公开(公告)号：US08742198B2

公开(公告)日：2014-06-03

申请号：US12957542

申请日：2010-12-01

申请人： Ning Wei ,  Xuedong Song ,  Ronnie L. Phillips

发明人： Ning Wei ,  Xuedong Song ,  Ronnie L. Phillips

IPC分类号： A61F13/15

CPC分类号： G01N21/78 ,  A61F13/84 ,  A61F2013/8473 ,  G01N33/521

摘要： A dehydration sensor having a stable, printable, buffered-ink composition that enables one to miniaturize the detection zone and permits both buffer and indicator dye to be applied in the same area of a detection zone, without need for a conventional, large buffer pad region. The ink composition includes a weak polymeric base as its primary buffering agent.

摘要翻译： 一种具有稳定的可印刷缓冲油墨组合物的脱水传感器，其使得能够使检测区域小型化并且允许将缓冲液和指示剂染料施加在检测区域的相同区域中，而不需要常规的大的缓冲垫区域 。 油墨组合物包括弱聚合物基料作为其主要缓冲剂。

公开(公告)号：US20140066870A1

公开(公告)日：2014-03-06

申请号：US13596605

申请日：2012-08-28

申请人： JunMo Gil ,  Ning Wei ,  JinHo Ryu ,  Xuedong Song

发明人： JunMo Gil ,  Ning Wei ,  JinHo Ryu ,  Xuedong Song

IPC分类号： C09D11/02 ,  A61L15/56

CPC分类号： C09D11/50 ,  A61F13/42 ,  A61F2013/422 ,  C09D11/037

摘要： The present disclosure relates to a color-changing composition and to a substrate having the color-changing compositions disposed thereon. The color-changing composition includes a leuco dye, a color-developer and a desensitizer. The color-changing composition changes from a colorless or largely colorless composition to color upon being wetted with an aqueous liquid. The color-changing composition remains colorless or largely colorless prior to exposure to high relative humidity conditions.

摘要翻译： 本公开涉及一种变色组合物和其上设置有变色组合物的基底。 变色组合物包括无色染料，显色剂和脱敏剂。 颜色变化组合物在用含水液体润湿时从无色或基本无色的组合物变为颜色。 变色组合物在暴露于高相对湿度条件之前保持无色或大部分无色。

公开(公告)号：US20130087065A1

公开(公告)日：2013-04-11

申请号：US13615719

申请日：2012-09-14

申请人： Manfred Biebl ,  Michael Gabler ,  Achim Hofmann ,  Dieter Leier ,  Ning Wei

发明人： Manfred Biebl ,  Michael Gabler ,  Achim Hofmann ,  Dieter Leier ,  Ning Wei

IPC分类号： B60R21/264 ,  C06D5/00

CPC分类号： B60R21/264 ,  B60R21/2644 ,  B60R2021/26017 ,  B60R2021/26029

摘要： A vehicle safety system includes a module including an airbag and an inflator. The inflator includes a housing (12) in which a combustion chamber (16) containing a pyrotechnic propellant is arranged in which hot gas is generated and which housing includes at least one escape orifice (22) toward the environment of the inflator (10), as well as a coolant reservoir (24) arranged in the housing (12) in which coolant is accommodated prior to activation of the inflator (10) and which has at least one coolant outlet orifice (28′). The coolant outlet orifice (28) is arranged in direct vicinity of the outlet orifice (22). Upon activation of the inflator (10) coolant flows out of the inflator into the protection system and wets an adjacent wall (32) of the protection system against which also the hot gas is flowing.

摘要翻译： 车辆安全系统包括具有气囊和充气机的模块。 充气机包括壳体（12），其中布置有包含烟火推进剂的燃烧室（16），其中产生热气体，并且哪个壳体包括朝向充气机（10）的环境的至少一个逸出孔（22） 以及布置在所述壳体（12）中的冷却剂储存器（24），其中在所述充气器（10）启动之前容纳冷却剂并且具有至少一个冷却剂出口孔（28'）。 冷却剂出口孔28布置在出口孔22附近。 在充气机（10）激活时，冷却剂从充气机流出进入保护系统，并润湿保护系统的相邻壁（32），热气也流过。

公开(公告)号：US08338128B2

公开(公告)日：2012-12-25

申请号：US12749814

申请日：2010-03-30

申请人： Jason Lye ,  John Gavin MacDonald ,  Ning Wei ,  Stephanie M. Martin

发明人： Jason Lye ,  John Gavin MacDonald ,  Ning Wei ,  Stephanie M. Martin

IPC分类号： C12Q1/22 ,  C12Q1/02

CPC分类号： C12Q1/04

摘要： Suitable dyes are used herein to indicate the presence of microbial contamination by spraying them onto surfaces in the form of an aqueous solution. The dye solution may also be allowed to dry, thus producing the dried residue of an aqueous solution. It's believed that these dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye.

