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公开(公告)号：US20130273593A1
公开(公告)日：2013-10-17
申请号：US13995524
申请日：2011-12-20
申请人： William E. Foltz , Francois Ahimou , G. Marco Bommarito , Robert A. Asmus , Louis C. Haddad , Tushar A. Kshirsagar
发明人： William E. Foltz , Francois Ahimou , G. Marco Bommarito , Robert A. Asmus , Louis C. Haddad , Tushar A. Kshirsagar
IPC分类号： C12Q1/25
CPC分类号： C12Q1/22 , C12Q1/25 , G01N21/78 , G01N31/226 , G01N33/573 , G01N2021/7786 , G01N2458/00
摘要： Sterilization indicators that include a neutralizer, such indicators useful for testing the effectiveness of a sterilization procedure by measuring the activity of an active enzyme whose activity is correlated with the survival of microorganisms.
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32.发明授权Pressure-sensitive poly(n-vinyl lactam) adhesive composition and skin covering articles using same 失效压敏聚（N-乙烯基内酰胺）粘合剂组合物和使用其的皮肤覆盖物品
公开(公告)号：US5389376A
公开(公告)日：1995-02-14
申请号：US139516
申请日：1993-10-15
IPC分类号： A61B5/0408 , A61K9/70 , A61L15/58 , A61N1/30 , C08F20/26 , C08F20/52 , C08F26/10 , C08F220/28 , C08F220/56 , C08F226/10 , C09J137/00 , C09J139/04 , H01R4/04 , A61F13/02
CPC分类号： A61K9/703 , A61K9/7053 , A61L15/58 , C09J139/04 , H01R4/04 , H01R2201/12 , Y10S522/912 , Y10S526/931
摘要： A hydrophilic, pressure-sensitive adhesive composition prepared by irradiating solid poly(N-vinyl lactam) with ionizing radiation to crosslink the poly(N-vinyl lactam) and thereafter mixing the radiation-crosslinked poly(N-vinyl lactam) with essentially unirradiated plasticizer in an amount sufficient to form a cohesive, pressure-sensitive adhesive composition. The composition is useful as a biomedical adhesive for transmitting or receiving electrical signals as a component of a biomedical electrode. The composition is also useful as a drug delivery device to deliver pharmaceuticals or other active ingredients to or through mammalian skin. The composition is also useful as a component in a skin covering for protecting mammalian skin or mammalian skin openings with antimicrobial agents. A method of preparation of the composition is also disclosed.
摘要翻译： 通过用电离辐射照射固体聚（N-乙烯基内酰胺）以交联聚（N-乙烯基内酰胺），然后将辐射交联的聚（N-乙烯基内酰胺）与基本上未照射的增塑剂混合而制备的亲水性压敏粘合剂组合物 其量足以形成粘合的压敏粘合剂组合物。 该组合物可用作生物医学粘合剂，用于作为生物医学电极的组分传输或接收电信号。 组合物还可用作药物递送装置，以将药物或其它活性成分递送至哺乳动物皮肤或通过哺乳动物皮肤。 组合物还可用作皮肤覆盖物中用于用抗微生物剂保护哺乳动物皮肤或哺乳动物皮肤开口的组分。 还公开了组合物的制备方法。
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33.发明授权Composite of a dispersed gel in an adhesive matrix and method for preparing same 失效粘合剂基质中分散凝胶的复合物及其制备方法
公开(公告)号：US5369155A
公开(公告)日：1994-11-29
申请号：US86324
申请日：1993-07-01
申请人： Robert A. Asmus
发明人： Robert A. Asmus
CPC分类号： A61L15/585 , A61L24/043 , A61F2013/0071 , A61L2400/14
摘要： A composite of a gel of swollen hydrocolloid dispersed in a pressure sensitive adhesive matrix is provided. The gel has a natural or synthetically derived hydrocolloid swollen with a non-volatile swelling agent, such that the gel may have a shear modulus of less than 6.2.times.10.sub.6 dynes/cm.sup.2 The gel-adhesive composite has continued skin adhesion whether applied to or existing in dry or moist skin conditions. The gel contributes a high moisture vapor transmission rate to attempt to maintain dry skin conditions while the adhesive maintains skin adhesion. The gel-adhesive composite may be used in a variety of tape, dressing, bandage, drape, or other skin contacting usage and may optionally include antimicrobial agents to treat the skin while adhesion continues.
