公开(公告)号：US09931400B2

公开(公告)日：2018-04-03

申请号：US14025403

申请日：2013-09-12

Applicant: Samsung Electronics Co., Ltd.

Inventor： Yun Ju Jeong ,  Kyung Ah Kim ,  Yun Jeong Song ,  Ji Min Lee ,  Hyo Seon Lee ,  Jae Hyun Choi ,  Saet Byoul Lee

IPC: A61K39/395 ,  A61K45/06 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K45/06 ,  C07K16/2863 ,  C07K2317/24

Abstract: Provided is a method of combination therapy for prevention or treatment of c-Met-induced or angiogenesis factor-induced diseases including co-administering an angiogenesis inhibitor and an anti-c-Met antibody or an antigen-binding fragment thereof to a patient.

公开(公告)号：US09850537B2

公开(公告)日：2017-12-26

申请号：US14604361

申请日：2015-01-23

Applicant: Samsung Electronics Co., Ltd.

Inventor： Bo Gyou Kim ,  Eunjin Lee ,  Kyung Ah Kim ,  Tae Jin Ahn

IPC: A61K39/00 ,  C12Q1/68 ,  C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  G01N33/574

CPC classification number: C12Q1/6876 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/3023 ,  C07K16/3046 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/32 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/574 ,  G01N2333/47 ,  G01N2800/52 ,  A61K2300/00

Abstract: A method of predicting an effect of a c-Met inhibitor and/or selecting a subject for application of a c-Met inhibitor using TFF1, a method of monitoring an effect of a c-Met inhibitor using TFF1, and a method of treating and/or preventing cancer including administering a c-Met inhibitor to the selected subject.

公开(公告)号：US09808507B2

公开(公告)日：2017-11-07

申请号：US14835376

申请日：2015-08-25

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seungja Oh ,  Kyung Ah Kim ,  Bo Gyou Kim ,  Seung Hyun Lee ,  Ji Min Lee

IPC: C07K16/22 ,  A61K38/18 ,  C07K16/28 ,  A61K39/00

CPC classification number: A61K38/18 ,  A61K38/1891 ,  A61K2039/507 ,  A61K2039/545 ,  C07K16/22 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  A61K2300/00

Abstract: An anti-c-Met/anti-Ang2 bispecific antibody including (a) an anti-c-Met antibody or antigen-binding fragment thereof and (b) an anti-Ang2 antibody or antigen-binding fragment thereof, a pharmaceutical composition including the anti-c-Met/anti-Ang2 bispecific antibody, and a method using the anti-c-Met/anti-Ang2 bispecific antibody.

公开(公告)号：US09717715B2

公开(公告)日：2017-08-01

申请号：US14081886

申请日：2013-11-15

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seung Hyun Lee ,  Geun Woong Kim ,  Kyung Ah Kim ,  Hye Won Park ,  Ho Yeong Song ,  Young Mi Oh ,  Saet Byoul Lee ,  Ji Min Lee ,  Kwang Ho Cheong ,  Yun Ju Jeong ,  Mi Young Cho ,  Jae Hyun Choi ,  Yun Jeong Song ,  Yoon Aa Choi

IPC: A61K39/395 ,  A61K31/437 ,  A61K31/517 ,  A61K31/44 ,  C07K16/28 ,  C12N5/16

CPC classification number: A61K31/437 ,  A61K31/44 ,  A61K31/517 ,  A61K39/3955 ,  A61K39/39558 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/30 ,  C12N5/163 ,  A61K2300/00

Abstract: A method for prevention or treatment of a cancer, comprising co-administering (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib or a combination thereof, to a subject in need thereof, and a pharmaceutical composition comprising (a) an anti-c-Met antibody or an antigen-binding fragment thereof, and (b) at least one of lapatinib, regorafenib, vemurafenib, or a combination thereof are provided.

公开(公告)号：US09650443B2

公开(公告)日：2017-05-16

申请号：US14228521

申请日：2014-03-28

Applicant: Samsung Electronics Co., Ltd.

