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公开(公告)号：US09026209B2
公开(公告)日：2015-05-05
申请号：US12830750
申请日：2010-07-06
申请人： Michael Vollkron , Michael Lippert
发明人： Michael Vollkron , Michael Lippert
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/3688
摘要： An implantable cardiac stimulator includes at least one first sensing unit for detecting intrinsic cardiac activities of a first ventricle, at least one ventricular stimulation unit for stimulating a second ventricle, and a stimulation control unit connected to the first sensing unit. The stimulation unit processed output signals of the first sensing unit and generates control signals for the stimulation units. The stimulation control unit derives a current intrinsic RR interval from detected ventricular intrinsic cardiac activities R of the first ventricle, and to determine from the RR interval a delay interval Δ, which begins with a ventricular event of the first ventricle and at the end of which the stimulation control unit triggers a stimulation of the second ventricle (unless it is suppressed).
摘要翻译： 植入式心脏刺激器包括用于检测第一心室的内在心脏活动的至少一个第一感测单元，用于刺激第二脑室的至少一个心室刺激单元和连接到第一感测单元的刺激控制单元。 刺激单元处理第一感测单元的输出信号并产生用于刺激单元的控制信号。 刺激控制单元从检测到的第一脑室的心室内心脏活动R导出当前内在RR间期，并且从RR间期确定延迟间隔＆Dgr，其从第一脑室的心室事件开始，并且在第 刺激控制单元触发第二脑室的刺激（除非被抑制）。
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公开(公告)号：US20120078342A1
公开(公告)日：2012-03-29
申请号：US13232290
申请日：2011-09-14
申请人： Michael Vollkron , Michael Lippert
发明人： Michael Vollkron , Michael Lippert
IPC分类号： A61F2/84
CPC分类号： A61B5/0538 , A61B5/1076 , A61B5/6852 , A61F2/958 , A61F2250/0001 , A61F2250/0096
摘要： The invention relates to a method for determining the position of a catheter in a blood vessel relative to a change in the vascular cross section, comprising the steps: providing a catheter that includes at least two electrodes which can be brought into electrically conductive contact with the surrounding blood while the catheter is being positioned in the blood vessel, wherein the two electrodes are installed on the catheter along the longitudinal axis at a defined distance from each other; advancing the catheter in the vessel to be treated, toward the change in the vascular cross section; and measuring the impedance across the two electrodes while the catheter is being advanced; and to a catheter for use in a method of this type.
摘要翻译： 本发明涉及一种用于确定导管在血管中相对于血管横截面变化的位置的方法，包括以下步骤：提供导管，该导管包括至少两个可与 当导管位于血管中时，围绕血液，其中两个电极沿着纵向轴线以彼此限定的距离安装在导管上; 推进待处理的血管中的导管朝向血管横截面的变化; 并且在导管正在前进时测量跨过两个电极的阻抗; 以及用于这种类型的方法的导管。
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公开(公告)号：US07593766B2
公开(公告)日：2009-09-22
申请号：US11614546
申请日：2006-12-21
IPC分类号： A61B5/04
CPC分类号： A61B5/053 , A61B5/046 , A61B5/0538 , A61N1/3621 , A61N1/36521 , A61N1/3925 , A61N1/395 , A61N1/3962
摘要： A detector for atrial fibrillation and/or atrial flutter comprises an atrial input for receiving an atrial signal representing an intraatrial electrogram or a time course of an intraatrial impedance, a ventricular input for receiving a ventricular event signal comprising information on an occurrence of a cyclically reoccurring ventricular event in chronological association to an atrial signal received via atrial input, an averaging unit adapted to average a plurality of sections of said atrial signal, each section to be considered for averaging starts or ends at a predetermined offset before a ventricular event, and to put out an averaged atrial signal, a peak amplitude determination unit adapted to determine peak-to-peak amplitude of said averaged atrial signal, and threshold comparator adapted to compare peak-to-peak amplitude of averaged atrial signal to predetermined reference value and to generate an AF warning signal if peak-to-peak amplitude of averaged atrial signal is less than predetermined threshold value.
