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公开(公告)号：US08695354B2
公开(公告)日：2014-04-15
申请号：US12989815
申请日：2009-04-24
IPC分类号： F25B21/00
CPC分类号： F25B21/00 , F25B2321/0022 , Y02B30/66
摘要： The thermal flux generating device (10) with magnetocaloric material comprises an external cylindrical shell (11), made out of metal or any other adequate material, which delimits the inside of the device (10). Inside this shell (11), a rotor (12) is mounted coaxially which consists of a rotary magnetic arrangement, at least one roughly circular ring of elements (13) comprising at least one magnetocaloric material, this ring is positioned coaxially around the rotor (12) and a set of electric coils (14), with radial axes, evenly positioned around the rotor (12) and which make up a stator (15) electrically supplied so as to create a rotating field that rotationally drives the magnetic arrangement.
摘要翻译： 具有磁热材料的热通量产生装置（10）包括由金属或任何其它适当的材料制成的外部圆柱形壳体（11），其限定了装置（10）的内部。 在该壳体（11）的内部，转子（12）同轴地安装，该旋转磁体装置包括至少一个包括至少一个磁热材料的至少一个大致圆形的元件环（13），该环围绕转子 12）和一组具有径向轴线的电动线圈（14），其均匀地围绕转子（12）定位，并且构成电气供应的定子（15），以产生旋转地驱动磁性装置的旋转场。
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公开(公告)号：US08518738B2
公开(公告)日：2013-08-27
申请号：US12306432
申请日：2007-06-29
申请人： Henning Sirringhaus , Shalom Goffri , Rene A. J. Janssen , Christopher Paul Radano , Paul Smith , Christian Muller , Pascal Wolfer , Natalie Stingelin-Stutzmann
发明人： Henning Sirringhaus , Shalom Goffri , Rene A. J. Janssen , Christopher Paul Radano , Paul Smith , Christian Muller , Pascal Wolfer , Natalie Stingelin-Stutzmann
IPC分类号： H01L33/16
CPC分类号： H01L51/0034 , H01L51/0012 , H01L51/0036 , H01L51/0541 , H01L51/0545 , H01L51/0566 , Y02E10/549
摘要： A method for forming a semiconductor body, the method comprising: forming a mixture of an organic semiconducting material and a binder material; causing the semiconducting material to at least partially solidify; and causing the binder material to crystallize in such a way as to cause the semiconducting material to at least partially segregate from the binder material.
摘要翻译： 一种形成半导体体的方法，所述方法包括：形成有机半导体材料和粘合剂材料的混合物; 使半导体材料至少部分地固化; 并使粘结剂材料以使半导体材料至少部分地与粘合剂材料分离的方式结晶。
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公开(公告)号：US08418476B2
公开(公告)日：2013-04-16
申请号：US12745062
申请日：2008-11-25
IPC分类号： F25B21/00
CPC分类号： F25B21/00 , F25B27/00 , F25B2321/0022 , Y02B30/66
摘要： A generator comprising at least one thermal stage having magnetocaloric elements (2) arranged around an axis and a magnetic arrangement (3) supported by a drive shaft (30) that rotates about the axis to subject the elements to a variation in magnetic field. The generator comprises pistons (70) to force heat transfer fluid through the elements with the pistons being driven in reciprocating translation within chambers (73) by at least one cam (71) that is rotationally driven the drive shaft (30). The generator comprises a forced circulation unit (8a) having planet gears (80) arranged around the central axis, supported by the body (72) of the generator and meshing with an inner crown gear (81) integral with the cam (71). Each gear (80) forms a gear pump that mixes the heat transfer fluid and places the fluid in forced circulation in the tanks (74) and the chambers (73).
