Chondroitinase ABC I and methods of analyzing therewith
    31.
    发明申请
    Chondroitinase ABC I and methods of analyzing therewith 有权
    软骨素酶ABC I及其分析方法

    公开(公告)号:US20070202563A1

    公开(公告)日:2007-08-30

    申请号:US11638094

    申请日:2006-12-13

    IPC分类号: C12Q1/34 C12N9/24

    CPC分类号: C12N9/88 A61K38/47 Y02A50/411

    摘要: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.

    摘要翻译: 本发明涉及软骨素酶ABCⅠ及其用途。 特别地,本发明涉及重组和修饰的软骨素酶ABCⅠ,其生产及其用途。 本发明的软骨素酶ABC I酶可用于多种目的,包括降解和分析多糖如糖胺聚糖(GAG)。 这些GAG可以包括硫酸软骨素,硫酸皮肤素,未硫酸化的软骨素和透明质酸。 软骨素酶ABC I酶也可用于促进神经再生,促进中风恢复,治疗脊髓损伤,治疗上皮疾病,治疗感染和治疗癌症等治疗方法。