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44 条记录 (耗时 0.053 秒)

    Methods and compositions for diagnosis and treatment of influenza
    32.
    发明申请
    Methods and compositions for diagnosis and treatment of influenza 有权
    用于流感诊断和治疗的方法和组成

    公开(公告)号：US20070161078A1

    公开(公告)日：2007-07-12

    申请号：US11481411

    申请日：2006-07-03

    申请人： Peter Lu ,  Joshua Rabinowitz ,  Michael Belmares

    发明人： Peter Lu ,  Joshua Rabinowitz ,  Michael Belmares

    IPC分类号： C12Q1/68 ,  C12P21/06

    CPC分类号： A61K38/07 ,  A61K38/08 ,  C07K5/1008 ,  C07K5/1013 ,  C07K5/1019 ,  C07K5/1021 ,  C07K7/06 ,  C12N2760/16111 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2500/02

    摘要： The invention provides method and compositions for determining the presence and amount of an influenza virus in a sample including high risk strains of Influenza A. Also provided are methods for determining whether a subject is infected with a influenza virus, as well as, the type and strain of the influenza virus. The methods involve contacting a sample from the subject with a PDZ polypeptides (PDZ) and/or PDZ ligands (PL) and determining whether binding interactions occur between PDZ and PL. Assays for identifying anti-viral agents are also provided, as well as, methods for using the compositions to alter PDZ binding to PL in influenza infected cells.

    摘要翻译： 本发明提供用于确定样品中流感病毒的存在和量的方法和组合物，其包括流感A的高风险菌株。还提供了确定受试者是否感染流感病毒的方法以及类型和 流感病毒株。 所述方法包括使来自受试者的样品与PDZ多肽（PDZ）和/或PDZ配体（PL）接触并确定在PDZ和PL之间是否发生结合相互作用。 还提供了用于鉴定抗病毒剂的测定法，以及使用该组合物改变流感病毒感染细胞中PDZ与PL结合的方法。

    Treatment of viral infections by modulation of host cell metabolic pathways
    33.
    发明授权
    Treatment of viral infections by modulation of host cell metabolic pathways 有权
    通过调节宿主细胞代谢途径治疗病毒感染

    公开(公告)号：US08158677B2

    公开(公告)日：2012-04-17

    申请号：US12156517

    申请日：2008-06-02

    申请人： Josh Munger ,  Bryson Bennett ,  Thomas Shenk ,  Joshua Rabinowitz

    发明人： Josh Munger ,  Bryson Bennett ,  Thomas Shenk ,  Joshua Rabinowitz

    IPC分类号： A61K31/34 ,  A61K31/38 ,  A61K31/35

    CPC分类号： A61K31/7076 ,  A61K31/122 ,  A61K31/15 ,  A61K31/194 ,  A61K31/22 ,  A61K31/221 ,  A61K31/336 ,  A61K31/337 ,  A61K31/341 ,  A61K31/351 ,  A61K31/357 ,  A61K31/365 ,  A61K31/381 ,  A61K31/403 ,  A61K31/405 ,  A61K31/44 ,  A61K31/4545 ,  A61K31/52 ,  A61K31/522 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/706 ,  Y02A50/463 ,  A61K2300/00

    摘要： Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.

    摘要翻译： 描述了响应于病毒感染发生的某些代谢物浓度和通量的变化。 所选代谢途径中的宿主细胞酶被选为干预的目标; 即恢复代谢通量以不利于病毒复制，或进一步破坏导致病毒感染细胞（但不是未感染细胞）“自杀”的代谢通量，以限制病毒传播。 虽然可以选择相关代谢途径中的任何酶，但在这些代谢途径的关键控制点的关键酶优选作为候选抗病毒药物靶标。 这些酶的抑制剂用于逆转或重定向病毒感染的作用。 使用体外和宿主细胞的筛选测定以及动物模型测试候选药物的抗病毒活性。 然后使用动物模型来测试候选化合物在预防和治疗病毒感染中的功效。 证明酶抑制剂的抗病毒活性。

