公开(公告)号：US08507527B2

公开(公告)日：2013-08-13

申请号：US12712959

申请日：2010-02-25

申请人： Yosuke Ueki ,  Yasuyuki Suzuki ,  Satoshi Fujioka

发明人： Yosuke Ueki ,  Yasuyuki Suzuki ,  Satoshi Fujioka

IPC分类号： A01N43/42 ,  A61K9/14

CPC分类号： A61K9/2054 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2027 ,  A61K31/445

摘要： The present invention provides a method for stabilizing an anti-dementia drug in a pharmaceutical composition containing the anti-dementia drug and a high molecular weight basic substance by adding a high molecular weight acidic substance to said pharmaceutical composition. Further, the present invention provides a pharmaceutical composition containing an anti-dementia drug and a high molecular basic substance in which a high molecular weight acidic substance is contained for stabilizing the anti-dementia drug. Furthermore, the present invention provides a method for manufacturing a pharmaceutical composition which comprises steps wherein a solution or suspension containing a high molecular weight acidic substance is added to a mixture of an anti-dementia drug and a high molecular weight basic substance for the sake of stabilizing the anti-dementia drug.

摘要翻译： 本发明提供了通过向所述药物组合物中加入高分子量酸性物质，在含有抗痴呆药物和高分子量碱性物质的药物组合物中稳定抗痴呆药物的方法。 此外，本发明提供含有抗痴呆药物和高分子碱性物质的药物组合物，其中含有高分子量酸性物质以稳定抗痴呆药物。 此外，本发明提供了一种制备药物组合物的方法，其包括以下步骤：将含有高分子量酸性物质的溶液或悬浮液加入到抗痴呆药物和高分子量碱性物质的混合物中， 稳定抗痴呆药物。

公开(公告)号：US07490929B2

公开(公告)日：2009-02-17

申请号：US11747501

申请日：2007-05-11

申请人： Takeo Seino ,  Satoshi Fujioka

发明人： Takeo Seino ,  Satoshi Fujioka

IPC分类号： B41J2/175

CPC分类号： B41J2/17553 ,  B41J2/17503 ,  B41J2/17513 ,  B41J2/1752 ,  B41J2/17523 ,  B41J2/17526 ,  B41J2/17546 ,  B41J2/17566 ,  B41J29/13

摘要： An ink cartridge and an ink cartridge holder maintain the relative position between the information reading section of the ink cartridge holder and the information storing unit of the ink cartridge, which should be aligned accurately, even if the ink cartridge has instability to the ink cartridge holder due to variation in each product. The ink cartridge which supplies ink to a recording apparatus includes: a substantially rectangular parallelepiped ink cartridge main body holding ink; a connection electrode section provided on part of a first side of the ink cartridge main body and including a connection terminal; an ink supply unit provided in a front surface intersecting the first wall; and a positioning section guiding a positioning member of the recording apparatus to the vicinity of the connection electrode on the front surface so that the positioning member opposes the connection electrode section in the direction parallel with the connection electrode section.

摘要翻译： 墨盒和墨盒保持器保持墨盒保持器的信息读取部分和墨盒的信息存储单元之间的相对位置，即使墨盒不稳定到墨盒支架 由于每个产品的变化。 向记录装置供给墨水的墨盒包括：保持墨水的大致长方体形状的墨盒主体; 连接电极部，设置在所述墨盒主体的第一侧的一部分上，并具有连接端子; 设置在与第一壁相交的前表面的供墨单元; 以及定位部，其将记录装置的定位构件引导到前表面上的连接电极附近，使得定位构件在与连接电极部分平行的方向上与连接电极部分相对。

公开(公告)号：US20080213368A1

公开(公告)日：2008-09-04

申请号：US11793722

申请日：2005-12-27

申请人： Yosuke Ueki ,  Yasuyuki Suzuki ,  Satoshi Fujioka

发明人： Yosuke Ueki ,  Yasuyuki Suzuki ,  Satoshi Fujioka

IPC分类号： A61K9/10 ,  A61K31/445

CPC分类号： A61K9/2054 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2027 ,  A61K31/445

