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公开(公告)号：US5814085A
公开(公告)日：1998-09-29
申请号：US843485
申请日：1997-04-16
申请人： Michael R. S. Hill
发明人： Michael R. S. Hill
CPC分类号： A61N1/056 , A61N1/3621 , A61N1/3987
摘要： A cardiac pacemaker with a rate stabilization pacing mode. The pacemaker varies the increment following a cycle ending in a sensed depolarization as a function of the underlying heart rate and may additionally vary the increment as a function of the prematurity of the most recently sensed depolarization relative to the preceding depolarization. A greater increment is generally provided if the underlying cycle length is greater, while the increment may be lessened following relatively more premature depolarizations. Prematurity may be determined by comparing the cycle (CLnew) ending in the most recently sensed depolarization with the previous cycle length (CLold), for example by calculating CLnew/CLold or CLold-CLnew. The mechanism for determining the duration of the increment provides for a more rapid return to a lower underlying heart rate, while still avoiding the short-long interval pattern sometimes associated with the onset of tachycardia.
摘要翻译： 具有速率稳定起搏模式的心脏起搏器。 心脏起搏器改变随着感觉去极化结束的周期之后的增量，作为潜在的心率的函数，并且还可以根据最近感测到的去极化相对于先前的去极化的早熟来增加增量。 如果潜在的循环长度较大，则通常提供更大的增量，而相对较早的去极化后，增量可能会减小。 早产可以通过将最近感测到的去极化结束的周期（CLnew）与先前的循环长度（CLold）进行比较来确定，例如通过计算CLnew / CLold或CLold-CLnew。 用于确定增量持续时间的机制提供了更快速地返回到较低的基础心率，同时仍然避免了与心动过速发作有时相关的短长间隔模式。
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公开(公告)号：US5549642A
公开(公告)日：1996-08-27
申请号：US293769
申请日：1994-08-19
申请人： Xiaoyi Min , Luc R. Mongeon , Rahul Mehra , Kenneth M. Anderson , Paul J. DeGroot , Michael R. S. Hill
发明人： Xiaoyi Min , Luc R. Mongeon , Rahul Mehra , Kenneth M. Anderson , Paul J. DeGroot , Michael R. S. Hill
IPC分类号： A61N1/39
CPC分类号： A61N1/3918 , A61N1/3962 , A61N1/395
摘要： A method and apparatus for treating atrial tachyarrhythmias, particularly atrial fibrillation. High energy pulses are delivered between electrodes located in the right atrium/SVC, the right ventricle and the coronary sinus/great vein, with the right ventricular and coronary sinus/great vein electrodes connected in common. Optionally a subcutaneous electrode, preferably located in the left pectoral area may also be employed, coupled in common to the right atrial/SVC electrode.
摘要翻译： 一种治疗房性快速性心律失常的方法和装置，特别是房颤。 高能量脉冲在位于右心房/ SVC，右心室和冠状窦/大静脉的电极之间传递，右心室和冠状窦/大静脉电极共同连接。 任选地，也可以使用优选位于左胸部区域的皮下电极，共同连接到右心房/ SVC电极。
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33.发明授权Techniques for placing medical leads for electrical stimulation of nerve tissue 有权放置用于电刺激神经组织的医疗线的技术公开(公告)号：US08315713B2
公开(公告)日：2012-11-20
申请号：US12433768
申请日：2009-04-30
申请人： John E. Burnes , Mary M. Morris , Michael R. S. Hill , Avram Scheiner , Ruth N. Klepfer , Matthew D. Bonner
发明人： John E. Burnes , Mary M. Morris , Michael R. S. Hill , Avram Scheiner , Ruth N. Klepfer , Matthew D. Bonner
IPC分类号： A61N1/00
CPC分类号： A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
摘要： This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient.
