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    Pharmaceutical composition comprising a bispecific antibody for epcam
    31.
    发明申请
    Pharmaceutical composition comprising a bispecific antibody for epcam 有权
    包含用于epcam的双特异性抗体的药物组合物

    公开(公告)号：US20070081993A1

    公开(公告)日：2007-04-12

    申请号：US10554851

    申请日：2004-05-26

    申请人： Peter Kufer ,  Meera Berry ,  Sonja Offner ,  Klaus Brischwein ,  Andreas Wolf

    发明人： Peter Kufer ,  Meera Berry ,  Sonja Offner ,  Klaus Brischwein ,  Andreas Wolf

    IPC分类号： A61K39/395

    CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/3076 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/00 ,  Y10S435/81 ,  Y10S435/975

    摘要： The present invention provides a pharmaceutical composition comprising a bispecific single chain antibody construct. Said bispecific single chain antibody construct is characterized to comprise or consist of at least two domains, whereby one of said at least two domains specifically binds to human EpCAM and comprises at least one CDR-H3 region comprising the amino acid sequence NXID antigen and a second domain binds to human CD3 antigen. The invention further provides a process for the production of the pharmaceutical composition of the invention, a method for the prevention, treatment or amelioration of a tumorous disease and the use of the disclosed bispecific single chain antibody construct and corresponding means in the prevention, treatment or amelioration of a tumorous disease.

    摘要翻译： 本发明提供包含双特异性单链抗体构建体的药物组合物。 所述双特异性单链抗体构建体的特征在于包含至少两个结构域或由至少两个结构域组成，其中所述至少两个结构域之一特异性结合人EpCAM并且包含至少一个CDR-H3区，其包含氨基酸序列NXID抗原和第二 结构域结合人CD3抗原。 本发明进一步提供了制备本发明的药物组合物的方法，一种预防，治疗或改善肿瘤疾病的方法，以及所公开的双特异性单链抗体构建体的用途和相应的手段，用于预防，治疗或 改善肿瘤疾病

    MEANS AND METHODS FOR THE TREATMENT OF TUMOROUS DISEASES
    33.
    发明申请
    MEANS AND METHODS FOR THE TREATMENT OF TUMOROUS DISEASES 有权
    治疗肿瘤疾病的手段和方法

    公开(公告)号：US20090291072A1

    公开(公告)日：2009-11-26

    申请号：US12095951

    申请日：2006-11-29

    申请人： Patrick Baeuerle ,  Peter Kufer ,  Matthias Klinger ,  Eugen Leo

    发明人： Patrick Baeuerle ,  Peter Kufer ,  Matthias Klinger ,  Eugen Leo

    IPC分类号： A61K39/395

    CPC分类号： A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2803 ,  C07K16/2809 ,  C07K2317/31

    摘要： Provided are pharmaceutical means and methods for the prevention, treatment or amelioration of indolent or aggressive B cell non-Hodgkin lymphoma (B NHL) and B cell leukemia comprising the administration of a bispecific single chain antibody construct to a subject in the need thereof and the use of said bispecific single chain antibody construct for the preparation of a pharmaceutical composition for the prevention, treatment or amelioration of indolent or aggressive B cell non-Hodgkin lymphoma (B NHL) and B cell leukemia, whereby said construct is to be administered for at least 1 week in specified daily doses. Moreover, the invention relates to kits comprising a bispecific single chain antibody construct to be used in accordance with this invention.

    摘要翻译： 提供了用于预防，治疗或改善无痛或侵袭性B细胞非霍奇金淋巴瘤（B NHL）和B细胞白血病的药物方法和方法，其包括在需要时向受试者施用双特异性单链抗体构建体， 使用所述双特异性单链抗体构建体来制备用于预防，治疗或改善无痛或侵袭性B细胞非霍奇金淋巴瘤（B NHL）和B细胞白血病的药物组合物，其中所述构建体将被施用于 至少1周，指定日剂量。 此外，本发明涉及包含根据本发明使用的双特异性单链抗体构建体的试剂盒。

    Real-time RT-PCR for the sensitive detection of multiple MAGE gene transcripts
    34.
    发明授权
    Real-time RT-PCR for the sensitive detection of multiple MAGE gene transcripts 有权
    用于灵敏检测多个MAGE基因转录物的实时RT-PCR

