摘要:
The present invention relates to novel comb polymers which bear poly-C2-C4-alkylene ether side chains A and functional groups B which at a pH of >12 are present in the form of anionic groups on a carbon backbone and also the salts of such comb polymers. The invention also relates to the use of these comb polymers as additives in preparations comprising a mineral binder. The polyalkylene ether side chains A have the following formula: *—U—(C(O))k—X-(Alk-O)n—Y—Z A.
摘要翻译:本发明涉及具有聚-C2-C4-亚烷基醚侧链A和官能团B的新型梳状聚合物,其pH> 12是以碳骨架上的阴离子基团的形式存在,以及其中的盐 梳状聚合物。 本发明还涉及这些梳状聚合物作为添加剂在包含矿物粘合剂的制剂中的用途。 聚亚烷基醚侧链A具有下式:* -U-(C(O))k -X-(Alk-O)n -Y-Z A
摘要:
The present invention relates to a (poly)peptide or a peptidomimetic thereof having the biological activity of Conkunitzin-S1, wherein said (poly)peptide is selected from (a) a polypeptide comprising or having the amino acid sequence of SEQ ID NO: 1; (b) a polypeptide having at least 85% sequence identity to SEQ ID NO:1; or (c) a fragment of a) or b); wherein said (poly)peptide or peptidomimetic specifically modulates the activity of a channel having the activity of a Kv1.7 containing channel, for the treatment or prevention of metabolic diseases or conditions, or secondary diseases or conditions related to said metabolic diseases or conditions. The present invention furthermore relates to a method of screening for (poly)peptides derived from Conkunitzin-S1 suitable for specifically modulating the activity of a channel having the activity of a Kv1.7 containing channel, comprising: (a) altering the amino acid sequence of Conkunitzin-S1 represented by SEQ ID NO: 1 by deleting and/or inserting and/or replacing at least one amino acid; and (b) determining the modulatory effect of the (poly)peptide obtained in step (a) (i) on a channel having the activity of a Kv1.7 containing channel and (ii) on channels, preferably potassium channels, not having the activity of a Kv1.7 containing channel, which are optionally expressed on the same cell as the channel having the activity of a Kv1.7 containing channel.
摘要翻译:本发明涉及具有Conkunitzin-S1生物活性的(多)肽或其肽模拟物,其中所述(多)肽选自(a)包含或具有SEQ ID NO:1的氨基酸序列的多肽 ; (b)与SEQ ID NO:1具有至少85%序列同一性的多肽; 或(c)a)或b)的片段; 其中所述(多)肽或肽模拟物特异性调节具有Kv1.7含有通道活性的通道的活性,用于治疗或预防代谢疾病或病症,或与所述代谢疾病或病症有关的继发性疾病或病症。 本发明还涉及一种筛选衍生自Conkunitzin-S1的(多)肽的方法,其适用于特异性调节含有Kv1.7含有通道活性的通道的活性,其包括:(a)改变氨基酸序列 通过删除和/或插入和/或替换至少一个氨基酸的由SEQ ID NO:1表示的Conkunitzin-S1; (b)确定步骤(a)(i)中获得的(多)肽对具有Kv1.7含有通道活性的通道的调节作用,和(ii)在不具有 包含Kv1.7的通道的活性,其任选地在与具有含有Kv1.7的通道的活性的通道相同的单元上表达。
摘要:
A process for preparing free-radically polymerizable carboxylic esters by reacting ethyllenically unsaturated carboxylic acids, carboxylic anhydrides or carbonyl halides (referred to collectively as carboxylic acid component) with a hydroxyl compound composed of at least 60% by weight of C2 to C4 alkoxy groups (and referred to for short as polyalkoxy compound), which comprises said reacting taking place in the presence of a polymerization inhibitor and of a reducing agent.
摘要:
The present invention relates to the use of water-soluble or water-dispersible polymers as additives in mineral building materials. The novel polymers are obtainable by polymerizing alkoxylated derivatives of 3-allyloxy-1,2-propanediol with ethylenically unsaturated mono- or dicarboxylic acids or the anhydrides, esters or mixtures thereof and, if appropriate, with one or more further ethylenically unsaturated monomers C.