摘要翻译： 用于心房颤动和/或心房颤动的检测器包括用于接收表示心房内电极电图或心房内阻抗的时间过程的心房信号的心房输入，用于接收心室事件信号的心室输入，所述心室输入包括关于周期性重现的发生的信息 按照与通过心房输入接收的心房信号的时间顺序关联的心室事件，适于平均所述心房信号的多个部分的平均单元，要被考虑用于在心室事件之前以预定偏移开始或结束的每个部分的平均单元，以及 放出平均的心房信号，峰值振幅确定单元，用于确定所述平均心房信号的峰 - 峰幅度;以及阈值比较器，用于将平均心房信号的峰 - 峰振幅与预定参考值进行比较，并产生 一个AF警告信号，如果平均心房信号的峰 - 峰幅度小于tha n个预定阈值。
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公开(公告)号：US07570990B2
公开(公告)日：2009-08-04
申请号：US11541054
申请日：2006-09-29
IPC分类号： A61B5/04
CPC分类号： A61B5/053 , A61B5/046 , A61B5/0538 , A61N1/3621 , A61N1/36521 , A61N1/3925 , A61N1/395 , A61N1/3962
摘要： Atrial fibrillation or flutter detector having impedance unit, with measurement input, connected to atrial electrode line having electrode for unipolar measurement of atrium impedance and implemented to generate atrial impedance signal obtained in unipolar manner so that impedance signal comprises multiple impedance values detected at different instants within particular atrial cycle for each atrial cycle, comprising atrial contraction and the following relaxation of the atrium, and having a signal input, via which ventricle signal is supplied to detector, which reflects instants of ventricular contractions in chronological assignment to impedance signal, the detector having an analysis unit, implemented to average multiple sequential impedance signal sections of unipolar atrial impedance signal, delimited by two sequential ventricular contractions with one another and determine maximum amplitude of averaged unipolar atrial impedance signal section, compare to comparison value, and if maximum amplitude of averaged unipolar atrial impedance signal
摘要翻译： 具有阻抗单元（具有测量输入）的心房颤动或颤振检测器连接到具有用于单极度测量心房阻抗的电极的心房电极线，并且被实现为产生以单极方式获得的心房阻抗信号，使得阻抗信号包括在不同时刻检测到的多个阻抗值 每个心房周期的特定心房周期，包括心房收缩和心房的随后松弛，并且具有信号输入，通过该信号输入将脑室信号提供给检测器，其将按时间顺序分配的心室收缩时间反映到阻抗信号，检测器具有 一个分析单元，用于平均单极性心房阻抗信号的多个顺序阻抗信号部分，由两个连续心室收缩相互间隔，并确定平均单极心房阻抗信号部分的最大振幅，与比较值相比，如果 平均单极心房阻抗信号的最大振幅<比较值，产生AF怀疑信号。
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公开(公告)号：US20070078356A1
公开(公告)日：2007-04-05
申请号：US11541054
申请日：2006-09-29
IPC分类号： A61B5/04
CPC分类号： A61B5/053 , A61B5/046 , A61B5/0538 , A61N1/3621 , A61N1/36521 , A61N1/3925 , A61N1/395 , A61N1/3962
摘要： A detector for atrial fibrillation or flutter (AF) having an impedance unit, which has a measurement input, to which an atrial electrode line having an electrode for a unipolar measurement of an impedance in the atrium is connected and is implemented to generate an atrial impedance signal obtained in a unipolar manner in such a way that the impedance signal comprises multiple impedance values detected at different instants within a particular atrial cycle for each atrial cycle, comprising an atrial contraction and the following relaxation of the atrium, and having a signal input, via which a ventricle signal is to be supplied to the detector, which reflects the instants of ventricular contractions in chronological assignment to the impedance signal, the detector having an analysis unit, which is implemented to average multiple sequential impedance signal sections of a unipolar atrial impedance signal, delimited by two sequential ventricular contractions in each case, with one another and to determine the maximum amplitude of the averaged unipolar atrial impedance signal section, compare it to a comparison value, and if the maximum amplitude of the averaged unipolar atrial impedance signal is less than a comparison value, to generate an AF suspicion signal.
