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公开(公告)号：US20090114808A1
公开(公告)日：2009-05-07
申请号：US11916430
申请日：2006-06-01
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analysed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.
摘要翻译： 公开了一种质谱法，其中分析了来自离子检测器的电压信号。 获得每个电压信号的第二差分，并且确定观察到的电压峰值的开始和结束时间。 然后确定每个电压峰值的强度和平均时间，并存储强度和时间值。 然后通过组合与多个实验运行中观察到的每个电压峰值相关的强度和时间值来形成中间复合质谱。 然后将各种时间和强度数据对被整合以产生平滑的连续质谱。 然后可以通过确定连续质谱的第二差分来进一步处理连续质谱。 可以确定在连续质谱中观察到的质量峰的开始和结束时间。 然后可以确定在连续质谱中观察到的每个质量峰的强度和质荷比。 然后可以显示或输出包括仅每个离子种类的强度值和质荷比的最终离散质谱。
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公开(公告)号：US08063358B2
公开(公告)日：2011-11-22
申请号：US11916430
申请日：2006-06-01
IPC分类号： H01J49/26
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analyzed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.
摘要翻译： 公开了一种质谱法，其中分析了来自离子检测器的电压信号。 获得每个电压信号的第二差分，并且确定观察到的电压峰值的开始和结束时间。 然后确定每个电压峰值的强度和平均时间，并存储强度和时间值。 然后通过组合与多个实验运行中观察到的每个电压峰值相关的强度和时间值来形成中间复合质谱。 然后将各种时间和强度数据对被整合以产生平滑的连续质谱。 然后可以通过确定连续质谱的第二差分来进一步处理连续质谱。 可以确定在连续质谱中观察到的质量峰的开始和结束时间。 然后可以确定在连续质谱中观察到的每个质量峰的强度和质荷比。 然后可以显示或输出包括仅每个离子种类的强度值和质荷比的最终离散质谱。
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公开(公告)号：US07635841B2
公开(公告)日：2009-12-22
申请号：US10498046
申请日：2002-12-12
IPC分类号： H01J49/00
CPC分类号： H01J49/062 , Y10T436/24
摘要： A method of mass spectrometry is disclosed wherein ions are trapped for a period of time T within an AC or RF ion guide maintained at a pressure P wherein the product P×T is at least 1 mbar-ms. The effect of trapping the ions according to a preferred embodiment is that singly charged ions which may, for example, comprise unwanted background ions are substantially lost from the trap whereas multiply charged analyte ions are maintained within the ion trap and can then be released for subsequent mass analysis.
摘要翻译： 公开了一种质谱法，其中在产品PxT至少为1毫巴的压力下，在保持在压力P的AC或RF离子导向器内捕获离子一段时间T。 捕获根据优选实施方案的离子的效果是，可以例如包含不想要的背景离子的单电荷离子从捕获阱基本上丢失，而多电荷分析物离子保持在离子阱内，然后可以释放以用于随后的 质量分析。
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公开(公告)号：US07297939B2
公开(公告)日：2007-11-20
申请号：US10868809
申请日：2004-06-17
IPC分类号： H01J49/00
CPC分类号： H01J49/421 , H01J49/0081
摘要： A mass spectrometer includes an ion detector positioned upstream of a quadrupole mass filter/analyser. Ions are passed through the quadrupole mass filter/analyser, stored in an ion trap and then passed back through the same mass filter/analyser before being detected by the upstream ion detector. With this arrangement, MS/MS experiments can be performed using an apparatus having only a single mass filter/analyser.
摘要翻译： 质谱仪包括位于四极质量过滤器/分析器上游的离子检测器。 离子通过四极质量过滤器/分析仪，储存在离子阱中，然后通过相同的质量过滤器/分析仪通过上游离子检测器检测。 利用这种布置，可以使用仅具有单个质量过滤器/分析器的装置来执行MS / MS实验。
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公开(公告)号：US06872939B2
公开(公告)日：2005-03-29
申请号：US10439225
申请日：2003-05-16
CPC分类号： H01J49/421 , H01J49/0081
摘要： A mass spectrometer includes an ion detector positioned upstream of a quadrupole mass filter/analyser. Ions are passed through the quadrupole mass filter/analyser, stored in an ion trap and then passed back through the same mass filter/analyser before being detected by the upstream ion detector. With this arrangement, MS/MS experiments can be performed using an apparatus having only a single mass filter/analyser.