摘要翻译： 本公开涉及用于在患者体内靠近神经组织布置医疗引线和电刺激和/或感测电极的额外的，内部的和经血管内的医疗引线放置技术。
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公开(公告)号：US07221979B2
公开(公告)日：2007-05-22
申请号：US10426610
申请日：2003-04-30
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61N1/205 , A61N1/36021
摘要： A method and apparatus for delivering corrective therapy through hormone regulation is provided. Inhibition of sympathetic fibers by spinal cord stimulation is used to regulate the levels of hormones such as catecholamines, renin, and calcitonin gene-related peptide. The invention utilizes a closed or open loop feedback system in which physiological parameters such as the concentrations of hormones and sympathetic indicators such as heart rate and urine production are monitored and used to determine the appropriate level of neurostimulation. The site of electrical stimulation includes, but is not limited to, the spinal cord at levels T7–L2 and the associated neural fibers within a region of the T7–L2 dermatomes
摘要翻译： 提供了一种通过激素调节进行矫正治疗的方法和装置。 通过脊髓刺激抑制交感神经纤维用于调节激素水平，如儿茶酚胺，肾素和降钙素基因相关肽。 本发明利用封闭或开环反馈系统，其中监测诸如心率和尿液产生之间的激素和交感神经指标的生理参数，并用于确定适当的神经刺激水平。 电刺激部位包括（但不限于）T7-L2级别的脊髓和T7-L2皮肌的区域内的相关神经纤维
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公开(公告)号：US07058447B2
公开(公告)日：2006-06-06
申请号：US10421537
申请日：2003-04-23
CPC分类号： A61B17/1355 , A61B17/00008 , A61B2017/00694 , A61N1/36114
摘要： A system of performing a medical procedure, such as surgery, is provided. The system comprises a compression member for compressing a body portion and a means for controlling the compression. Methods and devices for performing the medical procedure are also provided.
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36.发明授权Method and system for spinal cord stimulation prior to and during a medical procedure 有权在医疗过程之前和期间脊髓刺激的方法和系统公开(公告)号：US06690973B2
公开(公告)日：2004-02-10
申请号：US10215443
申请日：2002-08-09
IPC分类号： A61N1362
CPC分类号： A61N1/36014 , A61N1/36021 , A61N1/3625 , A61N1/385
摘要： A method of performing a medical procedure, such as surgery, is provided. The spinal cord is stimulated in order to control at least one physiological function. The medical procedure is performed and stimulation of the spinal cord is stopped.
摘要翻译： 提供了一种执行诸如手术的医疗程序的方法。 刺激脊髓以控制至少一种生理功能。 执行医疗程序并停止对脊髓的刺激。
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公开(公告)号：US06442429B1
公开(公告)日：2002-08-27
申请号：US09593200
申请日：2000-06-14
IPC分类号： A61N1362
CPC分类号： A61N1/3622
摘要： A medical device selects the most appropriate among various calculated escape intervals for use in the next cardiac cycle. This is particularly implemented in cardiac event in which a pacemaker is used to prevent multiple tachyarrhythmias. The prevention pacing modes may be simultaneously active, with the escape interval for each mode calculated and updated on a beat-by-beat basis. The medical device selects tachyarrhythmia prevention pacing modality to control the escape interval of the current cardiac cycle in order that a more appropriate method for calculating the escape interval based on the present condition of the patient, may be selected.
摘要翻译： 医疗设备选择在下一个心动周期中使用的各种计算的逃逸间隔中最合适的。 这在心脏事件中特别实现，其中使用起搏器来预防多发性快速性心律失常。 预防起搏模式可以同时处于活动状态，每个模式的逃脱间隔以逐个节拍为基础计算和更新。 医疗装置选择快速性心律失常预防起搏模式来控制当前心动周期的逃避间隔，以便可以选择基于患者的当前状况来计算逃逸间隔的更合适的方法。
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公开(公告)号：US06195584B1
公开(公告)日：2001-02-27
申请号：US09303279
申请日：1999-04-30
IPC分类号： A61N137
CPC分类号： A61N1/371 , A61N2001/083
摘要： A method and apparatus for determining the occurrence of a mis-location of an atrial electrode in a cardiac stimulation device having an atrial pulse generator coupled with the atrial electrode and a ventricular sense amplifier coupled to a ventricular electrode. The device paces the atrium in a first pacing mode employing atrial pacing pulses at a first energy level and in a test mode employs higher energy atrial pacing pulses. In the test mode the device measures PR intervals between atrial pacing pulses following sensed ventricular depolarizations and determines that the atrial electrode is mis-located responsive to occurrence of a threshold number of short PR intervals or that the atrial electrode is appropriately located responsive to occurrence of a threshold number of long PR intervals. Operation of the device in the test mode may be pre-conditioned on an absence of atrial tachyarrhythmia.