摘要： The present invention provides a method for stabilizing an anti-dementia drug in a pharmaceutical composition containing the anti-dementia drug and a high molecular weight basic substance by adding a high molecular weight acidic substance to said pharmaceutical composition. Further, the present invention provides a pharmaceutical composition containing an anti-dementia drug and a high molecular basic substance in which a high molecular weight acidic substance is contained for stabilizing the anti-dementia drug. Furthermore, the present invention provides a method for manufacturing a pharmaceutical composition which comprises steps wherein a solution or suspension containing a high molecular weight acidic substance is added to a mixture of an anti-dementia drug and a high molecular weight basic substance for the sake of stabilizing the anti-dementia drug.

摘要翻译： 本发明提供了通过向所述药物组合物中加入高分子量酸性物质，在含有抗痴呆药物和高分子量碱性物质的药物组合物中稳定抗痴呆药物的方法。 此外，本发明提供含有抗痴呆药物和高分子碱性物质的药物组合物，其中含有高分子量酸性物质以稳定抗痴呆药物。 此外，本发明提供了一种制备药物组合物的方法，其包括以下步骤：将含有高分子量酸性物质的溶液或悬浮液加入到抗痴呆药物和高分子量碱性物质的混合物中， 稳定抗痴呆药物。

公开(公告)号：US07220762B1

公开(公告)日：2007-05-22

申请号：US10110679

申请日：2000-10-19

申请人： Koji Ukai ,  Satoshi Fujioka ,  Mitsuru Mizuno ,  Makoto Yokoyama ,  Shigeru Aoki ,  Masao Kawamura

发明人： Koji Ukai ,  Satoshi Fujioka ,  Mitsuru Mizuno ,  Makoto Yokoyama ,  Shigeru Aoki ,  Masao Kawamura

IPC分类号： A61K31/4184 ,  A61K31/4439 ,  C07D401/12

CPC分类号： A61K9/2886 ,  A61K9/2009 ,  A61K9/2027 ,  A61K31/4439 ,  A61K47/02 ,  A61K47/32 ,  C07D401/12

摘要： The present invention provides a method for stabilizing an oral solid formulation containing a benzimidazole-based compound or a physiologically acceptable salt thereof. That is, it provides a method for stabilizing a benzimidazole-based compound or a physiologically acceptable salt thereof, comprising incorporating 1) a crospovidone or a crospovidone and 2) sodium hydroxide and/or potassium hydroxide to a benzimidazole-based compound or a physiologically acceptable salt thereof.

摘要翻译： 本发明提供一种稳定含有苯并咪唑类化合物或其生理上可接受的盐的口服固体制剂的方法。 也就是说，它提供了一种稳定基于苯并咪唑的化合物或其生理上可接受的盐的方法，包括将1）交聚维酮或交联聚维酮和2）氢氧化钠和/或氢氧化钾加入苯并咪唑基化合物或生理上可接受的盐 的盐。

公开(公告)号：US20060280789A1

公开(公告)日：2006-12-14

申请号：US11317897

申请日：2005-12-27

申请人： Yosuke Ueki ,  Satoshi Fujioka ,  Shigeru Aoki ,  Susan Abu-Shakra ,  J. Carter ,  Gary Dorough

发明人： Yosuke Ueki ,  Satoshi Fujioka ,  Shigeru Aoki ,  Susan Abu-Shakra ,  J. Carter ,  Gary Dorough

IPC分类号： A61K31/445 ,  A61K9/20

CPC分类号： A61K9/2054 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2027 ,  A61K31/445

摘要： The invention provides sustained release formulations of basic drugs, stereoisomers of basic drugs, pharmaceutically acceptable salts of basic drugs, and pharmaceutically acceptable salts of stereoisomers of basic drugs. The basic drugs may be anti-dementia drugs, such as cholinesterase inhibitors or memantine. In one embodiment, the cholinesterase inhibitor is donepezil.