摘要翻译： 质谱仪包括位于四极质量过滤器/分析器上游的离子检测器。 离子通过四极质量过滤器/分析仪，储存在离子阱中，然后通过相同的质量过滤器/分析仪通过上游离子检测器检测。 利用这种布置，可以使用仅具有单个质量过滤器/分析器的装置来执行MS / MS实验。
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公开(公告)号：US06762404B2
公开(公告)日：2004-07-13
申请号：US10178347
申请日：2002-06-25
IPC分类号： H01J4900
CPC分类号： H01J49/005 , H01J49/065
摘要： A mass spectrometer includes a fragmentation cell having a plurality of ring or plate-like electrodes with apertures through which ions are transmitted. An axial DC gradient is preferably maintained along at least a portion of the length of the fragmentation cell in order to improve the transit time of ions through the device.
摘要翻译： 质谱仪包括具有多个具有孔的环状或板状电极的分裂单元，离子被透过。 轴向DC梯度优选沿破碎细胞的长度的至少一部分保持，以便改善离子通过装置的通过时间。
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公开(公告)号：US07205538B2
公开(公告)日：2007-04-17
申请号：US11472278
申请日：2006-06-22
IPC分类号： H01J49/40
CPC分类号： H01J49/4225
摘要： A mass spectrometer is disclosed comprising an ion trap wherein ions which have been temporally separated according to their mass to charge ratio or ion mobility enter the ion trap. Once at least some of the ions have entered the ion trap, a plurality of ion trapping regions are created along the length of the ion trap in order to fractionate the ions. Alternatively, the ions may be received within one or more axial trapping regions which are translated along the ion trap with a velocity which is progressively reduced to zero.
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公开(公告)号：US07095013B2
公开(公告)日：2006-08-22
申请号：US10448057
申请日：2003-05-30
IPC分类号： H01J49/40
CPC分类号： H01J49/065
摘要： A mass spectrometer is disclosed having an ion guide which receives ions from either a pulsed ion source or an ion trap, or a continuous ion source. The ion guide emits packets of ions. The pulses of ions emitted from the ion guide may be synchronised with another device such as an ion detector, an orthogonal acceleration Time of Flight mass analyser, an ion trap or a mass filter.
摘要翻译： 公开了一种质谱仪，其具有从脉冲离子源或离子阱或连续离子源接收离子的离子导向器。 离子导向器发出离子束。 从离子导向器发射的离子的脉冲可以与诸如离子检测器，正交加速时间飞行质量分析器，离子阱或质量过滤器的另一装置同步。
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公开(公告)号：US07071467B2
公开(公告)日：2006-07-04
申请号：US10633702
申请日：2003-08-05
IPC分类号： H01J49/40
CPC分类号： H01J49/4225
摘要： A mass spectrometer is disclosed comprising an ion trap wherein ions which have been temporally separated according to their mass to charge ratio or ion mobility enter the ion trap. Once at least some of the ions have entered the ion trap, a plurality of ion trapping regions are created along the length of the ion trap in order to fractionate the ions. Alternatively, the ions may be received within one or more axial trapping regions which are translated along the ion trap with a velocity which is progressively reduced to zero.
摘要翻译： 公开了一种质谱仪，其包括离子阱，其中根据其质荷比或离子迁移率暂时分离的离子进入离子阱。 一旦至少一些离子已经进入离子阱，沿着离子阱的长度产生多个离子捕获区域，以分离离子。 或者，离子可以被接收在一个或多个沿着离子阱平移的轴向捕获区域中，其速度逐渐减小到零。
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公开(公告)号：US06977371B2
公开(公告)日：2005-12-20
申请号：US10457515
申请日：2003-06-10
申请人： Robert Harold Bateman , Kevin Giles
发明人： Robert Harold Bateman , Kevin Giles
CPC分类号： H01J49/065 , H01J49/005
摘要： A mass spectrometer is disclosed having a gas collision cell. An AC or RF ion guide comprising a plurality of ring electrodes which preferably have the same internal diameter is provided within the gas collision cell. The ion guide extends upstream and/or downstream of the gas collision cell so that ions may be continuously radially confined as they pass from a vacuum chamber maintained at a relatively low pressure, through an inlet differential pumping aperture to the gas collision cell, through the gas collision cell and then out of the gas collision cell through an outlet differential pumping aperture.
摘要翻译： 公开了一种具有气体碰撞池的质谱仪。 包含多个优选具有相同内径的环形电极的AC或RF离子导向器设置在气体碰撞室内。 离子导向件在气体碰撞室的上游和/或下游延伸，使得离子可以在维持在相对较低的压力的真空室中通过入口差动泵送孔通过气体碰撞室，从而连续地径向地限制，通过 气体碰撞池，然后通过出口差分泵浦孔径离开气体碰撞池。
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