摘要翻译： 一种发生器，包括至少一个具有绕轴线布置的磁热元件（2）的热级和由绕该轴线旋转以使元件受到磁场变化的驱动轴（30）支撑的磁性装置（3）。 所述发生器包括活塞（70），以迫使传热流体穿过所述元件，所述活塞通过由所述驱动轴（30）旋转驱动的至少一个凸轮（71）在腔室（73）内以往复平移方式被驱动。 发电机包括强制循环单元（8a），该强制循环单元（8a）具有围绕中心轴布置的行星齿轮（80），由发电机的主体（72）支撑，并与与凸轮（71）成一体的内冠齿轮（81）啮合。 每个齿轮（80）形成齿轮泵，该齿轮泵混合传热流体并将流体强制循环置于储罐（74）和腔室（73）中。
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公开(公告)号：US08348637B2
公开(公告)日：2013-01-08
申请号：US12670933
申请日：2008-06-23
IPC分类号： F01C1/18
CPC分类号： F04C2/084 , F04C2/18 , F04C14/10 , Y10T137/0318
摘要： A gear pump capable of alternately distributing a fluid in two distinct utilization circuits without the need for a switch. The gear pump (1) comprises two fluid outlet ports (5, 6) connected to two fluid utilization circuits and linked to the discharge chamber (C) of the pump via an integrated commutation (7). These commutation (7) comprise two distribution circuits (50, 60), located in a fixed support plate (70), and two buffer channels (30, 40), located in the rotary toothed wheels (3), arranged so as to alternately open and close the distribution circuits according to a commutation cycle that approximately corresponds to the rotation of the toothed wheels over half a revolution.
摘要翻译： 能够在不需要开关的情况下在两个不同的利用回路中交替地分配流体的齿轮泵。 齿轮泵（1）包括连接到两个流体利用回路的两个流体出口端口（5,6），并通过集成换向（7）连接到泵的排放室（C）。 这些换向（7）包括位于固定支撑板（70）中的两个分配回路（50,60）和位于旋转齿轮（3）中的两个缓冲通道（30,40） 根据大致对应于齿轮旋转半圈的换向循环来打开和关闭配电回路。
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公开(公告)号：US08258658B2
公开(公告)日：2012-09-04
申请号：US12989816
申请日：2009-04-24
IPC分类号： H02K9/00
CPC分类号： H02K9/00 , F25B21/00 , F25B2321/002 , H02K1/02 , H02K5/12 , H02K9/02 , H02K9/22 , H02K21/16 , Y02B30/66
摘要： The electric motor (10) of the rotary type comprises a circular peripheral frame (11) inside of which a stator (12) is mounted, and the stator (12) comprises electrical coils (13) having each an armature (13a) and a winding of conductive wires (13b). The electric motor (10) comprises equipment (14) which is movable in relation to the stator, this mobile equipment is in this case a rotor (15) arranged coaxially in relation to the stator (12). The rotor (15) comprises a set of electric coils (16) which are electromagnets. The armatures (13a) of the electric coils (13) and those of the electric coils (16) comprise advantageously at least one element out of reverse magnetocaloric material arranged so as to contribute to cooling of the electric motor.
摘要翻译： 旋转型电动机（10）包括圆周周边框架（11），其中安装有定子（12），定子（12）包括电线圈（13），每个电枢具有电枢（13a）和 绕组导线（13b）。 电动机（10）包括相对于定子可移动的设备（14），该移动设备在这种情况下是相对于定子（12）同轴设置的转子（15）。 转子（15）包括一组电磁线圈（16），它们是电磁体。 电线圈（13）的电枢（13a）和电线圈（16）的电枢有利地包括反向磁热材料中的至少一个元件，其布置成有助于电动机的冷却。
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公开(公告)号：US07910332B2
公开(公告)日：2011-03-22
申请号：US12153809
申请日：2008-05-23
申请人： Lars Soegaard Nielsen , Dietmar Weilguny , Anne Bondgaard Tolstrup , Finn C. Wiberg , Christian Muller
发明人： Lars Soegaard Nielsen , Dietmar Weilguny , Anne Bondgaard Tolstrup , Finn C. Wiberg , Christian Muller
CPC分类号： C12N15/1086 , C07K16/00 , C07K16/081
摘要： The invention relates to a method for manufacturing a recombinant polyclonal protein composition, in particular a recombinant polyclonal antibody composition. The method comprises obtaining a collection of cells transfected with a collection of variant nucleic acid sequences, wherein each cell in the collection is transfected with and capable of expressing one member of the collection, which encodes a distinct member of a polyclonal protein. The cells are cultured under suitable conditions for expression of the polyclonal protein, which is obtained from the cells or culture supernatant. The nucleic acid sequence is introduced into the cells by transfection with a collection of vectors. The present method is suitable for manufacturing recombinant polyclonal antibodies for therapeutic uses.
