公开(公告)号：US20050288720A1

公开(公告)日：2005-12-29

申请号：US10862011

申请日：2004-06-04

申请人： Jeffrey Ross ,  Julio Spinelli ,  Rodney Salo

发明人： Jeffrey Ross ,  Julio Spinelli ,  Rodney Salo

IPC分类号： A61N1/362

CPC分类号： A61N1/3627

摘要： A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. The pre-excitation pacing in conjunction with counterpulsation therapy serves to either prevent or minimize post-infarct remodeling.

摘要翻译： 心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。 预激励起搏结合反搏疗法可预防或最小化梗死后重塑。

公开(公告)号：US06892095B2

公开(公告)日：2005-05-10

申请号：US10036639

申请日：2001-12-31

申请人： Rodney Salo

发明人： Rodney Salo

IPC分类号： A61N1/05 ,  A61N1/362 ,  A61N1/365

CPC分类号： A61N1/056 ,  A61N1/3627 ,  A61N1/3655 ,  A61N1/36571 ,  A61N2001/0585

摘要： A body implantable system employs a lead system having at least one electrode and at least one thermal sensor at a distal end. The lead system is implanted within a patient's heart in a coronary vein of the left ventricle. The thermal sensor can be attached to a catheter that is disposed within an open lumen of the lead system. The thermal sensor senses a coronary vein temperature. The coronary vein temperature can be measured at a detector/energy delivery system and used as an activity indicator to adaptively control pacing rate. The measured coronary vein temperature can be also used with a left ventricular flow measurement to determine hemodynamic efficiency of the heart. A detected change in hemodynamic efficiency can be used by the detector/energy delivery system to modify the delivery of electrical pulses to the lead system.

摘要翻译： 身体可植入系统采用在远端具有至少一个电极和至少一个热传感器的引导系统。 引导系统植入患者的心脏左心室冠状静脉。 热传感器可以附接到布置在引导系统的开口腔内的导管。 热传感器感测冠状静脉温度。 冠状静脉温度可以在检测器/能量输送系统中测量，并用作活动指示器以自适应地控制起搏速率。 测量的冠状静脉温度也可用于左心室流量测量以确定心脏的血液动力学效率。 检测器/能量输送系统可以使用检测到的血液动力学效率的变化来修改对引导系统的电脉冲的传递。

公开(公告)号：US20050065568A1

公开(公告)日：2005-03-24

申请号：US10952346

申请日：2004-09-28

申请人： Lili Liu ,  Rodney Salo

发明人： Lili Liu ,  Rodney Salo

IPC分类号： A61N1/368 ,  A61N1/365

CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/3684

摘要： An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.

摘要翻译： 用电刺激治疗逆转心室重构的装置和方法。 通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。 随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。

公开(公告)号：US20080140144A1

公开(公告)日：2008-06-12

申请号：US12070080

申请日：2008-02-15

申请人： Lili Liu ,  Rodney Salo

发明人： Lili Liu ,  Rodney Salo

IPC分类号： A61N1/365

CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/3684

摘要： An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.

公开(公告)号：US07346394B2

公开(公告)日：2008-03-18

申请号：US10952346

申请日：2004-09-28

申请人： Lili Liu ,  Rodney Salo

发明人： Lili Liu ,  Rodney Salo

IPC分类号： A61N1/362

CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/3684

摘要： An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.

摘要翻译： 用电刺激治疗逆转心室重构的装置和方法。 通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。 随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。

公开(公告)号：US20060293716A1

公开(公告)日：2006-12-28

申请号：US11469620

申请日：2006-09-01

申请人： Andrew Kramer ,  Rodney Salo ,  Julio Spinelli ,  Bruce KenKnight

发明人： Andrew Kramer ,  Rodney Salo ,  Julio Spinelli ,  Bruce KenKnight

IPC分类号： A61N1/36

CPC分类号： A61N1/3627 ,  A61N1/365 ,  A61N1/36542 ,  A61N1/36585 ,  A61N1/368

摘要： An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.

公开(公告)号：US20050288721A1

公开(公告)日：2005-12-29

申请号：US10862716

申请日：2004-06-07

申请人： Steven Girouard ,  Jeffrey Ross ,  Rodney Salo

发明人： Steven Girouard ,  Jeffrey Ross ,  Rodney Salo

IPC分类号： A61M5/142 ,  A61M5/172 ,  A61N1/362 ,  A61N1/365

CPC分类号： A61M5/14276 ,  A61M5/1723 ,  A61M2205/3523 ,  A61M2205/3561 ,  A61M2210/125 ,  A61M2230/00 ,  A61N1/36585

摘要： A system delivers cardiac pacing therapy and chemical and/or biological therapy to modulate myocardial tissue growth in a heart after myocardial infarction (MI). The system includes an agent delivery device to release one or more agents to an MI region to modulate myocardial tissue growth in that region, and a cardiac rhythm management (CRM) device to deliver pacing pulses to enhance the effects of the one or more agents by altering myocardial wall stress and cardiac workload. In one embodiment, the system is an implantable system including an implantable agent delivery device and an implantable CRM device.