摘要翻译： 本发明提供碱性药物的缓释制剂，碱性药物的立体异构体，碱性药物的药学上可接受的盐，以及碱性药物的立体异构体的药学上可接受的盐。 碱性药物可能是抗痴呆药物，如胆碱酯酶抑制剂或美金刚。 在一个实施方案中，胆碱酯酶抑制剂是多奈哌齐。

公开(公告)号：US07137750B2

公开(公告)日：2006-11-21

申请号：US10820877

申请日：2004-04-09

申请人： Satoshi Fujioka ,  Takayuki Ishii ,  Yoshitaka Shimada

发明人： Satoshi Fujioka ,  Takayuki Ishii ,  Yoshitaka Shimada

IPC分类号： B41J11/02 ,  B41J11/06

CPC分类号： B41J11/009 ,  B41J3/46 ,  B41J11/0025 ,  B41J11/003 ,  B41J11/0035 ,  B41J11/0085 ,  B41J11/06 ,  B41J15/02 ,  B41J15/16 ,  B41J29/13 ,  B65H5/10 ,  B65H5/222

摘要： There are provided a suction unit which sucks a recording medium, and a unit which changes sucking force of the suction unit according to the property of the recording medium. Hereby, since the sucking force of the suction unit can be set according to a state of the recording medium. Therefore, for example, even if the recording medium is greatly curled, since its recording medium can be surely sucked on the transporting surface of the recording medium by the suction unit. Further, even if the recording medium has little rigidity and is thin, it is possible to prevent the recording medium from being stuck on the transporting surface of the recording medium by the suction unit.

摘要翻译： 设置有吸入记录介质的抽吸单元，以及根据记录介质的性质改变抽吸单元的抽吸力的单元。 因此，由于可以根据记录介质的状态来设定抽吸单元的吸引力。 因此，例如，即使记录介质被大幅度卷曲，由于其记录介质可以通过抽吸单元可靠地吸附在记录介质的传送表面上。 此外，即使记录介质的刚度小且薄，也可以防止记录介质被吸引单元卡在记录介质的传送表面上。

公开(公告)号：US20060159753A1

公开(公告)日：2006-07-20

申请号：US11317898

申请日：2005-12-27

申请人： Yosuke Ueki ,  Satoshi Fujioka

发明人： Yosuke Ueki ,  Satoshi Fujioka

IPC分类号： A61K9/22

CPC分类号： A61K9/2027 ,  A61K9/2054

摘要： A matrix type sustained-release preparation and a manufacturing method therefor are provided wherein dissolution with low pH dependence of a basic drug or a salt thereof at the early stage of dissolution can be ensured in a dissolution test, and wherein as the dissolution test proceeds, a ratio of a dissolution rate of the basic drug or the salt thereof in an acidic test solution to a dissolution rate of the basic drug or the salt thereof in a neutral test solution (dissolution rate in the acidic test solution/dissolution rate in the neutral test solution) decreases with dissolution time at the late stage of dissolution, as compared to the early stage of dissolution. According to the present invention, the matrix type sustained-release preparation contains a basic drug or a salt thereof and at least one enteric polymer, in which solubility of the basic drug or the salt thereof in a 0.1 N hydrochloric acid solution and a neutral aqueous solution, pH 6.0 is higher than in a basic aqueous solution, pH 8.0.

摘要翻译： 提供了一种基质型缓释制剂及其制备方法，其中在溶出试验中可以确保溶解初期碱性药物或其盐的低pH依赖性的溶解性，并且其中随着溶出试验的进行， 碱性药物或其盐在酸性试验溶液中的溶解速率与碱性药物或其盐在中性试验溶液中的溶解速率的比例（酸性试验溶液中的溶解速率/中性溶解速度 测试溶液）与溶解的早期相比在溶解后期的溶解时间下降。 根据本发明，基质型缓释制剂含有碱性药物或其盐和至少一种肠溶性聚合物，其中碱性药物或其盐在0.1N盐酸溶液和中性水溶液中的溶解度 溶液pH 6.0比碱性水溶液pH 8.0高。