摘要翻译： 本发明涉及制备重组多克隆蛋白质组合物，特别是重组多克隆抗体组合物的方法。 该方法包括获得用变体核酸序列的集合转染的细胞的集合，其中集合中的每个细胞被转染并能够表达编码多克隆蛋白的不同成员的集合的一个成员。 细胞在合适的条件下培养，用于表达从细胞或培养物上清液获得的多克隆蛋白质。 通过用载体的集合转染将核酸序列引入细胞。 本发明方法适用于制备用于治疗用途的重组多克隆抗体。
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公开(公告)号：US20100236258A1
公开(公告)日：2010-09-23
申请号：US12682899
申请日：2008-10-17
IPC分类号： F25B21/00
CPC分类号： F25B21/00 , F25B2321/0022 , Y02B30/66
摘要： A heat generator (1) comprising at least one thermal module (10) that comprises N adjacent magnetocaloric elements (2) arranged in a circle around a central axis (A) and subjected to a varying magnetic field caused by magnetic devices (3). The magnetocaloric elements (2) are associated with N pistons (40) subjected to an reciprocating translation movement by an actuating cam (70) to circulate the heat transfer fluid, contained in the thermal module (10), in two opposite directions, at the same time, so that a first fraction of the heat transfer fluid circulates towards a hot exchange chamber (5), through the magnetocaloric elements (2) and is subjected to a heating cycle, and a second fraction of the heat transfer fluid circulates towards a cold exchange chamber (6), through the magnetocaloric elements (2), and is subjected to a cooling cycle, and inversely. The exchange chambers (5, 6) are coupled with external circuits that use calories and frigories for heating, air-conditioning, tempering systems, etc.
摘要翻译： 一种热发生器（1），包括至少一个热模块（10），其包括围绕中心轴线（A）绕圆周布置并且经受由磁性装置（3）引起的变化的磁场的N个相邻的磁热元件（2）。 磁热元件（2）与通过致动凸轮（70）进行往复平移运动的N个活塞（40）相关联，以使包含在热模块（10）中的传热流体在两个相反的方向上循环 使得传热流体的第一部分通过磁热元件（2）朝向热交换室（5）循环并且经受加热循环，并且传热流体的第二部分朝向 冷交换室（6），通过磁热元件（2），并经受冷却循环，并且相反。 交换室（5,6）与加热，空调，回火系统等使用卡路里和冰箱的外部回路耦合。
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公开(公告)号：US20090320499A1
公开(公告)日：2009-12-31
申请号：US12306817
申请日：2007-07-09
CPC分类号： F25B21/00 , F25B2321/0022 , F25B2321/0023 , Y02B30/66
摘要： The present invention concerns a compact, multi-purpose magneto-calorific thermal generator of high thermal efficiency, having a maximal heat exchange coefficient, while being simple to industrialise in order to respond to a wide range of both industrial and domestic applications.The thermal generator (1) is characterised in that it comprises at least one thermal module (10) constituted from many thermal elements (40), stacked and arranged in order to delimit between each other channels for the circulation of heat transfer fluid, these channels being divided into hot channels in which the heat transfer fluid of the hot circuit flows and cold channels in which the heat transfer fluid of the cold circuit flows, the hot and cold channels being alternated between the said thermal elements (40) and in that the said thermal elements have fluid inlet and outlet orifices which communicate with each other so as to distribute the flow of heat transfer fluid of each hot and cold collector circuit respectively in the corresponding hot and cold channels.Applications: Heating, tempering, air conditioning or refrigeration in any industrial or domestic installation.