摘要翻译： 具有阻抗单元的具有阻抗单元的检测器，其具有测量输入，具有用于单极性测量心房中的阻抗的电极的心房电极线连接到该心电极线并被实施以产生心房阻抗 以单极方式获得的信号，使得阻抗信号包括在每个心房周期的特定心房周期内在不同时刻检测的多个阻抗值，包括心房收缩和心房的随后松弛，并具有信号输入， 通过其将心室信号提供给检测器，其将按时间顺序分配的心室收缩的瞬间反映到阻抗信号，检测器具有分析单元，其被实现为平均单极性心房阻抗的多个连续阻抗信号部分 信号，在每种情况下由两个顺序的心室收缩界定，彼此a nd确定平均单极心房阻抗信号区段的最大振幅，将其与比较值进行比较，如果平均单极心房阻抗信号的最大振幅小于比较值，则产生AF怀疑信号。
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公开(公告)号：US09247885B2
公开(公告)日：2016-02-02
申请号：US13185881
申请日：2011-07-19
申请人： Jens Kirchner , Michael Lippert
发明人： Jens Kirchner , Michael Lippert
CPC分类号： A61B5/0215 , A61B5/02028 , A61B5/04 , A61N1/36521 , A61N1/36564 , A61N1/36571 , A61N1/36585 , A61N1/3684 , A61N1/37211 , A61N1/3962
摘要： A medical device includes a preload determination unit for determining the preload of a ventricle for a cardiac cycle and providing a preload value representing the preload; a contractility determination unit for determining the contractility of the ventricle for the cardiac cycle and providing a contractility value representing the contractility; and an evaluation unit connected to the preload determination unit and the contractility determination unit, with the evaluation unit being configured to evaluate contractility values versus associated preload values.
摘要翻译： 医疗装置包括用于确定用于心动周期的心室的预载的预加载确定单元，并提供表示该预载荷的预载值; 用于确定心室周围心室的收缩性并提供表示收缩性的收缩力值的收缩力确定单元; 以及评估单元，其连接到所述预载确定单元和所述收缩性确定单元，所述评估单元被配置为评估与相关联的预载值相关的收缩性值。
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公开(公告)号：US20120035453A1
公开(公告)日：2012-02-09
申请号：US13186511
申请日：2011-07-20
申请人： Olaf Skerl , Michael Lippert
发明人： Olaf Skerl , Michael Lippert
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B8/12 , A61B8/4477 , A61B8/5223 , A61N1/3627 , A61N1/3704 , A61N1/3925 , A61N1/3956
摘要： An implant predicts decompensation of a patient's heart based on an acoustic pressure measurement. The implant includes first and second acoustic transducers, which are matched to each other and which rest in/on the patient's thorax. The first acoustic transducer emits an acoustic signal which has at least one first signal portion having a first frequency. The second acoustic transducer is designed to receive and re-emit the emitted acoustic signal, or to reflect it, such that the first acoustic transducer receives the emitted acoustic signal. A signal processing unit communicates with at least one of the two acoustic transducers and determines an attenuation value as a function of the attenuation of the received acoustic signal versus the originally emitted acoustic signal, and provides a prediction signal as a function of a comparison of the attenuation value to a threshold value, wherein the prediction signal indicates the development of decompensation.
摘要翻译： 植入物基于声压测量来预测患者心脏的代偿失调。 植入物包括第一和第二声学换能器，它们彼此匹配并且被置于患者胸部中/之上。 第一声换能器发射具有至少一个具有第一频率的第一信号部分的声信号。 第二声换能器被设计成接收和重新发射所发射的声信号或反射它，使得第一声换能器接收所发射的声信号。 信号处理单元与两个声换能器中的至少一个通信，并且将衰减值确定为接收的声信号相对于最初发出的声信号的衰减的函数，并且提供预测信号作为 衰减值到阈值，其中预测信号指示发生失代偿。
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38.发明申请公开(公告)号：US20070156058A1
公开(公告)日：2007-07-05
申请号：US11614546
申请日：2006-12-21
IPC分类号： A61B5/04
CPC分类号： A61B5/053 , A61B5/046 , A61B5/0538 , A61N1/3621 , A61N1/36521 , A61N1/3925 , A61N1/395 , A61N1/3962
摘要： A detector for atrial fibrillation and/or atrial flutter comprises an atrial input for receiving an atrial signal representing an intraatrial electrogram or a time course of an intraatrial impedance, a ventricular input for receiving a ventricular event signal comprising information on an occurrence of a cyclically reoccurring ventricular event in chronological association to an atrial signal received via atrial input, an averaging unit adapted to average a plurality of sections of said atrial signal, each section to be considered for averaging starts or ends at a predetermined offset before a ventricular event, and to put out an averaged atrial signal, a peak amplitude determination unit adapted to determine peak-to-peak amplitude of said averaged atrial signal, and threshold comparator adapted to compare peak-to-peak amplitude of averaged atrial signal to predetermined reference value and to generate an AF warning signal if peak-to-peak amplitude of averaged atrial signal is less than predetermined threshold value.