公开(公告)号：US20060152567A1

公开(公告)日：2006-07-13

申请号：US10546516

申请日：2004-04-30

申请人： Satoshi Fujioka ,  Yasuyuki Sakato

发明人： Satoshi Fujioka ,  Yasuyuki Sakato

IPC分类号： B41J2/01

CPC分类号： B41J13/103 ,  B41J11/006 ,  B65H1/04 ,  B65H2402/343 ,  B65H2405/11164 ,  B65H2405/114 ,  B65H2405/1142 ,  B65H2405/115 ,  B65H2405/3321 ,  B65H2511/12

摘要： A feeder includes a guide section 141d for guiding a medium while partially abutting one side of the medium in feeding the medium. Accordingly, the frictional resistance occurring between one side of the medium and the guide section can be lessened, so that a feed failure such as paper break or a paper jam can be prevented from occurring. Therefore, paper of various sizes can be reliably fed.

摘要翻译： 馈送器包括用于引导介质的引导部141d，同时在馈送介质的同时部分地邻接介质的一侧。 因此，可以减小在介质的一侧和引导部之间发生的摩擦阻力，从而可以防止发生诸如纸张断裂或卡纸的进给故障。 因此，能够可靠地供给各种尺寸的纸。

公开(公告)号：US06877920B2

公开(公告)日：2005-04-12

申请号：US10392327

申请日：2003-03-20

申请人： Satoshi Fujioka

发明人： Satoshi Fujioka

IPC分类号： B41J15/04 ,  B65H16/06 ,  B41J11/26

CPC分类号： B65H75/242 ,  B65H16/06 ,  B65H2301/41369 ,  B65H2511/14 ,  B65H2801/36 ,  B65H2220/11

摘要： A holding device is provided with adapters capable of dealing with a case where the hollow shaft portions of a roll-like fixing medium differ in inner diameter. Thus, it is unnecessary to have a complete set of roll paper supporting members to be used every time the hollow shaft portions of the roll-like fixing medium differ in inner diameter. As the size of such an adapter can be made at least smaller than the size of the roll paper supporting members, the adapter is easily stocked under control.

摘要翻译： 保持装置设置有能够处理卷状固定介质的中空轴部在内径不同的情况下的适配器。 因此，每当卷状固定介质的中空轴部分内径不同时，就不需要使用一套完整的卷筒纸支撑件。 由于这种适配器的尺寸可以至少小于卷纸支撑件的尺寸，所以适配器易于储存。

公开(公告)号：US20050001888A1

公开(公告)日：2005-01-06

申请号：US10903633

申请日：2004-07-30

申请人： Takeo Seino ,  Satoshi Fujioka

发明人： Takeo Seino ,  Satoshi Fujioka

IPC分类号： B41J2/01 ,  B41J2/175

CPC分类号： B41J2/17553 ,  B41J2/17503 ,  B41J2/17513 ,  B41J2/1752 ,  B41J2/17523 ,  B41J2/17526 ,  B41J2/17546 ,  B41J2/17566 ,  B41J29/13

摘要： An ink cartridge and an ink cartridge holder for maintaining the relative position between the information reading section of the ink cartridge holder and the information storing unit of the ink cartridge, which should be aligned accurately, even if the ink cartridge has instability to the ink cartridge holder due to the variation in each products. The ink cartridge which supplies ink to a recording apparatus includes: a substantially rectangular parallelepiped ink cartridge main body holding the ink; a connection electrode section provided on a part of a first side of the ink cartridge main body and including a connection terminal; an ink supply unit provided in a front surface which intersects the first wall; and a positioning section guiding a positioning member of the recording apparatus to the vicinity of the connection electrode on the front surface so that the positioning member opposes to the connection electrode section in the direction parallel with the connection electrode section.

摘要翻译： 一种墨盒和墨盒保持器，用于保持墨盒保持器的信息读取部分和墨盒的信息存储单元之间的相对位置，即使墨盒对墨盒不稳定，也应准确对准 持有人由于每个产品的变化。 向记录装置供给墨水的墨盒包括：保持墨水的基本上长方体的墨盒主体; 连接电极部，其设置在所述墨盒主体的第一侧的一部分上并且包括连接端子; 设置在与所述第一壁相交的前表面的供墨单元; 以及定位部，其将记录装置的定位构件引导到前表面上的连接电极附近，使得定位构件在与连接电极部分平行的方向上与连接电极部相对。