摘要翻译： 系统提供心脏起搏治疗和化学和/或生物治疗以调节心肌梗塞（MI）后心脏中的心肌组织生长。 该系统包括用于将一个或多个药剂释放到MI区域以调节该区域中的心肌组织生长的药剂递送装置，以及心律管理（CRM）装置，以递送起搏脉冲以增强一种或多种药剂的作用 改变心肌壁压力和心脏工作量。 在一个实施例中，该系统是包括可植入剂递​​送装置和可植入CRM装置的可植入系统。

公开(公告)号：US20050149143A1

公开(公告)日：2005-07-07

申请号：US10745921

申请日：2003-12-24

申请人： Imad Libbus ,  Rodney Salo

发明人： Imad Libbus ,  Rodney Salo

IPC分类号： A61N1/36 ,  A61N1/365 ,  A61N1/18

CPC分类号： A61N1/36117 ,  A61N1/36057 ,  A61N1/36564

摘要： An aspect relates to an implantable medical device. An embodiment of the device comprises a pulse generator, sensor circuitry, a lead, and a controller. The pulse generator generates baroreflex stimulation pulses. The lead is adapted to be electrically connected to the pulse generator and to the sensor circuitry. The lead includes an electrode to distribute the baroreflex stimulation pulses to a baroreflex site and a pressure sensor to provide a signal indicative of blood pressure to the sensor circuitry. The controller is connected to the pulse generator and the sensor circuitry. The controller adapted to adjust the baroreflex stimulation pulses based on the blood pressure. Other aspects are provided herein.

摘要翻译： 一个方面涉及可植入医疗装置。 该装置的实施例包括脉冲发生器，传感器电路，引线和控制器。 脉冲发生器产生压力反射刺激脉冲。 引线适于电连接到脉冲发生器和传感器电路。 引线包括用于将压力反射刺激脉冲分布到压力反射部位的电极和压力传感器，以向传感器电路提供指示血压的信号。 控制器连接到脉冲发生器和传感器电路。 控制器适于基于血压调节压力反射刺激脉冲。 本文提供了其他方面。

公开(公告)号：US20050102002A1

公开(公告)日：2005-05-12

申请号：US10703398

申请日：2003-11-07

申请人： Rodney Salo ,  Matthew Salo

发明人： Rodney Salo ,  Matthew Salo

IPC分类号： A61N1/362 ,  A61N1/365 ,  A61N1/372

CPC分类号： A61N1/3627 ,  A61N1/36514

摘要： Pacing pulses are delivered to one or more cardiac regions to improve diastolic performance in patients having diastolic dysfunction and/or heart failure. A cardiac pacing system executes a pacing algorithm using a parameter indicative of the diastolic performance as an input. The pacing pulses excite the one or more cardiac regions to redistribute the loading on the ventricular wall during diastole, thereby improving the diastolic performance by lowering the degree of cardiac wall motion dyssynchrony associated with diastolic dysfunction.

摘要翻译： 将起搏脉冲输送到一个或多个心脏区域以改善具有舒张功能障碍和/或心力衰竭的患者的舒张性能。 心脏起搏系统使用表示舒张性能的参数作为输入来执行起搏算法。 起搏脉冲激发一个或多个心脏区域以在舒张期期间重新分布心室壁上的负荷，从而通过降低与舒张功能障碍相关的心脏壁运动不同步的程度来改善舒张性能。

公开(公告)号：US07738967B2

公开(公告)日：2010-06-15

申请号：US11651311

申请日：2007-01-09

申请人： Rodney Salo

发明人： Rodney Salo

IPC分类号： A61N1/00

CPC分类号： A61N1/056 ,  A61N1/3627 ,  A61N1/3655 ,  A61N1/36571 ,  A61N2001/0585

摘要： Methods of cardiac pacing involve sensing left ventricular electrical rhythms, sensing left ventricular blood flow rate, and sensing a coronary vein blood temperature. The methods further involve modifying delivery of synchronized electrical signals to the patient's heart based at least in part on the sensed coronary vein blood temperature and sensed left ventricular flow rate.

摘要翻译： 心脏起搏方法涉及感测左心室电节律，感测左心室血流速度，以及感测冠状静脉血液温度。 所述方法还包括至少部分地基于感测的冠状静脉血液温度和感测的左心室流率来修改同步电信号到患者心脏的传送。