公开(公告)号：US08155756B2

公开(公告)日：2012-04-10

申请号：US12392964

申请日：2009-02-25

申请人： Michael Yang ,  Euljoon Park ,  Kyungmoo Ryu ,  Stuart Rosenberg ,  Michael J. Coyle

发明人： Michael Yang ,  Euljoon Park ,  Kyungmoo Ryu ,  Stuart Rosenberg ,  Michael J. Coyle

IPC分类号： A61N1/00 ,  A61B5/05 ,  A61B5/02

CPC分类号： A61N1/056 ,  A61B5/0422 ,  A61B5/06 ,  A61N1/3627 ,  A61N1/36578 ,  A61N1/3684 ,  A61N2001/0585

摘要： An exemplary method includes use of a multielectrode device that can help position a cardiac stimulation lead to an optimal site in the heart based at least in part on cardiac motion information acquired via the multielectrode device and one or more pairs of current delivery electrodes that establish potential fields (e.g., for use as a coordinate system). An exemplary multielectrode device may be a multielectrode catheter or a multifilar, electrode-bearing guidewire. Various other exemplary methods, devices, systems, etc., are also disclosed.

摘要翻译： 一种示例性方法包括使用多电极装置，该多电极装置能够至少部分地基于通过多电极装置获得的心脏运动信息和建立潜在的一对或多对电流输送电极来帮助将心脏刺激引导到心脏中的最佳位置 字段（例如，用作坐标系）。 示例性的多电极装置可以是多电极导管或多电极，带电极的导丝。 还公开了各种其它示例性方法，装置，系统等。

公开(公告)号：US20090157136A1

公开(公告)日：2009-06-18

申请号：US12392964

申请日：2009-02-25

申请人： Michael Yang ,  Euljoon Park ,  Kyungmoo Ryu ,  Stuart Rosenberg ,  Michael J. Coyle

发明人： Michael Yang ,  Euljoon Park ,  Kyungmoo Ryu ,  Stuart Rosenberg ,  Michael J. Coyle

IPC分类号： A61N1/362 ,  A61B5/02

CPC分类号： A61N1/056 ,  A61B5/0422 ,  A61B5/06 ,  A61N1/3627 ,  A61N1/36578 ,  A61N1/3684 ,  A61N2001/0585

摘要： An exemplary method includes use of a multielectrode device that can help position a cardiac stimulation lead to an optimal site in the heart based at least in part on cardiac motion information acquired via the multielectrode device and one or more pairs of current delivery electrodes that establish potential fields (e.g., for use as a coordinate system). An exemplary multielectrode device may be a multielectrode catheter or a multifilar, electrode-bearing guidewire. Various other exemplary methods, devices, systems, etc., are also disclosed.

摘要翻译： 一种示例性方法包括使用多电极装置，其可以帮助将心脏刺激引导定位到心脏中的最佳部位，至少部分地基于通过多电极装置获取的心脏运动信息和建立潜在的一对或多对电流输送电极 字段（例如，用作坐标系）。 示例性的多电极装置可以是多电极导管或多电极，带电极的导丝。 还公开了各种其它示例性方法，装置，系统等。

公开(公告)号：US20120165643A1

公开(公告)日：2012-06-28

申请号：US13416211

申请日：2012-03-09

申请人： Michael Yang ,  Euljoon Park ,  Kyungmoo Ryu ,  Stuart Rosenberg ,  Michael J. Coyle

发明人： Michael Yang ,  Euljoon Park ,  Kyungmoo Ryu ,  Stuart Rosenberg ,  Michael J. Coyle

IPC分类号： A61B5/042

CPC分类号： A61N1/056 ,  A61B5/0422 ,  A61B5/06 ,  A61N1/3627 ,  A61N1/36578 ,  A61N1/3684 ,  A61N2001/0585

摘要： An exemplary method includes use of a multielectrode device that can help position a cardiac stimulation lead to an optimal site in the heart based at least in part on cardiac motion information acquired via the multielectrode device and one or more pairs of current delivery electrodes that establish potential fields (e.g., for use as a coordinate system). An exemplary mutlielectrode device may be a multielectrode catheter or a multifilar, electrode-bearing guidewire. Various other exemplary methods, devices, systems, etc., are also disclosed.

