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    Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue
    31.
    发明授权
    Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue 失效
    用于无针头间质注射用于消融心脏组织的流体的装置和方法

    公开(公告)号：US07975703B2

    公开(公告)日：2011-07-12

    申请号：US11513561

    申请日：2006-08-31

    申请人： Scott E. Jahns

    发明人： Scott E. Jahns

    IPC分类号： A61B18/12

    CPC分类号： A61B18/14 ,  A61B17/3203 ,  A61B2017/00247 ,  A61B2018/00351 ,  A61B2018/00392 ,  A61B2018/00809 ,  A61B2018/1472

    摘要： Methods and apparatus for delivering precise amounts of fluid under pressure into cardiac tissue for the purpose of facilitating ablation of the tissue along a desired lesion line. One method injects fluid under pressure through a discharge orifice in a needle-less injection device. The injected fluid can be a cytotoxic fluid and/or a highly conductive fluid injected in conjunction with radio frequency ablation to create an ablative virtual electrode. The injected fluid can provide deeper and narrower conduction paths and resulting lesions. Radio frequency ablation can be performed at the same time as the fluid injection, using the injection device as an electrode, or subsequent to the fluid injection, using a separate device. In some methods, the injected fluid is a protective fluid, injected to protect tissue adjacent to the desired lesion line. Fluid delivery can be endocardial, epicardial, and epicardial on a beating heart. The present methods find one use in performing maze procedures to treat atrial fibrillation.

    摘要翻译： 用于在压力下将精确量的流体输送到心脏组织中以便于沿着期望的病变线消融组织的目的的方法和装置。 一种方法通过无针注射装置中的排放孔将压力下的流体注入流体。 注射的流体可以是与射频消融一起注射的细胞毒性流体和/或高度导电的流体，以产生消融的虚拟电极。 注入的流体可以提供更深和更窄的传导路径以及所导致的损伤。 射频消融可以在使用注射装置作为电极或者在流体注射之后使用单独的装置与流体注射同时进行。 在一些方法中，注射的流体是保护性流体，被注射以保护邻近所需病变线的组织。 流体输送可以是搏动心脏的心内膜，心外膜和心外膜。 本方法可用于进行迷宫手术来治疗房颤。

    DEVICES AND METHODS FOR INTERSTITIAL INJECTION OF BIOLOGIC AGENTS INTO TISSUE
    35.
    发明申请
    DEVICES AND METHODS FOR INTERSTITIAL INJECTION OF BIOLOGIC AGENTS INTO TISSUE 有权
    用于生物组织的内部注射用于组织的装置和方法

    公开(公告)号：US20100063475A1

    公开(公告)日：2010-03-11

    申请号：US12621037

    申请日：2009-11-18

    申请人： Scott E. Jahns ,  Gary S. Oehme ,  Matthew D. Bonner ,  James R. Keogh

    发明人： Scott E. Jahns ,  Gary S. Oehme ,  Matthew D. Bonner ,  James R. Keogh

    IPC分类号： A61M31/00 ,  A61M5/32

    CPC分类号： A61B17/3478 ,  A61B17/00234 ,  A61B17/205 ,  A61B2017/00247 ,  A61B2017/00876 ,  A61B2017/2936 ,  A61B2017/2943 ,  A61B2017/306 ,  A61B2018/00392 ,  A61B2090/034 ,  A61M5/32 ,  A61M2025/0086 ,  A61M2025/0087

    摘要： Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for transversely driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force transverse to the shaft. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.

    摘要翻译： 将生物制剂注入组织的装置和方法。 设备具有细长的轴和远端注射头，用于将针横向驱动到组织中，并通过针将药剂注射到组织中。 沿着轴引导的纵向力可以平移到与轴垂直的针驱动力​​。 一些装置提供可控的可变针穿透深度。 设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。 其他装置包括用于驱动和缩回针的可充气构件。 还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。 本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。

    Methods and Apparatus for Locating Body Vessels and Occlusions in Body Vessels
    36.
    发明申请
    Methods and Apparatus for Locating Body Vessels and Occlusions in Body Vessels 审中-公开
    用于定位体内血管和闭塞的方法和装置

    公开(公告)号：US20090137900A1

    公开(公告)日：2009-05-28

    申请号：US12362658

    申请日：2009-01-30

    申请人： Mathew D. Bonner ,  Cynthia T. Clague ,  Scott E. Jahns ,  James R. Keogh

    发明人： Mathew D. Bonner ,  Cynthia T. Clague ,  Scott E. Jahns ,  James R. Keogh

    IPC分类号： A61B5/05

    CPC分类号： A61B5/06 ,  A61B5/062 ,  A61B2017/00022 ,  A61B2017/00243 ,  A61B2017/00252 ,  A61B2017/22001 ,  A61B2090/061

    摘要： Methods and apparatus employed to locate body vessels and occlusions in body vessels finding particular utility in cardiac surgery, particularly minimally invasive cardiac surgery to locate cardiac arteries and occlusions in cardiac arteries are disclosed. An elongated vessel lumen probe incorporating a lumen probe element at or near the elongated vessel lumen probe distal end is advanced into the vessel lumen. A vessel surface probe manipulated by the surgeon and having a surface probe element sensor is employed to detect the lumen probe element and to follow the progress of the vessel lumen probe element as it approaches and is advanced through or is blocked by an occlusion. In the location of a coronary artery, the surface probe element sensor is moved about against the epicardium over the suspected location of the artery of interest until a surface probe element sensor of the present invention at the surface probe distal end interacts with the lumen probe element of the vessel lumen probe.

