ ID NO：7，SEQ。 SEQ ID NO：8，SEQ。 编号：9，SEQ。 编号：10，SEQ。 编号：11，SEQ。 SEQ ID NO：12，SEQ。 SEQ ID NO：13，SEQ。 SEQ ID NO：14，SEQ。 编号：15，SEQ。 编号：16，SEQ。 编号：17，SEQ。 编号：18，SEQ。 编号：19，SEQ。 SEQ ID NO：20，SEQ。 编号：21，SEQ。 编号：22，SEQ。 编号：23，SEQ。 SEQ ID NO：24，SEQ。 编号：25，SEQ。 编号：26，SEQ。 编号：27，SEQ。 编号：28，SEQ。 编号：29，SEQ。 SEQ ID NO：30，SEQ。 编号：31，SEQ。 编号：32，SEQ。 编号：33，SEQ。 编号：34，SEQ。 编号：35，SEQ。 SEQ ID NO：36，所述氨基酸序列对应于针对人转铁蛋白受体的抗体的重链（CDR-H）或轻链（CDR-L）的可变结构域的抗原互补决定区（CDR） （TfR）。 本发明还涉及药物组合物，其包含治疗有效量的至少一种如本申请中所定义的分子结构与药学上可接受的载体组合。

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