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公开(公告)号：US20050282743A1
公开(公告)日：2005-12-22
申请号：US10485788
申请日：2002-08-02
CPC分类号： C07K5/1008 , A61K38/00 , C07K1/047 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K5/1021 , C07K5/1024 , C07K14/4702 , G01N33/5005
摘要： The invention provides reagents and methods for inhibiting or enhancing interactions between proteins in cells, particularly interactions between a PDZ protein and a PL protein. Reagents and methods that are provided are useful for treatment of a variety of diseases and conditions in a variety of cell types.
摘要翻译： 本发明提供用于抑制或增强细胞中蛋白质之间的相互作用的试剂和方法，特别是PDZ蛋白和PL蛋白之间的相互作用。 提供的试剂和方法可用于治疗各种细胞类型中的各种疾病和病症。
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公开(公告)号：US20050214869A1
公开(公告)日：2005-09-29
申请号：US11131054
申请日：2005-05-16
申请人： Peter Lu , Joshua Rabinowitz , Johannes Schweizer
发明人： Peter Lu , Joshua Rabinowitz , Johannes Schweizer
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/705 , C12Q1/68 , C40B40/10 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/566 , G06F19/00
CPC分类号： G01N33/566 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K48/00 , B01J2219/00659 , B01J2219/00725 , C07K14/705 , C07K2319/00 , C12N2310/315 , C40B40/10 , Y02A90/26 , Y10S436/809
摘要： The invention provides reagents and methods for inhibiting or enhancing interactions between proteins in hematopoietic cells and other cells involved in the mediation of an immune response. Reagents and methods provided are useful for treatment of a variety of diseases and conditions mediated by immune system cells.
摘要翻译： 本发明提供了用于抑制或增强造血细胞中的蛋白质与涉及免疫应答中介的其它细胞之间的相互作用的试剂和方法。 提供的试剂和方法可用于治疗由免疫系统细胞介导的多种疾病和病症。
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公开(公告)号：US20050037969A1
公开(公告)日：2005-02-17
申请号：US10938249
申请日：2004-09-10
申请人： Peter Lu , Joshua Rabinowitz , Johannes Schweizer
发明人： Peter Lu , Joshua Rabinowitz , Johannes Schweizer
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K19/00 , C12Q1/68 , A61K39/395
CPC分类号： C07K14/47 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4702 , C07K14/705 , C07K19/00 , C07K2319/00 , C12N2310/315 , G01N2333/70571
摘要： The invention provides reagents and methods for inhibiting or enhancing interactions between proteins in hematopoietic cells and other cells involved in the mediation of an immune response. Reagents and methods provided are useful for treatment of a variety of diseases and conditions mediated by immune system cells.
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公开(公告)号：US20050221388A1
公开(公告)日：2005-10-06
申请号：US11131042
申请日：2005-05-16
申请人： Peter Lu , Joshua Rabinowitz , Johannes Schweizer
发明人： Peter Lu , Joshua Rabinowitz , Johannes Schweizer
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/705 , C12Q1/68 , C40B40/10 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/566 , G06F19/00
CPC分类号： G01N33/566 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K48/00 , B01J2219/00659 , B01J2219/00725 , C07K14/705 , C07K2319/00 , C12N2310/315 , C40B40/10 , Y02A90/26 , Y10S436/809
摘要： The invention provides reagents and methods for inhibiting or enhancing interactions between proteins in hematopoietic cells and other cells involved in the mediation of an immune response. Reagents and methods provided are useful for treatment of a variety of diseases and conditions mediated by immune system cells.