    摘要翻译： 公开了用于定位身体血管和身体血管闭塞的方法和装置，其在心脏手术中特别有用，特别是在心脏动脉中定位心脏动脉和闭塞的微创心脏手术。 在细长血管腔探针末端处或其附近并入管腔探针元件的细长血管腔探针被推入血管内腔。 由外科医生操作并具有表面探针元件传感器的血管表面探针被用于检测内窥镜元件，并且随着血管腔探针元件的进入而进入并被阻塞阻塞。 在冠状动脉的位置，表面探针元件传感器在目标动脉的疑似位置上靠近心外膜移动，直到本发明的表面探针元件传感器在表面探针远端与内腔探针元件相互作用 的血管腔探针。

    Ablation system and method of use
    37.
    发明授权
    Ablation system and method of use 有权
    消融系统和使用方法

    公开(公告)号：US07250048B2

    公开(公告)日：2007-07-31

    申请号：US10923178

    申请日：2004-08-20

    申请人： David E. Francischelli ,  Scott E. Jahns

    发明人： David E. Francischelli ,  Scott E. Jahns

    IPC分类号： A61B18/18

    CPC分类号： A61B18/1206 ,  A61B18/14 ,  A61B18/1442 ,  A61B2017/00092 ,  A61B2018/0016 ,  A61B2018/00351 ,  A61B2018/00363 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00886 ,  A61B2018/1467 ,  A61B2218/002

    摘要： A system and method for creating lesions and assessing their completeness or transmurality. Assessment of transmurality of a lesion is accomplished by monitoring the impedance of the tissue to be ablated. Rather than attempting to detect a desired drop or a desired increase impedance, completeness of a lesion is detected in response to the measured impedance remaining at a stable level for a desired period of time, referred to as an impedance plateau. The mechanism for determining transmurality of lesions adjacent individual electrodes or pairs may be used to deactivate individual electrodes or electrode pairs, when the lesions in tissue adjacent these individual electrodes or electrode pairs are complete, to create an essentially uniform lesion along the line of electrodes or electrode pairs, regardless of differences in tissue thickness adjacent the individual electrodes or electrode pairs. Complete or partial submersion in a fluid of the ablating portion of the ablation device may be detected prior to, during or following an ablation procedure.

    摘要翻译： 用于创建病变并评估其完整性或透视性的系统和方法。 通过监测要消融的组织的阻抗来评估病变的透壁性。 不是试图检测到期望的下降或期望的增加阻抗，而是响应于被测量的阻抗保持在稳定的电平，在期望的时间段（被称为阻抗平台）来检测损伤的完整性。 当邻近这些单独的电极或电极对的组织中的损伤完成时，用于确定邻近各个电极或对的损伤的透壁性的机制可用于使单个电极或电极对失活，以产生沿电极线或基本均匀的病变 电极对，而不管邻近各个电极或电极对的组织厚度的差异。 完全或部分浸没在消融装置的消融部分的流体中可以在消融过程之前，期间或之后检测。

    Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure
    38.
    发明授权
    Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure 有权

    公开(公告)号：US07225019B2

    公开(公告)日：2007-05-29

    申请号：US10724978

    申请日：2003-12-01

    申请人： Scott E. Jahns ,  Michael R. S. Hill ,  James R. Keogh

    发明人： Scott E. Jahns ,  Michael R. S. Hill ,  James R. Keogh

    IPC分类号： A61N1/362

    CPC分类号： A61N1/36017 ,  A61N1/36114 ,  A61N1/385

    摘要： A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ. The stimulation of the nerve is stopped in order to adjust the beating of the heart to a second condition, such as a beating condition. The heart itself may also be stimulated to a beating condition, such as by pacing. The stimulation of the nerve may be continued in order to allow the medical procedure to be continued. A sensor to sense a characteristic of a fluid or tissue, such as an impending contraction, may be also used during the medical procedure. Systems and devices for performing the medical procedure are also provided.

    Method and system for nerve stimulation prior to and during a medical procedure
    40.
    发明授权
    Method and system for nerve stimulation prior to and during a medical procedure 有权
    在医疗过程之前和期间神经刺激的方法和系统

    公开(公告)号：US07184829B2

    公开(公告)日：2007-02-27

    申请号：US10768999

    申请日：2004-01-30

    申请人： Michael R. S. Hill ,  Scott E. Jahns ,  James R. Keogh

    发明人： Michael R. S. Hill ,  Scott E. Jahns ,  James R. Keogh

    IPC分类号： A61N1/362

    CPC分类号： A61N1/36114 ,  A61N1/056 ,  A61N1/362 ,  A61N1/36514 ,  A61N1/37288 ,  A61N1/385 ,  A61N1/39

    摘要： A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ. The stimulation of the nerve is stopped in order to adjust the beating of the heart to a second condition, such as a beating condition. The heart itself may also be stimulated to a beating condition, such as by pacing. The stimulation of the nerve may be continued in order to allow the medical procedure to be continued. Systems and devices for performing the medical procedure are also provided.

    摘要翻译： 提供了一种执行诸如手术的医疗程序的方法。 刺激神经以将心脏的跳动调节到第一状态，例如停止或减缓的状态。 医疗程序在心脏或另一个器官上进行。 停止对神经的刺激，以便将心脏的跳动调节到第二状态，例如打浆状态。 心脏本身也可能被刺激到跳动状态，例如通过起搏。 可以继续刺激神经以允许继续医疗程序。 还提供用于执行医疗程序的系统和设备。