公开(公告)号：US07387600B1

公开(公告)日：2008-06-17

申请号：US11879849

申请日：2007-07-18

申请人： Ying Sun ,  Chi Sun

发明人： Ying Sun ,  Chi Sun

IPC分类号： B23Q3/157

CPC分类号： B23Q3/15706 ,  B23Q3/15534 ,  Y10T483/1755 ,  Y10T483/1795

摘要： A tool support device for a machine tool includes a housing disposed beside a tool spindle, a tool storage rack having a shaft rotatably attached to the housing, a plate secured to the shaft and rotatably received in the housing, a number of rollers disposed on the plate, an axle rotatably disposed in the housing and having a rotary member which includes a helical groove for engaging with the rollers and for rotating the plate and the shaft and the tool storage rack relative to the tool spindle, the tool support device includes a compact structure for suitably shielding and protecting the tool support device and for preventing the tool support device from being contaminated and damaged by dirt and cut chips.

摘要翻译： 一种用于机床的工具支撑装置包括：设置在工具主轴旁边的壳体，具有可旋转地附接到壳体的轴的工具存储架，固定到轴上并可旋转地容纳在壳体中的板，设置在壳体上的多个辊 板，可旋转地设置在壳体中并具有旋转构件的旋转构件，该旋转构件包括用于与辊接合并用于相对于工具主轴旋转板和轴以及工具存储架的螺旋槽，工具支撑装置包括紧凑型 用于适当地屏蔽和保护工具支撑装置的结构，并且用于防止工具支撑装置被污物和切屑所污染并损坏。

公开(公告)号：US20080038225A1

公开(公告)日：2008-02-14

申请号：US11835157

申请日：2007-08-07

申请人： Ying Sun ,  Yat Sun Or ,  Zhe Wang

发明人： Ying Sun ,  Yat Sun Or ,  Zhe Wang

IPC分类号： A61K31/425 ,  A61K31/41 ,  A61K31/44 ,  A61K31/7056 ,  A61K38/21 ,  A61P31/12 ,  C07D249/04 ,  C07D277/30 ,  C07D401/12

CPC分类号： C07K5/0804 ,  A61K38/00 ,  C07D207/24 ,  C07D409/14 ,  C07D417/04 ,  C07D417/14

摘要： The present invention relates to compounds of Formula I or II, or pharmaceutically acceptable salts, esters or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering to the subject a pharmaceutical composition comprising a compound of the present invention.

摘要翻译： 本发明涉及式I或II的化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过向受试者施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

公开(公告)号：US20070281885A1

公开(公告)日：2007-12-06

申请号：US11759080

申请日：2007-06-06

申请人： Ying Sun ,  Deqiang Niu ,  Guoyou Xu ,  Yat Sun Or ,  Zhe Wang

发明人： Ying Sun ,  Deqiang Niu ,  Guoyou Xu ,  Yat Sun Or ,  Zhe Wang

IPC分类号： A61K38/12 ,  C07K5/12

CPC分类号： A61K38/4886 ,  A61K38/21 ,  A61K38/212 ,  A61K38/215 ,  A61K38/45 ,  A61K38/52 ,  C07K5/0804 ,  C07K5/0812 ,  C07K7/06 ,  A61K2300/00

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

公开(公告)号：US20070060862A1

公开(公告)日：2007-03-15

申请号：US11590380

申请日：2006-10-31

申请人： Ying Sun ,  Jue-Chen Liu ,  Jeffrey Wu ,  James Hauschild

发明人： Ying Sun ,  Jue-Chen Liu ,  Jeffrey Wu ,  James Hauschild

IPC分类号： A61N1/30

CPC分类号： A61N1/0492 ,  A61K8/19 ,  A61K8/20 ,  A61K8/27 ,  A61K8/365 ,  A61K8/368 ,  A61K2800/28 ,  A61K2800/83 ,  A61N1/0428 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/205 ,  A61N1/30 ,  A61N1/303 ,  A61N1/325 ,  A61Q19/008 ,  A61Q19/02 ,  A61Q19/08 ,  A61Q19/10

摘要： The present invention features a device having a barrier membrane contacting surface, the device containing: a power source; a first conductive electrode; a second conductive electrode; and a reservoir; wherein said power source is in electric communication with said first conductive electrode and said second conductive electrode, wherein said first conductive electrode and said second conductive electrode are arranged such that they are both capable of being in ionic communication with a carrier upon the inclusion of said carrier to said reservoir; and the use thereof.

摘要翻译： 本发明的特征在于具有阻挡膜接触表面的装置，该装置包括：电源; 第一导电电极; 第二导电电极; 和一个水库; 其中所述电源与所述第一导电电极和所述第二导电电极电连通，其中所述第一导电电极和所述第二导电电极被布置成使得它们能够在包含所述第一导电电极和所述第二导电电极时能够与载体离子连通 载体到所述储存器; 及其用途。

公开(公告)号：US07176208B2

公开(公告)日：2007-02-13

申请号：US10826743

申请日：2004-04-16

申请人： Suanne Nakajima ,  Zhenwei Miao ,  Ying Sun ,  Datong Tang ,  Guoyou Xu ,  Brian Porter ,  Yat Sun Or ,  Zhe Wang

发明人： Suanne Nakajima ,  Zhenwei Miao ,  Ying Sun ,  Datong Tang ,  Guoyou Xu ,  Brian Porter ,  Yat Sun Or ,  Zhe Wang

