公开(公告)号：US20050136504A1

公开(公告)日：2005-06-23

申请号：US11050763

申请日：2005-02-07

申请人： Masashi Ogawa ,  Tsutomo Hamaoka ,  Yutaka Tamura ,  Tetsuhiko Tachikawa ,  Ikuo Hasegawa ,  Shusaku Yoshiki ,  Kohji Hasegawa ,  Junji Nishigaki

发明人： Masashi Ogawa ,  Tsutomo Hamaoka ,  Yutaka Tamura ,  Tetsuhiko Tachikawa ,  Ikuo Hasegawa ,  Shusaku Yoshiki ,  Kohji Hasegawa ,  Junji Nishigaki

IPC分类号： C12Q1/37

CPC分类号： C12Q1/37 ,  G01N2333/78 ,  G01N2333/96486

摘要： A method for measuring protease such as matrix metalloproteinase which comprising steps of (1) bringing a biological sample such as protease-containing tissue slices and tissue extracts into contact with a thin membrane which comprises a protease substrate and a hardening agent and is formed on a surface of a support; and (2) detecting the trace of digestion formed on the thin membrane by the action of protease with the naked eyes or under a microscope, and a thin membrane used for said method.

摘要翻译： 一种测定蛋白酶如基质金属蛋白酶的方法，包括以下步骤：（1）将含有蛋白酶的组织切片和组织提取物的生物样品与包含蛋白酶底物和硬化剂的薄膜接触，并形成在 支撑面; 和（2）用肉眼或显微镜检测蛋白酶作用下薄膜上形成的消化痕迹，以及用于所述方法的薄膜。

公开(公告)号：US06891639B1

公开(公告)日：2005-05-10

申请号：US09648116

申请日：2000-08-25

申请人： Takayuki Nabeshima ,  Katsuaki Tajima ,  Toshio Tsuboi ,  Junji Nishigaki ,  Daisetsu Tohyama

发明人： Takayuki Nabeshima ,  Katsuaki Tajima ,  Toshio Tsuboi ,  Junji Nishigaki ,  Daisetsu Tohyama

IPC分类号： H04N1/60 ,  G03F3/08 ,  G06F15/00 ,  G06T5/00 ,  H04N1/46

CPC分类号： H04N1/6027 ,  H04N1/603

摘要： An apparatus, a method and a system for image processing with a color correction device are provided in which the number of times of automatic execution of calibration is reduced and the performance of an image output apparatus is used adequately. The apparatus includes a color space conversion portion 110 for converting input image data D1 into data D1s of a standard color space and a reproduction range decision portion 111 for deciding whether the input image data D1s that were converted into the standard color space are within a reference range of a color reproduction in an image output. If it is decided that the input image data are out of the reference range, the calibration is performed so that the color reproduction range is made close to the reference range.

摘要翻译： 提供了一种用于具有颜色校正装置的图像处理的装置，方法和系统，其中减少了自动执行校准的次数，并且充分地使用了图像输出装置的性能。 该装置包括用于将输入图像数据D 1转换为标准色彩空间的数据D 1 s的色彩空间转换部分110和用于判定转换成标准色彩的输入图像数据D 1 s的再现范围决定部分111 空间在图像输出中的颜色再现的参考范围内。 如果确定输入图像数据在参考范围之外，则执行校准，使得颜色再现范围接近参考范围。

公开(公告)号：US06642375B2

公开(公告)日：2003-11-04

申请号：US09731279

申请日：2000-12-06

申请人： Hiroko Inomata ,  Hiroshi Shinoki ,  Masayoshi Kojima ,  Yukio Sudo ,  Junji Nishigaki ,  Osamu Seshimoto

发明人： Hiroko Inomata ,  Hiroshi Shinoki ,  Masayoshi Kojima ,  Yukio Sudo ,  Junji Nishigaki ,  Osamu Seshimoto

IPC分类号： C07H1904

CPC分类号： G01N33/582

摘要： The present invention provides a fluorescent substance which is represented by a formula: A-B-C wherein A is a residue of natural or synthetic nucleotide, oligonucleotide, polynucleotide, or derivative thereof, and binds to B at a base moiety in said residue, or A is a residue of avidin or streptavidin; B is a divalent linking group or a single bond; and C is a monovalent group derived from a general formula (I) and binds to B at a reactive group present in R1 or R2: wherein R1 and R2 each independently represent an alkyl group that may be substituted with a reactive group capable of covalently bonding to A-B-; R3, R4, R5, and R6 each independently represent an alkyl group, and R3 and R4, and/or R5 and R6 may bind to each other to form a saturated carbon-ring together with a carbon atom(s) to which they bind; V1, V2, V3, V4, V5, V6, V7, V8, V9 and V10 each independently represent a hydrogen atom or a monovalent substituent, and two adjacent groups thereof may bind to form a ring; L1, L2, and L3 represent a substituted or unsubstituted methine group; each of m, n, s, and t represents 0 or 1, provided that m+n=1 and s+t=1; p represents 1, 2, or 3; M represents a counter ion; and q represents a number required to neutralize the charge of a molecule. The fluorescent substance of the present invention is useful as a labeling substance for nucleic acids, or as a reagent for analyzing biological components such as nucleic acids, proteins or sugars.

