公开(公告)号：US20070156058A1

公开(公告)日：2007-07-05

申请号：US11614546

申请日：2006-12-21

申请人： Thomas Faber ,  Michael Lippert ,  Marc Schweika-Kresimon

发明人： Thomas Faber ,  Michael Lippert ,  Marc Schweika-Kresimon

IPC分类号： A61B5/04

CPC分类号： A61B5/053 ,  A61B5/046 ,  A61B5/0538 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/3925 ,  A61N1/395 ,  A61N1/3962

摘要： A detector for atrial fibrillation and/or atrial flutter comprises an atrial input for receiving an atrial signal representing an intraatrial electrogram or a time course of an intraatrial impedance, a ventricular input for receiving a ventricular event signal comprising information on an occurrence of a cyclically reoccurring ventricular event in chronological association to an atrial signal received via atrial input, an averaging unit adapted to average a plurality of sections of said atrial signal, each section to be considered for averaging starts or ends at a predetermined offset before a ventricular event, and to put out an averaged atrial signal, a peak amplitude determination unit adapted to determine peak-to-peak amplitude of said averaged atrial signal, and threshold comparator adapted to compare peak-to-peak amplitude of averaged atrial signal to predetermined reference value and to generate an AF warning signal if peak-to-peak amplitude of averaged atrial signal is less than predetermined threshold value.

摘要翻译： 用于心房颤动和/或心房颤动的检测器包括用于接收表示心房内电极电图或心房内阻抗的时间过程的心房信号的心房输入，用于接收心室事件信号的心室输入，所述心室输入包括关于周期性重现的发生的信息 按照与通过心房输入接收的心房信号的时间顺序关联的心室事件，适于平均所述心房信号的多个部分的平均单元，要被考虑用于在心室事件之前以预定偏移开始或结束的每个部分的平均单元，以及 放出平均的心房信号，峰值振幅确定单元，用于确定所述平均心房信号的峰 - 峰幅度;以及阈值比较器，用于将平均心房信号的峰 - 峰振幅与预定参考值进行比较，并产生 一个AF警告信号，如果平均心房信号的峰 - 峰幅度小于tha n个预定阈值。

公开(公告)号：US20070078356A1

公开(公告)日：2007-04-05

申请号：US11541054

申请日：2006-09-29

申请人： Thomas Faber ,  Michael Lippert ,  Marc Schweika-Kresimon

发明人： Thomas Faber ,  Michael Lippert ,  Marc Schweika-Kresimon

IPC分类号： A61B5/04

CPC分类号： A61B5/053 ,  A61B5/046 ,  A61B5/0538 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/3925 ,  A61N1/395 ,  A61N1/3962

摘要： A detector for atrial fibrillation or flutter (AF) having an impedance unit, which has a measurement input, to which an atrial electrode line having an electrode for a unipolar measurement of an impedance in the atrium is connected and is implemented to generate an atrial impedance signal obtained in a unipolar manner in such a way that the impedance signal comprises multiple impedance values detected at different instants within a particular atrial cycle for each atrial cycle, comprising an atrial contraction and the following relaxation of the atrium, and having a signal input, via which a ventricle signal is to be supplied to the detector, which reflects the instants of ventricular contractions in chronological assignment to the impedance signal, the detector having an analysis unit, which is implemented to average multiple sequential impedance signal sections of a unipolar atrial impedance signal, delimited by two sequential ventricular contractions in each case, with one another and to determine the maximum amplitude of the averaged unipolar atrial impedance signal section, compare it to a comparison value, and if the maximum amplitude of the averaged unipolar atrial impedance signal is less than a comparison value, to generate an AF suspicion signal.

