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1.Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto 审中-公开
标题翻译: 血凝素多肽,以及与其相关的试剂和方法公开(公告)号:US20090269342A1
公开(公告)日:2009-10-29
申请号:US12348266
申请日:2009-01-02
申请人: Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
发明人: Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
IPC分类号: A61K39/395 , C07K14/00 , C12N15/11 , C12N15/00 , C12N5/06 , C07K16/18 , C12N7/00 , A61K38/02 , C40B40/10 , C40B30/04 , G01N33/566
CPC分类号: G01N33/56983 , C07K14/005 , C12N2760/16122 , G01N2333/11 , G01N2400/10 , G01N2500/02
摘要: The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.
摘要翻译: 本发明提供了一种用于分析聚糖和与其结合的相互作用配偶体之间的相互作用的系统。 本发明还提供结合伞形拓扑聚糖的HA多肽,以及与其相关的试剂和方法。
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2.HEMAGGLUTININ POLYPEPTIDES, AND REAGENTS AND METHODS RELATING THERETO 审中-公开
标题翻译: HEMAGGLUTININ POLYPEPTIDES,以及与其相关的试剂和方法公开(公告)号:US20090081193A1
公开(公告)日:2009-03-26
申请号:US11969040
申请日:2008-01-03
申请人: Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
发明人: Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
IPC分类号: A61K39/395 , C07K14/435 , C07H21/00 , C12N15/64 , C12N1/21 , A61K31/7088 , A61P31/16 , C07K16/08 , C12N7/01 , C40B40/12 , A61K38/16
CPC分类号: G01N33/5308 , G01N2400/10
摘要: The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.
摘要翻译: 本发明提供了一种用于分析聚糖和与其结合的相互作用配偶体之间的相互作用的系统。 本发明还提供结合伞形拓扑聚糖的HA多肽,以及与其相关的试剂和方法。
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公开(公告)号:US08815522B2
公开(公告)日:2014-08-26
申请号:US12348265
申请日:2009-01-02
申请人: Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
发明人: Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
IPC分类号: G01N33/53 , A61K31/702 , A61K31/715 , C07H3/06
CPC分类号: G01N33/56983 , G01N2333/11 , G01N2400/10
摘要: The present invention provides umbrella-topology glycan decoys. The present invention provides systems and methods treating influenza infection utilizing inventive umbrella-topology glycan decoys. The present invention provides methods for identifying novel umbrella-topology glycan decoys.
摘要翻译: 本发明提供伞形拓扑聚糖诱饵。 本发明提供利用本发明的伞形拓扑聚糖诱饵治疗流感感染的系统和方法。 本发明提供了鉴定新型伞形拓扑聚糖诱饵的方法。
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4.Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto 审中-公开
标题翻译: 血凝素多肽,以及与其相关的试剂和方法公开(公告)号:US20100061990A1
公开(公告)日:2010-03-11
申请号:US12301126
申请日:2007-08-14
申请人: Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
发明人: Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
IPC分类号: A61K39/395 , G01N33/53 , C40B40/12
CPC分类号: G01N33/5308 , G01N2400/10
摘要: The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.
摘要翻译: 本发明提供了一种用于分析聚糖和与其结合的相互作用配偶体之间的相互作用的系统。 本发明还提供了结合伞形拓扑聚糖的HA多肽,以及与其相关的试剂和方法。
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公开(公告)号:US20100004195A1
公开(公告)日:2010-01-07
申请号:US12348265
申请日:2009-01-02
申请人: Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
发明人: Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
IPC分类号: A61K31/702 , C12Q1/70 , C07H1/00
CPC分类号: G01N33/56983 , G01N2333/11 , G01N2400/10
摘要: The present invention provides umbrella-topology glycan decoys. The present invention provides systems and methods treating influenza infection utilizing inventive umbrella-topology glycan decoys. The present invention provides methods for identifying novel umbrella-topology glycan decoys.
摘要翻译: 本发明提供伞形拓扑聚糖诱饵。 本发明提供利用本发明的伞形拓扑聚糖诱饵治疗流感感染的系统和方法。 本发明提供了鉴定新型伞形拓扑聚糖诱饵的方法。
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6.Hemagglutinin polypeptides, and reagents and methods relating thereto 审中-公开
标题翻译: 血凝素多肽,以及与其有关的试剂和方法公开(公告)号:US20080241918A1
公开(公告)日:2008-10-02
申请号:US11893171
申请日:2007-08-14
申请人: Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
发明人: Ram Sasisekharan , Karthik Viswanathan , Aarthi Chandrasekaran , Rahul Raman , Aravind Srinivasan , S. Raguram , Viswanathan Sasisekharan
CPC分类号: G01N33/5308 , G01N2400/10
摘要: The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.
摘要翻译: 本发明提供了一种用于分析聚糖和与其结合的相互作用配偶体之间的相互作用的系统。 本发明还提供结合伞形拓扑聚糖的HA多肽,以及与其相关的试剂和方法。
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7.Engineered polypeptide agents for targeted broad spectrum influenza neutralization 有权
标题翻译: 用于靶向广谱流感中和的工程多肽试剂公开(公告)号:US08637456B2
公开(公告)日:2014-01-28
申请号:US13015455
申请日:2011-01-27
申请人: Ram Sasisekharan , Karthik Viswanathan , Venkataramanan Soundararajan , S. Raguram , Viswanathan Sasisekharan , Vidya Subramanian
发明人: Ram Sasisekharan , Karthik Viswanathan , Venkataramanan Soundararajan , S. Raguram , Viswanathan Sasisekharan , Vidya Subramanian
CPC分类号: A61K38/162 , A61K9/0053 , A61K9/0073 , A61K38/00 , C07K14/001 , C07K14/005 , C12N7/00 , C12N2760/16122 , C12N2760/16133 , G01N33/56983 , G01N2333/11
摘要: The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (HA) polypeptides and/or HA receptors, and reagents and methods relating thereto. The present invention provides a system for analyzing interactions between infolds and the interaction partners that bind to them.
摘要翻译: 本发明提供用于广谱流感中和的新型药剂。 本发明提供通过结合流感病毒和/或血凝素(HA)多肽和/或HA受体来抑制流感感染的试剂,以及与其相关的试剂和方法。 本发明提供了一种用于分析信息与与之结合的交互伙伴之间的相互作用的系统。
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公开(公告)号:US20100125043A1
公开(公告)日:2010-05-20
申请号:US11915194
申请日:2007-08-14
IPC分类号: C40B30/04
CPC分类号: G01N33/5308 , G01N2400/10
摘要: The present invention provides a system for analyzing glycans and their interaction partners. The inventive system is particularly useful in the identification and analysis of glycoprotein binding interactions.
摘要翻译: 本发明提供了一种用于分析聚糖及其相互作用配偶体的系统。 本发明的系统特别可用于鉴定和分析糖蛋白结合相互作用。
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