公开(公告)号：US08481565B2

公开(公告)日：2013-07-09

申请号：US11793722

申请日：2005-12-27

申请人： Yosuke Ueki ,  Yasuyuki Suzuki ,  Satoshi Fujioka

发明人： Yosuke Ueki ,  Yasuyuki Suzuki ,  Satoshi Fujioka

IPC分类号： A01N43/42 ,  A61K9/14

CPC分类号： A61K9/2054 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2027 ,  A61K31/445

摘要： The present invention provides a method for stabilizing an anti-dementia drug in a pharmaceutical composition containing the anti-dementia drug and a high molecular weight basic substance by adding a high molecular weight acidic substance to said pharmaceutical composition. Further, the present invention provides a pharmaceutical composition containing an anti-dementia drug and a high molecular basic substance in which a high molecular weight acidic substance is contained for stabilizing the anti-dementia drug. Furthermore, the present invention provides a method for manufacturing a pharmaceutical composition which comprises steps wherein a solution or suspension containing a high molecular weight acidic substance is added to a mixture of an anti-dementia drug and a high molecular weight basic substance for the sake of stabilizing the anti-dementia drug.

公开(公告)号：US07431439B2

公开(公告)日：2008-10-07

申请号：US10835278

申请日：2004-04-30

申请人： Satoshi Fujioka

发明人： Satoshi Fujioka

IPC分类号： B41J2/175 ,  B41J29/38

CPC分类号： B41J2/17523 ,  B41J2/17596

摘要： In a device for supplying liquid from a liquid cartridge to a liquid ejection head via a liquid supply channel, a cartridge chamber accommodates the liquid cartridge. A valve is disposed between the liquid cartridge and the liquid supply channel. A control lever is adapted to be manually operated by a user to control the valve so as to connect or disconnect the liquid cartridge and the liquid supply channel.

摘要翻译： 在用于经由液体供应通道将液体从液体盒提供到液体喷射头的装置中，盒室容纳液体盒。 阀设置在液体盒和液体供应通道之间。 控制杆适于由用户手动操作以控制阀，以便连接或断开液体盒和液体供应通道。

公开(公告)号：US20070208016A1

公开(公告)日：2007-09-06

申请号：US10590976

申请日：2005-03-04

申请人： Yasuyuki Suzuki ,  Satoshi Fujioka

发明人： Yasuyuki Suzuki ,  Satoshi Fujioka

IPC分类号： A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  A61K31/4035

CPC分类号： A61K47/02 ,  A61K9/1611 ,  A61K9/19 ,  A61K9/2077 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/5377 ,  A61K33/00 ,  A61K2300/00 ,  C07D209/44

摘要： The present invention provides a composition containing a benzamidine derivative that does not decompose even when placed under humidification conditions and a method for stabilizing a benzamidine derivative. According to the present invention, decomposition reaction of a benzamidine derivative can be suppressed by adding to a benzamidine derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, at least one type of electrolyte selected from the group consisting of halide salts of alkaline metal or alkaline earth metal and alkaline metal salts or alkaline earth metal salts of perchloric acid.

摘要翻译： 本发明提供含有即使在加湿条件下也不分解的苯甲脒衍生物的组合物和稳定苯甲脒衍生物的方法。 根据本发明，通过加入由通式（I）表示的苯甲脒衍生物或其药理学上可接受的盐，可以抑制苄脒衍生物的分解反应，至少一种选自以下的电解质： 碱金属或碱土金属和高氯酸的碱金属盐或碱土金属盐。

公开(公告)号：US20070129402A1

公开(公告)日：2007-06-07

申请号：US11475255

申请日：2006-06-27

申请人： Yosuke Ueki ,  Satoshi Fujioka ,  Shigeru Aoki

发明人： Yosuke Ueki ,  Satoshi Fujioka ,  Shigeru Aoki

IPC分类号： A61K31/445

CPC分类号： A61K9/1635 ,  A61K9/1652 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/445

摘要： The invention provides sustained release formulations comprising donepezil, stereoisomers of donepezil, pharmaceutically acceptable salts of donepezil, or pharmaceutically acceptable salts of stereoisomers of donepezil. The formulations have desirable pharmacokinetic characteristics. Examples include AUC, Tmax, Cmax, dosage-corrected AUC, and dosage-corrected Cmax.

