Laser microdissection apparatus and method
    33.
    发明申请
    Laser microdissection apparatus and method 有权
    激光显微解剖设备及方法

    公开(公告)号:US20060087643A1

    公开(公告)日:2006-04-27

    申请号:US11222281

    申请日:2005-09-08

    IPC分类号: G01N1/00

    摘要: Systems and methods for automated laser microdissection are disclosed. In one variation, targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition to the location of an interior of a cut path. In another variation, a sample of biological material is mounted onto a polymer membrane which is then placed onto a substrate. Targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition with the targeted biological material on the side of the biological material. In yet another variation, a sample of biological material is mounted onto a polymer membrane which is then inverted onto a substrate. Targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition with the targeted biological material on the side of the polymer membrane. Then, an UV laser cuts along a cut path around the targeted portions of biological material in a closed cut path or a substantially closed cut path defining an interior and an exterior portion of the tissue sample. In a substantially closed cut path, bridges are left spanning the interior of the cut path and the exterior of the cut path. An IR laser activates at least a portion of the transfer film such that the transfer film in the vicinity of targeted portion adheres to the biological material interior to the cut path. The transfer film is then removed separating the targeted portions of biological material which are adhered to the transfer film from the remaining portion of the tissue sample.

    摘要翻译: 公开了用于自动激光显微切割的系统和方法。 在一个变型中,手动或自动选择目标生物材料,并且将转移膜并排放置在切割路径的内部的位置。 在另一个变体中,将生物材料样品安装在聚合物膜上,然后将其放置在基底上。 手动或自动选择靶向生物材料,并将转移膜与生物材料侧面上的靶向生物材料并置放置。 在另一个变体中,将生物材料样品安装在聚合物膜上,然后将其反转到基底上。 手动或自动选择目标生物材料,并将转移膜与聚合物膜侧面上的目标生物材料并置放置。 然后,UV激光沿着围绕生物材料的目标部分的切割路径沿封闭的切割路径或限定组织样本的内部和外部部分的基本封闭的切割路径切割。 在基本封闭的切割路径中,跨越切割路径的内部和切割路径的外部。 红外激光激活转印膜的至少一部分,使得目标部分附近的转印膜附着在生物材料内部至切割路径。 然后除去转移膜,从生物材料的目标部分分离出粘附到转移膜上的剩余部分的组织样品。

    Method for numerical position control of motor-driven shafts
    35.
    发明授权
    Method for numerical position control of motor-driven shafts 失效
    电机轴数值位置控制方法

    公开(公告)号:US4906908A

    公开(公告)日:1990-03-06

    申请号:US248557

    申请日:1988-09-23

    IPC分类号: G05D3/12 G05B19/18 G05B19/19

    CPC分类号: G05B19/186

    摘要: In a method for numerical position control of motordriven shafts whose rotations are to be synchronous with one another under a certain transmission ratio a control loop is provided for each shaft. A speed setpoint, weighted with the corresponding transmission ratio, is applied as a position setpoint per unit of time simultaneously to the control loops of the respective shafts. If the actual speeds of the shafts differ from one another due to a disturbance within the controlled system, the difference between these actual speeds is used to readjust the speed and the position within the speed controlled section of one of the control loops. Overshoot of the position of a shaft, which might be caused by direct adding of the position setpoint onto the speed control loop is avoided by the fact that a control element produces a delay having the time response corresponding to a delay introduced by the respective control section for speed and adds this delay to the position setpoint prior to integration (14 to 17, 24 to 27).

    摘要翻译: 在用于在一定传动比下旋转彼此同步的运动轴的数字位置控制的方法中,为每个轴提供控制回路。 以相应的传动比加权的转速设定值作为每单位时间的位置设定值同时施加到相应轴的控制回路。 如果由于受控系统内的干扰,轴的实际速度彼此不同,则这些实际速度之间的差异被用于重新调整其中一个控制回路的速度控制部分内的速度和位置。 通过控制元件产生具有对应于由各个控制部分引入的延迟的时间响应的延迟,可以避免可能由位置设定点直接添加到速度控制环路而导致的轴的位置的过冲 为了速度,并且在积分之前将这个延迟增加到位置设定值(14到17,24到27)。