摘要翻译： 提供分散在压敏粘合剂基质中的溶胀水胶体凝胶的复合物。 凝胶具有天然或合成衍生的水性胶体与非挥发性溶胀剂溶胀，使得凝胶可以具有小于6.2×10 6达因/ cm 2的剪切模量。凝胶粘合剂复合材料具有持续的皮肤粘附性，不管其是否应用于或存在于 干燥或潮湿的皮肤状况。 凝胶具有很高的水汽透过率，试图在粘合剂保持皮肤粘附性的同时保持皮肤干燥状态。 胶粘剂复合材料可以用于各种胶带，敷料，绷带，悬垂或其它皮肤接触用途，并且可以任选地包括抗微生物剂以在粘合继续的同时治疗皮肤。
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公开(公告)号：US20110166492A1
公开(公告)日：2011-07-07
申请号：US13119225
申请日：2009-09-23
CPC分类号： A61L15/60 , A61F13/0256 , A61F2013/00753 , A61L15/46 , A61L15/58 , A61L2300/404 , A61L2300/602
摘要： An adhesive hydrogel dressing as well as methods of applying the dressing to a patient. The dressing generally comprises an adhesive hydrogel pad, a backing layer, and an adhesive layer on the backing layer facing the hydrogel pad. The adhesive layer and backing layer form a perimeter around the hydrogel pad and hold the hydrogel pad in place on an application surface. A release element is in contact with at least a portion of the edge of the hydrogel pad proximate the area that the hydrogel pad and release liner separate during liner removal.
摘要翻译： 粘合剂水凝胶敷料以及将敷料施用于患者的方法。 敷料通常包括粘合剂水凝胶垫，背衬层和位于背衬层上面向水凝胶垫的粘合剂层。 粘合剂层和背衬层形成围绕水凝胶垫的周边，并将水凝胶垫保持在施加表面上的适当位置。 释放元件与水凝胶垫的边缘的至少一部分接近邻近在衬垫移除期间水凝胶垫和释放衬垫分离的区域。
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公开(公告)号：US06897059B2
公开(公告)日：2005-05-24
申请号：US10014736
申请日：2001-12-11
CPC分类号： G01N31/226 , A61L2/28 , C12Q1/22
摘要： A sterilization indicator for testing the effectiveness of a sterilization procedure comprises a source of an enzyme, a sterilant-resistant chemical associated with the enzyme, and a substrate that reacts with the enzyme to form a detectable enzyme-modified product that provides an indication of the failure of the sterilization procedure. The sterilant-resistant chemical may be a polyglycerol alkyl ester, polyglycerol alkyl ether, an ethoxylated polyhydric alcohol ester, or a polyhydric alcohol ether. The indicator may be used to test the effectiveness of a hydrogen peroxide plasma sterilization procedure and may be provided with a non-challenge test pack or a lumen-challenge test pack.
摘要翻译： 用于测试灭菌程序的有效性的消毒指示剂包括酶的来源，与酶相关的杀菌剂抗性化学品，以及与酶反应形成可检测的酶修饰产物的底物，其提供 灭菌程序失败。 杀菌剂抗性化学品可以是聚甘油烷基酯，聚甘油烷基醚，乙氧基化多元醇酯或多元醇醚。 该指示剂可用于测试过氧化氢等离子体灭菌方法的有效性，并且可以提供非挑战性测试包或流明挑战测试包。
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公开(公告)号：US06355448B1
公开(公告)日：2002-03-12
申请号：US09228712
申请日：1999-01-12
IPC分类号： C12Q122
CPC分类号： G01N31/226 , A61L2/28 , C12Q1/22
摘要： A sterilization indicator for testing the effectiveness of a sterilization procedure comprises a source of an enzyme, a sterilant-resistant chemical associated with the enzyme, and a substrate that reacts with the enzyme to form a detectable enzyme-modified product that provides an indication of the failure of the sterilization procedure. The sterilant-resistant chemical may be a polyglycerol alkyl ester, polyglycerol alkyl ether, an ethoxylated polyhydric alcohol ester, or a polyhydric alcohol ether. The indicator may be used to test the effectiveness of a hydrogen peroxide plasma sterilization procedure and may be provided with a non-challenge test pack or a lumen-challenge test pack.
摘要翻译： 用于测试灭菌程序的有效性的消毒指示剂包括酶的来源，与酶相关的杀菌剂抗性化学品，以及与酶反应形成可检测的酶修饰产物的底物，其提供 灭菌程序失败。 杀菌剂抗性化学品可以是聚甘油烷基酯，聚甘油烷基醚，乙氧基化多元醇酯或多元醇醚。 该指示剂可用于测试过氧化氢等离子体灭菌方法的有效性，并且可以提供非挑战性测试包或流明挑战测试包。
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37.发明授权Two-phase composites of ionically-conductive pressure-sensitive adhesive, biomedical electrodes using the composites, and methods of preparing the composite and the biomedical electrodes 失效离子导电压敏粘合剂的两相复合材料，使用复合材料的生物医学电极以及制备复合材料和生物医学电极的方法
公开(公告)号：US5338490A
公开(公告)日：1994-08-16
申请号：US114971
申请日：1993-08-31
申请人： Timothy M. Dietz , Robert A. Asmus , Rosa Uy
发明人： Timothy M. Dietz , Robert A. Asmus , Rosa Uy
CPC分类号： A61B5/04087 , A61L24/0094
摘要： A two-phase composite of ionically-conductive pressure-sensitive adhesive, biomedical electrodes using the composite and methods of preparing the composite and the electrode are disclosed. The continuous phase is a hydrophilic, solid state pressure-sensitive adhesive composition ionically-conductive regardless of an amount of water present in the composition. The discontinuous phase are domains of a hydrophobic pressure-sensitive adhesive which enhances adhesion of the composite to mammalian skin while maintaining acceptable alternating current impedance of the composite.