摘要翻译： 本发明提供包含多奈哌齐，多奈哌齐的立体异构体，多奈哌齐的药学上可接受的盐或多奈哌齐的立体异构体的药学上可接受的盐的缓释制剂。 制剂具有所需的药代动力学特征。 实例包括AUC，Tmax，Cmax，剂量校正的AUC和剂量校正的C max。

公开(公告)号：US07121543B2

公开(公告)日：2006-10-17

申请号：US10347521

申请日：2003-01-21

申请人： Satoshi Fujioka

发明人： Satoshi Fujioka

IPC分类号： B65H31/00

CPC分类号： B41J11/0005 ,  B41J13/106 ,  B41J15/042 ,  B65H31/00 ,  B65H2301/16 ,  B65H2402/31 ,  B65H2701/11312

摘要： In a receiver for receiving a recording medium discharged from a recording apparatus, a pivotable receiving member receives the recording medium. A pivotable supporting member supports the receiving member so as to place one of a plurality of pivoting angles of the receiving member respectively associated with a plurality of using modes of the receiver. The receiver is provided in the leg section of the recording apparatus which is arranged below a discharging section from which the recording medium is discharged.

公开(公告)号：US20060160852A1

公开(公告)日：2006-07-20

申请号：US11317238

申请日：2005-12-27

申请人： Susumu Kimura ,  Yosuke Ueki ,  Satoshi Fujioka

发明人： Susumu Kimura ,  Yosuke Ueki ,  Satoshi Fujioka

IPC分类号： A61K31/445 ,  A61K31/13

CPC分类号： A61K45/06 ,  A61K9/2018 ,  A61K9/209 ,  A61K31/13 ,  A61K31/445 ,  A61K2300/00

摘要： An object of the present invention is to provide, for the case of implementing a therapeutic method in which at least two kinds of anti-dementia drugs are used together, a composition that has a good therapeutic effect on the dementia, and also gives excellent compliance. Another object of the present invention is to provide a composition containing at least two kinds of the anti-dementia drugs, for which release of the anti-dementia drugs from the composition is controlled, whereby a combined effect of the anti-dementia drugs can be achieved well. Still another object of the present invention is to provide: a composition, for which the frequency of administration and the amount taken are reduced, and hence compliance can be improved; and a method of manufacturing such a composition. According to the present invention, there are provided a composition containing at least two kinds of the anti-dementia drugs; such a composition containing at least one sustained release portion containing an anti-dementia drug; and such a composition containing at least one cholinesterase inhibitor, and at least one N-methyl-D-aspartate receptor antagonist.

摘要翻译： 本发明的目的是提供一种治疗方法，其中至少两种抗痴呆药物一起使用，具有对痴呆具有良好治疗效果的组合物，并且还具有优异的依从性 。 本发明的另一个目的是提供一种含有至少两种抗痴呆药物的组合物，其中控制抗痴呆药物从组合物中的释放，由此抗痴呆药物的组合效果可以是 做得很好 本发明的另一个目的是提供：给药频率和使用量减少的组合物，从而可以提高顺应性; 以及制造这种组合物的方法。 根据本发明，提供含有至少两种抗痴呆药物的组合物; 这种组合物含有至少一种含有抗痴呆药物的持续释放部分; 和含有至少一种胆碱酯酶抑制剂和至少一种N-甲基-D-天冬氨酸受体拮抗剂的组合物。