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5.发明申请METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF VIRAL AND BACTERIAL INFECTIONS 审中-公开用于诊断和治疗病毒和细菌感染的方法和组合物公开(公告)号：US20070014803A1
公开(公告)日：2007-01-18
申请号：US11428531
申请日：2006-07-03
申请人： Peter Lu , Joshua Rabinowitz , Michael Belmares
发明人： Peter Lu , Joshua Rabinowitz , Michael Belmares
CPC分类号： G01N33/5695 , C07K14/005 , C07K14/35 , C07K16/1289 , C12N2720/12322 , C12N2730/10122 , C12N2740/16222 , C12N2740/16322 , C12N2760/18522 , C12N2770/24022 , C12N2770/24222 , G01N33/56983 , G01N33/56988 , G01N33/5761 , G01N2333/14 , G01N2333/35 , Y02A50/53 , Y02A50/60
摘要： The invention provides method and compositions for determining the presence and amount of a virus such as HIV-1, HIV-2, Hepatitis B, Hepatitis C, RSV, Rotavirus A, and M. tuberculosis in a sample. Also provided are methods for determining whether a subject is infected with HIV, as well as, the type. The methods involve contacting a sample from the subject with a PDZ polypeptide (PDZ) or other PL binding factor and/or PDZ ligands (PL) and determining whether binding interactions occur between PDZ or other binding factor and PL. Assays for identifying anti-viral and anti-bacterial agents are also provided, as well as, methods for using the compositions to alter PDZ binding to PL in viral or bacterial infected cells.
摘要翻译： 本发明提供了用于确定样品中HIV-1，HIV-2，乙型肝炎，丙型肝炎，RSV，轮状病毒A和结核分枝杆菌等病毒的存在和量的方法和组合物。 还提供了用于确定受试者是否感染HIV的方法以及类型。 所述方法包括使受试者的样品与PDZ多肽（PDZ）或其他PL结合因子和/或PDZ配体（PL）接触，并确定在PDZ或其他结合因子与PL之间是否发生结合相互作用。 还提供了用于鉴定抗病毒和抗细菌剂的测定法，以及使用组合物改变病毒或细菌感染细胞中PDZ与PL结合的方法。
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公开(公告)号：US20070161078A1
公开(公告)日：2007-07-12
申请号：US11481411
申请日：2006-07-03
申请人： Peter Lu , Joshua Rabinowitz , Michael Belmares
发明人： Peter Lu , Joshua Rabinowitz , Michael Belmares
CPC分类号： A61K38/07 , A61K38/08 , C07K5/1008 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C07K7/06 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2500/02
摘要： The invention provides method and compositions for determining the presence and amount of an influenza virus in a sample including high risk strains of Influenza A. Also provided are methods for determining whether a subject is infected with a influenza virus, as well as, the type and strain of the influenza virus. The methods involve contacting a sample from the subject with a PDZ polypeptides (PDZ) and/or PDZ ligands (PL) and determining whether binding interactions occur between PDZ and PL. Assays for identifying anti-viral agents are also provided, as well as, methods for using the compositions to alter PDZ binding to PL in influenza infected cells.
摘要翻译： 本发明提供用于确定样品中流感病毒的存在和量的方法和组合物，其包括流感A的高风险菌株。还提供了确定受试者是否感染流感病毒的方法以及类型和 流感病毒株。 所述方法包括使来自受试者的样品与PDZ多肽（PDZ）和/或PDZ配体（PL）接触并确定在PDZ和PL之间是否发生结合相互作用。 还提供了用于鉴定抗病毒剂的测定法，以及使用该组合物改变流感病毒感染细胞中PDZ与PL结合的方法。
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公开(公告)号：US20070292899A1
公开(公告)日：2007-12-20
申请号：US11747830
申请日：2007-05-11
申请人： Stephen Lovell , Lydia Blank , Virginia Crews , Nancy Hasse , Peter Lu , Johannes Schweizer
发明人： Stephen Lovell , Lydia Blank , Virginia Crews , Nancy Hasse , Peter Lu , Johannes Schweizer
CPC分类号： C07K14/005 , C07K1/145 , C07K14/82 , C12N7/00 , C12N2710/20051 , G01N33/56983 , G01N2333/025
摘要： Methods for producing a protein extract from cells, such as cells containing viral proteins, are provided. In general terms, the methods involve: increasing the pH of the cells to a pH of at least about pH 10.0 to produce an intermediate composition, and then, in the presence of a non-ionic detergent, neutralizing the pH of the intermediate composition to produce the protein extract. Kits and compositions for practicing the subject methods are also provided.
