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    Hybrid implantable cochlear stimulator hearing aid system
    31.
    发明授权
    Hybrid implantable cochlear stimulator hearing aid system 有权
    混合植入式耳蜗刺激助听器系统

    公开(公告)号：US06754537B1

    公开(公告)日：2004-06-22

    申请号：US09979804

    申请日：2001-11-13

    申请人： William Vanbrooks Harrison ,  Janusz A. Kuzma ,  Alfred E. Mann ,  Thomas J. Balkany

    发明人： William Vanbrooks Harrison ,  Janusz A. Kuzma ,  Alfred E. Mann ,  Thomas J. Balkany

    IPC分类号： A61N118

    CPC分类号： A61N1/36036 ,  A61N1/0541

    摘要： A hybrid cochlear implant hearing aid sytem (10) provides low frequency acoustic energy boost, if needed, and high frequency direct neural stimulation. Tinnitus suppression may also be provided. The neurons responsible for sensing high frequency sounds are located at the basal end of the cochlea. A short basal electrode (52) that extends into the cochlea only at the basal region allows direct stimulation of these neurons by an appropriately-controlled cochlear stimulator (50). The basal electrode array typically has from four to eight electrode contacts (54). The design of the electrode array allows the surgeon to place the array using minimally invasive surgical techniques and requires no cochleostomy. The electrode array is thin, and can typically be inserted directly through the round window membrane to make contact with, or to be positioned in close proximity to, the modiolus wall in the basal region of the cochlea. The hybrid implantable cochlear stimulator and hearing aid system relies primarily on the cochlear stimulator portion of the system for being able to sense high frequency sounds, and relies primarily on normal hearing processes, or other acoustic boosting devices and systems, for being able to sense lower frequency sounds.

    摘要翻译： 混合耳蜗植入式助听器系统（10）提供低频声能增强，如果需要，以及高频直接神经刺激。 也可以提供耳鸣抑制。 负责感测高频声音的神经元位于耳蜗的基端。 仅在基底区域延伸到耳蜗的短基底电极（52）允许通过适当控制的耳蜗刺激器（50）直接刺激这些神经元。 基极电极阵列通常具有四至八个电极触点（54）。 电极阵列的设计允许外科医生使用微创手术技术来放置阵列，并且不需要耳蜗造口术。 电极阵列是薄的，并且通常可以直接插入通过圆窗膜以与耳蜗的基底区域中的闭孔壁接触或靠近位置。 混合植入式耳蜗刺激器和助听器系统主要依赖于系统的人工耳蜗刺激器部分，以便能够感测高频声音，并且主要依赖于正常听力过程或其他声学增强装置和系统，以便能够感测较低频 频率声音。

    Method and apparatus for infusing liquids using a chemical reaction in an implanted infusion device
    32.
    发明授权
    Method and apparatus for infusing liquids using a chemical reaction in an implanted infusion device 失效
    用于在植入的输注装置中使用化学反应注入液体的方法和装置

    公开(公告)号：US06520936B1

    公开(公告)日：2003-02-18

    申请号：US09590482

    申请日：2000-06-08

    申请人： Alfred E. Mann

    发明人： Alfred E. Mann

    IPC分类号： A61M3700

    CPC分类号： A61M5/14276 ,  A61M5/14593 ,  A61M2005/14204 ,  A61M2005/14513 ,  A61M2205/8243 ,  A61M2209/045

    摘要： Embodiments of implantable infusion pumps are provided that use a process of converting a first substance to a second gaseous substance (e.g. by electrolysis) to provide a motivating force to expel a desired fluid (e.g. drug or medication) from the pump into the body of a patient. An expandable sack may be provided around a gas producing electrolytic cell, such that as the gas expands it displaces a portion of the volume originally allocated to the desired fluid, and thereby forces the fluid from the pump. Pumps may be provided with a double septum to allow refilling of the desired fluid while simultaneously allowing removal of the generated gas from the system while using a single needle. Recharging of pump batteries may occur by direct electrical conduction through one or more needles and/or by r.f. energy transfer. Programming of the pump may occur by way of conductive paths provided by one or more needles or by means of r.f. transfer. A pressure regulator may be provided in vicinity to an outlet port of the pump so as to enable more reliable operation of the pump when subjected to changes in ambient pressure. A one-way valve may also be provided to reduce risk of back flow into the pump.