摘要翻译： 具有阻抗单元的具有阻抗单元的检测器，其具有测量输入，具有用于单极性测量心房中的阻抗的电极的心房电极线连接到该心电极线并被实施以产生心房阻抗 以单极方式获得的信号，使得阻抗信号包括在每个心房周期的特定心房周期内在不同时刻检测的多个阻抗值，包括心房收缩和心房的随后松弛，并具有信号输入， 通过其将心室信号提供给检测器，其将按时间顺序分配的心室收缩的瞬间反映到阻抗信号，检测器具有分析单元，其被实现为平均单极性心房阻抗的多个连续阻抗信号部分 信号，在每种情况下由两个顺序的心室收缩界定，彼此a nd确定平均单极心房阻抗信号区段的最大振幅，将其与比较值进行比较，如果平均单极心房阻抗信号的最大振幅小于比较值，则产生AF怀疑信号。

公开(公告)号：US08965493B2

公开(公告)日：2015-02-24

申请号：US13040926

申请日：2011-03-04

申请人： Olaf Skerl ,  Michael Lippert ,  Gerald Czygan

发明人： Olaf Skerl ,  Michael Lippert ,  Gerald Czygan

IPC分类号： A61B5/04 ,  A61B5/053 ,  A61B5/00

CPC分类号： A61B5/0535 ,  A61B5/6846 ,  A61B5/7207 ,  A61B2562/0209 ,  A61B2562/043

摘要： An electromedical implant for monitoring a thoracic property of a living being is provided that includes a detector arrangement including an impedance measuring unit and an electrode arrangement, which are equipped to capture a measurement signal associated with the thoracic property in the form of an impedance signal; a monitoring arrangement, which is connected to the detector arrangement and equipped to generate a parameter from the measurement signal that is indicative of the thoracic property, and an evaluation unit, which is connected to the monitoring arrangement and equipped to determine an evaluation result regarding the thoracic property based on the parameter. According to the invention, the electrode arrangement comprises at least a plurality of mutually isolated electrodes, which are disposed on the housing and operatively connected by way of the impedance measuring unit and which can be separately controlled, wherein an electrode body has a strip shape.

摘要翻译： 提供了一种用于监测生命体的胸部性质的电植入物，其包括检测器装置，所述检测器装置包括阻抗测量单元和电极装置，其被配备为以阻抗信号的形式捕获与胸部特性相关联的测量信号; 监视装置，其连接到所述检测器装置，并且被配备为从所述测量信号生成指示胸部特性的参数;以及评估单元，所述评估单元连接到所述监视装置并被配备以确定关于所述检测装置的评估结果 胸部属性基于参数。 根据本发明，电极布置包括至少多个相互隔离的电极，它们设置在壳体上并且通过阻抗测量单元可操作地连接并且可以被单独控制，其中电极体具有带状。

公开(公告)号：US08491485B2

公开(公告)日：2013-07-23

申请号：US13038428

申请日：2011-03-02

申请人： Gerald Czygan ,  Michael Lippert ,  Olaf Skerl

发明人： Gerald Czygan ,  Michael Lippert ,  Olaf Skerl

IPC分类号： A61B5/024 ,  A61B5/026

CPC分类号： A61B5/0535 ,  A61B5/029 ,  A61B5/0295 ,  A61B5/0402 ,  A61B5/6846 ,  A61B5/721 ,  A61B5/7214 ,  A61B5/7275

摘要： An electromedical implant (100, 101, 102, 103) for monitoring a cardiac blood flow (B1) of a patient includes a detector (10, 10′, 10″) which obtains a first measurement signal (S1) associated with the cardiac blood flow (B1) and a second measurement signal (S2) associated with the epithoracic, peripheral blood flow (B2). A monitoring assembly (20) then generates a first parameter (P1) from the first measurement signal (S1) which is indicative of a time (tsys) at which blood is ejected from the heart, and a second parameter (2) from the second measurement signal (S2) which is indicative of a time (tgef) of a blood pulse in the thoracic tissue which is associated with the ejection of blood. An evaluation unit (30) then generates a pulse transit time (Δt=tgef−tsys) from the first parameter (P1) and the second parameter (P2). The detector (10, 10′, 10″) includes an impedance measuring unit (12) having an electrode assembly (11, 11′) for detection of at least the second measurement signal (S2) in the form of an impedance signal.

