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124 条记录 (耗时 0.086 秒)

    Media for Clostridium Bacterium
    32.
    发明申请
    Media for Clostridium Bacterium 有权
    梭菌属细菌培养基

    公开(公告)号：US20070111288A1

    公开(公告)日：2007-05-17

    申请号：US11609449

    申请日：2006-12-12

    申请人： Ping Wang ,  Stephen Donovan

    发明人： Ping Wang ,  Stephen Donovan

    IPC分类号： C12P21/06 ,  C12N1/20 ,  C07H21/04 ,  C12N15/74 ,  C07K14/33

    CPC分类号： C12N1/20 ,  C07K14/33 ,  C12N9/6489 ,  C12P21/02 ,  C12Y304/24069 ,  Y10S435/842

    摘要： Animal product free (APF) media and processes for the culture and fermentation of botulinum toxin producing Clostridium botulinum bacteria. The botulinum toxin obtained can be used for formulating and compounding botulinum toxin pharmaceutical compositions. The APF media can contain significantly reduced levels of meat or dairy by-products and use non-animal based products instead of the animal-derived products. Preferably, the APF media used are substantially free or free of animal derived products.

    摘要翻译： 不含动物产品（APF）的培养基和产生肉毒杆菌毒素的肉毒杆菌的培养和发酵过程。 获得的肉毒杆菌毒素可用于配制和配制肉毒杆菌毒素药物组合物。 APF媒体可以显着降低肉类或乳制品副产品的含量，并使用非动物产品，而不是动物衍生产品。 优选地，所用的APF介质基本上是游离的或没有动物衍生的产品。

    Transdermal botulinum toxin administration for the treatment of spastic muscle pain
    33.
    发明申请
    Transdermal botulinum toxin administration for the treatment of spastic muscle pain 有权
    透皮肉毒杆菌毒素治疗痉挛肌肉疼痛

    公开(公告)号：US20060188525A1

    公开(公告)日：2006-08-24

    申请号：US11159511

    申请日：2005-06-22

    申请人： Stephen Donovan

    发明人： Stephen Donovan

    IPC分类号： A61K39/08 ,  A61K31/045

    CPC分类号： A61N7/00 ,  A61K9/127 ,  A61K9/7084 ,  A61K31/045 ,  A61K38/4893 ,  A61K41/0028 ,  A61K47/10 ,  Y02A50/469

    摘要： Pharmaceutical compositions for transdermal administration of neurotoxins to a patient include a neurotoxin, such as a botulinum toxin, and an enhancing agent that facilitates absorption of the neurotoxin through the skin of the patient and does not eliminate the bioactivity associated with the neurotoxin. The pharmaceutical compositions are topically applied on a patient, and may be provided in a transdermal patch.

    摘要翻译： 用于向患者透皮施用神经毒素的药物组合物包括神经毒素，例如肉毒杆菌毒素和促进神经毒素通过患者皮肤吸收的增强剂，并且不消除与神经毒素相关的生物活性。 药物组合物局部施用于患者，并且可以提供在透皮贴剂中。

    Botulinum neurotoxin-substance P conjugate or fusion protein for treating pain
    34.
    发明授权
    Botulinum neurotoxin-substance P conjugate or fusion protein for treating pain 失效
    肉毒杆菌神经毒素物质P缀合物或用于治疗疼痛的融合蛋白

    公开(公告)号：US07056729B2

    公开(公告)日：2006-06-06

    申请号：US09938112

    申请日：2001-08-23

    申请人： Stephen Donovan

    发明人： Stephen Donovan

    IPC分类号： C12N15/09 ,  C07N21/04

    CPC分类号： C07K14/33 ,  A61K38/00 ,  A61K47/6415 ,  A61K47/642 ,  A61K48/00 ,  C07K7/22 ,  C07K2319/00

    摘要： Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety, wherein the targeting moiety is selected from a group consisting of transmission compounds which can be released from neurons upon the transmission of pain signals by the neurons, and compounds substantially similar to the transmission compounds.