    公开(公告)号：US07491814B2

    公开(公告)日：2009-02-17

    申请号：US10536932

    申请日：2003-11-28

    申请人： Peter Kufer ,  Ingo Mecklenburg

    发明人： Peter Kufer ,  Ingo Mecklenburg

    IPC分类号： C07H21/04 ,  C12P19/34

    CPC分类号： C12Q1/6886 ,  C12Q2600/16

    摘要： The present invention relates to a highly sensitive real-time RT-PCR method for specifically detecting the expression of more than one MAGE gene. The present invention further relates to a diagnostic composition for carrying out such a real-time RT-PCR as well as to oligonucleotides suitable for the cDNA synthesis reaction prior to real-time PCR amplification of more than one marker from the MAGE gene family. To enable the quantitative measurement of MAGE gene expression in a clinical sample an RT-protocol was invented using very sophisticated non-standard conditions to accomplish real-time PCR amplification of cDNA of several MAGE family members in relation to a comparative normalizing reference gene as internal control.

    摘要翻译： 本发明涉及用于特异性检测多于一个MAGE基因表达的高灵敏度实时RT-PCR方法。 本发明还涉及用于在来自MAGE基因家族的多个标记物进行实时PCR扩增之前进行这种实时RT-PCR的诊断组合物以及适用于cDNA合成反应的寡核苷酸。 为了能够在临床样品中定量测量MAGE基因表达，使用非常复杂的非标准条件发明了RT-方案，以实现与几个MAGE家族成员相对于比较归一化参考基因作为内部的cDNA的实时PCR扩增 控制。

    Novel real-time rt-pcr for the sensitive detection of multiple mage gene transcripts
    35.
    发明申请
    Novel real-time rt-pcr for the sensitive detection of multiple mage gene transcripts 有权
    用于灵敏检测多个法师基因转录本的新型实时rt-pcr

    公开(公告)号：US20060147928A1

    公开(公告)日：2006-07-06

    申请号：US10536932

    申请日：2003-11-28

    申请人： Peter Kufer ,  Ingo Mecklenburg

    发明人： Peter Kufer ,  Ingo Mecklenburg

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6886 ,  C12Q2600/16

    摘要： The present invention relates to a highly sensitive real-time RT-PCR method for specifically detecting the expression of more than one MAGE gene. The present invention further relates to a diagnostic composition for carrying out such a real-time RT-PCR as well as to oligonucleotides suitable for the cDNA synthesis reaction prior to real-time PCR amplification of more than one marker from the MAGE gene family. To enable the quantitative measurement of MAGE gene expression in a clinical sample an RT-protocol was invented using very sophisticated non-standard conditions to accomplish real-time PCR amplification of cDNA of several MAGE family members in relation to a comparative normalizing reference gene as internal control.

    摘要翻译： 本发明涉及用于特异性检测多于一个MAGE基因表达的高灵敏度实时RT-PCR方法。 本发明还涉及用于在来自MAGE基因家族的多个标记物进行实时PCR扩增之前进行这种实时RT-PCR的诊断组合物以及适用于cDNA合成反应的寡核苷酸。 为了能够在临床样品中定量测量MAGE基因表达，使用非常复杂的非标准条件发明了RT-方案，以实现与几个MAGE家族成员相对于比较归一化参考基因作为内部的cDNA的实时PCR扩增 控制。

    Method of Treating a Patient or Exempting a Patient From Further Treatment Subsequent to Tumor Removal
    37.
    发明申请
    Method of Treating a Patient or Exempting a Patient From Further Treatment Subsequent to Tumor Removal 审中-公开
    治疗患者的方法或免除患者除去肿瘤后进一步治疗的方法

    公开(公告)号：US20160208338A1

    公开(公告)日：2016-07-21

    申请号：US15001348

    申请日：2016-01-20

    申请人： Peter Kufer

    发明人： Peter Kufer

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16

    摘要： Described is method of treating a patient or exempting a patient from further treatment subsequent to tumor removal such as surgery. The method involves performing a highly sensitive real-time PCR for specific detection of transcripts for more than one MAGE gene and a reference gene such as porphobilinogen desaminase (PBGD), glyceraldehyd-3-phosphate dehydrogenase (GAPDH), beta-2-microglobin or beta-actin in a tissue sample of a tumor patient.