摘要翻译： 用于监测患者的心脏血流（B1）的电植入物（100,101,102,103）包括检测器（10,10'，10“），其获得与心脏相关联的第一测量信号（S1） 血液流（B1）和与脑外周血流（B2）相关联的第二测量信号（S2）。 监测组件（20）然后从第一测量信号（S1）产生指示从心脏喷出血液的时间（tsys）的第一参数（P1），以及来自第二测量信号的第二参数（2） 测量信号（S2），其指示与血液喷射相关联的胸部组织中的血液脉冲的时间（tgef）。 评估单元（30）然后从第一参数（P1）和第二参数（P2）产生脉冲传播时间（Deltat = tgef-tsys）。 检测器（10,10'，10“）包括具有用于以阻抗信号的形式检测至少第二测量信号（S2）的电极组件（11,11'）的阻抗测量单元（12）。

公开(公告)号：US20110029035A1

公开(公告)日：2011-02-03

申请号：US12830750

申请日：2010-07-06

申请人： Michael Vollkron ,  Michael Lippert

发明人： Michael Vollkron ,  Michael Lippert

IPC分类号： A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/3684 ,  A61N1/3688

摘要： An implantable cardiac stimulator includes at least one first sensing unit for detecting intrinsic cardiac activities of a first ventricle, at least one ventricular stimulation unit for stimulating a second ventricle, and a stimulation control unit connected to the first sensing unit. The stimulation unit processed output signals of the first sensing unit and generates control signals for the stimulation units. The stimulation control unit derives a current intrinsic RR interval from detected ventricular intrinsic cardiac activities R of the first ventricle, and to determine from the RR interval a delay interval Δ, which begins with a ventricular event of the first ventricle and at the end of which the stimulation control unit triggers a stimulation of the second ventricle (unless it is suppressed).

摘要翻译： 植入式心脏刺激器包括用于检测第一心室的内在心脏活动的至少一个第一感测单元，用于刺激第二脑室的至少一个心室刺激单元和连接到第一感测单元的刺激控制单元。 刺激单元处理第一感测单元的输出信号并产生用于刺激单元的控制信号。 刺激控制单元从检测到的第一脑室的心室内心脏活动R导出当前内在RR间期，并且从RR间期确定延迟间隔＆Dgr，其从第一脑室的心室事件开始，并且在第 刺激控制单元触发第二脑室的刺激（除非被抑制）。

公开(公告)号：US07702389B2

公开(公告)日：2010-04-20

申请号：US11559626

申请日：2006-11-14

申请人： Gerald Czygan ,  Michael Lippert

发明人： Gerald Czygan ,  Michael Lippert

IPC分类号： A61N1/00

CPC分类号： A61N1/3627

摘要： The invention concerns implantable cardiac stimulation devices in general which have at least one stimulation pulse generator (A-STIM; RV-STIM; LV-STIM) to selectively generate a stimulation pulse for delivery to one of at least two different chambers of a heart, said chambers include right and left atria and right and left ventricles, at least one impedance measuring stage (I, U, IMP) being connected to electrodes or connectors for such electrodes to measure an intracardiac impedance when in use, a control unit (CTRL) connected to the stimulation pulse generator and to the impedance measuring unit and being adapted to process a minimum impedance value for a heart cycle to trigger stimulation pulses for two different chambers of the heart with an adjustable time delay (VVD; AVD) and to adjust said time delay depending upon the measured intracardiac impedance minimum value. According to the invention the control unit is adapted to adjust the time delay such that the minimum value of the intracardiac impedance during one heart cycle is minimized or such that the AVD delay is equal to the time interval between an atrial event and the point of time when the minimum impedance value occurs after said atrial contraction.

