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334 条记录 (耗时 0.052 秒)

    Self-righting systems, methods, and related components
    31.
    发明授权
    Self-righting systems, methods, and related components 有权

    公开(公告)号：US11541015B2

    公开(公告)日：2023-01-03

    申请号：US16614229

    申请日：2018-05-17

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer

    IPC分类号： A61K9/48 ,  A61M5/142 ,  A61M37/00 ,  A61M5/158 ,  A61M5/145 ,  A61B10/06

    摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

    THERMALLY CONTROLLED RECONFIGURABLE MEDICAL DEVICES
    34.
    发明申请
    THERMALLY CONTROLLED RECONFIGURABLE MEDICAL DEVICES 有权

    公开(公告)号：US20220023602A1

    公开(公告)日：2022-01-27

    申请号：US17293804

    申请日：2019-11-15

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Sahab Babaee ,  Simo Pajovic ,  Ester Caffarel Salvador

    IPC分类号： A61M31/00

    摘要： Systems and methods related to reconfigurable medical devices are described. In some embodiments, a reconfigurable medical device may include a central core and a plurality of arms. The arms may be rotatably coupled to the central core such that the plurality of arms may rotate outwards away from the central core to selectively reconfigure the reconfigurable device between a retracted configuration and an expanded configuration. In an initial state, the arms may be biased outwards away from the central core into the expanded configuration. When the reconfigurable device is exposed to a temperature greater than a threshold temperature, the arms may be biased towards the central core into the retracted configuration. In some embodiments, a reconfigurable medical device may include therapeutic compound-loaded needles coupled to distal portions of the arms.

    MILLINEEDLE SYSTEMS FOR ESOPHAGEAL DRUG DELIVERY
    35.
    发明申请
    MILLINEEDLE SYSTEMS FOR ESOPHAGEAL DRUG DELIVERY 有权

    公开(公告)号：US20220008701A1

    公开(公告)日：2022-01-13

    申请号：US17293799

    申请日：2019-11-15

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Ester Caffarel Salvador ,  Sahab Babaee ,  Simo Pajovic

    IPC分类号： A61M31/00 ,  A61M37/00

    摘要： Systems and methods related to reconfigurable medical devices are described. In some embodiments, a reconfigurable medical device may include a central core and a plurality of arms. The arms may be rotatably coupled to the central core such that the plurality of arms may rotate outwards away from the central core to selectively reconfigure the reconfigurable device between a retracted configuration and an expanded configuration. In an initial state, the arms may be biased outwards away from the central core into the expanded configuration. When the reconfigurable device is exposed to a temperature greater than a threshold temperature, the arms may be biased towards the central core into the retracted configuration. In some embodiments, a reconfigurable medical device may include therapeutic compound-loaded needles coupled to distal portions of the arms.

    Self-righting articles
    36.
    发明授权
    Self-righting articles 有权

    公开(公告)号：US11179341B2

    公开(公告)日：2021-11-23

    申请号：US16614083

    申请日：2018-05-17

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer

    IPC分类号： A61M5/142 ,  A61M5/158 ,  A61K9/48 ,  A61J3/07 ,  A61K9/00 ,  A61B5/145 ,  A61B10/02 ,  A61M37/00 ,  A61N1/32 ,  A61N1/36 ,  A61M5/20 ,  A61M5/32 ,  A61M31/00 ,  A61K38/28 ,  A61N1/05

    摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

    RESIDENCE STRUCTURES AND RELATED METHODS
    39.
    发明申请
    RESIDENCE STRUCTURES AND RELATED METHODS 有权

    公开(公告)号：US20210113460A1

    公开(公告)日：2021-04-22

    申请号：US17126786

    申请日：2020-12-18

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： Andrew Bellinger ,  Shiyi Zhang ,  Carlo Giovanni Traverso ,  Robert S. Langer ,  Stacy Mo ,  Tyler Grant ,  Mousa Jafari ,  Dean Liang Glettig ,  Angela DiCiccio ,  Lowell L. Wood, JR. ,  Philip A. Eckhoff

    IPC分类号： A61K9/00 ,  A61K31/65 ,  A61K9/48 ,  A61M31/00 ,  A61K47/58 ,  A61K47/40 ,  A61K47/32 ,  C08G18/73 ,  C08G18/42 ,  A61K31/7048 ,  C08L33/14 ,  A61K47/34 ,  A61K31/357 ,  A61K47/42 ,  A61K47/69 ,  C08G83/00 ,  C08L33/02 ,  C08L33/08 ,  C08G63/08 ,  A61K47/10

    摘要： Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.