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公开(公告)号：US20070042942A1
公开(公告)日：2007-02-22
申请号：US11589614
申请日：2006-10-30
申请人： Martin Linsell , Paul Fatheree , Michael Leadbetter , Yan Zhu , J. Judice
发明人： Martin Linsell , Paul Fatheree , Michael Leadbetter , Yan Zhu , J. Judice
CPC分类号： B82Y5/00 , A61K9/0014 , A61K9/0019 , A61K38/00 , A61K47/40 , A61K47/6951 , C07K9/008
摘要： Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
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公开(公告)号：US20050159344A1
公开(公告)日：2005-07-21
申请号：US11080130
申请日：2005-03-15
申请人： Martin Linsell , Paul Fatheree , Michael Leadbetter , Yan Zhu , J. Judice
发明人： Martin Linsell , Paul Fatheree , Michael Leadbetter , Yan Zhu , J. Judice
CPC分类号： B82Y5/00 , A61K9/0014 , A61K9/0019 , A61K38/00 , A61K47/40 , A61K47/6951 , C07K9/008
摘要： Disclosed are glycopeptide derivatives substituted at the C-terminus and/or the R-terminus with a substituent that comprises one or more saccharide groups and a carboxy group; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
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公开(公告)号：US07786136B2
公开(公告)日：2010-08-31
申请号：US12008840
申请日：2008-01-15
申请人： Paul Fatheree , Roland Gendron , Adam A Goldblum , Daniel D Long , Daniel Marquess , S. Derek Turner , Seok-Ki Choi
发明人： Paul Fatheree , Roland Gendron , Adam A Goldblum , Daniel D Long , Daniel Marquess , S. Derek Turner , Seok-Ki Choi
IPC分类号： A61K31/46
CPC分类号： C07D451/04
摘要： The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供了新的吲唑 - 甲酰胺5-HT4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US07534889B2
公开(公告)日：2009-05-19
申请号：US12136891
申请日：2008-06-11
申请人： Seok-Ki Choi , Paul Fatheree , Adam A Goldblum , Lan Jiang , Daniel D Long , Daniel Marquess , S. Derek Turner
发明人： Seok-Ki Choi , Paul Fatheree , Adam A Goldblum , Lan Jiang , Daniel D Long , Daniel Marquess , S. Derek Turner
IPC分类号： C07D215/00 , A01N43/90
CPC分类号： C07D451/04
摘要： The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供新的喹啉酮 - 甲酰胺5-HT 4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US07498442B2
公开(公告)日：2009-03-03
申请号：US12075740
申请日：2008-03-13
申请人： Seok-Ki Choi , Paul Fatheree , Roland Gendron , Adam A Goldblum , Lan Jiang , Daniel D Long , Daniel Marquess
发明人： Seok-Ki Choi , Paul Fatheree , Roland Gendron , Adam A Goldblum , Lan Jiang , Daniel D Long , Daniel Marquess
IPC分类号： C07D215/00 , C07D471/02
CPC分类号： C07D451/04
摘要： The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供新的喹啉酮 - 甲酰胺5-HT 4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20080255187A1
公开(公告)日：2008-10-16
申请号：US12136891
申请日：2008-06-11
申请人： Seok-Ki Choi , Paul Fatheree , Adam A. Goldblum , Lan Jiang , Daniel D. Long , Daniel Marquess , S. Derek Turner
发明人： Seok-Ki Choi , Paul Fatheree , Adam A. Goldblum , Lan Jiang , Daniel D. Long , Daniel Marquess , S. Derek Turner
IPC分类号： A61K31/439 , A61P1/00
CPC分类号： C07D451/04
摘要： The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供新颖的喹啉酮 - 甲酰胺5-HT 4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT 4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US07419989B2
