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公开(公告)号：US08626291B2
公开(公告)日：2014-01-07
申请号：US13192713
申请日：2011-07-28
IPC分类号： A61N1/365
CPC分类号： A61N1/371 , A61N1/3684 , A61N1/3686 , A61N1/3712
摘要： An implantable device and associated method detect anodal capture during electrical stimulation. A first pacing pulse is delivered using a first cathode and a first anode. A second pacing pulse is delivered using the first cathode and a second anode. A first response to the first pacing pulse and a second response to the second pacing pulse are measured. Anodal capture of the first pacing pulse at the first anode is detected in response to a first difference between the first response and the second response.
摘要翻译： 可植入装置和相关方法在电刺激期间检测阳极捕获。 使用第一阴极和第一阳极传送第一起搏脉冲。 使用第一阴极和第二阳极传送第二起搏脉冲。 测量对第一起搏脉冲的第一响应和对第二起搏脉冲的第二响应。 响应于第一响应和第二响应之间的第一差异来检测在第一阳极处的第一起搏脉冲的阳极捕获。
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公开(公告)号：US20130289636A1
公开(公告)日：2013-10-31
申请号：US13652815
申请日：2012-10-16
CPC分类号： A61N1/36167 , A61N1/3606 , A61N1/3962
摘要： Pulseless electrical activity (PEA) is reduced or eliminated. A medical electrical lead is implanted to deliver high voltage therapy to a fibrillating heart. Another medical electrical lead delivers electrical stimulation through an electrode proximate phrenic nerve tissue in response to the delivery of high voltage therapy to the fibrillating heart.
摘要翻译： 无脉动电活动（PEA）减少或消除。 植入医用电导线以将高电压治疗提供给原纤维心脏。 响应于向原纤维心脏递送高电压治疗，另一医疗电导线通过靠近膈神经组织的电极进行电刺激。
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公开(公告)号：US08504158B2
公开(公告)日：2013-08-06
申请号：US13103735
申请日：2011-05-09
IPC分类号： A61N1/00
CPC分类号： A61N1/3611 , A61B5/0452 , A61B5/0826 , A61B5/4836 , A61B5/686 , A61N1/3601 , F04C2270/0421
摘要： A method includes estimating a cardiac signal of a patient, estimating a length of a cardiac refractory period based in part on the cardiac signal and selectively adjusting the length of phrenic nerve electrical stimulation to be delivered to the patient based on the estimated length of the cardiac refractory period. In some examples the method includes delivering phrenic nerve stimulation for approximately the entire refractory period. The phrenic nerve stimulation may be used to treat a variety of breathing disorders.
摘要翻译： 一种方法包括估计患者的心脏信号，部分地基于心脏信号估计心脏不应期的长度，并且基于估计的心脏长度来选择性地调节要递送给患者的膈神经电刺激的长度 不应期。 在一些实例中，该方法包括在大约整个不应期内输送膈神经刺激。 膈神经刺激可用于治疗各种呼吸障碍。
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公开(公告)号：US08478413B2
公开(公告)日：2013-07-02
申请号：US13192256
申请日：2011-07-27
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61N1/36139 , A61N1/36178
摘要： A system and associated method deliver a respiration therapy. Stimulation pulses are delivered to activate a right portion of a patient's diaphragm and to activate a left portion of a patient's diaphragm. A control processor determines dyssynchrony of a respiratory response to the stimulation pulses and adjusts a stimulation control parameter controlling the delivering of the stimulation pulses in response to dyssynchrony of the respiratory response.
