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    SULFASALAZINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER
    32.
    发明申请
    SULFASALAZINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER 审中-公开
    生物可降解聚合物载体中的磺胺嘧啶配方

    公开(公告)号：US20090264478A1

    公开(公告)日：2009-10-22

    申请号：US12105375

    申请日：2008-04-18

    申请人： Stephen M. Cox ,  Christopher M. Hobot ,  John M. Zanella ,  Vanja M. King ,  William F. McKay ,  Kathy L. Remsen

    发明人： Stephen M. Cox ,  Christopher M. Hobot ,  John M. Zanella ,  Vanja M. King ,  William F. McKay ,  Kathy L. Remsen

    IPC分类号： A61K31/4402 ,  A61P29/00

    CPC分类号： A61K31/635 ,  A61K9/0024 ,  A61K47/34

    摘要： Effective treatments of acute pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulfasalazine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    摘要翻译： 提供了长时间的急性疼痛和/或炎症的有效治疗。 通过在目标部位或其附近施用有效量的柳氮磺吡啶可以减轻由不同来源引起的疼痛，包括但不限于椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节疼痛 作为手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

    Clonidine Formulation in a Polyorthoester Carrier
    33.
    发明申请
    Clonidine Formulation in a Polyorthoester Carrier 有权
    多聚酯载体中的可乐定配方

    公开(公告)号：US20090263448A1

    公开(公告)日：2009-10-22

    申请号：US12412024

    申请日：2009-03-26

    申请人： Christopher M. Hobot ,  Phillip E. McDonald ,  Keith R. Hildebrand

    发明人： Christopher M. Hobot ,  Phillip E. McDonald ,  Keith R. Hildebrand

    IPC分类号： A61K9/00

    CPC分类号： A61K31/4168 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/06 ,  A61K9/1647 ,  A61K31/415 ,  A61K47/34

    摘要： Effective treatments of acute pain for extended periods of time are provided. The treatments include the administration of one or more drug depots at or near a target site wherein the drug depots include an effective amount of clonidine formulated within a polyorthoester. By administration of one or more drug depots at or near the target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.

    摘要翻译： 提供了长期急性疼痛的有效治疗方法。 治疗包括在靶位点处或附近施用一个或多个药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的可乐定。 通过管理目标部位处或附近的一个或多个药物库，可以减轻由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊柱脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。

    Baclofen Formulation in a Polyorthoester Carrier
    35.
    发明申请
    Baclofen Formulation in a Polyorthoester Carrier 有权
    巴洛芬在聚原酸酯载体中的配方

    公开(公告)号：US20090208554A1

    公开(公告)日：2009-08-20

    申请号：US12426021

    申请日：2009-04-17

    申请人： Christopher M. Hobot ,  Michael E. Benz ,  Keith R. Hildebrand ,  Bryant J. Pudil

    发明人： Christopher M. Hobot ,  Michael E. Benz ,  Keith R. Hildebrand ,  Bryant J. Pudil

    IPC分类号： A61F2/04 ,  A61K31/195

    CPC分类号： A61K31/197 ,  A61K9/0024 ,  A61K47/34

    摘要： Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of baclofen formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least thirty days, at least sixty days, at least one hundred days or at least one hundred and thirty-five days.

    摘要翻译： 提供长时间有效的疼痛治疗。 治疗包括给药一种或多种药物储库，其中药物贮库包括配制在聚原酸酯内的有效量的巴氯芬。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施例中，浮雕可以是至少三十天，至少六十天，至少一百天或至少一百三十五天。

    Medical devices containing segmented polyurethane biomaterials
    37.
    发明授权
    Medical devices containing segmented polyurethane biomaterials 失效
    含有分段聚氨酯生物材料的医疗器械

    公开(公告)号：US06915168B1

    公开(公告)日：2005-07-05

    申请号：US09423332

    申请日：1998-05-08

    申请人： Michael D. Benz ,  Kelvin Bonnema ,  Edward Didomenico ,  Christopher M. Hobot ,  David L. Miller

    发明人： Michael D. Benz ,  Kelvin Bonnema ,  Edward Didomenico ,  Christopher M. Hobot ,  David L. Miller

    IPC分类号： A61L31/06 ,  A61N1/02 ,  A61N1/05

    CPC分类号： A61L31/06

    摘要： In one aspect, the present invention relates to a medical device, such as a medical electrical lead, comprising a biomaterial formed from a polymer comprising urethane groups and saturated linear polyethylene moieties wherein the saturated linear polethylene moieties have greater than 12 carbon atoms per moiety. In another aspect, the present invention relates medical devices comprising a biomaterial formed from segmented polymers or polymers having an elongation of greater than 50%. Exemplified polymers contain compounds of the formula HO—(CH2)n—OH wherein n is greater than 12.

    摘要翻译： 一方面，本发明涉及一种医疗装置，例如医用电导线，其包含由包含氨基甲酸酯基团和饱和线性聚乙烯部分的聚合物形成的生物材料，其中饱和直链极性亚乙基部分每个部分具有大于12个碳原子。 另一方面，本发明涉及包含由具有大于50％的伸长率的分段聚合物或聚合物形成的生物材料的医疗装置。 示例性聚合物含有式HO-（CH 2）n -OH的化合物，其中n大于12。