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148 条记录 (耗时 0.026 秒)

    Process for preparing MeO-Peg-protected dihydroquinine or dihydroquinidine derivatives, new dihydroquinine or dihydroquinidine derivatives and their use
    31.
    发明授权
    Process for preparing MeO-Peg-protected dihydroquinine or dihydroquinidine derivatives, new dihydroquinine or dihydroquinidine derivatives and their use 失效
    制备MeO-Peg-保护的二氢奎尼丁或二氢奎尼丁衍生物的方法，新的二氢喹啉或二氢奎尼丁衍生物及其用途

    公开(公告)号：US06326327B1

    公开(公告)日：2001-12-04

    申请号：US09699743

    申请日：2000-10-30

    申请人： Carsten Bolm ,  Arne Gerlach ,  Karlheinz Drauz ,  Andreas Bommarius

    发明人： Carsten Bolm ,  Arne Gerlach ,  Karlheinz Drauz ,  Andreas Bommarius

    IPC分类号： C08G6500

    CPC分类号： C07D487/04 ,  C07B53/00 ,  C07D453/04

    摘要： It is known that dihydroquinine or dihydroquinidine derivatives can be successfully used as ligands in the enantioselective dihydroxylation. The new disclosed ligand systems based on dihydroquinine/quinidine, unlike the prior art ligands, can be recycled after enantioselective dihydroxylation by precipitating and filtering the reaction medium, and be reused in the reaction medium. Also disclosed are the ligand systems (I) and (IV), process for preparing the same and their use in the enantioselective dihydroxiation of double bonds.

    摘要翻译： 已知二氢奎尼丁或二氢奎尼丁衍生物可以成功地用作对映选择性二羟基化的配体。 与现有技术的配体不同，新公开的基于二氢喹啉/奎尼丁的配体体系可以通过沉淀和过滤反应介质在对映选择性二羟基化之后再循环，并在反应介质中重新使用。 还公开了配体体系（I）和（IV），其制备方法及其在双键对映体选择性二氢化中的用途。

    Process for preparing optically active beta-aminocarboxylic acids from racemic n-acylated beta-aminocarboxylic acids
    36.
    发明申请
    Process for preparing optically active beta-aminocarboxylic acids from racemic n-acylated beta-aminocarboxylic acids 审中-公开
    从外消旋的N-酰化β-氨基羧酸制备光学活性β-氨基羧酸的方法

    公开(公告)号：US20050153401A1

    公开(公告)日：2005-07-14

    申请号：US10508088

    申请日：2003-03-07

    申请人： Harald Groger ,  Harald Trauthwein ,  Karlheinz Drauz ,  Stefan Buchholz ,  Christiane Sacherer ,  Helge Werner

    发明人： Harald Groger ,  Harald Trauthwein ,  Karlheinz Drauz ,  Stefan Buchholz ,  Christiane Sacherer ,  Helge Werner

    IPC分类号： C12P41/00 ,  C12R1/69 ,  C12P13/04

    CPC分类号： C12P41/007

    摘要： A process is described for preparing optically active β-atninocarboxylic acids from racemic N-acylated β-aminocarboxylic acids by cnantiosclccthc hydrolysis of the N-acylated β-aminocarboxylic acid in the presence of a hydrolase by way of biocatalyst, wherein the N-acyl substituent of the N-acylated β-aminocarboxylic acid (I) exhibits Structure I in which R1, R2 are each selected, independently of one another, from H, halogen, alkiyl residues, OH, alkoxy residues and aryloxy residues; R3 is selected from halogen, alkoxy residues and aryloxy residues; (II) Structure IIA or IIB or the structure of the corresponding salts or (III) Structure III or the structure of the corresponding salt.

    摘要翻译： 描述了一种用于通过在水解酶存在下通过生物催化剂的N-酰化β-氨基羧酸水解N-外酰基化的β-氨基羧酸来制备光学活性β-阿魏酸的方法，其中N-酰基取代基 的N-酰化的β-氨基羧酸（I）表现出结构I，其中R 1，R 2各自彼此独立地选自H，卤素， 烷基残基，OH，烷氧基残基和芳氧基残基; R 3选自卤素，烷氧基残基和芳氧基残基; （II）结构IIA或IIB或相应盐的结构或（III）结构III或相应盐的结构。

    Method of producing oxazolidinones, the use thereof and oxazolidinones
    40.
    发明授权
    Method of producing oxazolidinones, the use thereof and oxazolidinones 失效
    生产恶唑烷酮的方法，其用途和恶唑烷酮

    公开(公告)号：US06437145B1

    公开(公告)日：2002-08-20

    申请号：US09542278

    申请日：2000-04-04

    申请人： Karlheinz Drauz ,  Günter Knaup ,  Stefan Retzow

    发明人： Karlheinz Drauz ,  Günter Knaup ,  Stefan Retzow

    IPC分类号： C07D26308

    CPC分类号： C07D263/18 ,  C07C231/14 ,  C07C237/22

    摘要： The invention concerns a method of producing oxazolidinones of formula (I), wherein R1-R5 have the meanings given in the description, by reacting cyclical anhydrides of formula (II) with carbonyl compounds of general formula (III) at temperatures between ambient temperature and approximately 150° C. The invention also concerns the production of the cyclical anhydrides of formula (II) by reacting N-protected aminodicarboxylic acids of formula (IV) with a dehydrating agent in situ. The invention further concerns the use of oxazolidinones of formula (I) for the &agr;-selective production of esters of formula (V) and amides of general formula (VII).

    摘要翻译： 本发明涉及一种制备式（I）的恶唑烷酮的方法，其中R1-R5具有本说明书中给出的含义，通式（II）的环状酸酐与通式（III）的羰基化合物在环境温度和 本发明还涉及式（II）的环状酸酐通过将式（Ⅳ）的N-保护的氨基二羧酸与脱水剂原位反应来生产。 本发明还涉及式（I）的恶唑烷酮在通式（Ⅴ）的酯和通式（Ⅶ）的酰胺的α-选择性生产中的应用。