摘要翻译： 提供了从细胞如含有病毒蛋白的细胞产生蛋白质提取物的方法。 一般来说，所述方法包括：将细胞的pH增加至至少约pH 10.0的pH以产生中间体组合物，然后在非离子型洗涤剂的存在下将中间体组合物的pH中和至 产生蛋白质提取物。 还提供了用于实践主题方法的工具包和作品。
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公开(公告)号：US20050255460A1
公开(公告)日：2005-11-17
申请号：US11053076
申请日：2005-02-07
IPC分类号： A61K38/00 , C07K14/705 , C12Q1/42 , C12Q1/48 , C12Q1/70 , G01N33/564 , G01N33/566 , G01N33/574 , G01N33/68
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
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公开(公告)号：US20120141502A1
公开(公告)日：2012-06-07
申请号：US13265332
申请日：2010-04-20
申请人： Eric Dixon , Rainer Blaesius , Stephen Simkins , Steven L. Knapp , George Brough , Karen Lenz , Johannes Schweizer , Peter Lu , David Garman , Jon Silver , Charles Mahoney , Chamorro Somoza Diaz-Sarmiento
发明人： Eric Dixon , Rainer Blaesius , Stephen Simkins , Steven L. Knapp , George Brough , Karen Lenz , Johannes Schweizer , Peter Lu , David Garman , Jon Silver , Charles Mahoney , Chamorro Somoza Diaz-Sarmiento
IPC分类号： A61K39/395 , A61P31/20 , C40B30/04 , C12Q1/70 , C40B40/10
CPC分类号： G01N33/5748 , C07K16/084 , C07K2317/33 , C07K2317/34 , C07K2317/76 , G01N33/56983 , G01N2333/025 , G01N2469/10
摘要： The subject invention provides an antibody composition for detecting E6 protein of at least one HPV strain in a sample. The subject antibodies may be used to detect oncogenic HPV E6 proteins in a sample, and the antibodies find use in a variety of diagnostic and therapeutic applications, including methods of diagnosing and treating cancer. Kits for performing the subject methods and containing the subject antibodies are also provided. Also disclosed in the present invention is a method of generating an antibody that specifically binds to amino-terminus of E6 proteins of at least two HPV strains.
摘要翻译： 本发明提供了用于检测样品中至少一种HPV病毒株的E6蛋白的抗体组合物。 受试抗体可用于检测样品中的致癌HPV E6蛋白，并且抗体可用于多种诊断和治疗应用，包括诊断和治疗癌症的方法。 还提供了用于进行受试方法并含有目标抗体的试剂盒。 本发明还公开了产生特异性结合至少两种HPV病毒株的E6蛋白的氨基末端的抗体的方法。
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公开(公告)号：US20070099199A1
公开(公告)日：2007-05-03
申请号：US11403141
申请日：2006-04-11
申请人： Peter Lu , Christoph Bagowski , Johannes Schweizer , Chamorro Diaz-Sarmiento , Jonathan Garman , Michael Belmares
发明人： Peter Lu , Christoph Bagowski , Johannes Schweizer , Chamorro Diaz-Sarmiento , Jonathan Garman , Michael Belmares
CPC分类号： C07K14/005 , A61K38/00 , C07K14/47 , C07K14/705 , C07K2319/00 , C12N7/00 , C12N2710/20022 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02
摘要： The invention provides methods and compositions for treating pathogen infections, particularly human papillomavirus infections. Specifically, the invention provides a method of screening that involves determining an effect of a candidate agent on binding of an E6 protein from an oncogenic strain of HPV to a polypeptide containing the amino acid sequence of a particular PDZ domain from the cellular protein MAGI-1. The invention provides methods to treat diseases associated with expression of pathogen proteins by modulating their interactions with MAGI-1, and a number of isolated peptides useful in such methods. Also provided are kits for performing the subject methods.
摘要翻译： 本发明提供了用于治疗病原体感染，特别是人乳头瘤病毒感染的方法和组合物。 具体地，本发明提供了一种筛选方法，其涉及确定候选试剂对来自HPV的致癌菌株的E6蛋白与含有来自细胞蛋白MAGI-1的特定PDZ结构域的氨基酸序列的多肽的结合的影响 。 本发明提供了通过调节与MAGI-1的相互作用来治疗与病原体蛋白表达相关的疾病的方法，以及在这些方法中有用的许多分离的肽。 还提供了用于执行主题方法的套件。
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