摘要翻译： 一种示例性方法包括使用多电极装置，该多电极装置能够至少部分地基于通过多电极装置获得的心脏运动信息和建立潜在的一对或多对电流输送电极来帮助将心脏刺激引导到心脏中的最佳位置 字段（例如，用作坐标系）。 示例性的聚电极装置可以是多电极导管或多针，电极轴承导丝。 还公开了各种其它示例性方法，装置，系统等。

公开(公告)号：US20100042174A1

公开(公告)日：2010-02-18

申请号：US12190545

申请日：2008-08-12

申请人： Steve Koh ,  Michael Yang ,  Kyungmoo Ryu

发明人： Steve Koh ,  Michael Yang ,  Kyungmoo Ryu

IPC分类号： A61N1/368

CPC分类号： A61N1/368 ,  A61N1/36585 ,  A61N1/3684 ,  A61N1/3688 ,  A61N1/3708

摘要： An exemplary method for multi-tier pacing includes delivering single site, left ventricular pacing, sensing patient activity; comparing the sensed patient activity to a patient activity threshold and, if the sensed patient activity exceeds the patient activity threshold, then delivering multi-site, left ventricular pacing for a predetermined period of time and, after the predetermined period of time, delivering single, site left ventricular pacing. In such a method, the period of time may be determined based on cardio-pulmonary demand. Other exemplary technologies are also disclosed.

摘要翻译： 用于多层起搏的示例性方法包括递送单位点，左心室起搏，感测患者活动; 将感测的患者活动与患者活动阈值进行比较，并且如果所感测的患者活动超过患者活动阈值，则在预定时间段内递送多部位左心室起搏，并且在预定时间段之后，递送单个， 现场左心室起搏。 在这种方法中，可以基于心肺 - 肺部需求来确定时间段。 还公开了其它示例性技术。

公开(公告)号：US20120046564A1

公开(公告)日：2012-02-23

申请号：US12861573

申请日：2010-08-23

申请人： Steve Koh ,  Michael Yang ,  Ryan Rooke ,  Stuart Rosenberg ,  Wenbo Hou

发明人： Steve Koh ,  Michael Yang ,  Ryan Rooke ,  Stuart Rosenberg ,  Wenbo Hou

IPC分类号： A61B5/0402

CPC分类号： A61B5/0422 ,  A61B5/686 ,  A61B5/7282 ,  A61B2576/023 ,  A61N1/365 ,  A61N1/3702

摘要： A system and method are provided for monitoring ischemic development. The system and method identify a non-physiologic event and obtain cardiac signals along multiple sensing vectors, wherein at least a portion of the sensing vectors extend to or from electrodes located proximate to the left ventricle. The system and method monitor a segment of interest in the cardiac signals obtained along the multiple sensing vectors to identify deviations in the segment of interest from a baseline. The system and method record at least one of timing or segment shift information associated with the deviations in the segments of interest; and identify at least one of size, direction of development or rate of progression of an ischemia region based on the at least one of timing or segment shift information.

摘要翻译： 提供了一种用于监测缺血发育的系统和方法。 系统和方法识别非生理事件并且沿着多个感测向量获得心脏信号，其中至少一部分感测向量延伸到位于靠近左心室的电极。 系统和方法监测沿着多个感测向量获得的心脏信号中的感兴趣区段，以识别感兴趣区段中的偏离基线。 系统和方法记录与感兴趣的部分中的偏差相关联的定时或分段移位信息中的至少一个; 并且基于定时或段位移信息中的至少一个来识别缺血区域的大小，发育方向或进展速度中的至少一个。

公开(公告)号：US08447389B2

公开(公告)日：2013-05-21

申请号：US12861573

申请日：2010-08-23

申请人： Steve Koh ,  Michael Yang ,  Ryan Rooke ,  Stuart Rosenberg ,  Wenbo Hou

发明人： Steve Koh ,  Michael Yang ,  Ryan Rooke ,  Stuart Rosenberg ,  Wenbo Hou

IPC分类号： A61B5/0452

CPC分类号： A61B5/0422 ,  A61B5/686 ,  A61B5/7282 ,  A61B2576/023 ,  A61N1/365 ,  A61N1/3702

摘要： A system and method are provided for monitoring ischemic development. The system and method identify a non-physiologic event and obtain cardiac signals along multiple sensing vectors, wherein at least a portion of the sensing vectors extend to or from electrodes located proximate to the left ventricle. The system and method monitor a segment of interest in the cardiac signals obtained along the multiple sensing vectors to identify deviations in the segment of interest from a baseline. The system and method record at least one of timing or segment shift information associated with the deviations in the segments of interest; and identify at least one of size, direction of development or rate of progression of an ischemia region based on the at least one of timing or segment shift information.