    摘要翻译： 描述了治疗患者或免除患者在肿瘤去除之后的进一步治疗（例如手术）的方法。 该方法包括对多于一个MAGE基因和参考基因例如胆色素原脱氨酶（PBGD），甘油醛-3-磷酸脱氢酶（GAPDH），β-2-微球蛋白或其它多肽的转录物进行特异性检测的高灵敏度实时PCR 肿瘤患者组织样本中的β-肌动蛋白。

    Bispecific single chain antibodies with specificity for high molecular weight target antigens
    38.
    发明授权
    Bispecific single chain antibodies with specificity for high molecular weight target antigens 有权
    具有对高分子靶标抗原特异性的双特异性单链抗体

    公开(公告)号：US09260522B2

    公开(公告)日：2016-02-16

    申请号：US13122271

    申请日：2009-10-01

    申请人： Peter Kufer ,  Claudia Blümel ,  Roman Kischel

    发明人： Peter Kufer ,  Claudia Blümel ,  Roman Kischel

    IPC分类号： C07K16/30 ,  C07K16/28 ,  A61K39/00

    CPC分类号： C07K16/2809 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/005 ,  C07K16/2851 ,  C07K16/2863 ,  C07K16/3069 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/732 ,  C12N15/1037

    摘要： The present invention provides a method for the selection of bispecific single chain antibodies comprising a first binding domain capable of binding to an epitope of CD3 and a second binding domain capable of binding to the extracellular domain cell surface antigens with a high molecular weight extracellular domain. Moreover, the invention provides bispecific single chain antibodies produced by the use of the method of the invention, nucleic acid molecules encoding these antibodies, vectors comprising such nucleic acid molecules and methods for the production of the antibodies. Furthermore, the invention provides pharmaceutical compositions comprising bispecific single chain antibodies of the invention, medical uses of the same and methods for the treatment of diseases comprising the administration of bispecific single chain antibodies of the invention.

    摘要翻译： 本发明提供了选择双特异性单链抗体的方法，其包含能够结合CD3表位的第一结合结构域和能够与高分子量细胞外结构域结合细胞外结构域细胞表面抗原的第二结合结构域。 此外，本发明提供了通过使用本发明的方法产生的双特异性单链抗体，编码这些抗体的核酸分子，包含该核酸分子的载体和用于产生抗体的方法。 此外，本发明提供包含本发明的双特异性单链抗体的药物组合物，其医学用途以及治疗包括施用本发明的双特异性单链抗体的疾病的方法。

    MEANS AND METHODS FOR THE TREAMENT OF TUMOROUS DISEASES
    40.
    发明申请
    MEANS AND METHODS FOR THE TREAMENT OF TUMOROUS DISEASES 审中-公开
    肿瘤疾病的手段和方法

    公开(公告)号：US20130095103A1

    公开(公告)日：2013-04-18

    申请号：US13219120

    申请日：2011-08-26

    申请人： Patrick Baeuerle ,  Peter Kufer ,  Matthias Klinger ,  Eugen Leo

    发明人： Patrick Baeuerle ,  Peter Kufer ,  Matthias Klinger ,  Eugen Leo

    IPC分类号： A61K39/395 ,  A61K45/06

    CPC分类号： A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2803 ,  C07K16/2809 ,  C07K2317/31

    摘要： Provided are pharmaceutical means and methods for the prevention, treatment or amelioration of indolent or aggressive B cell non-Hodgkin lymphoma (B NHL) and B cell leukemia comprising the administration of a bispecific single chain antibody construct to a subject in the need thereof and the use of said bispecific single chain antibody construct for the preparation of a pharmaceutical composition for the prevention, treatment or amelioration of indolent or aggressive B cell non-Hodgkin lymphoma (B NHL) and B cell leukemia, whereby said construct is to be administered for at least 1 week in specified daily doses. Moreover, the invention relates to kits comprising a bispecific single chain antibody construct to be used in accordance with this invention.

    摘要翻译： 提供了用于预防，治疗或改善无痛或侵袭性B细胞非霍奇金淋巴瘤（B NHL）和B细胞白血病的药物方法和方法，其包括在需要时向受试者施用双特异性单链抗体构建体， 使用所述双特异性单链抗体构建体来制备用于预防，治疗或改善无痛或侵袭性B细胞非霍奇金淋巴瘤（B NHL）和B细胞白血病的药物组合物，其中所述构建体将被施用于 至少1周，指定日剂量。 此外，本发明涉及包含根据本发明使用的双特异性单链抗体构建体的试剂盒。