公开(公告)号：US09353368B2

公开(公告)日：2016-05-31

申请号：US12601508

申请日：2008-05-22

Applicant: Melissa Kelley ,  Amanda Birmingham ,  Jon Karpilow ,  Anastasia Khvorova ,  Kevin Sullivan

Inventor： Melissa Kelley ,  Amanda Birmingham ,  Jon Karpilow ,  Anastasia Khvorova ,  Kevin Sullivan

IPC: C12N15/11 ,  C07H21/04 ,  C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2320/30 ,  C12N2330/30 ,  C12Q1/6869

Abstract: The present disclosure provides a non-naturally occurring miRNA having a stem-loop structure comprising a scaffold derived from a first endogenous miRNA (e.g., miR-196a-2 or miR-204), a mature strand derived from a second endogenous miRNA, and a star strand sequence that is at least partially complementary to the mature strand sequence. The present disclosure also provides a non-naturally occurring miRNA having a stem-loop structure comprising a scaffold derived from an endogenous miRNA (e.g., miR-196a-2 or miR-204), a mature strand designed t be at least partially complementary to a target RNA, and a star strand sequence that is at least partially complementary to the mature strand sequence. The methods and compositions of the disclosure may be used to mediate gene silencing via the RNAi pathway.

Abstract translation: 本公开提供了非天然存在的具有茎环结构的miRNA，其包含源自第一内源miRNA（例如，miR-196a-2或miR-204）的支架，源自第二内源miRNA的成熟链，以及 与成熟链序列至少部分互补的星形链序列。 本公开还提供了非天然存在的miRNA，其具有包含源自内源miRNA（例如，miR-196a-2或miR-204）的支架的茎环结构，成熟链被设计为至少部分地与 靶RNA和与成熟链序列至少部分互补的星形链序列。 本公开的方法和组合物可用于通过RNAi途径介导基因沉默。

公开(公告)号：US20140109113A1

公开(公告)日：2014-04-17

申请号：US14116611

申请日：2012-05-09

Applicant: E. Webb Stacy ,  Kevin Sullivan ,  Paul Picciano ,  Can Keskin

Inventor： E. Webb Stacy ,  Kevin Sullivan ,  Paul Picciano ,  Can Keskin

IPC: G06F9/54

CPC classification number: A63F13/60 ,  A63F2300/6009 ,  A63F2300/8017 ,  G06F9/542 ,  G09B9/08

Abstract: Processor based systems and methods of defining a scenario event comprising the steps of identifying an event having an event attribute and generalizing the event attribute to define a generalized event whereby the generalized event is the scenario event. In some embodiments, the steps further comprise identifying a first and second event, generalizing a first and second event attribute to define a first and second generalized event and connecting the first and second generalized event in a continuous envelope to create a scenario envelope. Also disclosed are processor based systems and methods of monitoring an activity comprising the steps of monitoring an activity having an activity attribute and comparing the activity attribute to an event envelope to determine a status of the activity relative to the event envelope.

Abstract translation: 基于处理器的系统和定义场景事件的方法包括以下步骤：识别具有事件属性的事件并概括该事件属性以定义广义事件，从而广义事件是场景事件。 在一些实施例中，所述步骤还包括识别第一和第二事件，推广第一和第二事件属性以定义第一和第二广义事件并且将连续包络中的第一和第二广义事件连接以创建场景包络。 还公开了基于处理器的系统和监视活动的方法，包括以下步骤：监视具有活动属性的活动并将活动属性与事件包络进行比较，以确定活动相对于事件包络的状态。

公开(公告)号：US20110177931A1

公开(公告)日：2011-07-21

申请号：US13120984

申请日：2009-09-25

Applicant: James Kelland ,  Henry Petithory ,  Kevin Sullivan

Inventor： James Kelland ,  Henry Petithory ,  Kevin Sullivan

IPC: B04B7/18

CPC classification number: B01L3/50215 ,  A61B10/0038 ,  B01L2200/025 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2300/0854 ,  B01L2400/0478 ,  B01L2400/0683

