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公开(公告)号：US20120189608A1
公开(公告)日：2012-07-26
申请号：US13390033
申请日：2010-08-24
申请人： Yves Briers , Rob Lavigne , Maarten Walmagh , Stefan Miller
发明人： Yves Briers , Rob Lavigne , Maarten Walmagh , Stefan Miller
IPC分类号： A61K38/47 , C07K14/21 , C12N1/21 , C12N1/19 , C12N5/10 , A01P1/00 , C12N15/63 , C12N15/62 , A01N37/18 , C12Q1/34 , A61P31/04 , C12N9/24 , C12N15/56
CPC分类号： C12N9/2462 , A01N43/50 , A23L3/3571 , A61K38/00 , A61K38/47 , C07K7/08 , C07K14/195 , C07K14/21 , C07K14/43518 , C07K2319/21 , C07K2319/55 , C12Q1/04 , C12Q1/34 , C12Y302/01017 , G01N2333/928
摘要： The present invention relates to a polypeptide with an amino acid sequence according to SEQ ID NO: 1 and fragments or derivatives thereof. The present invention further relates to fusion proteins comprising said polypeptide and an additional peptide stretch fused to said polypeptide at the N- or C-terminus. Moreover, the present invention relates to nucleic acid molecules encoding said polypeptide or fusion protein, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid molecules or said vectors. In addition, the present invention relates to said polypeptide or fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means, as cosmetic substance or as sanitizing agent. The present invention also relates to the use of said polypeptide or fusion protein for the treatment or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries. Furthermore, the present invention relates to a pharmaceutical composition comprising said polypeptide or fusion protein.
摘要翻译： 本发明涉及具有根据SEQ ID NO：1的氨基酸序列及其片段或衍生物的多肽。 本发明还涉及包含所述多肽的融合蛋白和在N-或C-末端与所述多肽融合的另外的肽拉伸。 此外，本发明涉及编码所述多肽或融合蛋白的核酸分子，包含所述核酸分子的载体和包含所述核酸分子或所述载体的宿主细胞。 此外，本发明涉及用作药物的所述多肽或融合蛋白，特别是用作治疗或预防革兰氏阴性细菌感染，作为诊断手段，作为化妆品或消毒剂。 本发明还涉及所述多肽或融合蛋白用于治疗或预防食品的食品加工设备，食品加工厂，与食品接触的表面，医疗器械的革兰氏阴性细菌污染， 在医院和手术中的表面。 此外，本发明涉及包含所述多肽或融合蛋白的药物组合物。
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公开(公告)号：US20120189606A1
公开(公告)日：2012-07-26
申请号：US13380312
申请日：2010-06-28
申请人： Rob Lavigne , Stefan Miller , Yves Briers , Guido Volckaert , Maarten Walmagh
发明人： Rob Lavigne , Stefan Miller , Yves Briers , Guido Volckaert , Maarten Walmagh
IPC分类号： A61K38/46 , C12N9/96 , C12N15/63 , A01N37/46 , C12N5/10 , C12Q1/34 , C12N1/21 , A61P31/04 , A01P1/00 , C12Q1/68 , G01N33/53 , G01N21/64 , C12N15/62 , C12N1/19
CPC分类号： A61K38/47 , A61K38/00 , A61L2/00 , C07K14/005 , C07K14/4723 , C07K2319/00 , C07K2319/20 , C12N9/2462 , C12N9/503 , C12N15/52 , C12N15/62 , C12Y302/01017 , Y02A50/475 , Y02A50/478 , Y02A50/479
摘要： The present invention relates to antimicrobial agents against Gram-negative bacteria, in particular to fusion proteins composed of an enzyme having the activity of degrading the cell wall of Gram-negative bacteria and a peptide stretch fused to the enzyme at the N- or C-terminus. Moreover, the present invention relates to nucleic acid molecules encoding said fusion protein, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid molecules or said vectors. In addition, the present invention relates to said fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means or as cosmetic substance. The present invention also relates to the treatment or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries. Furthermore, the present invention relates to a pharmaceutical composition comprising said fusion protein.
摘要翻译： 本发明涉及抗革兰氏阴性细菌的抗微生物剂，特别涉及由具有降解革兰氏阴性细菌细胞壁的活性的酶组成的融合蛋白，以及与N-或C- 终点。 此外，本发明涉及编码所述融合蛋白的核酸分子，包含所述核酸分子的载体和包含所述核酸分子或所述载体的宿主细胞。 此外，本发明涉及用作药物的所述融合蛋白，特别是用于治疗或预防革兰氏阴性细菌感染，作为诊断手段或化妆品物质。 本发明还涉及食品加工设备，食品加工厂，与食品接触的表面，医疗器械，医院和手术中的表面的革兰氏阴性细菌污染的治疗或预防。 此外，本发明涉及包含所述融合蛋白的药物组合物。
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公开(公告)号：US20070042357A1
公开(公告)日：2007-02-22
申请号：US11445451
申请日：2006-05-31
申请人： Stefan Miller
发明人： Stefan Miller
CPC分类号： C12Q1/04 , C12Q2304/10 , G01N33/56911 , G01N33/56983 , G01N2333/924
摘要： The present invention relates to a method to detect bacteria, the method comprising the following steps: coupling of the bacteriophages and/or bacteriophage proteins to a support, incubating the support coupled with the bacteriophages and/or bacteriophage proteins with a sample, optionally removing the sample and the bacteria in the sample not bound to the bacteriophages and/or bacteriophage proteins, optionally adding substances permeabilizing or destroying the bacterial membrane, and detecting the bacteria in the sample bound to the bacteriophages and/or bacteriophage proteins, wherein the bound bacteria are not subjected to a cultivation step.
摘要翻译： 本发明涉及一种检测细菌的方法，该方法包括以下步骤：将噬菌体和/或噬菌体蛋白偶联到载体上，将与噬菌体和/或噬菌体蛋白质偶联的载体与样品一起孵育，任选地除去 样品和样品中的细菌不结合噬菌体和/或噬菌体蛋白质，任选地添加渗透或破坏细菌膜的物质，以及检测与噬菌体和/或噬菌体蛋白质结合的样品中的细菌，其中结合的细菌是 没有进行培养步骤。
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公开(公告)号：US07087376B2
公开(公告)日：2006-08-08
申请号：US10060618
申请日：2002-01-30
申请人： Stefan Miller
发明人： Stefan Miller
CPC分类号： C12Q1/04 , C12Q2304/10 , G01N33/56911 , G01N33/56983 , G01N2333/924
摘要： The present invention relates to a method to detect bacteria, the method comprising the following steps: coupling of the bacteriophages and/or bacteriophage proteins to a support, incubating the support coupled with the bacteriophages and/or bacteriophage proteins with a sample, optionally removing the sample and the bacteria in the sample not bound to the bacteriophages and/or bacteriophage proteins, optionally adding substances permeabilizing or destroying the bacterial membrane, and detecting the bacteria in the sample bound to the bacteriophages and/or bacteriophage proteins, wherein the bound bacteria are not subjected to a cultivation step.
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