IPC分类号： C07D401/12 ,  C07D409/14 ,  A61K31/38 ,  A61K31/395 ,  A61P31/12

CPC分类号： C07K5/0802 ,  A61K38/212 ,  A61K38/215 ,  C07D487/04 ,  C07K5/0804 ,  A61K2300/00

摘要： The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20060270724A1

公开(公告)日：2006-11-30

申请号：US11436732

申请日：2006-05-17

申请人： Jonathan Houze ,  Jiwen Liu ,  Zhihua Ma ,  Julio Medina ,  Michael Schmitt ,  Rajiv Sharma ,  Ying Sun ,  Yingcai Wang ,  Liusheng Zhu

发明人： Jonathan Houze ,  Jiwen Liu ,  Zhihua Ma ,  Julio Medina ,  Michael Schmitt ,  Rajiv Sharma ,  Ying Sun ,  Yingcai Wang ,  Liusheng Zhu

IPC分类号： C07D249/08 ,  C07D233/61 ,  A61K31/4196 ,  A61K31/4172

CPC分类号： C07D277/24 ,  C07B2200/07 ,  C07C235/34 ,  C07D233/64 ,  C07D249/08 ,  C07D257/04 ,  C07D263/32 ,  C07D417/12

摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole ring; and R1 has the values provided herein. The present invention also provides compositions, uses, and methods for use of the compounds, for instance, for treatment of type II diabetes.

摘要翻译： 本发明提供了可用于例如用于调节受试者中具有通式I的胰岛素水平的化合物：其中Q是任选取代的苯基; L是一个键或O; P是苯或任选取代的噻唑环; 且R 1具有本文提供的值。 本发明还提供了用于治疗II型糖尿病的化合物的组合物，用途和方法。

公开(公告)号：US07133717B2

公开(公告)日：2006-11-07

申请号：US09795908

申请日：2001-02-28

申请人： Anthony F. Coston ,  Ying Sun ,  Ralph W. Oakeson ,  Stephen J. Wisniewski ,  Jonas C. T. Wang

发明人： Anthony F. Coston ,  Ying Sun ,  Ralph W. Oakeson ,  Stephen J. Wisniewski ,  Jonas C. T. Wang

IPC分类号： A61N1/30

CPC分类号： A61N1/325 ,  A61B5/14514 ,  A61N1/0428 ,  A61N1/306

摘要： The present invention relates to a method and a device for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of: ablating said membrane with an electric current from an array of treatment electrodes; and utilizing a driving force to move said molecule through said perforated membrane.

公开(公告)号：US20060239554A1

公开(公告)日：2006-10-26

申请号：US11387339

申请日：2006-03-23

申请人： Ying Sun ,  Leo Grady ,  Gareth Funka-Lea ,  Thomas O'Donnell

发明人： Ying Sun ,  Leo Grady ,  Gareth Funka-Lea ,  Thomas O'Donnell

IPC分类号： G06K9/34

CPC分类号： G06T19/00 ,  G06T7/11 ,  G06T2207/10088 ,  G06T2207/20092 ,  G06T2207/20156 ,  G06T2207/30048 ,  G06T2210/41

摘要： A system and method for automatically determining the standard cardiac image views as defined by the American Heart Association from volumetric data of the chest including the heart. The system and method can be used by a health practitioner to quickly see the two dimensional views from which a diagnosis is generally made. The left ventricle is detected. Then the relative orientation of the right ventricle is determined and the standard cardiac views are determined.

摘要翻译： 用于根据包括心脏在内的胸部的体积数据自动确定由美国心脏协会定义的标准心脏图像视图的系统和方法。 健康从业者可以使用该系统和方法来快速查看通常进行诊断的二维视图。 检测到左心室。 然后确定右心室的相对方向，并确定标准心脏视图。

公开(公告)号：US20060122128A1

公开(公告)日：2006-06-08

申请号：US11008581

申请日：2004-12-07

申请人： Yat Or ,  Datong Tang ,  Yonghua Gai ,  Ying Sun ,  Guoyou Xu ,  Zhe Wang

发明人： Yat Or ,  Datong Tang ,  Yonghua Gai ,  Ying Sun ,  Guoyou Xu ,  Zhe Wang

IPC分类号： A61K31/7048 ,  C07H17/08

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了具有抗菌性质的式（I）化合物或其药学上可接受的盐，酯或前药。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US20060094608A1

公开(公告)日：2006-05-04

申请号：US11299884

申请日：2005-12-12

申请人： Nawaz Ahmad ,  Ying Sun ,  Shun Lin

发明人： Nawaz Ahmad ,  Ying Sun ,  Shun Lin

IPC分类号： C10M105/14 ,  A61K9/06

CPC分类号： A61K47/38 ,  A61K9/0034 ,  A61K9/06 ,  A61K31/415 ,  A61K31/4174 ,  A61K31/496 ,  A61K45/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/46 ,  Y10S424/14 ,  Y10S514/944 ,  Y10S514/967 ,  A61K2300/00

摘要： This invention relates to substantially anhydrous warming, non-toxic and nonirritating lubricating compositions containing polyhydric alcohols and an insulating agent. The invention also relates to methods of using such compositions for lubrication, administration of active ingredients and for preventing or treating dysmenorrhea.