Abstract: A centrifugal assembly is provided that can be used in common laboratory fixed angle or swinging bucket centrifuges for the separation of material, such as parasitic ova, based on particle density. The centrifugal assembly allows the fluid level to be gently adjusted to form a meniscus without disruption of the buoyant matter, such as ova. The centrifugal assembly also enables a user to easily and hygienically collect and transfer a measured amount of a sample, such as fecal material, and to break apart and mix the sample with a floatation fluid contained in a centrifuge tube.

Abstract translation: 提供了一种离心组件，可用于普通的实验室固定角度或摆动式离心机中，用于基于颗粒密度分离材料，如寄生卵。 离心组件允许轻轻地调整液面以形成弯月面而不破坏浮力物质，例如ova。 离心组件还使得使用者能够容易且卫生地收集和转移测量量的诸如粪便材料的样品，并且将样品与包含在离心管中的浮选流体分开并混合。

公开(公告)号：US07806381B2

公开(公告)日：2010-10-05

申请号：US11842442

申请日：2007-08-21

Applicant: Tammy Sisk Horne ,  Kevin Sullivan

Inventor： Tammy Sisk Horne ,  Kevin Sullivan

IPC: A47F5/00

CPC classification number: E04G25/06 ,  E04G25/061 ,  E04G2025/047 ,  Y10T403/32467

Abstract: A stabilization and support strut for use in rescue operations in buildings, trenches, vehicle accidents, and the like has secure deployment features including first and second inter-fitting collar assemblies, the first collar assembly including a first collar, circumferentially based spring-biased piston-retaining pins mounted in the collar for fitting into orifices in a piston body, and a locking pin for precluding rotation and axial movement of the first collar on the strut; and the second collar assembly including a second collar rotatingly secured on the barrel with a portion of the second collar underlying the first and having a circumferentially inclined ratchet surface for snugly engaging the piston-retaining pins upon rotation of the second collar, the second collar further including rotatable studs for engaging the barrel and precluding rotation of the second collar about the barrel when snug against the piston-retaining pins.

Abstract translation: 用于在建筑物，沟槽，车辆事故等中的救援操作中的稳定和支撑支柱具有安全的展开特征，包括第一和第二相互嵌合的套环组件，第一套环组件包括第一套环，周向基于弹簧偏置的活塞 - 安装在轴环中的销钉，用于装配到活塞体中的孔中;以及锁定销，用于排除第一颈圈在支柱上的旋转和轴向移动; 并且所述第二套环组件包括旋转地固定在所述筒上的第二轴环，所述第二轴环的一部分位于所述第一轴套的下方并且具有周向倾斜的棘轮表面，用于在所述第二轴环旋转时紧密地接合所述活塞保持销， 包括用于接合桶的可旋转螺柱，并且当紧贴活塞保持销时阻止第二轴环围绕筒的旋转。

公开(公告)号：US07562369B1

公开(公告)日：2009-07-14

申请号：US09890536

申请日：2000-01-28

Applicant: Julie Salamone ,  Alan Clarke ,  Paul Kiely ,  Ronald C Witham, Jr. ,  Kevin Sullivan

Inventor： Julie Salamone ,  Alan Clarke ,  Paul Kiely ,  Ronald C Witham, Jr. ,  Kevin Sullivan

IPC: G06F9/00

CPC classification number: G06F9/54 ,  H04L29/06 ,  H04L67/2842 ,  H04L67/34 ,  H04L69/329

Abstract: A computer implemented method of activating a process. The method includes the steps of generating one or more first plug-ins each configured to activate a target process, dynamically registering the first plug-ins with a second plug-in, and permanently storing information relating to each registered first plug-in. A server computer in a client-server computer system that includes one or more first plug-ins each configured to activate a target process, and a second plug-in configured to dynamically register the first plug-ins and to permanently store information relating to the registered first plug-ins.