摘要翻译： 提供了一种用于监测缺血发育的系统和方法。 系统和方法识别非生理事件并且沿着多个感测向量获得心脏信号，其中至少一部分感测向量延伸到位于靠近左心室的电极。 系统和方法监测沿着多个感测向量获得的心脏信号中的感兴趣区段，以识别感兴趣区段中的偏离基线。 系统和方法记录与感兴趣的部分中的偏差相关联的定时或分段移位信息中的至少一个; 并且基于定时或段位移信息中的至少一个来识别缺血区域的大小，发育方向或进展速度中的至少一个。

公开(公告)号：US20070239244A1

公开(公告)日：2007-10-11

申请号：US11691335

申请日：2007-03-26

申请人： Kevin L. Morgan ,  Steven R. Conger ,  Anna Barlow ,  Stuart Rosenberg ,  Wenbo Hou ,  Michael Yang ,  Sheldon Williams

发明人： Kevin L. Morgan ,  Steven R. Conger ,  Anna Barlow ,  Stuart Rosenberg ,  Wenbo Hou ,  Michael Yang ,  Sheldon Williams

IPC分类号： A61N1/05

CPC分类号： A61N1/059 ,  A61N1/057 ,  A61N1/0587 ,  A61N2001/058

摘要： The intrapericardial lead includes a lead body having a proximal portion and a flexible, pre-curved distal end portion. The distal end portion carries at least one electrode assembly containing an electrode adapted to engage pericardial tissue. The distal end portion further carries a pre-curved flexible wire member having ends attached to spaced apart points along the distal end portion of the lead body, the flexible wire member having a normally expanded state wherein an intermediate portion of the wire member is spaced apart from the distal end portion, and a generally straightened state wherein the wire member and the distal end portion are disposed in a more parallel, adjacent relationship so as to present a small frontal area to facilitate delivery into the pericardial space. The wire member re-expands to its normal state after delivery into the percaridal space to anchor the distal end portion of the lead body relative to the pericardial tissue.

摘要翻译： 心包内引线包括具有近端部分和柔性的预弯曲远端部分的引线体。 远端部分携带至少一个电极组件，其包含适于接合心包组织的电极。 远端部分还承载预弯曲的柔性线构件，其具有沿着引线本体的远端部附接到间隔开的点的端部，柔性线构件具有正常膨胀状态，其中线构件的中间部分间隔开 以及大致直线状态，其中所述线构件和所述远端部分布置成更平行的相邻关系，以便呈现小的前部区域以便于输送到心包空间中。 导线部件在输送到大面积空间之后，再膨胀至其正常状态，以相对于心包组织锚固引线主体的远端部分。

公开(公告)号：US20110106233A1

公开(公告)日：2011-05-05

申请号：US13005448

申请日：2011-01-12

申请人： Kevin L. Morgan ,  Steven R. Conger ,  Anna Barlow ,  Stuart Rosenberg ,  Wenbo Hou ,  Michael Yang ,  Sheldon Williams

发明人： Kevin L. Morgan ,  Steven R. Conger ,  Anna Barlow ,  Stuart Rosenberg ,  Wenbo Hou ,  Michael Yang ,  Sheldon Williams

IPC分类号： A61N1/05

CPC分类号： A61N1/059 ,  A61N1/057 ,  A61N1/0587 ,  A61N2001/058

摘要： The intrapericardial lead includes a lead body having a proximal portion and a flexible, pre-curved distal end portion. The distal end portion carries at least one electrode assembly containing an electrode adapted to engage pericardial tissue. The distal end portion further carries a pre-curved flexible wire member having ends attached to spaced apart points along the distal end portion of the lead body, the flexible wire member having a normally expanded state wherein an intermediate portion of the wire member is spaced apart from the distal end portion, and a generally straightened state wherein the wire member and the distal end portion are disposed in a more parallel, adjacent relationship so as to present a small frontal area to facilitate delivery into the pericardial space. The wire member re-expands to its normal state after delivery into the pericardial space to anchor the distal end portion of the lead body relative to the pericardial tissue.