    Delivery of caffeine through an inhalation route
    35.
    发明申请
    Delivery of caffeine through an inhalation route 失效

    公开(公告)号：US20060257328A1

    公开(公告)日：2006-11-16

    申请号：US11488302

    申请日：2006-07-18

    申请人： Joshua Rabinowitz

    发明人： Joshua Rabinowitz

    IPC分类号： A61K9/14 ,  A61L9/04 ,  A61K31/522

    CPC分类号： A61K9/007 ,  A61K9/0073 ,  A61K31/52 ,  A61K31/522 ,  Y10S514/958

    摘要： The present invention relates to the delivery of caffeine through an inhalation route. Specifically, it relates to aerosols containing caffeine that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of caffeine. In a method aspect of the present invention, caffeine is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of caffeine, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering caffeine through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of caffeine; and, b) a device that forms a caffeine containing aerosol from the composition, for inhalation by the mammal.

    Cardiac safe, rapid medication delivery
    36.
    发明申请
    Cardiac safe, rapid medication delivery 审中-公开
    心脏安全，快速用药

    公开(公告)号：US20060120962A1

    公开(公告)日：2006-06-08

    申请号：US11248598

    申请日：2005-10-12

    申请人： Joshua Rabinowitz ,  Peter Lloyd

    发明人： Joshua Rabinowitz ,  Peter Lloyd

    IPC分类号： A61K49/00 ,  A61K9/14 ,  A61L9/04

    CPC分类号： A61K9/0019 ,  A61K9/007 ,  A61K9/0073

    摘要： The disclosure provides methods and compositions for providing an effective dose of an active agent and/or drug composition to a subject by inhalation. The methods of the disclosure are useful in determining a maximal effective dose that limits cardiovascular damage upon inhalation.

    摘要翻译： 本公开提供了通过吸入向受试者提供有效剂量的活性剂和/或药物组合物的方法和组合物。 本公开的方法可用于确定在吸入时限制心血管损伤的最大有效剂量。

    Methods for monitoring severity of panic attacks and other rapidly evolving medical events in real time
    39.
    发明申请
    Methods for monitoring severity of panic attacks and other rapidly evolving medical events in real time 审中-公开
    监测恐慌发作严重程度及其他快速发展的医疗事件的方法

    公开(公告)号：US20050131739A1

    公开(公告)日：2005-06-16

    申请号：US10996114

    申请日：2004-11-23

    申请人： Joshua Rabinowitz ,  Roman Skowronski

    发明人： Joshua Rabinowitz ,  Roman Skowronski

    IPC分类号： A61B5/16 ,  G06F19/00 ,  G06Q10/00 ,  G06F17/60 ,  A61B5/00

    CPC分类号： G06Q10/109 ,  A61B5/16 ,  A61B5/165 ,  A61B5/411 ,  G06Q50/22

    摘要： The present invention provides novel methods of recording a medical event in real-time. One aspect of the invention comprises providing a subject an electronic diary for recording one or more aspects of a medical event, wherein the diary electronically records a time at which entries to the diary are made without requiring the subject to input the time of each entry and wherein the diary further prompts the subject to make an entry in the diary at various time intervals. Other aspects of the invention include methods of determining whether a medical treatment produces a therapeutic effect in a subject using real-time data; methods of measuring response of a subject experiencing panic attack symptoms to a treatment in real-time; and methods of assessing the relative effectiveness in real-time of a first medical treatment and a second medical treatment.

    摘要翻译： 本发明提供了实时记录医疗事件的新颖方法。 本发明的一个方面包括向受试者提供用于记录医疗事件的一个或多个方面的电子日记，其中日记以电子方式记录在日志的条目下进行的时间，而不要求受试者输入每个记录的时间， 其中日记进一步提示受试者以不同的时间间隔在日记中进入。 本发明的其它方面包括使用实时数据确定医疗治疗是否在受试者中产生治疗效果的方法; 测量遭受恐慌症状的受试者对实时治疗的反应的方法; 以及评估第一次医疗和第二次医疗的实时相对有效性的方法。