Abstract translation: 一种激活过程的计算机实现方法。 该方法包括以下步骤：生成一个或多个第一插件，每个插件被配置为激活目标进程，用第二插件动态地注册第一插件，并且永久地存储与每个注册的第一插件有关的信息。 客户机 - 服务器计算机系统中的服务器计算机，其包括被配置为激活目标进程的一个或多个第一插件，以及第二插件，被配置为动态地注册第一插件并且永久地存储与 注册了第一个插件。

公开(公告)号：US20080162707A1

公开(公告)日：2008-07-03

申请号：US11617556

申请日：2006-12-28

Applicant: Robert L. Beck ,  Kevin Sullivan ,  Peter Loveless

Inventor： Robert L. Beck ,  Kevin Sullivan ,  Peter Loveless

IPC: G06F15/16

CPC classification number: G06F21/6218 ,  G06F2221/2137 ,  H04L69/28

Abstract: A user object is created via an administrator interface. The user object indicates access to system resources for an individual user. The user object is provided a permission time period specifying when a user associated with the object can access the system resource with a computing device. To access the resource, the computing device would generate a request or attempt to access the system resource. In response the request or access attempt, the user object is read to determine when the user of the computing device can access the resource. The user of the computing device could be provided access to the resource during the time period and denied access to the resource outside of the time period.

Abstract translation: 通过管理员界面创建用户对象。 用户对象指示访问单个用户的系统资源。 为用户对象提供了一个许可时间段，指定何时与对象相关联的用户可以使用计算设备访问系统资源。 为了访问资源，计算设备将产生请求或尝试访问系统资源。 响应于请求或访问尝试，读取用户对象以确定计算设备的用户何时可以访问资源。 可以提供计算设备的用户在该时间段期间对资源的访问，并且在该时间段之外拒绝对资源的访问。

公开(公告)号：US20060016664A1

公开(公告)日：2006-01-26

申请号：US10897515

申请日：2004-07-23

Applicant: Robert Pallini ,  Kevin Sullivan ,  Werner Guilford

Inventor： Robert Pallini ,  Kevin Sullivan ,  Werner Guilford

IPC: B65G13/00

CPC classification number: B65G39/025 ,  F16C29/046 ,  F16C2326/58

Abstract: An extended life ball transfer unit has a housing with a well of generally cup-shaped configuration with at least the lower portion of its surface being defined by a pair of radii mutually offset to opposite sides from its vertical axis to generate a gothic church arch cross section. A passage extends therethrough at the base of the housing well. Sealed in the well is a spherical conveyor ball having a radius of smaller length than the radii defining the lower surface of the well, and the well defining radii having their origins above the center of the conveyor ball. A multiplicity of spherical bearing balls is disposed between the conveyor ball and at least the lower portion of the well. The bearing balls support the conveyor ball and transferring the load from the conveyor ball to the housing over an annular area defined by an arc of about 5-15° with its center spaced about 30°-40° upwardly from the passage. A annular cap is seated in the upper portion of the well and has an inner surface portion bearing against the surface of the conveyor ball to provide a sealing action limiting debris from passing into the lower portion of the well.

Abstract translation: 延长寿命的球传递单元具有壳体，其具有大致杯状构造的孔，其表面的至少下部由相对偏移到与其垂直轴线相对的侧面的一对半径限定，以产生哥特式教堂拱形十字 部分。 通道在壳体的底部延伸穿过其中。 密封在井中的是具有比限定井的下表面的半径小的半径的球形输送球，并且阱限定半径的起源位于输送球的中心之上。 多个球形轴承滚珠设置在传送滚珠与孔的至少下部之间。 轴承球支撑输送球，并将负载从输送球传递到壳体上，在由大约5-15°的弧度限定的环形区域上，其中心与通道向上间隔约30°-40°。 环形盖位于井的上部，并且具有抵靠输送球表面的内表面部分，以提供限制碎屑进入井的下部的密封动作。