公开(公告)号：US20050042285A1

公开(公告)日：2005-02-24

申请号：US10938554

申请日：2004-09-13

申请人： Koji Ukai ,  Masaki Ichikawa ,  Takashi Kato ,  Yukiko Sugaya ,  Yasuyuki Suzuki ,  Shigeru Aoki ,  Akira Kato ,  Masao Kawamura ,  Satoshi Fujioka

发明人： Koji Ukai ,  Masaki Ichikawa ,  Takashi Kato ,  Yukiko Sugaya ,  Yasuyuki Suzuki ,  Shigeru Aoki ,  Akira Kato ,  Masao Kawamura ,  Satoshi Fujioka

IPC分类号： A61K9/20 ,  A61K31/4184 ,  A61K31/4439

CPC分类号： A61K31/4439 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K31/4184

摘要： The present invention provides a chemically stable pharmaceutical preparation of a benzimidazole type compound. That is, the present invention relates to a composition comprising at least one substance selected from sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide, aminoalkyl methaacrylate copolymer E, arginine aspartate, hydroxypropyl cellulose and crospovidone incorporated into a benzimidazole type compound or an alkali metal salt thereof.

摘要翻译： 本发明提供苯并咪唑型化合物的化学稳定的药物制剂。 也就是说，本发明涉及包含至少一种选自碳酸钠，碳酸钾，氢氧化钠，氢氧化钾，氨基烷基甲基丙烯酸酯共聚物E，精氨酸天冬氨酸盐，羟丙基纤维素和交聚维酮中的物质的组合物，其结合到苯并咪唑型化合物或碱 金属盐。

公开(公告)号：US20050041075A1

公开(公告)日：2005-02-24

申请号：US10835278

申请日：2004-04-30

申请人： Satoshi Fujioka

发明人： Satoshi Fujioka

IPC分类号： B41J2/175

CPC分类号： B41J2/17523 ,  B41J2/17596

摘要： In a device for supplying liquid from a liquid cartridge to a liquid ejection head via a liquid supply channel, a cartridge chamber accommodates the liquid cartridge. A valve is disposed between the liquid cartridge and the liquid supply channel. A control lever is adapted to be manually operated by a user to control the valve so as to connect or disconnect the liquid cartridge and the liquid supply channel.

摘要翻译： 在用于经由液体供应通道将液体从液体盒提供到液体喷射头的装置中，盒室容纳液体盒。 阀设置在液体盒和液体供应通道之间。 控制杆适于由用户手动操作以控制阀，以便连接或断开液体盒和液体供应通道。

公开(公告)号：US6164767A

公开(公告)日：2000-12-26

申请号：US352941

申请日：1999-07-14

申请人： Masahiro Nakamura ,  Hayato Nishikaze ,  Nobuhito Takahashi ,  Seiji Mochizuki ,  Kazuhisa Kawakami ,  Keiichi Ohshima ,  Satoshi Fujioka

发明人： Masahiro Nakamura ,  Hayato Nishikaze ,  Nobuhito Takahashi ,  Seiji Mochizuki ,  Kazuhisa Kawakami ,  Keiichi Ohshima ,  Satoshi Fujioka

IPC分类号： B41J2/165 ,  F04B43/12 ,  B41J2/175

CPC分类号： B41J2/16547 ,  B41J2/16508 ,  B41J2/16511 ,  B41J2/16532 ,  B41J23/025 ,  F04B43/1253 ,  F04B43/1276 ,  F04B43/1292

摘要： A tube pump for an ink jet printer includes a driving wheel that is selectively driven in a forward or reverse direction in accordance with the rotation of a drive source. The driving wheel contains two slots that extend symmetrically and radially from the center of the driving wheel. The pump also includes two rollers that are coupled to the drive wheel via roller shafts respectively extending from a radial center of the rollers into the slots. A pressing piece is also provided that forces the shafts into the radially outermost end of the slots to press a tube of the tube pump when said drive wheel rotates in reverse and forces the shafts into the radially innermost end of the slots to not press the tube when said drive wheel rotates in the forward direction. In an alternative arrangement, the tube pump contains a pump chamber, and a tube having an .alpha.-like-shaped loop portion is inserted into and disposed along the inner wall of the pump chamber. A driving wheel train is provided, rotated around a shaft of the pump chamber, and has a single roller that cooperates with the inner wall of the pump chamber to press the tube. Also, a guide slot is formed in the driving wheel train to transfer the roller between a tube pressurizing state and a tube nonpressurizing state based on the rotation of the driving wheel train.