摘要翻译： 本发明提供一种荧光物质，其由下式表示：AB-C，其中A是天然或合成的核苷酸，寡核苷酸，多核苷酸或其衍生物的残基，并与所述残基中的碱基部分的B结合，或A是 抗生物素蛋白或链霉亲和素的残基; B是二价连接基团或单键; 和C是衍生自通式（I）的一价基团，并且在R 1或R 2中存在的反应性基团上与B结合：其中R 1和R 2各自独立地表示烷基， 可以被能够与AB-共价结合的反应性基团取代; R 3，R 4，R 5和R 6各自独立地表示烷基，R 3和R 4和/或R 5和R 6独立地表示烷基， 可以彼此结合形成饱和碳环与它们所结合的碳原子一起; V 1，V 2，V 3，V 4，V 5，V 6，V 7，V 8，V 9和V 10 独立地表示氢原子或一价取代基，其两个相邻基团可以结合形成环; L 1，L 2和L 3表示取代或未取代的次甲基; m，n，s和t中的每一个表示0或1，条件是m + n = 1且s + t = 1; p表示1,2或3; M表示抗衡离子; q表示中和分子电荷所需的数。 本发明的荧光物质可用作核酸的标记物质，或用作分析核酸，蛋白质或糖类等生物成分的试剂。

公开(公告)号：US06301395B1

公开(公告)日：2001-10-09

申请号：US08988469

申请日：1997-12-10

申请人： Junji Nishigaki ,  Yoshihiko Hirota ,  Koji Tsukada

发明人： Junji Nishigaki ,  Yoshihiko Hirota ,  Koji Tsukada

IPC分类号： G06K940

CPC分类号： G06T5/004 ,  G06T5/20

摘要： A neighborhood select circuit of an image processing apparatus includes a comparator receiving a predetermined signal and output data from a contour enhancement unit for comparing the received inputs and providing a comparison result signal according to the comparison result, a neighborhood maximum value-minimum value circuit and neighborhood minimum value-maximum value circuit receiving data output from the contour enhancement unit, and a selector for receiving the output from the neighborhood maximum value-minimum value circuit, the neighborhood minimum value-maximum value circuit and the comparator. In the neighborhood maximum value-minimum value circuit, the target pixel data in the data output from the contour enhancement unit is substituted with the maximum data in the data of the surrounding pixels, and the target pixel data subjected to the process is substituted with the minimum value in the data of the surrounding pixels.

摘要翻译： 图像处理装置的邻域选择电路包括：比较器，接收预定信号，并输出来自轮廓增强单元的数据，用于比较接收到的输入，并根据比较结果提供比较结果信号;邻域最大值 - 最小值电路; 接收从轮廓增强单元输出的数据的邻域最小值 - 最大值电路，以及用于接收邻近最大值 - 最小值电路，邻域最小值 - 最大值电路和比较器的输出的选择器。 在邻域最大值 - 最小值电路中，将从轮廓增强单元输出的数据中的目标像素数据替换为周围像素的数据中的最大数据，并且将经过处理的目标像素数据替换为 周围像素数据的最小值。

公开(公告)号：US5538836A

公开(公告)日：1996-07-23

申请号：US559251

申请日：1995-11-15

申请人： Fumitaka Ueda ,  Junji Nishigaki ,  Tetsuo Nakamura

发明人： Fumitaka Ueda ,  Junji Nishigaki ,  Tetsuo Nakamura

IPC分类号： G03C1/035 ,  G03C1/16 ,  G03C1/18 ,  G03C1/83 ,  G03C7/30 ,  G03C1/46

CPC分类号： G03C1/16 ,  G03C1/832 ,  G03C7/3029 ,  G03C7/3022

摘要： A silver halide color photographic material having an excellent color reproducibility, high sensitivity and excellent graininess.The silver halide color photographic material contains at least one of each blue-sensitive emulsion, green-sensitive emulsion, red-sensitive emulsion layer and hydrophilic colloid layers, in which the hydrophilic colloid layer contains a compound of formula (I) and the silver halide emulsion layer, which gives an interlayer effect to said red-sensitive layer, contains a silver halide emulsion spectrally sensitized with a compound represented by formulae (II) and (III). ##STR1##