公开(公告)号：US20050251470A1

公开(公告)日：2005-11-10

申请号：US11184502

申请日：2005-07-15

Applicant: Kevin Sullivan

Inventor： Kevin Sullivan

IPC: G06Q30/00 ,  G06F17/60

CPC classification number: G06Q30/02 ,  G06Q20/10 ,  G06Q20/105 ,  G06Q30/00 ,  G06Q40/00 ,  G06Q40/04

Abstract: A computerized method and system for implementing such method, the method comprising establishing a card payment instrument account for an approved customer and an investment account for the benefit of the approved customer. A rebate is calculated periodically based on credit card usage and the rebate is applied to fund the investment account periodically. The rebate is the only flnding of the investment account accomplished through the card payment instrument account.

Abstract translation: 一种用于实现这种方法的计算机化方法和系统，所述方法包括为获得批准的客户的利益建立用于已批准客户的卡支付工具账户和投资账户。 根据信用卡使用情况定期计算回扣，并定期回馈投资账户。 退款是通过卡支付工具账户完成的投资账户的唯一折扣。

公开(公告)号：US06745938B2

公开(公告)日：2004-06-08

申请号：US10103861

申请日：2002-03-25

Applicant: Kevin Sullivan

Inventor： Kevin Sullivan

IPC: G06F1760

CPC classification number: G06Q40/02 ,  G06Q20/24 ,  G06Q20/387

Abstract: An apparatus and method for a card payment instrument providing that a percentage of consumer spending is rebated to the consumer for payment of premiums or the like for an account with an insurance company. In one version, an applicant provides a benefiting insurance account number to which the rebate is credited based on the rebate amount. The rebate is automatically submitted by the card issuer to the insurance account and, depending on the sizes of the rebate and premium, the cardholder may receive a bill reflecting a reduced premium or even a credit from the insurance concern. In another version, the rebate is submitted as a two-party check which can be cashed by the consumer or submitted by the consumer to the insurance company for cashing.

Abstract translation: 一种用于卡支付工具的装置和方法，其提供消费者支出的百分比被退还给消费者以支付与保险公司的帐户的保费等。 在一个版本中，申请人提供一个有益保险帐号，退款金额根据退款金额抵扣。 发卡机构自动将退款提交给保险账户，根据退款和保费的大小，持卡人可能会收到一个反映保险费降低的费用甚至是保险金的信用证。 在另一个版本中，退款作为双方支票提交，可以由消费者兑现或由消费者提交给保险公司进行兑现。

公开(公告)号：US5243761A

公开(公告)日：1993-09-14

申请号：US853637

申请日：1992-03-18

Applicant: Kevin Sullivan ,  Arnold E. Redsicker ,  Thomas W. Hotchkiss

Inventor： Kevin Sullivan ,  Arnold E. Redsicker ,  Thomas W. Hotchkiss

IPC: A62B3/00 ,  B23D17/00 ,  B23D17/06

CPC classification number: B23D17/06 ,  A62B3/005 ,  B23D17/00

Abstract: A rescue tool as incorporated into a portable unit both the tool operating mechanism and the hydraulic power means necessary to provide a self-contained tool. An elongated tool body comprises the rescue tool mechanism and its associated hydraulic actuator unit, an air/oil intensifier pump for driving the hydraulic actuator unit, the control valves for the pump, and an air valve for actuating the hydraulic control valves to their control positions, whereby the only hose connection to the portable unit is a single air hose for supplying high pressure air.

Abstract translation: 一种将便携式装置结合在一起的救援工具，即工具操作机构和提供独立工具所需的液压动力装置。 一个细长的工具主体包括救援工具机构及其相关的液压执行器单元，用于驱动液压致动器单元的空气/油增压器泵，用于泵的控制阀以及用于将液压控制阀致动到其控制位置的空气阀 由此与便携式单元的唯一软管连接是用于供应高压空气的单个空气软管。