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公开(公告)号：US08524722B2
公开(公告)日：2013-09-03
申请号：US12678288
申请日：2008-09-02
申请人： Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirstin Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffmann , Gerhard Siemeister , Ulf Bömer
发明人： Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirstin Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffmann , Gerhard Siemeister , Ulf Bömer
IPC分类号： A01N43/54 , A01N43/40 , A61K31/505 , A61K31/445 , C07D239/00 , C07D471/00 , C07D491/00 , C07D401/00 , C07D405/00 , C07D409/00
CPC分类号： C07D495/14 , C07D491/147 , C07D519/00
摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
摘要翻译： 本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。
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公开(公告)号：US20100168240A1
公开(公告)日：2010-07-01
申请号：US12529713
申请日：2008-03-15
申请人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Dieter Lang
发明人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Dieter Lang
IPC分类号： A61K31/194 , C07C65/28 , A61P9/04 , A61P9/12 , A61P9/10
CPC分类号： C07C65/28
摘要： The invention relates to novel substituted dibenzoic acid derivatives of formula (I), wherein A represents a group of formula (II) or (III), to methods for producing the same, and to their use in the treatment and/or prophylaxis of diseases. The invention also relates to the use of said substances in the production of drugs for the treatment and/or prophylaxis of diseases, especially in the treatment and/or prevention of cardiovascular diseases.
摘要翻译： 本发明涉及式（I）的新型取代二苯甲酸衍生物，其中A代表式（II）或（III）的基团，其制备方法及其在治疗和/或预防疾病中的用途 。 本发明还涉及所述物质在制备药物中用于治疗和/或预防疾病的用途，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US08217063B2
公开(公告)日：2012-07-10
申请号：US12529342
申请日：2008-03-15
申请人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Dieter Lang
发明人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Dieter Lang
IPC分类号： C07D207/24 , C07D233/32 , C07D249/12 , C07D255/02 , C07D211/74 , C07D239/10 , C07D241/08 , C07D223/08 , C07D263/18 , C07D271/07 , C07D265/10 , C07D265/32 , C07D273/02 , C07D273/04 , C07D273/06 , A61K31/4015 , A61K31/4166 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/4412 , A61K31/45 , A61K31/513 , A61K31/53 , A61K31/535 , A61K31/5375 , A61K31/539 , A61K31/5395
CPC分类号： C07D207/267 , C07D211/76 , C07D239/10 , C07D263/22 , C07D265/32
摘要： The present application relates to novel lactam-substituted dicarboxylic acid derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型内酰胺取代的二羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病，特别是用于治疗的药物的用途 和/或预防心血管疾病。
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公开(公告)号：US20100197680A1
公开(公告)日：2010-08-05
申请号：US12529342
申请日：2008-03-15
申请人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Dieter Lang
发明人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Dieter Lang
IPC分类号： A61K31/5375 , C07D207/12 , A61K31/40 , C07D265/32 , C07D263/04 , A61K31/421 , C07D211/00 , A61K31/445 , C07D239/04 , A61K31/513 , A61P9/00 , A61P9/12 , A61P9/10
CPC分类号： C07D207/267 , C07D211/76 , C07D239/10 , C07D263/22 , C07D265/32
摘要： The present application relates to novel lactam-substituted dicarboxylic acid derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型内酰胺取代的二羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病，特别是用于治疗的药物的用途 和/或预防心血管疾病。
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公开(公告)号：US20140256718A1
公开(公告)日：2014-09-11
申请号：US14130586
申请日：2012-06-26
申请人： Jürgen Klar , Verena Vöhringer , Joachim Telser , Mario Lobell , Frank Süssmeier , Volkhart Min-Jian Li , Michael Böttger , Stefan Golz , Dieter Lang , Karl-Heinz Schlemmer , Thomas Schlange , Andreas Schall , Wenlang Fu
发明人： Jürgen Klar , Verena Vöhringer , Joachim Telser , Mario Lobell , Frank Süssmeier , Volkhart Min-Jian Li , Michael Böttger , Stefan Golz , Dieter Lang , Karl-Heinz Schlemmer , Thomas Schlange , Andreas Schall , Wenlang Fu
IPC分类号： A61K31/5377 , C07D487/04 , A61K31/53
CPC分类号： A61K31/5377 , A61K31/4427 , A61K31/53 , C07D401/04 , C07D487/04
摘要： This invention relates to novel 5-[(hydroxymethyl)aryl]-substituted pyrrolo[2,1-f][1,2,4]triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.