摘要翻译： 本发明涉及具有最大热交换系数的具有高热效率的紧凑型多功能磁热发电机，同时易于工业化以便响应工业和家用应用的广泛范围。 热发生器（1）的特征在于，其包括由多个热元件（40）构成的至少一个热模块（10），其被堆叠和布置以便在彼此之间限定用于传热流体循环的通道 被分成热通道的热通道流动的热通道和冷回路的传热流体流过的冷通道，热和冷通道在所述热元件（40）之间交替，并且其中 所述热元件具有彼此连通的流体入口和出口孔，以将每个热和冷收集器回路的传热流体流分别分配在相应的热和冷通道中。 应用：任何工业或家庭设备中的加热，回火，空调或制冷。
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公开(公告)号：US20090198055A1
公开(公告)日：2009-08-06
申请号：US12349479
申请日：2009-01-06
申请人： Mark Henderson , Steven Jungles , Gabriele Roidl , Robert Baffi , Adriano Indolese , Christian Muller , Philipp Schmidt , Stefan Kaiser
发明人： Mark Henderson , Steven Jungles , Gabriele Roidl , Robert Baffi , Adriano Indolese , Christian Muller , Philipp Schmidt , Stefan Kaiser
IPC分类号： C07D475/04
CPC分类号： C07D487/04
摘要： The present disclosure provides a method that efficiently produces (6R)-tetrahydrobiopterin in high yield and purity. The method includes the step of hydrolyzing diacetylbiopterin to biopterin under basic conditions in a biphasic mixture comprising an organic phase and an aqueous phase. After substantially complete hydrolysis of diacetylbiopterin, the aqueous phase containing biopterin can be separated from the organic phase containing most of the organic impurities, which avoids the time-consuming step of isolating biopterin as a solid. The aqueous solution containing biopterin is stereoselectively hydrogenated to (6R)-tetrahydrobiopterin under basic conditions and high hydrogen pressure in the presence of a metal catalyst (e.g., a platinum catalyst). To improve the purification of an acid addition salt of (6R)-tetrahydrobiopterin (e.g., (6R)-tetrahydrobiopterin dihydrochloride), any residual salts (e.g., sodium salts) in the aqueous solution after the hydrogenation reaction can be removed by contacting the aqueous solution with an ion (e.g., cation) exchange resin or column. Alternatively, removal of residual salts from the aqueous solution can be omitted if an organic amine (e.g., diethylamine or triethylamine) rather than an inorganic base is used in the hydrolysis and/or hydrogenation reactions.
摘要翻译： 本公开提供了以高产率和纯度有效生产（6R） - 四氢生物蝶呤的方法。 该方法包括在碱性条件下在包含有机相和水相的两相混合物中将二乙酰生物蝶呤水解成生物蝶呤的步骤。 在二乙酰生物蝶呤基本上完全水解后，含有生物蝶呤的水相可以从含有大部分有机杂质的有机相中分离出来，这避免了将生物蝶呤分离成固体的耗时的步骤。 含有生物蝶呤的水溶液在碱性条件下，在金属催化剂（如铂催化剂）存在下，氢压高，立体选择氢化为（6R） - 四氢生物喋呤。 为了改善（6R） - 四氢生物蝶呤（例如（6R） - 四氢生物喋呤二盐酸盐）的酸加成盐的纯化，氢化反应后的水溶液中的任何残留盐（例如钠盐）可以通过使水溶液 溶液与离子（如阳离子）交换树脂或色谱柱。 或者，如果在水解和/或氢化反应中使用有机胺（例如二乙胺或三乙胺）而不是无机碱，则可以从水溶液中除去残留的盐。
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公开(公告)号：US20080236172A1
公开(公告)日：2008-10-02
申请号：US12065133
申请日：2006-08-16
IPC分类号： F25B21/00
CPC分类号： F25B21/00 , F25B2321/0022 , Y02B30/66
摘要： The present invention proposes a thermal generator which is non-polluting, has very good energy efficiency, is of simple and economical design and uses little energy, at the same time as being capable of further development, flexible and modular. In this thermal generator (1), the thermal elements (3) composed of magneto-calorific material each comprises two separate collector circuits (31 and 32), a “hot” collector circuit connected to a hot heat transfer fluid circuit (51) and a “cold” collector circuit (32) linked to a cold heat transfer fluid circuit (52). The heat transfer fluid is made to move alternately in one or the other of the collector circuits (31 and 32) depending on whether or not the thermal elements (3) are subjected to the magnetic field generated by the magnets (40) moving in rotation around a central axis (B) with respect to the thermal elements (3). The heat transfer fluid circuits (51 and 52) are partly incorporated in a plate (2) carrying the said thermal elements (3) and connected to external circuits which have heat exchangers (55 and 56) using the calories and frigories generated by those thermal elements (3).
摘要翻译： 本发明提出一种无污染的热发生器，具有非常好的能量效率，设计简单经济，能耗少，能够进一步开发，灵活和模块化。 在该热发生器（1）中，由磁热材料构成的热元件（3）分别包含两个分开的收集电路（31,32），连接到热传热流体回路（51）的“热” 连接到冷传热流体回路（52）的“冷”收集器回路（32）。 根据热元件（3）是否受到由旋转的磁体（40）产生的磁场的影响，使传热流体交替地在一个或另一个集电器电路（31和32）中移动 围绕中心轴线（B）相对于热元件（3）。 传热流体回路（51和52）部分地结合在承载所述热元件（3）的板（2）中，并连接到使用由这些热量产生的热量和热量的热交换器（55和56）的外部回路 元素（3）。
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