摘要翻译： 用于心房颤动和/或心房颤动的检测器包括用于接收表示心房内电极电图或心房内阻抗的时间过程的心房信号的心房输入，用于接收心室事件信号的心室输入，所述心室输入包括关于周期性重现的发生的信息 按照与通过心房输入接收的心房信号的时间顺序关联的心室事件，适于平均所述心房信号的多个部分的平均单元，要被考虑用于在心室事件之前以预定偏移开始或结束的每个部分的平均单元，以及 放出平均的心房信号，峰值振幅确定单元，用于确定所述平均心房信号的峰 - 峰幅度;以及阈值比较器，用于将平均心房信号的峰 - 峰振幅与预定参考值进行比较，并产生 一个AF警告信号，如果平均心房信号的峰 - 峰幅度小于tha n个预定阈值。
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39.发明授权Method for determining a variable control parameter for an implantable medical device 有权用于确定可植入医疗装置的可变控制参数的方法公开(公告)号：US06405085B1
公开(公告)日：2002-06-11
申请号：US09599257
申请日：2000-06-23
申请人： Harald Graupner , Michael Lippert
发明人： Harald Graupner , Michael Lippert
IPC分类号： A61N1365
CPC分类号： A61N1/36514
摘要： An inventive method for determining a variable control parameter for an implantable medical device comprises the following procedural steps: measuring a physiological base parameter that is significant for the control parameter, after a trigger event has occurred, determining a measuring-signal curve for the base parameter from the above measuring process, determining a certain event type of the trigger event, selecting a reference signal curve in dependence on the determined event type, comparing the measuring signal curve to the selected reference signal curve, determining a comparison value that is representative for the difference between the measuring signal curve and the reference signal curve, and determining the control parameter from the comparison value according to a predefined calculation algorithm.
摘要翻译： 用于确定可植入医疗装置的可变控制参数的发明方法包括以下程序步骤：在触发事件发生之后测量对控制参数有效的生理基准参数，确定基本参数的测量信号曲线 从上述测量过程中，确定触发事件的某个事件类型，根据确定的事件类型选择参考信号曲线，将测量信号曲线与所选择的参考信号曲线进行比较，确定代表 测量信号曲线与参考信号曲线之间的差异，并根据预定义的计算算法从比较值确定控制参数。
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公开(公告)号：US20120245476A1
公开(公告)日：2012-09-27
申请号：US13227522
申请日：2011-09-08
申请人： Olaf Skerl , Michael Lippert , Jens Kirchner
发明人： Olaf Skerl , Michael Lippert , Jens Kirchner
CPC分类号： A61B5/1102 , A61B5/0006 , A61N1/36571 , A61N1/36578 , A61N1/3682 , A61N1/3684
摘要： An implantable medical device includes an integrated or connectable implantable three-dimensional acceleration sensor, and a ballistocardiogram (BCG) capturing unit that is connected or connectable to the acceleration sensor. The BCG evaluation unit processes an acceleration signal provided by the acceleration sensor and derives a BCG from the 3D accelerometer output signal. A BCG evaluation unit is connected to the BCG capturing unit, and is designed to evaluate a BCG provided by the BCG capturing unit and supply an output signal representing stroke volume.
摘要翻译： 可植入医疗装置包括可组装或可连接的可植入三维加速度传感器，以及连接或连接到加速度传感器的圆心形图（BCG）捕获单元。 BCG评估单元处理由加速度传感器提供的加速度信号，并从3D加速度计输出信号导出BCG。 BCG评估单元连接到BCG捕获单元，并被设计为评估由BCG捕捉单元提供的BCG并提供表示笔画音量的输出信号。
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