Inventor： Yun Jeong Song ,  Ho Yeong Song ,  Seung Hyun Lee ,  Kyung Ah Kim ,  Yun Ju Jeong

IPC: C07K16/46 ,  A61K39/00 ,  C07K16/28 ,  C07K14/71

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K14/71 ,  C07K2317/10 ,  C07K2317/24 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

Abstract: There are provided a fusion protein formed by coupling of anti-c-Met antibody and VEGF-binding fragment, a bispecific antibody comprising the fusion protein, a polynucleotide encoding the fusion protein, a transformant comprising the polynucleotide, a pharmaceutical composition comprising the bispecific antibody as an active ingredient, and a method for preparing the bispecific antibody which is targeted at c-Met and VEGF at the same time, with improved anticancer and anti-angiogenesis effects, comprising coupling an anti-c-Met antibody with a VEGF-binding fragment.

公开(公告)号：US09535055B2

公开(公告)日：2017-01-03

申请号：US14229073

申请日：2014-03-28

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Bo Gyou Kim ,  Kyung Ah Kim

IPC: C12Q1/00 ,  G01N33/50 ,  C12Q1/68 ,  G01N33/574

CPC classification number: G01N33/5011 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57492 ,  G01N2510/00 ,  G01N2800/52

Abstract: There are provided a composition for determining the efficacy of a c-Met antibody including marker genes and a method for determining the efficacy of a c-Met antibody using the marker genes.

Abstract translation: 提供了用于确定包括标记基因的c-Met抗体的功效的组合物和使用标记基因确定c-Met抗体的功效的方法。

公开(公告)号：US09249221B2

公开(公告)日：2016-02-02

申请号：US14231470

申请日：2014-03-31

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seung Hyun Lee ,  Kyung Ah Kim ,  Kwang Ho Cheong ,  Ho Yeong Song

IPC: A61K39/395 ,  C07K16/28 ,  C07K16/30

CPC classification number: C07K16/2863 ,  C07K16/3023 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided is a humanized and affinity-matured anti-c-Met antibody, a pharmaceutical composition including the antibody, and a method of preventing and/or treating c-Met-related disease using the antibody.

Abstract translation: 提供人源化和亲和力成熟的抗c-Met抗体，包含该抗体的药物组合物，以及使用该抗体预防和/或治疗c-Met相关疾病的方法。

公开(公告)号：US20150017170A1

公开(公告)日：2015-01-15

申请号：US14327172

申请日：2014-07-09

Applicant: Samsung Electronics Co., Ltd.

Inventor： Young Mi OH ,  Kyung Ah Kim

IPC: C12Q1/37 ,  A61K45/06 ,  A61K39/395

CPC classification number: C12Q1/37 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/573 ,  G01N33/57446 ,  G01N2333/95 ,  G01N2500/04

Abstract: A method of selecting a subject for administration of an anti-c-Met antibody, comprising (i) determining the presence or the amount of a ubiquitin peptidase, (ii) determining the presence or expression level of a ubiquitin peptidase coding gene, or (iii) measuring the activity of a ubiquitin peptidase, in a biological sample; as well as related methods.

Abstract translation: 选择用于施用抗c-Met抗体的受试者的方法，包括（i）确定泛素肽酶的存在或量，（ii）确定泛素肽酶编码基因的存在或表达水平，或（ iii）测量生物样品中泛素肽酶的活性; 以及相关方法。

公开(公告)号：US20140154251A1

公开(公告)日：2014-06-05

申请号：US14081917

申请日：2013-11-15

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seung Hyun LEE ,  Geun Woong Kim ,  Kyung Ah Kim ,  Hye Won Park ,  Ho Yeong Song ,  Young Mi Oh ,  Saet Byoul Lee ,  Ji Min Lee ,  Kwang Ho Cheong ,  Yun Ju Jeong ,  Mi Young Cho ,  Jae Hyun Choi ,  Yun Jeong Song ,  Yoon Aa Choi

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92

Abstract: An anti-c-Met antibody or antibody fragment and pharmaceutical composition comprising same, as well as a method for preventing and treating cancer by administering the antibody to a subject are provided.

Abstract translation: 提供了抗c-Met抗体或抗体片段及包含其的药物组合物，以及通过向受试者施用抗体来预防和治疗癌症的方法。