摘要翻译： 公开了一种离子导电压敏粘合剂的两相复合材料，使用复合材料的生物医学电极以及制备复合材料和电极的方法。 连续相是离子导电的亲水性固态压敏粘合剂组合物，而不管组合物中存在的水量如何。 不连续相是疏水性压敏粘合剂的结构域，其增强了复合材料对哺乳动物皮肤的粘附，同时保持了复合材料的可接受的交流阻抗。
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公开(公告)号：US4931282A
公开(公告)日：1990-06-05
申请号：US125377
申请日：1987-11-25
申请人： Robert A. Asmus , Daniel C. Duan
发明人： Robert A. Asmus , Daniel C. Duan
CPC分类号： A61L15/58 , A61L24/0015 , A61L24/06 , A61L2300/106 , A61L2300/406 , Y10S526/931
摘要： A pressure-sensitive medical sealant composition comprising (a) a crosslinked, swellable polymeric matrix made from an N-vinyl lactam monomer and a multi-ethylenically unsaturated compound, wherein the ethylenic groups are vinyl groups, allyl groups or methallyl groups, which groups are bonded to nitrogen or oxygen atoms; (b) a plasticizer; and (c) an antimicrobial. The medical sealant is highly moisture vapor transmissive and is capable of incorporating large concentrations of iodine. The composition can be used in a variety of medical applications including as a teat plug, a wound or burn dressing, or as a sealant to seal junctions between medical instruments penetrating the skin and the skin. A method of preparing the medical sealant composition in a caulkable form is also disclosed.
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公开(公告)号：US09457123B2
公开(公告)日：2016-10-04
申请号：US13119225
申请日：2009-09-23
CPC分类号： A61L15/60 , A61F13/0256 , A61F2013/00753 , A61L15/46 , A61L15/58 , A61L2300/404 , A61L2300/602
摘要： An adhesive hydrogel dressing as well as methods of applying the dressing to a patient. The dressing generally comprises an adhesive hydrogel pad, a backing layer, and an adhesive layer on the backing layer facing the hydrogel pad. The adhesive layer and backing layer form a perimeter around the hydrogel pad and hold the hydrogel pad in place on an application surface. A release element is in contact with at least a portion of the edge of the hydrogel pad proximate the area that the hydrogel pad and release liner separate during liner removal.
摘要翻译： 粘合剂水凝胶敷料以及将敷料施用于患者的方法。 敷料通常包括粘合剂水凝胶垫，背衬层和位于背衬层上面向水凝胶垫的粘合剂层。 粘合剂层和背衬层形成围绕水凝胶垫的周边，并将水凝胶垫保持在施加表面上的适当位置。 释放元件与水凝胶垫的边缘的至少一部分接近邻近在衬垫移除期间水凝胶垫和释放衬垫分离的区域。
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公开(公告)号：US09242022B2
公开(公告)日：2016-01-26
申请号：US12352189
申请日：2009-01-12
申请人： Robert A. Asmus , David R. Holm , Daniel T. Popko , Richard L. Jacobson , Terrance M. Smorch , Donald G. Peterson , Steven B. Heinecke
发明人： Robert A. Asmus , David R. Holm , Daniel T. Popko , Richard L. Jacobson , Terrance M. Smorch , Donald G. Peterson , Steven B. Heinecke
CPC分类号： A61L15/60 , A61L15/46 , A61L15/58 , A61L2300/206 , A61L2300/404
摘要： An adhesive hydrogel dressing as well as to methods of applying the dressing to a patient is described. The dressing generally comprises an adhesive hydrogel pad, a backing layer, and an adhesive layer on the backing layer facing the hydrogel pad. The adhesive layer and backing layer form a perimeter around the hydrogel pad and hold the hydrogel pad in place on an application surface. The adhesive hydrogel pad is formed with at least a portion of the perimeter of the hydrogel pad tapered proximate the area that the hydrogel pad and release liner separate during liner removal.
摘要翻译： 描述了粘合性水凝胶敷料以及将敷料施用于患者的方法。 敷料通常包括粘合剂水凝胶垫，背衬层和位于背衬层上面向水凝胶垫的粘合剂层。 粘合剂层和背衬层形成围绕水凝胶垫的周边，并将水凝胶垫保持在施加表面上的适当位置。 粘合剂水凝胶垫片形成有水凝胶垫片的周边的至少一部分在靠近在衬垫移除期间水凝胶垫和释放衬垫分离的区域逐渐变细。
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