摘要翻译： 合适的染料在本文中用于通过以水溶液的形式将它们喷雾到表面上来表示存在微生物污染。 染料溶液也可以干燥，从而产生水溶液的干燥残余物。 据信这些染料响应于环境极性的变化而改变颜色。 由于水是极性溶剂，大多数细菌都是由非极性物质制成的，所以细菌的存在会改变环境的极性，引发肉眼可见的变化。

公开(公告)号：US08173380B2

公开(公告)日：2012-05-08

申请号：US12872225

申请日：2010-08-31

申请人： Kaiyuan Yang ,  Ning Wei ,  Shawn Ray Feaster

发明人： Kaiyuan Yang ,  Ning Wei ,  Shawn Ray Feaster

IPC分类号： G01N33/53

CPC分类号： G01N33/558 ,  G01N33/54366

摘要： A diagnostic test kit for detecting an analyte residing in a test sample is provided. The kit employs a lateral flow device that contains a membrane. A metering channel is formed in the membrane that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay. Such a metering channel is particularly effective for embodiments in which the test sample has a relatively low volume, such as less than about 100 microliters, in some embodiments from about 0.5 to about 25 microliters, and in some embodiments, from about 1 to about 10 microliters. For example, whole blood drops obtained from patients with a lancet typically have a volume of less than about 3 microliters. Despite their low volume, the present inventors have discovered that the blood drops may still be accurately analyzed for the presence of an analyte using lateral flow detection techniques.

摘要翻译： 提供了用于检测驻留在测试样品中的分析物的诊断测试试剂盒。 该套件采用包含膜的侧向流动装置。 在膜中形成计量通道，其能够在测定开始时将受控体积的测试样品输送到检测区。 这样的计量通道对于其中测试样品具有相对较小的体积，例如小于约100微升，在一些实施方案中为约0.5至约25微升，且在一些实施方案中为约1至约10 微升。 例如，从具有刺血针的患者获得的全血滴通常具有小于约3微升的体积。 尽管本发明人的体积小，但是本发明人已经发现，使用侧流检测技术仍然可以精确地分析血液滴定分析物的存在。

公开(公告)号：US08034397B2

公开(公告)日：2011-10-11

申请号：US12891967

申请日：2010-09-28

申请人： Kaiyuan Yang ,  Ning Wei ,  Rosann Kaylor ,  Chibueze Obinna Chidebelu-Eze ,  Zdravko Savov Atanassov

发明人： Kaiyuan Yang ,  Ning Wei ,  Rosann Kaylor ,  Chibueze Obinna Chidebelu-Eze ,  Zdravko Savov Atanassov

IPC分类号： G01N1/31

CPC分类号： G01N33/587 ,  G01N33/558

摘要： Hollow particles for use in various types of assay devices are provided. Due to their hollow or voided structure, the particles may exhibit a variety of beneficial properties. For instance, hollow particles are generally lightweight, and thus, relatively inexpensive in comparison to other types of particles. Hollow particles may also form a stable system without requiring refrigeration or rotation. In addition, hollow particles may possess enhanced light diffraction capabilities, which may be particularly beneficial in certain types of assay devices, e.g., diffraction-based assay devices.

摘要翻译： 提供了用于各种类型的测定装置的中空颗粒。 由于其中空或空隙结构，颗粒可能表现出各种有益的性质。 例如，中空颗粒通常是轻质的，因此与其它类型的颗粒相比相对便宜。 中空颗粒也可以形成稳定的系统，而不需要制冷或旋转。 此外，中空颗粒可以具有增强的光衍射能力，这在某些类型的测定装置中是特别有益的，例如基于衍射的测定装置。

公开(公告)号：US07858568B2

公开(公告)日：2010-12-28

申请号：US12692003

申请日：2010-01-22

申请人： John Gavin MacDonald ,  Yanbin Huang ,  Kaiyuan Yang ,  Jaeho Kim ,  Ning Wei

发明人： John Gavin MacDonald ,  Yanbin Huang ,  Kaiyuan Yang ,  Jaeho Kim ,  Ning Wei

IPC分类号： A61K7/00

CPC分类号： C11D3/221 ,  C11D3/0042 ,  C11D3/40

摘要： There is provided a color change composition that remains stable in a single phase and that contains an indicator that produces an observable color change after a period of time to show that sufficient cleaning has been done or to indicate the thoroughness of the cleaning. This use indicating color change is useful for, for example, in soap for teaching children to wash their hands for a sufficient period of time. This composition may be added to many different base materials to indicate time of use or as a way to introduce enjoyment to the activity.