摘要:
The present invention relates to a process for the preparation of poly-C2-C4-alkylene glycol monoacrylic acid esters and monomethacrylic acid esters, and a process for the preparation of copolymers of such poly-C2-C4-alkylene glycol mono(meth)acrylic acid esters with acrylic acid or methacrylic acid and the use of the polymers as a plasticizing additive in cement-containing preparations.The preparation of the poly-C2-C4-alkylene glycol monoacrylic acid esters and monomethacrylic acid esters is effected by reacting acrylic anhydride or methacrylic anhydride ((meth)acrylic anhydride A below) with a poly-C2-C4-alkylene glycol compound P carrying at least one OH group in the presence of a base, the base being selected from basic compounds which have a solubility in the poly-C2-C4-alkylene glycol compound P of not more than 10 g/l at 90° C., and the molar ratio of (meth)acrylic anhydride A to compound P (molar ratio A:P) being in the range from 1:1 to 1.095:1, preferably in the range from 1.005:1 to 1.09:1, in particular in the range from 1.01:1 to 1.085:1 and particularly preferably in the range from 1.02:1 to 1.08:1.The preparation of copolymers of (meth)acrylic acid with poly-C2-C4-alkylene glycol mono(meth)acrylic acid esters comprises: i) preparation of a poly-C2-C4-alkylene glycol mono(meth)acrylic acid ester by reacting (meth)acrylic anhydride A with a poly-C2-C4-alkylene glycol compound P carrying at least one OH group in the presence of a base by processes according to the invention, and ii) free radical copolymerization of the poly-C2-C4-alkylene glycol mono(meth)acrylic acid ester obtained in step i) with acrylic acid and/or methacrylic acid and, if appropriate, further ethylenically unsaturated monomers.
摘要:
The present invention relates to polymers which comprise, as monomeric building blocks, (poly)alkylene oxide-substituted diallylamines, ethylenically unsaturated monomers B, and, if appropriate, one or more further ethylenically unsaturated monomers and, if appropriate, crosslinkers, and to the use thereof as additives in cosmetic preparations.
摘要:
Rylene dyes of the general formula I where the variables are defined as follows: R is hydrogen; optionally substituted C1-C30-alkyl, C5-C8-cycloalkyl, aryl or hetaryl; R′ is bromine; cyano; —NR32; optionally substituted aryloxy, arylthio, hetaryloxy or hetarylthio; optionally substituted C3-C18-alk-1-ynyl; X, Y are both hydrogen or together are a radical of the formula Ia n is 2, 3, 4 or additionally 1 when X and Y are a radical of the formula Ia; n′ is from 1 to 4; m is from 0 to 6.
摘要:
The present invention relates to the use of functionalized perylene-3,4,9,10-tetracarboxylic acid diimides as initiator and/or co-reactant for polymerization reactions, to polymers prepared using the perylene-3,4,9,10-tetracarboxylic acid diimide compounds, to the use of these colored and/or fluorescent polymers, and to novel functionalized perylenetetracarboxylic acid diimides.
摘要:
An ethylene terpolymer wax comprising, as monomer building blocks, from 35 to 95% by weight of ethylene, from 0.1 to 40% by weight of at least one ester of the formula I where R1 is selected from hydrogen, C1-C10-alkyl, C3-C12-cycloalkyl and C6-C14-aryl R2 are identical or different and are selected from hydrogen and C1-C10-alkyl, R3 is selected from C1-C10-alkyl, C3-C12-cycloalkyl and C6-C14-aryl and n is an integer from 2 to 100, and from 0.1 to 25% by weight of at least one carboxylic acid of the formula II where R4 is selected from hydrogen, C1-C10-alkyl, C3-C12-cycloalkyl and C6-C14-aryl.
摘要:
The invention relates to a method for handling phone numbers in a mobile station and a mobile station. According to the invention, numbers (3a, 3b, 3c) are handled in groups (1a, 1b, 1c) which have different attributes (2a, 2b, 2c). The attributes (2a, 2b, 2c) mean e.g. rights to generate a ringing tone. In a certain operating mode, only a call belonging to a group (1a, 1b, 1c) which in that operating mode has the right to call the mobile station, will generate a ringing tone. The attributes (2a, 2b, 2c) also mean group-specific ringing tones which represent the type of the group (1a, 1b, 1c). The attributes (2a, 2b, 2c) further mean symbols on the display of a mobile station.