公开(公告)日：2008-09-02
申请号：US11314591
申请日：2005-12-21
申请人： Paul Fatheree , Roland Gendron , Adam A Goldblum , Daniel D Long , Daniel Marquess , S. Derek Turner , Seok-Ki Choi
发明人： Paul Fatheree , Roland Gendron , Adam A Goldblum , Daniel D Long , Daniel Marquess , S. Derek Turner , Seok-Ki Choi
IPC分类号： C07D401/14
CPC分类号： C07D451/04
摘要： The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供了新的吲唑 - 甲酰胺5-HT 4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT 4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20060276467A1
公开(公告)日：2006-12-07
申请号：US11500078
申请日：2006-08-07
申请人： Seok-Ki Choi , Paul Fatheree , David Green , Daniel Marquess
发明人： Seok-Ki Choi , Paul Fatheree , David Green , Daniel Marquess
IPC分类号： A61K31/5377 , A61K31/445 , A61K31/40 , C07D207/04 , C07D211/20 , A61K31/138
CPC分类号： C07D213/30 , A61K31/135 , A61K31/401 , A61K31/4152 , A61K31/417 , A61K31/4184 , A61K31/4402 , A61K31/4465 , A61K31/5375 , C07C217/08 , C07C217/30 , C07C217/36 , C07C217/76 , C07C217/84 , C07C255/54 , C07C2601/18 , C07C2602/10 , C07D207/09 , C07D211/26 , C07D213/38 , C07D213/65 , C07D215/20 , C07D233/56 , C07D233/64 , C07D235/06 , C07D295/13 , C07D317/54 , C07D333/16
摘要： The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).
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公开(公告)号：US07396933B2
公开(公告)日：2008-07-08
申请号：US11267720
申请日：2005-11-04
申请人： Seok-Ki Choi , Paul Fatheree , Roland Gendron , Adam A Goldblum , Lan Jiang , Daniel D Long , Daniel Marquess
发明人： Seok-Ki Choi , Paul Fatheree , Roland Gendron , Adam A Goldblum , Lan Jiang , Daniel D Long , Daniel Marquess
IPC分类号： C07D215/00
CPC分类号： C07D451/04
摘要： The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20050130966A1
公开(公告)日：2005-06-16
申请号：US11052504
申请日：2005-02-04
申请人： Seok-Ki Choi , Paul Fatheree , David Green , Daniel Marquess
发明人： Seok-Ki Choi , Paul Fatheree , David Green , Daniel Marquess
IPC分类号： A61K31/135 , A61K31/401 , A61K31/4152 , A61K31/417 , A61K31/4184 , A61K31/4402 , A61K31/4465 , A61K31/5375 , A61P25/00 , C07C217/08 , C07C217/30 , C07C217/36 , C07C217/76 , C07C217/84 , C07C255/54 , C07D207/09 , C07D211/26 , C07D213/30 , C07D213/38 , C07D213/65 , C07D215/20 , C07D231/12 , C07D233/54 , C07D233/61 , C07D233/76 , C07D235/06 , C07D295/13 , C07D317/54 , C07D333/16 , A61K31/5377 , A61K31/4025 , A61K31/4545
CPC分类号： C07D213/30 , A61K31/135 , A61K31/401 , A61K31/4152 , A61K31/417 , A61K31/4184 , A61K31/4402 , A61K31/4465 , A61K31/5375 , C07C217/08 , C07C217/30 , C07C217/36 , C07C217/76 , C07C217/84 , C07C255/54 , C07C2601/18 , C07C2602/10 , C07D207/09 , C07D211/26 , C07D213/38 , C07D213/65 , C07D215/20 , C07D233/56 , C07D233/64 , C07D235/06 , C07D295/13 , C07D317/54 , C07D333/16
摘要： The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).
摘要翻译： 本发明提供了钠通道调节化合物，其可用于治疗与钠通道活性相关的疾病或病症，例如神经性疼痛。 本发明还提供包含本发明化合物的药物组合物，以及包括向哺乳动物（例如人）施用此类化合物或盐的治疗方法。
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