摘要翻译： 本发明涉及一般具有至少一个刺激脉冲发生器（A-STIM; RV-STIM; LV-STIM）的可植入心脏刺激装置，以选择性地产生用于递送至心脏的至少两个不同室中的一个的刺激脉冲， 所述腔室包括右心房和左心房以及右心室和左心室，至少一个阻抗测量平台（I，U，IMP）连接到用于这种电极的电极或连接器，用于在使用时测量心内阻抗，控制单元（CTRL） 连接到刺激脉冲发生器和阻抗测量单元，并且适于处理用于心脏周期的最小阻抗值以用可调节的时间延迟（VVD; AVD）触发心脏的两个不同腔室的刺激脉冲，并且调整所述 时间延迟取决于测量的心内阻抗最小值。 根据本发明，控制单元适于调整时间延迟，使得在一个心脏周期期间心内阻抗的最小值被最小化或使得AVD延迟等于心房事件与时间点之间的时间间隔 当在所述心房收缩之后发生最小阻抗值时。

公开(公告)号：US20090048524A1

公开(公告)日：2009-02-19

申请号：US12190113

申请日：2008-08-12

申请人： Hans-Jurgen WILDAU ,  Gerald Czygan ,  Michael Diebold ,  Michael Lippert ,  Claus Harder ,  Thomas Schmitz-Rode

发明人： Hans-Jurgen WILDAU ,  Gerald Czygan ,  Michael Diebold ,  Michael Lippert ,  Claus Harder ,  Thomas Schmitz-Rode

IPC分类号： A61B5/0215

CPC分类号： A61B5/0215 ,  A61B5/0031 ,  A61B5/02156 ,  A61B5/02158 ,  A61B5/6862 ,  A61B5/6876 ,  A61B5/6882 ,  A61B2560/0219 ,  A61B2560/0252 ,  A61B2560/0257

摘要： Implantable pressure measuring unit for internal pressure measurement in a blood vessel or heart of a patient, having a pressure sensor having electrical signal output, fixing means adapted to the intended measurement location for fixing the pressure sensor, a power supply unit of the pressure sensor, a signal detection unit connected by a line to the signal output of the pressure sensor, and a transmitting unit connected to a measurement data output of the signal detection unit, in particular for wireless transmission of measurement data to an analysis unit, in particular outward from the patient body.

摘要翻译： 一种用于在患者的血管或心脏中进行内部压力测量的可植入压力测量单元，具有具有电信号输出的压力传感器，适于用于固定压力传感器的预期测量位置的固定装置，压力传感器的电源单元， 信号检测单元，其通过线路连接到压力传感器的信号输出;以及发送单元，连接到信号检测单元的测量数据输出，特别是用于将测量数据无线传输到分析单元，特别是从 病人身体。

公开(公告)号：US20060135886A1

公开(公告)日：2006-06-22

申请号：US11293398

申请日：2005-12-02

申请人： Michael Lippert ,  Gerald Czygan

发明人： Michael Lippert ,  Gerald Czygan

IPC分类号： A61N1/368

CPC分类号： A61B5/0031 ,  A61B5/0537

摘要： An electromedical implant includes a measuring signal generator, an impedance measuring unit to determine the impedance of human or animal tissue, a control unit which, for controlling the measuring signal generator and the impedance measuring unit, is at least indirectly connected to the measuring signal generator and to the impedance measuring unit, as well as an electrode arrangement comprising at least two electrodes which can be directly or indirectly connected or at least temporarily connected to the measuring signal generator and to the impedance measuring unit, or to a connection for such an electrode arrangement. The measuring signal generator is designed to generate and emit a current pulse or a series of current pulses, and the control unit is designed at a specific point in time to cause the measuring signal generator (to generate and emit a current pulse, and to cause the impedance measuring unit to measure the voltage that is present between the electrodes connected to the measuring signal generator and the impedance measuring unit after the passing of at least two time periods of different length that start with commencement of the current pulse being emitted and end before the end of emitting the current pulse, and to issue a voltage value which in each case represents the measured voltage.