摘要翻译： 心包内引线包括具有近端部分和柔性的预弯曲远端部分的引线体。 远端部分携带至少一个电极组件，其包含适于接合心包组织的电极。 远端部分还承载预弯曲的柔性线构件，其具有沿着引线本体的远端部附接到间隔开的点的端部，柔性线构件具有正常膨胀状态，其中线构件的中间部分间隔开 以及大致直线状态，其中所述线构件和所述远端部分布置成更平行的相邻关系，以便呈现小的前部区域以便于输送到心包空间中。 导线部件在输送到心包空间之后再膨胀至正常状态，以相对于心包组织锚固引线主体的远端部分。

公开(公告)号：US07899555B2

公开(公告)日：2011-03-01

申请号：US11691335

申请日：2007-03-26

申请人： Kevin L. Morgan ,  Steven R. Conger ,  Anna Barlow ,  Stuart Rosenberg ,  Wenbo Hou ,  Michael Yang ,  Sheldon Williams

发明人： Kevin L. Morgan ,  Steven R. Conger ,  Anna Barlow ,  Stuart Rosenberg ,  Wenbo Hou ,  Michael Yang ,  Sheldon Williams

IPC分类号： A61N1/05

CPC分类号： A61N1/059 ,  A61N1/057 ,  A61N1/0587 ,  A61N2001/058

摘要： The intrapericardial lead includes a lead body having a proximal portion and a flexible, pre-curved distal end portion. The distal end portion carries at least one electrode assembly containing an electrode adapted to engage pericardial tissue. The distal end portion further carries a pre-curved flexible wire member having ends attached to spaced apart points along the distal end portion of the lead body, the flexible wire member having a normally expanded state wherein an intermediate portion of the wire member is spaced apart from the distal end portion, and a generally straightened state wherein the wire member and the distal end portion are disposed in a more parallel, adjacent relationship so as to present a small frontal area to facilitate delivery into the pericardial space. The wire member re-expands to its normal state after delivery into the percaridal space to anchor the distal end portion of the lead body relative to the pericardial tissue.

摘要翻译： 心包内引线包括具有近端部分和柔性的预弯曲远端部分的引线体。 远端部分携带至少一个电极组件，其包含适于接合心包组织的电极。 远端部分还承载预弯曲的柔性线构件，其具有沿着引线本体的远端部附接到间隔开的点的端部，柔性线构件具有正常膨胀状态，其中线构件的中间部分间隔开 以及大致直线状态，其中所述线构件和所述远端部分布置成更平行的相邻关系，以便呈现小的前部区域以便于输送到心包空间中。 导线部件在输送到大面积空间之后，再膨胀至其正常状态，以相对于心包组织锚固引线主体的远端部分。

公开(公告)号：US08406902B2

公开(公告)日：2013-03-26

申请号：US13005448

申请日：2011-01-12

申请人： Kevin L. Morgan ,  Steven R. Conger ,  Anna Barlow ,  Stuart Rosenberg ,  Wenbo Hou ,  Michael Yang ,  Sheldon Williams

发明人： Kevin L. Morgan ,  Steven R. Conger ,  Anna Barlow ,  Stuart Rosenberg ,  Wenbo Hou ,  Michael Yang ,  Sheldon Williams

IPC分类号： A61N1/05

CPC分类号： A61N1/059 ,  A61N1/057 ,  A61N1/0587 ,  A61N2001/058

摘要： The intrapericardial lead includes a lead body having a proximal portion and a flexible, pre-curved distal end portion. The distal end portion carries at least one electrode assembly containing an electrode adapted to engage pericardial tissue. The distal end portion further carries a pre-curved flexible wire member having ends attached to spaced apart points along the distal end portion of the lead body, the flexible wire member having a normally expanded state wherein an intermediate portion of the wire member is spaced apart from the distal end portion, and a generally straightened state wherein the wire member and the distal end portion are disposed in a more parallel, adjacent relationship so as to present a small frontal area to facilitate delivery into the pericardial space. The wire member re-expands to its normal state after delivery into the pericardial space to anchor the distal end portion of the lead body relative to the pericardial tissue.

摘要翻译： 心包内引线包括具有近端部分和柔性的预弯曲的远端部分的引线体。 远端部分携带至少一个电极组件，其包含适于接合心包组织的电极。 远端部分还承载预弯曲的柔性线构件，其具有沿着引线本体的远端部附接到间隔开的点的端部，柔性线构件具有正常膨胀状态，其中线构件的中间部分间隔开 以及大致直线状态，其中所述线构件和所述远端部分布置成更平行的相邻关系，以便呈现小的前部区域以便于输送到心包空间中。 导线部件在输送到心包空间之后再膨胀至正常状态，以相对于心包组织锚固引线主体的远端部分。