公开(公告)号：US11725171B2

公开(公告)日：2023-08-15

申请号：US16502245

申请日：2019-07-03

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael E. Goodwin ,  Nephi D. Jones

IPC: C12M1/00 ,  C12M3/00 ,  C12M1/06 ,  C12M1/34 ,  B01F27/61 ,  B01F27/07 ,  B01F27/113 ,  B01F27/213 ,  B01F27/2121 ,  B01F27/231 ,  B01F33/00 ,  B01F35/513 ,  B01F35/22 ,  B01F35/71

CPC classification number: C12M23/14 ,  B01F27/071 ,  B01F27/113 ,  B01F27/213 ,  B01F27/2121 ,  B01F27/2312 ,  B01F27/61 ,  B01F33/86 ,  B01F35/2209 ,  B01F35/513 ,  C12M23/26 ,  C12M23/48 ,  C12M23/52 ,  C12M27/02 ,  C12M27/06 ,  C12M41/00 ,  B01F35/715

Abstract: A fluid mixing system includes a support housing having an interior surface bounding a chamber. A flexible bag is disposed within the chamber of the support housing, the flexible bag having an interior surface bounding a compartment. An impeller is disposed within the chamber of the flexible bag. A drive shaft is coupled with the impeller such that rotation of the drive shaft facilitates rotation of the impeller. A drive motor assembly is coupled with the draft shaft and is adapted to rotate the drive shaft. An adjustable arm assembly is coupled with the drive motor assembly and is adapted to move the drive motor assembly which in turn moves the position of the drive shaft and impeller. An electrical controller can control movement of the adjustable arm.

公开(公告)号：US11591556B2

公开(公告)日：2023-02-28

申请号：US16863702

申请日：2020-04-30

Applicant: LIFE TECHNOLOGIES CORPORATION ,  Takeda Pharmaceutical Company Limited

Inventor： Kurt T. Kunas ,  Robert V. Oakley ,  Fauad F. Hasan ,  Michael E. Goodwin ,  Jeremy K. Larsen ,  Nephi D. Jones

IPC: C12M1/00 ,  B01F27/07 ,  B01F27/88 ,  B01F27/91 ,  B01F33/00 ,  B01F35/51 ,  B01F35/513 ,  C12M1/06 ,  C12M1/12 ,  B01F101/44

Abstract: A reactor system includes a support housing having an interior surface bounding a chamber, the chamber having a vertically extending central longitudinal axis. A flexible bag is disposed within the chamber of the support housing and has an interior surface bounding a compartment. A mixing element is disposed within the compartment of the flexible bag. A drive element, such as a drive shaft, is secured the mixing element, wherein the mixing element is laterally offset from and/or is angled relative to the vertically extending central longitudinal axis of the support housing.

公开(公告)号：US11371634B2

公开(公告)日：2022-06-28

申请号：US15863031

申请日：2018-01-05

Applicant: Life Technologies Corporation

Inventor： Ryan S. Beus ,  Brandon R. Burtenshaw ,  Eric Davis ,  Patrick L. Draper ,  Michael E. Goodwin ,  Brandon M. Knudsen ,  Jeremy K. Larsen ,  Kevin R. Pickup

IPC: F16L33/207 ,  A61M39/12 ,  B29C65/56 ,  B29C65/68 ,  B29C65/00 ,  F16L33/22 ,  B29L31/24

Abstract: A method for coupling a tube to a tube fitting includes radially outwardly expanding a tubular compression collar from a constricted state to an expanded state, the compression collar having a throughway extending there through and being made of a resiliently flexible material. An end of the tube is inserted within the throughway of the expanded compression collar, the tube bounding a passageway. A tube fitting is inserted within the passageway of the tube. The compression collar is allowed to resiliently rebound back towards the constricted state so that the compression collar pushes the tube against the tube fitting.

公开(公告)号：US11162062B2

公开(公告)日：2021-11-02

申请号：US16715087

申请日：2019-12-16

Applicant: Life Technologies Corporation

Inventor： Christopher D. Brau ,  Nephi D. Jones ,  Benjamin R. Madsen ,  Michael E. Goodwin

IPC: C12N1/00 ,  C12M1/00 ,  B01F13/02 ,  B01F3/04 ,  C12M1/02 ,  C12M1/34 ,  B01F7/22 ,  B01F15/00 ,  C12M1/06 ,  B01F11/00

Abstract: A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall extending therebetween. A tube has a first end and an opposing second end, the first end of the tube being disposed within the compartment of the container. A nozzle is disposed within the compartment of the container and has at least one outlet, the nozzle being coupled with the tube so that a gas can be passed through the tube and out the at least one outlet of the nozzle. The nozzle is sufficiently buoyant so that when a fluid is disposed within the compartment of the container, the nozzle floats on the fluid.