摘要翻译： 一种用于确定在具有与心房电极耦合的心房脉冲发生器和耦合到心室电极的心室感应放大器的心脏刺激装置中心房电极错位的发生的方法和装置。 该装置以第一起搏模式采用心房起搏脉冲在第一能级进行起搏，并且在测试模式中采用更高能量的心房起搏脉冲。 在测试模式中，该装置测量感测到的心室去极化之后的心房起搏脉冲之间的PR间隔，并且确定心房电极响应于出现阈值数量的短PR间期而错位，或者心房电极适当地位于响应于 长PR间隔的阈值数。 在测试模式下的装置的操作可以在没有心房快速性心律失常的情况下进行预处理。
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39.发明授权
公开(公告)号：US6091988A
公开(公告)日：2000-07-18
申请号：US70690
申请日：1998-04-30
CPC分类号： A61N1/3956 , A61N1/3622 , A61N1/3987
摘要： An implantable anti-tachyarrhythmia device which delivers atrial cardioversion or defibrillation pulses heart in response to detection of atrial tachyarrhythmias. The pulses are synchronized to atrial and ventricular events in such a fashion as to assure they occur outside of the vulnerable periods associated with both chambers. The device is provided with a pulse synchronizer which defines a first synchronization interval initiated following a sensed atrial event and a second synchronization interval initiated responsive to a sensed ventricular event and a pulse triggerer which triggers delivery of a cardioversion or defibrillation pulse responsive to the first and second synchronization intervals simultaneously being underway. In particular, the pulse triggerer may be responsive to initiation of the first synchronization interval during the second synchronization interval. In addition, the synchronizer may also define minimum time intervals following ventricular events and the triggerer may additionally be responsive to expiration of a defined minimum time interval following a ventricular event preceding the sensed ventricular event which initiated the second synchronization interval currently underway.
摘要翻译： 一种可植入的抗快速性心律失常装置，其响应于心房快速性心律失常的检测而传送心房心脏复律或除颤脉冲心脏。 这些脉冲以这样的方式与心房和心室事件同步，以确保它们发生在与两个腔室相关联的脆弱周期之外。 该装置设置有脉冲同步器，该脉冲同步器限定在感测的心房事件之后启动的第一同步间隔和响应于感测到的心室事件而发起的第二同步间隔和脉冲触发器，其响应于第一和第二同步间隔触发心脏复律或除颤脉冲的传递 第二同步间隔同时进行。 特别地，脉冲触发器可以响应于在第二同步间隔期间启动第一同步间隔。 此外，同步器还可以定义心室事件之后的最小时间间隔，并且触发器可以另外响应于起始于当前正在进行的第二同步区间的感测的心室事件之前的心室事件之后的限定的最小时间间隔的到期。
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公开(公告)号：US5893882A
公开(公告)日：1999-04-13
申请号：US767657
申请日：1996-12-17
CPC分类号： A61N1/3622 , A61N1/3688
摘要： A pacemaker provided with a mode switching feature adapted to stabilize ventricular heart rate during atrial fibrillation. In a preferred embodiment of the invention, the device nominally operates in an atrial synchronized pacing mode such as DDD, DDDR, VDD or VDDR. In response to detection of atrial rhythm characteristics consistent with atrial fibrillation, the device switches into a non-atrial synchronized, ventricular rate stabilization pacing mode with the base ventricular pacing rate modulated on a beat by beat basis based upon preceding intrinsic or paced ventricular heartbeat intervals to adjust the pacing interval towards a desired preset rate stabilization target pacing interval which is typically less than the programmed base pacing interval of the device. While the ventricular rate stabilization mode is in effect, the current pacing interval is set equal to the preceding intrinsic or paced interval, with an increment if the preceding interval is less than the desired or target pacing interval, as typically will be the case, or with a decrement if the preceding interval is greater than the desired pacing interval. In a preferred embodiment of the invention, the device paces both the atria and ventricles in a DDI rate stabilization pacing mode with the ventricular pacing interval being modulated.
摘要翻译： 心脏起搏器配有模式切换功能，适用于在心房颤动期间稳定心室心率。 在本发明的优选实施例中，该装置名义上以心房同步起搏模式（例如DDD，DDDR，VDD或VDDR）操作。 为了响应与心房颤动一致的心房节律特征的检测，该装置转换成非心房同步的心室速率稳定起搏模式，其基本心室起搏速度基于先前的内在或起搏心室心跳间隔以搏动为基础进行调整 以将起搏间隔调整到期望的预设速率稳定化目标起搏间隔，其通常小于设备的编程的基本起搏间隔。 当心室速率稳定模式有效时，当前的起搏间隔被设置为等于前面的固有或起搏间隔，如果前一个间隔小于所需的或目标起搏间隔，增量（通常为这种情况），或 如果前一个间隔大于所需的起搏间隔，则递减。 在本发明的优选实施例中，该装置以调节心室起搏间隔的DDI速率稳定起搏模式对心房和心室起搏。
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