摘要翻译： 本发明涉及式（I）的新的5 - [（羟甲基）芳基] - 取代的吡咯并[2,1-f] [1,2,4]三嗪-4-胺，用于制备这些化合物， 含有这些化合物的药物组合物，以及这些化合物或组合物用于治疗血管生成相关病症，特别是血管发生相关性眼部疾病的用途。
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公开(公告)号：US07985876B2
公开(公告)日：2011-07-26
申请号：US12529713
申请日：2008-03-15
申请人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Dieter Lang
发明人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Dieter Lang
IPC分类号： C07C63/00
CPC分类号： C07C65/28
摘要： The invention relates to novel substituted dibenzoic acid derivatives of formula (I), wherein A represents a group of formula (II) or (III), to methods for producing the same, and to their use in the treatment and/or prophylaxis of diseases. The invention also relates to the use of said substances in the production of drugs for the treatment and/or prophylaxis of diseases, especially in the treatment and/or prevention of cardiovascular diseases.
摘要翻译： 本发明涉及式（I）的新型取代二苯甲酸衍生物，其中A代表式（II）或（III）的基团，其制备方法及其在治疗和/或预防疾病中的用途 。 本发明还涉及所述物质在制备药物中用于治疗和/或预防疾病的用途，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20110021493A1
公开(公告)日：2011-01-27
申请号：US12678288
申请日：2008-09-02
申请人： Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirsten Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffman , Gerhard Siemeister , Ulf Bömer
发明人： Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirsten Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffman , Gerhard Siemeister , Ulf Bömer
IPC分类号： C07D495/14 , A61K31/519 , A61K31/496 , A61K31/5377 , C07D491/147 , A61K31/4375 , A61K31/553 , A61K31/55 , A61P35/04 , A61P9/12 , A61P17/06 , A61P1/00
CPC分类号： C07D495/14 , C07D491/147 , C07D519/00
摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
摘要翻译： 本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。
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公开(公告)号：US20100029772A1
公开(公告)日：2010-02-04
申请号：US12083814
申请日：2006-10-17
申请人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr , Dieter Lang
发明人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr , Dieter Lang
IPC分类号： A61K31/194 , C07C63/331
CPC分类号： C07C65/28
摘要： The present application relates to novel dicarboxylic acid derivatives, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型二羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病，特别是用于治疗和/或预防疾病的药物的用途。 预防心血管疾病。
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公开(公告)号：US08530505B2
公开(公告)日：2013-09-10
申请号：US13360107
申请日：2012-01-27
申请人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
发明人： Alexander Straub , Thomas Lampe , Jens Pohlmann , Susanne Röhrig , Elisabeth Perzborn , Karl-Heinz Schlemmer , Joseph Pernerstorfer
IPC分类号： A61K31/42 , C07D409/14
CPC分类号： C07D498/04 , A61K31/5377 , C07D333/38 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
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40.发明授权Aminoacyl prodrug derivatives and medicaments for treatment of thromboembolic disorders 有权氨基酰基前药衍生物和治疗血栓栓塞障碍的药物公开(公告)号：US08362015B2
公开(公告)日：2013-01-29
申请号：US12438097
申请日：2007-08-23
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译： 本申请涉及5-氯-N - （{（5S）-2-氧代-3- [4-（3-氧代吗啉-4-基）苯基] -1,3-恶唑烷-5-基的前药衍生物 ）甲基）噻吩-2-甲酰胺，其制备方法，它们用于治疗和/或预防疾病的用途，以及它们用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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