摘要翻译： 用于喷墨打印机的管式泵包括根据驱动源的旋转而选择性地沿正向或反向驱动的驱动轮。 驱动轮包含从驱动轮的中心对称和径向延伸的两个槽。 泵还包括两个辊，其通过分别从辊的径向中心延伸到槽中的辊轴联接到驱动轮。 还提供一个按压片，当所述驱动轮反向旋转时，迫使所述轴进入所述狭槽的径向最外端，以挤压所述管泵的管，并迫使所述轴进入所述狭槽的径向最内端以不按压所述管 当所述驱动轮沿向前方向旋转时。 在另一种配置中，管泵包含泵室，并且具有α状环状部分的管插入并设置在泵室的内壁上。 提供驱动轮系，围绕泵室的轴旋转，并且具有与泵室的内壁配合以压紧管的单个辊。 此外，在驱动轮系中形成引导槽，以基于驱动轮系的旋转在辊加压状态和管非加压状态之间转移辊。

公开(公告)号：US5297871A

公开(公告)日：1994-03-29

申请号：US800106

申请日：1991-11-29

申请人： Satoshi Fujioka

发明人： Satoshi Fujioka

IPC分类号： B41J2/505 ,  B41J11/42 ,  B41J19/96 ,  B41J19/92

CPC分类号： B41J11/42 ,  B41J2/505

摘要： A vertical forms control apparatus for a printer, and a printing method, which corrects dot pitch errors in the subscanning direction. A paper feeding control apparatus is provided with a print head scanned in a direction of paper width and having a plurality (N) of dot forming elements aligned with a dot pitch (P) in a direction in which the paper is advanced, a pulse motor connected to a paper advancing mechanism via a transmission such that the pulse motor requires a plurality of steps to make a rotation corresponding to the dot pitch (P), and a microcomputer for outputting drive pulses to the pulse motor 1, the drive pulses indicating the number-of-steps-for-an-advancement-of-one-line (P.times.N) plus correction steps. In printing across a plurality of lines with the lines connected together, if blank spaces or overlaps are developed, pulses in a number required for rotating the pulse motor in an amount corresponding to the width of the blank spaces or overlaps are added to or subtracted from a standard value so that the pulse motor undergoes a correct amount of rotation for each line. By this arrangement, errors between lines due to machining errors of parts can be corrected so that image data formed of a plurality of lines can be printed with a high quality with no blank spaces and overlaps.

摘要翻译： 用于打印机的垂直成型控制装置和校正副扫描方向上的点间距误差的打印方法。 送纸控制装置设置有沿纸张宽度扫描的打印头，并且具有沿纸方向前进的点间距（P）排列的多个（N）个点形成元件，脉冲电机 通过变速器连接到送纸机构，使得脉冲电动机需要多个步骤来进行与点间距（P）相对应的旋转;以及微计算机，用于向脉冲电动机1输出驱动脉冲，驱动脉冲指示 （P * N）加上校正步骤。 在跨线连接在一起的多条线路上，如果产生空格或重叠，则将与脉冲宽度相对应的脉冲电机旋转所需的脉冲数加到或减去 一个标准值，使得脉冲电机经历每行的正确旋转量。 通过这种布置，可以校正由于零件的加工误差导致的线之间的误差，使得可以以高质量打印由多条线形成的图像数据，没有空格和重叠。