    摘要翻译： 提供了可植入输液泵的实施方案，其使用将第一物质转化为第二气态物质（例如通过电解）的方法，以提供驱动力以将期望的流体（例如药物或药物）从泵排入体内 患者。 可以在产生气体的电解池周围设置可膨胀袋，使得当气体膨胀时，其移动初始分配给期望流体的体积的一部分，从而迫使来自泵的流体。 泵可以设置有双隔膜，以允许重新填充所需的流体，同时在使用单个针的同时允许从系统中除去产生的气体。 泵电池的充电可以通过一个或多个针和/或r.f的直接电传导而发生。 能量转移。 泵的编程可以通过由一个或多个针或通过r.f提供的导电路径进行。 转让。 可以在泵的出口附近设置压力调节器，以便在受到环境压力变化时使泵更可靠地运行。 还可以提供单向阀以减少回流到泵中的风险。

    Inflatable cochlear electrode array and method of making same
    33.
    发明授权
    Inflatable cochlear electrode array and method of making same 失效
    充气耳蜗电极阵列及其制作方法

    公开(公告)号：US06266568B1

    公开(公告)日：2001-07-24

    申请号：US09300800

    申请日：1999-04-27

    申请人： Alfred E. Mann ,  Thomas H. R. Lenarz ,  Janusz A. Kuzma ,  William Vanbrooks Harrison

    发明人： Alfred E. Mann ,  Thomas H. R. Lenarz ,  Janusz A. Kuzma ,  William Vanbrooks Harrison

    IPC分类号： A61N104

    CPC分类号： A61N1/0541

    摘要： An inflatable cochlear electrode array adapted for insertion into a human cochlear includes a flexible carrier on which a multiplicity of spaced-apart electrode contacts are carried, preferably along one side, e.g., a medial side, of the carrier. The flexible carrier also includes an inflatable compartment or section. In one embodiment, the inflatable section is located at the distal tip of the electrode array on a side of the flexible carrier that is opposite the electrode contacts. In another embodiment, the inflatable compartment or section is located along at least one half of the full length of the flexible carrier, forming a spine. In either embodiment, the electrode is readily inserted into the cochlea to a desired depth while the inflatable compartment or section remains in a deflated state. Thereafter, a desired modiolus-hugging position is achieved by inflating the inflatable compartment or section by injecting therein a suitable biocompatible fluid. A method of making an inflatable cochlear electrode is also disclosed.

    摘要翻译： 适于插入到人类耳蜗中的充气耳蜗电极阵列包括柔性载体，其上承载有多个间隔开的电极触点，优选地沿载体的一侧，例如内侧。 柔性载体还包括可充气的隔室或部分。 在一个实施例中，可充气部分位于与电极接触件相对的柔性载体侧上的电极阵列的远端。 在另一个实施例中，可充气隔室或部分沿柔性载体的全长的至少一半定位，形成脊柱。 在任一实施例中，电极容易地插入耳蜗到期望的深度，同时可充气隔间或部分保持在放气状态。 此后，通过在其中注射合适的生物相容性流体来使充气室或部分膨胀来实现所需的夹层位置。 还公开了制造充气耳蜗电极的方法。

    Liquid-vapor pressure reservoir for medication infusion pump
    34.
    发明授权
    Liquid-vapor pressure reservoir for medication infusion pump 失效
    用于药物灌注泵的液体蒸汽压力储存器

    公开(公告)号：US5167633A

    公开(公告)日：1992-12-01

    申请号：US619650

    申请日：1990-11-29

    申请人： Alfred E. Mann ,  Peter C. Lord

    发明人： Alfred E. Mann ,  Peter C. Lord

    IPC分类号： A61M5/00 ,  A61M1/36 ,  A61M5/142 ,  A61M37/00

    CPC分类号： A61M5/14276 ,  Y10S128/12

    摘要： An improved and simplified pressure reservoir is provided for use with an implantable medication infusion pump to maintain a selected medication in liquid form with a pump housing under a substantially constant pressure. The pressure reservoir comprises a hollow structural enclousre having at least one flexible resilient wall and is adapted to be filled with a selected quantity of a pressure fluid, such as a selected fluorocarbon in a liquid-vapor state, prior to mounting of the reservoir as a structural unit into the infusion pump housing. Within the pump housing, the flexible reservoir wall defines one side of a medication chamber, with the pressure fluid undergoing appropriate change of state to expand or contact the reservoir in a manner maintaining the medication under a substantially constant pressure. The improved reservoir can be provided in a variety of structural shapes and/or utilized in pump housings of various size and shape to permit the pump size to be reduced, or, in the alternative, to increase pump medication capacity without increasing pump housing size.

