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    Pharmaceutical composition comprising a bispecific antibody for epcam
    3.
    发明申请
    Pharmaceutical composition comprising a bispecific antibody for epcam 有权
    包含用于epcam的双特异性抗体的药物组合物

    公开(公告)号：US20070081993A1

    公开(公告)日：2007-04-12

    申请号：US10554851

    申请日：2004-05-26

    申请人： Peter Kufer ,  Meera Berry ,  Sonja Offner ,  Klaus Brischwein ,  Andreas Wolf

    发明人： Peter Kufer ,  Meera Berry ,  Sonja Offner ,  Klaus Brischwein ,  Andreas Wolf

    IPC分类号： A61K39/395

    CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/3076 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/00 ,  Y10S435/81 ,  Y10S435/975

    摘要： The present invention provides a pharmaceutical composition comprising a bispecific single chain antibody construct. Said bispecific single chain antibody construct is characterized to comprise or consist of at least two domains, whereby one of said at least two domains specifically binds to human EpCAM and comprises at least one CDR-H3 region comprising the amino acid sequence NXID antigen and a second domain binds to human CD3 antigen. The invention further provides a process for the production of the pharmaceutical composition of the invention, a method for the prevention, treatment or amelioration of a tumorous disease and the use of the disclosed bispecific single chain antibody construct and corresponding means in the prevention, treatment or amelioration of a tumorous disease.

    摘要翻译： 本发明提供包含双特异性单链抗体构建体的药物组合物。 所述双特异性单链抗体构建体的特征在于包含至少两个结构域或由至少两个结构域组成，其中所述至少两个结构域之一特异性结合人EpCAM并且包含至少一个CDR-H3区，其包含氨基酸序列NXID抗原和第二 结构域结合人CD3抗原。 本发明进一步提供了制备本发明的药物组合物的方法，一种预防，治疗或改善肿瘤疾病的方法，以及所公开的双特异性单链抗体构建体的用途和相应的手段，用于预防，治疗或 改善肿瘤疾病

    DOMAIN-GRAFTED ANTIBODIES
    5.
    发明申请
    DOMAIN-GRAFTED ANTIBODIES 审中-公开
    DOMAIN-GRAFTED抗体

    公开(公告)号：US20090241202A1

    公开(公告)日：2009-09-24

    申请号：US12095822

    申请日：2006-12-14

    申请人： Peter Kufer ,  Tobias Raum ,  Petra Lutterbüse ,  Bernd Schlereth ,  Klaus Brischwein ,  Robert Hofmeister

    发明人： Peter Kufer ,  Tobias Raum ,  Petra Lutterbüse ,  Bernd Schlereth ,  Klaus Brischwein ,  Robert Hofmeister

    IPC分类号： A61K49/00 ,  C07K16/00 ,  C12N15/63 ,  C12N5/00 ,  C12P21/00

    CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/462 ,  C07K2317/732

    摘要： The present invention relates to antibodies. Specifically, the present invention relates to antibodies composed of novel combinations of inter-species antibody domains (“domain-grafted antibodies”). The present invention further relates to compositions comprising such domain-grafted antibodies, as well as methods for producing such domain-grafted antibodies. Finally, the present invention relates to methods of evaluating the in vivo biological effect of such domain-grafted antibodies as well as uses of such domain-grafted antibodies for cross-species evaluation of the in vivo activity antibodies intended for human therapy.

    摘要翻译： 本发明涉及抗体。 具体地，本发明涉及由物种间抗体结构域（“结构域接枝抗体”）的新型组合构成的抗体。 本发明还涉及包含这种结构域接枝抗体的组合物，以及生产这种结构域接枝抗体的方法。 最后，本发明涉及评价这种结构域接枝抗体的体内生物学效应的方法以及这种结构域接枝抗体用于物种评价用于人类治疗的体内活性抗体的用途。