摘要翻译： 提供了颜色变化组合物，其在单一相中保持稳定，并且包含在一段时间之后产生可观察到的颜色变化的指示剂，以显示已经进行足够的清洁或指示清洁的彻底性。 指示颜色变化的这种用途对于例如在肥皂中教孩子们洗手足够长时间是有用的。 这种组合物可以添加到许多不同的基础材料中以指示使用时间或作为向活动引入享受的方式。

公开(公告)号：US07838258B2

公开(公告)日：2010-11-23

申请号：US12570713

申请日：2009-09-30

申请人： Kaiyuan Yang ,  Shawn R. Feaster ,  Ning Wei ,  Rosann M. Kaylor ,  Chibueze O. Chidebelu-Eze

发明人： Kaiyuan Yang ,  Shawn R. Feaster ,  Ning Wei ,  Rosann M. Kaylor ,  Chibueze O. Chidebelu-Eze

IPC分类号： G01N33/53 ,  G01N33/543

CPC分类号： G01N33/54366 ,  B01L3/5023 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0825 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0683 ,  G01N33/558 ,  Y10S436/825 ,  Y10T436/107497 ,  Y10T436/108331

摘要： A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. The kit includes a housing, and a membrane disposed within the housing having a detection region and a collection region. A blood sample meter is provided having a first end for absorption of a blood sample, a filtering section adjacent to the first end that filters red blood cell components from the blood sample, and a storage section adjacent to the filtering section that receives plasma or serum from the filtering section. An opening in the housing is sized for insertion of the sample meter into the housing such that the storage section of the sample meter is disposed in fluid communication with the collection region of the membrane. The plasma or serum is transferred from the storage section of the sample meter to the collection region of the membrane for subsequent migration to the detection region.

摘要翻译： 提供了用于检测驻留在测试样品中的分析物的诊断方法和相关测试试剂盒。 套件包括壳体和设置在壳体内的膜，其具有检测区域和收集区域。 提供血样计，其具有用于吸收血液样本的第一端，与第一端相邻的过滤部分，其从血液样品中过滤红细胞成分，以及与过滤部相邻的存储部，其接收血浆或血清 从过滤部分。 壳体中的开口的尺寸适于将样品计量器插入壳体中，使得样品计量器的存储部分设置成与膜的收集区域流体连通。 将血浆或血清从样品计量器的储存部分转移到膜的收集区域，以便随后迁移到检测区域。

公开(公告)号：US07829328B2

公开(公告)日：2010-11-09

申请号：US11440956

申请日：2006-05-25

申请人： Kaiyuan Yang ,  Ning Wei ,  Rosann Kaylor ,  Chibueze Obinna Chidebelu-Eze ,  Zdravko Savov Atanassov

发明人： Kaiyuan Yang ,  Ning Wei ,  Rosann Kaylor ,  Chibueze Obinna Chidebelu-Eze ,  Zdravko Savov Atanassov

IPC分类号： C12M1/34

CPC分类号： G01N33/587 ,  G01N33/558

摘要： Hollow particles for use in various types of assay devices are provided. Due to their hollow or voided structure, the particles may exhibit a variety of beneficial properties. For instance, hollow particles are generally lightweight, and thus, relatively inexpensive in comparison to other types of particles. Hollow particles may also form a stable system without requiring refrigeration or rotation. In addition, hollow particles may possess enhanced light diffraction capabilities, which may be particularly beneficial in certain types of assay devices, e.g., diffraction-based assay devices.

摘要翻译： 提供了用于各种类型的测定装置的中空颗粒。 由于其中空或空隙结构，颗粒可能表现出各种有益的性质。 例如，中空颗粒通常是轻质的，因此与其它类型的颗粒相比相对便宜。 中空颗粒也可以形成稳定的系统，而不需要制冷或旋转。 此外，中空颗粒可以具有增强的光衍射能力，这在某些类型的测定装置中是特别有益的，例如基于衍射的测定装置。

公开(公告)号：US20080026484A1

公开(公告)日：2008-01-31

申请号：US11867788

申请日：2007-10-05

申请人： James Takeuchi ,  Xuedong Song ,  Kaiyuan Yang ,  Ning Wei ,  Shawn Feaster

发明人： James Takeuchi ,  Xuedong Song ,  Kaiyuan Yang ,  Ning Wei ,  Shawn Feaster

IPC分类号： G01N1/28 ,  G01N1/38

CPC分类号： G01N33/558 ,  Y10S436/825 ,  Y10T436/107497 ,  Y10T436/108331 ,  Y10T436/25375 ,  Y10T436/25625

摘要： A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. A sample membrane is utilized having a collection region and a detection region, the collection region having a known saturation volume for the intended test sample. A barrier is defined between the collection region and the detection region. The collection region is saturated with the test sample having a volume of less than about 100 microliters so that a known volume of the test sample is contained in the collection region. The barrier is removed from between the collection region and detection region of the membrane and a diluent is supplied to the collection region of the membrane to facilitate flow of the test sample from the collection region to the detection region of the membrane.

摘要翻译： 提供了用于检测驻留在测试样品中的分析物的诊断方法和相关测试试剂盒。 使用具有收集区域和检测区域的样品膜，所述收集区域具有用于预期测试样品的已知饱和体积。 在收集区域和检测区域之间限定屏障。 收集区域用体积小于约100微升的测试样品饱和，使得已知体积的测试样品被包含在收集区域中。 从收集区域和膜的检测区域之间移除屏障，并且将稀释剂供应到膜的收集区域，以促进测试样品从收集区域流到膜的检测区域。