摘要翻译： 具有优异的颜色再现性，高灵敏度和优异颗粒性的卤化银彩色照相材料。 卤化银彩色照相材料含有感蓝乳剂，感绿乳液，感红乳剂层和亲水胶体层中的至少一种，其中亲水胶体层含有式（I）化合物和卤化银 对所述红色敏感层产生层间效应的乳剂层含有用式（II）和（III）表示的化合物进行光谱增感的卤化银乳剂。 （一）图像（二）<图像>（三）

公开(公告)号：US5449594A

公开(公告)日：1995-09-12

申请号：US159748

申请日：1993-12-01

申请人： Fumitaka Ueda ,  Junji Nishigaki

发明人： Fumitaka Ueda ,  Junji Nishigaki

IPC分类号： G03C1/16 ,  G03C1/14 ,  G03C1/18 ,  G03C1/83 ,  G03C7/30 ,  G03C1/46

CPC分类号： G03C1/14 ,  G03C1/832 ,  G03C7/3003

摘要： A silver halide color photographic light-sensitive material includes a support having provided thereon at least one blue-sensitive silver halide emulsion layer, at least one green-sensitive silver halide emulsion layer, at least one red-sensitive silver halide emulsion layer, and at least one hydrophilic colloid layer. The hydrophilic colloid layer contains a compound represented by Formula I below, a silver halide emulsion layer having an interlayer effect on the red-sensitive layer is also provided, and the layer with the interlayer effect contains a silver halide emulsion spectrally sensitized with a sensitizing dye represented by Formula (III) below. ##STR1##

摘要翻译： 卤化银彩色摄影感光材料包括其上设置有至少一个蓝敏感卤化银乳剂层，至少一种感绿卤化银乳剂层，至少一种感红卤化银乳剂层和 至少一个亲水胶体层。 亲水胶体层含有下述通式I所示的化合物，还提供了对红色感光层具有层间作用的卤化银乳剂层，具有层间效应的层含有用增感染料光谱增感的卤化银乳剂 由下式（III）表示。

公开(公告)号：US5384234A

公开(公告)日：1995-01-24

申请号：US85174

申请日：1993-07-02

申请人： Fumitaka Ueda ,  Junji Nishigaki ,  Akihiko Ikegawa

发明人： Fumitaka Ueda ,  Junji Nishigaki ,  Akihiko Ikegawa

IPC分类号： G03C1/16 ,  G03C1/14 ,  G03C1/18 ,  G03C1/29 ,  G03C7/305 ,  G03C1/46

CPC分类号： G03C1/29 ,  G03C1/14 ,  G03C7/30529

摘要： The present invention provides a silver halide color photographic photosensitive material which has high saturation, excellent color reproduction and excellent graininess, the material comprising a silver halide emulsion layer which imparts an interlayer effect to a red sensitive silver halide emulsion layer is spectrally sensitized with a sensitizing dye represented by formula (I) and contains a development inhibitor releasing compound represented by formula (II). ##STR1##

摘要翻译： 本发明提供了一种具有高饱和度，优异色彩再现性和优异颗粒性的卤化银彩色照相感光材料，包含赋予红色感光卤化银乳剂层的层间效应的卤化银乳剂层的材料用敏化剂进行光谱增感 由式（I）表示的染料并含有由式（II）表示的显影抑制剂释放化合物。 （I）（II）

公开(公告)号：US4906553A

公开(公告)日：1990-03-06

申请号：US347852

申请日：1989-05-05

申请人： Akihiko Ikegawa ,  Minoru Yamada ,  Masaki Okazaki ,  Junji Nishigaki

发明人： Akihiko Ikegawa ,  Minoru Yamada ,  Masaki Okazaki ,  Junji Nishigaki

IPC分类号： G03C1/12 ,  G03C5/26

CPC分类号： G03C1/12 ,  G03C5/26 ,  Y10S430/164

摘要： A process for processing a silver halide black and white photographic material, which comprises processing, after imagewise exposing, a silver halide black and white photographic material spectrally sensitized by a sensitizing dye with a processing solution containing at least one compound satisfying the following condition 1 and/or a salt thereof in an amount of at least 5.times.10.sup.-5 mol/liter;Condition 1:when 4 ml of an aqueous solution of 8.0.times.10.sup.-2 mol/liter of the compound is added to a mixture of 2 ml of an aqueous solution of 4.0.times.10.sup.-4 mol/liter of anhydro-5,5'-dichloro-9-ethyl-3,3'-bis(3-sulfopropyl)thiacarbocyanine hydroxide.pyridinium salt and 1 ml of an aqueous solution of 1.0.times.10.sup.-1 mol/liter of potassium chloride and the resultant solution is diluted with water to 10 ml, the molecular extinction coefficient of the aqueous solution at 624 nm is not higher than 1.0.times.10.sup.5.