摘要翻译： 电动植入物包括测量信号发生器，用于确定人体或动物组织的阻抗的阻抗测量单元，用于控制测量信号发生器和阻抗测量单元的控制单元至少间接连接到测量信号发生器 和阻抗测量单元，以及包括至少两个电极的电极装置，所述至少两个电极可以直接或间接连接或至少临时连接到测量信号发生器和阻抗测量单元，或者连接到这种电极 安排。 测量信号发生器被设计成产生和发出电流脉冲或一系列电流脉冲，并且控制单元被设计在特定的时间点，以使得测量信号发生器（产生和发射电流脉冲，并引起 所述阻抗测量单元用于测量在连接到所述测量信号发生器的电极和所述阻抗测量单元之间存在的电压，所述电压在经过所述至少两个不同长度的时间段之后，所述至少两个不同长度的时间段从所述当前脉冲的开始开始并被发射 发射电流脉冲的结束，并发出在每种情况下表示测量电压的电压值。

公开(公告)号：US09026209B2

公开(公告)日：2015-05-05

申请号：US12830750

申请日：2010-07-06

申请人： Michael Vollkron ,  Michael Lippert

发明人： Michael Vollkron ,  Michael Lippert

IPC分类号： A61N1/368 ,  A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/3684 ,  A61N1/3688

摘要： An implantable cardiac stimulator includes at least one first sensing unit for detecting intrinsic cardiac activities of a first ventricle, at least one ventricular stimulation unit for stimulating a second ventricle, and a stimulation control unit connected to the first sensing unit. The stimulation unit processed output signals of the first sensing unit and generates control signals for the stimulation units. The stimulation control unit derives a current intrinsic RR interval from detected ventricular intrinsic cardiac activities R of the first ventricle, and to determine from the RR interval a delay interval Δ, which begins with a ventricular event of the first ventricle and at the end of which the stimulation control unit triggers a stimulation of the second ventricle (unless it is suppressed).

摘要翻译： 植入式心脏刺激器包括用于检测第一心室的内在心脏活动的至少一个第一感测单元，用于刺激第二脑室的至少一个心室刺激单元和连接到第一感测单元的刺激控制单元。 刺激单元处理第一感测单元的输出信号并产生用于刺激单元的控制信号。 刺激控制单元从检测到的第一脑室的心室内心脏活动R导出当前内在RR间期，并且从RR间期确定延迟间隔＆Dgr，其从第一脑室的心室事件开始，并且在第 刺激控制单元触发第二脑室的刺激（除非被抑制）。

公开(公告)号：US20100268294A1

公开(公告)日：2010-10-21

申请号：US12749723

申请日：2010-03-30

申请人： Michael Vollkron ,  Gerald Czygan ,  Thomas Kraemer ,  Michael Lippert ,  Olaf Skerl

发明人： Michael Vollkron ,  Gerald Czygan ,  Thomas Kraemer ,  Michael Lippert ,  Olaf Skerl

IPC分类号： A61N1/365 ,  G06N5/02 ,  G06F11/07 ,  G06F17/00 ,  A61B5/021 ,  A61B5/0452 ,  A61N1/39

CPC分类号： A61N1/3627 ,  A61B5/0215 ,  A61B5/02158 ,  A61B5/053 ,  A61B5/1076 ,  A61N1/365 ,  A61N1/36521 ,  A61N1/36528 ,  A61N1/36564 ,  A61N1/36578

摘要： Embodiments relate to a heart monitor, which is connected to or can be connected to at least one sensor for pressure and volume data or equivalent substitute variables and which comprises an evaluation unit for processing at least one input signal reflecting the temporal course of pressure and volume data or equivalent substitute variables of the heart. The evaluation unit is configured such that it segments the input signal in accordance with individual completed cardiac cycles and examines segments of the input signal obtained in this way as to whether a particular segment of the input signal represents a PV diagram, which corresponds to specified quality conditions regarding the direction of circulation, morphology and distance between a starting and end values.

摘要翻译： 实施例涉及心脏监测器，心脏监测器连接到或可以连接至至少一个用于压力和体积数据或等效替代变量的传感器，并且其包括用于处理反映压力和体积的时间过程的至少一个输入信号的评估单元 数据或等效替代变量的心脏。 评估单元被配置为使得其根据各个完成的心动周期来分段输入信号，并且检查以这种方式获得的输入信号的段是关于输入信号的特定段是否表示对应于指定质量的PV图 关于循环方向，形态以及起始和终点之间的距离的条件。