摘要翻译： 系统和相关方法提供呼吸治疗。 输送刺激脉冲以激活患者隔膜的右侧部分并激活患者隔膜的左侧部分。 控制处理器确定对刺激脉冲的呼吸响应的不同步，并且调整响应于呼吸响应的不同步来控制刺激脉冲的传递的刺激控制参数。
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公开(公告)号：US20130131749A1
公开(公告)日：2013-05-23
申请号：US13301113
申请日：2011-11-21
CPC分类号： A61N1/3627 , A61N1/3686 , A61N1/371
摘要： An implantable device and associated method for delivering a multi-site pacing therapy includes electrodes for sensing cardiac signals and delivering cardiac pacing pulses. Electrodes positioned at first and second selected pacing sites are used to deliver pacing pulses to a first heart chamber using a bipole comprising the first electrode and the second electrode. A controller is configured to determine if anodal and cathodal capture can be achieved during pacing using the bipole. Responsive to anodal and cathodal capture being achieved, the controller selects a multi-site pacing configuration comprising the bipole for singly pacing the first and second pacing sites
摘要翻译： 用于递送多部位起搏治疗的可植入装置和相关联的方法包括用于感测心脏信号和递送心脏起搏脉冲的电极。 使用位于第一和第二选定的起搏部位的电极，使用包括第一电极和第二电极的双极将起搏脉冲输送到第一心室。 控制器被配置为确定在使用双极的起搏期间是否可以实现阳极和阴极捕获。 响应于实现阳极和阴极捕获，控制器选择包括用于单步起搏第一和第二起搏部位的双极的多位置起搏配置
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公开(公告)号：US20130131748A1
公开(公告)日：2013-05-23
申请号：US13301084
申请日：2011-11-21
CPC分类号： A61N1/3684 , A61N1/368 , A61N1/3686 , A61N1/3712
摘要： An implantable device and associated method for delivering a multi-site pacing therapy includes electrodes for sensing cardiac signals and delivering cardiac pacing pulses to a first pacing site along a heart chamber and a therapy delivery module for delivering cardiac pacing pulses to a patient's heart via the electrodes. A sensing module measures an activation time at multiple pacing electrode sites along the heart chamber in response to delivering pacing pulses at the first pacing site. A controller is configured to identify a second pacing site from the plurality of pacing electrode sites in response to the activation times measured during pacing at the first site.
摘要翻译： 用于递送多部位起搏治疗的可植入装置和相关联的方法包括用于感测心脏信号并将心脏起搏脉冲输送到沿着心脏室的第一起搏部位的电极和用于经由心脏起搏器将心脏起搏脉冲输送到患者心脏的治疗递送模块 电极。 响应于在第一起搏部位输送起搏脉冲，感测模块测量沿着心室的多个起搏电极部位的激活时间。 控制器被配置为响应于在第一站点的起搏期间测量的激活时间，从多个起搏电极位置识别第二起搏部位。
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公开(公告)号：US08391964B2
公开(公告)日：2013-03-05
申请号：US12463470
申请日：2009-05-11
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/726 , A61N1/3702
摘要： Techniques are described for detecting conduction abnormalities in a heart of a patient. In particular, an IMD may be configured to obtain electrical signals corresponding to cardiac activity of the heart of the patient and periodically analyze a most recent electrical signal of the obtained electrical signals to detect an electrical conduction abnormality of the heart. The IMD adjusts a frequency at which the most recent electrical signal is analyzed based on at least one physiological parameter of the patient. For example, the IMD may increase the frequency at which the most recent electrical signal is analyzed when a heart rate parameter has significantly changed and the number of detected premature ventricular contractions (PVCs) is greater than or equal to a threshold number. In this manner, the most recent electrical signal is analyzed at a higher frequency in situations in which conduction abnormalities are more likely.
摘要翻译： 描述了用于检测患者心脏中的传导异常的技术。 特别地，可以将IMD配置为获得对应于患者心脏的心脏活动的电信号，并且周期性地分析所获得的电信号的最新电信号以检测心脏的电传导异常。 IMD基于患者的至少一个生理参数来调整分析最近的电信号的频率。 例如，当心率参数已经显着改变并且检测到的早产性心室收缩（PVC）的数量大于或等于阈值数量时，IMD可以增加最近的电信号被分析的频率。 以这种方式，在导电异常更可能的情况下，以更高的频率分析最新的电信号。
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公开(公告)号：US06988215B2
公开(公告)日：2006-01-17
申请号：US09952914
申请日：2001-09-14
IPC分类号： G06F1/12
CPC分类号： G06F1/3209 , A61N1/372 , G06F1/08 , G06F1/12 , G06F1/3203 , G06F1/3215 , G06F1/324 , Y02D10/126
摘要： A method and an apparatus for synchronizing clock domains. A slow clock signal is received. A circuit in a slow clock domain is operated based upon the slow clock signal. A fast clock signal is received. The slow clock signal is synchronized using the fast clock signal. The operation of the circuit is modified from the slow clock domain to the fast clock domain, modifying the operation comprising changing a clock operation frequency during a non-transition period of the slow clock.
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