    摘要翻译： 用于治疗疼痛的药剂，用于制备药剂的方法和通过向患者施用治疗有效量的药剂来治疗疼痛的方法。 所述试剂可以包含连接到靶向部分的梭菌神经毒素或其组分或片段或衍生物，其中所述靶向部分选自由传递化合物组成的组，所述传播化合物在通过所述靶向部分传递疼痛信号时可从神经元释放 神经元和基本上类似于透射化合物的化合物。

    Media for clostridium bacterium and processes for obtaining a clostridial toxin
    35.
    发明申请
    Media for clostridium bacterium and processes for obtaining a clostridial toxin 有权
    梭菌细菌的培养基和获得梭菌毒素的方法

    公开(公告)号：US20050238668A1

    公开(公告)日：2005-10-27

    申请号：US11072050

    申请日：2005-03-03

    申请人： Ping Wang ,  Stephen Donovan

    发明人： Ping Wang ,  Stephen Donovan

    IPC分类号： A61K39/08 ,  C07K14/33 ,  C12N1/20 ,  C12N9/64 ,  C12P21/02

    CPC分类号： C12N1/20 ,  C07K14/33 ,  C12N9/6489 ,  C12P21/02 ,  C12Y304/24069 ,  Y10S435/842

    摘要： Animal product free (APF) media and processes for the culture and fermentation of botulinum toxin producing Clostridium botulinum bacteria. The botulinum toxin obtained can be used for formulating and compounding botulinum toxin pharmaceutical compositions. The APF media can contain significantly reduced levels of meat or dairy by-products and use non-animal based products instead of the animal-derived products. Preferably, the APF media used are substantially free or free of animal derived products.

    摘要翻译： 不含动物产品（APF）的培养基和产生肉毒杆菌毒素的肉毒杆菌的培养和发酵过程。 获得的肉毒杆菌毒素可用于配制和配制肉毒杆菌毒素药物组合物。 APF媒体可以显着降低肉类或乳制品副产品的含量，并使用非动物产品，而不是动物产品。 优选地，所用的APF介质基本上是游离的或没有动物衍生的产品。

    Animal product free media and processes for obtaining a botulinum toxin
    37.
    发明申请
    Animal product free media and processes for obtaining a botulinum toxin 有权
    动物产品免费培养基和获得肉毒杆菌毒素的方法

    公开(公告)号：US20050069562A1

    公开(公告)日：2005-03-31

    申请号：US10672876

    申请日：2003-09-25

    申请人： Stephen Donovan

    发明人： Stephen Donovan

    IPC分类号： C12N1/20 ,  C12N9/64 ,  C12P21/02 ,  C07K14/33 ,  A61K39/08 ,  C07H21/04

    CPC分类号： C12N1/20 ,  C12N9/52 ,  C12P21/02 ,  C12Y304/24069 ,  Y10S435/842

    摘要： Media and processes for the fermentation of Clostridium botulinum and obtaining a botulinum toxin for use in formulating botulinum toxin pharmaceutical compositions. The growth media can contain significantly reduced levels of meat or dairy by-products using non-animal based products to replace the animal-derived products. Preferably, the media used are substantially free of animal derived products.

    摘要翻译： 用于发酵肉毒杆菌的培养基和方法，并获得用于配制肉毒杆菌毒素药物组合物的肉毒杆菌毒素。 生长培养基可以使用非动物产品来显着降低肉类或乳制品副产品的含量，以取代动物来源的产品。 优选地，所用介质基本上不含动物衍生产品。

    Parkinson's disease treatment
    39.
    发明授权
    Parkinson's disease treatment 失效
    帕金森病治疗

    公开(公告)号：US06620415B2

    公开(公告)日：2003-09-16

    申请号：US09904113

    申请日：2001-07-11

    申请人： Stephen Donovan

    发明人： Stephen Donovan

    IPC分类号： A61K3908

    CPC分类号： A61K38/4893 ,  A61K38/00 ,  Y02A50/469 ,  Y10S514/937 ,  Y10S514/963

    摘要： Methods for treating a movement disorder by intracranial administration to a human patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin type A.

    摘要翻译： 通过颅内给予治疗有效量的神经毒素（例如A型肉毒杆菌毒素）来治疗运动障碍的方法。

    Clostridial toxin derivatives and methods for treating pain
    40.
    发明授权
    Clostridial toxin derivatives and methods for treating pain 有权

    公开(公告)号：US06500436B2

    公开(公告)日：2002-12-31

    申请号：US09922093

    申请日：2001-08-03

    申请人： Stephen Donovan

    发明人： Stephen Donovan

    IPC分类号： C07K1900

    CPC分类号： A61K38/4893 ,  A61K47/6415 ,  A61K47/642 ,  A61K48/00 ,  C07K7/22 ,  C07K14/33 ,  C07K2319/00

    摘要： Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety, wherein the targeting moiety is selected from a group consisting of transmission compounds which can be released from neurons upon the transmission of pain signals by the neurons, and compounds substantially similar to the transmission compounds.