公开(公告)号：US20200255780A1

公开(公告)日：2020-08-13

申请号：US16863702

申请日：2020-04-30

Applicant: LIFE TECHNOLOGIES CORPORATION ,  Baxalta Incorporated ,  BAXALTA GMBH

Inventor： Kurt T. Kunas ,  Robert V. Oakley ,  Fauad F. Hasan ,  Michael E. Goodwin ,  Jeremy K. Larsen ,  Nephi D. Jones

IPC: C12M1/00 ,  B01F7/00 ,  B01F7/16 ,  B01F7/22 ,  B01F15/00 ,  C12M1/06 ,  C12M1/12

Abstract: A reactor system includes a support housing having an interior surface bounding a chamber, the chamber having a vertically extending central longitudinal axis. A flexible bag is disposed within the chamber of the support housing and has an interior surface bounding a compartment. A mixing element is disposed within the compartment of the flexible bag. A drive element, such as a drive shaft, is secured the mixing element, wherein the mixing element is laterally offset from and/or is angled relative to the vertically extending central longitudinal axis of the support housing.

公开(公告)号：US10539467B2

公开(公告)日：2020-01-21

申请号：US16034122

申请日：2018-07-12

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael E. Goodwin

IPC: G01K1/14 ,  C12M1/26 ,  C12M1/28 ,  C12M1/00 ,  C12M1/34 ,  C12M3/00 ,  C12M1/06 ,  G01N1/10

Abstract: A container system includes a flexible bag, a probe port, and a probe. The probe port includes an elongated tubular member having an interior surface bounding a first passageway extending between a first end and an opposing second end, the tubular member being made of a polymeric or elastomeric material and being flexible. The probe port also includes a flange coupled to the tubular member and radially outwardly projecting therefrom, the flange being secured to the flexible bag so that the first end of the tubular member projects into a chamber of the flexible bag while the second end of the first passageway of the tubular member is accessible from outside of the flexible bag. The probe can be received within the first passageway of the probe port.

公开(公告)号：US10519413B2

公开(公告)日：2019-12-31

申请号：US15916635

申请日：2018-03-09

Applicant: Life Technologies Corporation

Inventor： Christopher D. Brau ,  Nephi D. Jones ,  Benjamin R. Madsen ,  Michael E. Goodwin

IPC: C12M1/04 ,  C12M1/00 ,  B01F13/02 ,  B01F3/04 ,  C12M1/02 ,  C12M1/34 ,  B01F7/22 ,  B01F15/00 ,  C12M1/06 ,  B01F11/00

Abstract: A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall extending therebetween. A tube has a first end and an opposing second end, the first end of the tube being disposed within the compartment of the container. A nozzle is disposed within the compartment of the container and has at least one outlet, the nozzle being coupled with the tube so that a gas can be passed through the tube and out the at least one outlet of the nozzle. The nozzle is sufficiently buoyant so that when a fluid is disposed within the compartment of the container, the nozzle floats on the fluid.

公开(公告)号：US20190329192A1

公开(公告)日：2019-10-31

申请号：US16510438

申请日：2019-07-12

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael E. Goodwin ,  Nephi D. Jones ,  Derik R. West

IPC: B01F3/04 ,  B01F15/00 ,  C12M1/00

Abstract: A container assembly includes a flexible bag having an interior surface bounding a chamber and an opposing exterior surface. The bag has a bottom end wall that includes a first sparger and a second sparger. The first sparger and the second sparger each have a flexible first sheet overlying a flexible second sheet, the first sheet and the second sheet being secured together so as to form a sparging area bounded between the first sheet and the second sheet, at least a portion of the first sheet overlying the sparging area being gas permeable so that gas can pass from the sparging area, through the first sheet, and into the chamber.

公开(公告)号：US10166306B2

公开(公告)日：2019-01-01

申请号：US15642015

申请日：2017-07-05

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael E. Goodwin ,  Nephi D. Jones ,  Bradley H. Buchanan

IPC: A61L2/00 ,  G01N21/01 ,  G01N23/00 ,  A61L2/08 ,  A61L2/26

Abstract: A container includes a first wall made of a polymeric material, a second wall made of a polymeric material, and a plurality of elongated baffles, spacers or seam lines formed between the first wall and the second wall to form a plurality of separate fluid flow paths. Each of the plurality of fluid flow paths are separated from the other fluid flow paths by at least one of the baffles, spacers or seam lines. Each of the plurality of fluid flow paths have a first end in fluid communication with an inlet and have a second end in fluid communication with an outlet.

公开(公告)号：US10150090B2

公开(公告)日：2018-12-11

申请号：US15937610

申请日：2018-03-27

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael E. Goodwin ,  Wade A. Cornia ,  Jacob D. Lee

IPC: B01F7/16 ,  C12M1/06 ,  B01F7/00 ,  B01F13/00 ,  B01F15/00 ,  C12M1/00

Abstract: A bioreactor system includes a support housing having an interior surface bounding a compartment, the support housing having a sidewall with an opening extending therethrough and communicating with the compartment. A rack is secured to the support housing in alignment with the opening. An elongated first shaft has a first end and an opposing second end, the first end of the first shaft being secured to the rack so that the second end of the first shaft projects outwardly away from the sidewall of the support housing. A structure is secured to the first shaft towards the second end of the first shaft, the structure outwardly projecting away from the first shaft. A collapsible bag bounds a chamber and is at least partially disposed within the compartment of the support housing. A member projects from the collapsible bag and passes through the opening on the sidewall, the structure restraining movement of the member.