    NEURAL STIMULATOR WITH PERCUTANEOUS CONNECTIVITY
    36.
    发明申请
    NEURAL STIMULATOR WITH PERCUTANEOUS CONNECTIVITY 有权
    神经刺激器具有连贯性

    公开(公告)号：US20120203318A1

    公开(公告)日：2012-08-09

    申请号：US13500731

    申请日：2010-09-30

    申请人： Alfred E. Mann ,  Tom Xiaohai He

    发明人： Alfred E. Mann ,  Tom Xiaohai He

    IPC分类号： A61N1/00

    CPC分类号： A61N1/0539 ,  A61M39/0247 ,  A61M2039/0261 ,  A61M2039/0267 ,  A61N1/0536 ,  A61N1/36017 ,  A61N1/36128

    摘要： An implantable neurostimulation system includes both implantable and external components. Electrical connectivity between the external and implanted components is achieved through a plurality of feedthrough pins located within an insulative wall of a percutaneous port embedded in the skin. The percutaneous port has the general shape and appearance of a small thimble, embedded in the skin with its open end facing outwardly from the skin surface, and with its closed end located below the skin surface, thereby forming a cavity or dimple in the skin. Various plugs or cartridges can be removably inserted into the cavity of the percutaneous port, in various orientations, to facilitate appropriate connectivity between the external and implanted components of the system through selected ones of the feedthrough pins. A mesh edging secured around the periphery wall of the port promotes tissue ingrowth and vascularization, thereby forming a percutaneous seal around the port that prevents infection.

    摘要翻译： 植入式神经刺激系统包括可植入和外部组件。 外部和植入部件之间的电连接通过位于皮肤内的经皮端口的绝缘壁内的多个穿通针来实现。 经皮端口具有嵌入皮肤中的小套管的一般形状和外观，其开口端从皮肤表面向外，并且其封闭端位于皮肤表面下方，从而在皮肤中形成空腔或凹坑。 可以以各种取向将各种插头或药筒可移除地插入到经皮端口的空腔中，以通过选定的馈通针来促进系统的外部部件和植入部件之间的适当连接。 围绕端口的周围壁固定的网状边缘促进组织向内生长和血管形成，从而在端口周围形成防止感染的经皮密封。

    Hybrid multi-function electrode array
    37.
    发明申请
    Hybrid multi-function electrode array 审中-公开
    混合多功能电极阵列

    公开(公告)号：US20100331913A1

    公开(公告)日：2010-12-30

    申请号：US11261432

    申请日：2005-10-28

    申请人： Alfred E. Mann ,  William Vanbrooks Harrison

    发明人： Alfred E. Mann ,  William Vanbrooks Harrison

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0541 ,  A61N1/36036

    摘要： A hybrid electrode array includes a basal array section and a distal array section. The basal array section is configured to provide high frequency stimulation. The basal array section is configured to extend into the cochlea up to a region where electrical stimulation provides recovery for high frequency loss. The distal array section is configured to be attached to a distal tip of the basal array section and is configured to extend into the cochlear to a region where electrical stimulation provides recovery for middle to low frequency hearing loss. For progressive hearing loss treatment, the distal array section is not activated during initial stages of hearing loss allowing the patient to rely on a combination of acoustic stimulation and high frequency stimulation provided by the basal array section. As hearing loss progresses, the distal array section is selectively activated to treat lower frequency hearing loss using lower frequency stimulation.

    摘要翻译： 混合电极阵列包括基底阵列部分和远端阵列部分。 基础阵列部分被配置为提供高频刺激。 基底阵列部分被配置成延伸到耳蜗直到电刺激为高频丢失提供恢复的区域。 远端阵列部分被配置为附接到基部阵列部分的远侧末端，并且被配置为延伸到耳蜗到电刺激提供中低频听力损失恢复的区域。 对于进行性听力损失治疗，远端阵列部分在听力损失的初始阶段期间不被激活，允许患者依靠由基部阵列部分提供的声刺激和高频刺激的组合。 随着听力损失的进行，远端阵列部分被选择性地激活以使用较低频率的刺激来治疗较低频率的听力损失。