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公开(公告)号：US4873308A
公开(公告)日：1989-10-10
申请号：US251418
申请日：1988-09-30
IPC分类号： A61L27/00 , C08G18/10 , C08G18/32 , C08G18/38 , C08G18/65 , C08G18/66 , C08G18/73 , C08G18/75
CPC分类号： C08G18/3206 , C08G18/3212 , C08G18/3831 , C08G18/75
摘要： Highly stable, segmented, aliphatic polyurethanes prepared by particular processes are disclosed. The segmented polyurethanes of this invention are substantially free of ester and ether linkages and are found to be particularly hydrolytically and oxidatively stable. The polyurethanes of this invention are prepared by a particular two stage process involving the formation of a prepolymer and subsequent reaction with simultaneously or sequentially added diisocyanate and diol monomers.
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公开(公告)号：US5278200A
公开(公告)日：1994-01-11
申请号：US968796
申请日：1992-10-30
CPC分类号： A61L33/0041 , A61L33/0088
摘要： Biocompatible heparin-like material and surfaces thereof are made by co-polymerization of acrylic acid (AA) and 2-acrylamido-2-methyl propane sulfonic acid (AMPS) and attaching the copolymer to a suitable substrate or blending the copolymer into a suitable substrate. The material produced also possesses surface slip-properties and some decreased bacterial and platelet adherence.
摘要翻译： 通过丙烯酸（AA）和2-丙烯酰氨基-2-甲基丙磺酸（AMPS）的共聚合制备生物相容性肝素样材料及其表面，并将共聚物连接到合适的底物上或将共聚物共混成合适的底物 。 所生产的材料还具有表面滑爽性，并且一些减少的细菌和血小板粘附。
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3.发明授权
公开(公告)号：US5001210A
公开(公告)日：1991-03-19
申请号：US416798
申请日：1989-10-03
CPC分类号： C08G18/5045 , C08G18/3831 , C08G18/61 , C08G71/04
摘要： By reacting polyamines with cyclic carbonates, di-poly-(hydroxyalkyl urethanes) are produced. These diols and polyols are particularly useful for the synthesis of polyurethanes by reaction with diisocyanates or polyisocyanates.
摘要翻译： 通过使多胺与环状碳酸酯反应，生成二聚（羟基烷基氨基甲酸酯）。 这些二醇和多元醇特别可用于通过与二异氰酸酯或多异氰酸酯反应来合成聚氨酯。
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4.发明授权Medical electrical lead with polymeric monolithic controlled release device and method of manufacture 失效具有聚合物单片控制释放装置的医用电线和制造方法
公开(公告)号：US4972848A
公开(公告)日：1990-11-27
申请号：US398220
申请日：1989-08-23
申请人： Edward D. Di Domenico , Christopher M. Hobot , Kenneth B. Stokes , Arthur J. Coury , Phong D. Doan , Richard D. Sandstrom
发明人： Edward D. Di Domenico , Christopher M. Hobot , Kenneth B. Stokes , Arthur J. Coury , Phong D. Doan , Richard D. Sandstrom
CPC分类号： A61K9/0024 , A61K9/2031 , A61K9/7007 , A61N1/0568 , A61N1/0573
摘要： A cardiac pacing lead or other stimulation lead carrying a steroid compounded within a polymer matrix. The steroid is dispersed in thermoplastic or thermoset polyurethane or polyurea forming monomers or prepolymers. The mixture is then chain extended by addition of the appropriate difunctional or multifunctional isocyanate, hydroxyl or amine curing agent to form a solid polymer. The resulting formulation is molded or cast into a desired shape, and incorporated in the distal end of a medical electrical lead, adjacent to or within the electrode. In a preferred embodiment, the medical lead employs an extendable helix which is screwed into body tissue, and the polymer containing the drug takes the form of a generally dimensionally stable annular member mounted to the lead, encircling the helix.
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公开(公告)号：US4883854A
公开(公告)日：1989-11-28
申请号：US251261
申请日：1988-09-30
CPC分类号： C08G18/3831 , C08G18/5045 , C08G18/61 , C08G71/04
摘要： By reacting polyamines with ethylene carbonate, hydroxyethyl urethane diols and polyols are produced. These diols and polyols are particularly useful for the synthesis of polyurethanes by reaction with diisocyanates or polyisocyanates.
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公开(公告)号：US08940315B2
公开(公告)日：2015-01-27
申请号：US12426031
申请日：2009-04-17
CPC分类号： A61K31/197 , A61K9/0024 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of a benzodiazepine, such as midazolam, formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供长时间有效的疼痛治疗。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的苯二氮卓类，如咪达唑仑。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。
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公开(公告)号：US08822546B2
公开(公告)日：2014-09-02
申请号：US12325514
申请日：2008-12-01
申请人： Michael Eric Benz , Christopher M. Hobot , Phillip Edward McDonald , Lian Leon Luo , John Kramer
发明人： Michael Eric Benz , Christopher M. Hobot , Phillip Edward McDonald , Lian Leon Luo , John Kramer
IPC分类号： A61K31/045 , A61K47/34 , A61K31/4168 , A61K9/00 , A61K31/445
CPC分类号： A61K9/0024 , A61K31/4168 , A61K31/445 , A61K47/34
摘要： Flowable pharmaceutical depots are described. The flowable pharmaceutical depot includes a polyester, such as a polylactic acid or a poly(trimethylene carbonate) endcapped with a primary alcohol and a pain relieving therapeutic agent, such as a post operative pain relieving therapeutic agent. Method of making and using the same are also described.
摘要翻译： 描述了可流动药剂库。 可流动的药物贮库包括聚酯，例如聚乳酸或用伯醇封端的聚（碳酸三亚甲基酯）和缓痛治疗剂，如手术后疼痛缓解治疗剂。 还描述了制造和使用它们的方法。
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8.发明申请METHODS AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN COMPRISING A LOCAL ANESTHETIC 有权用于治疗包括局部麻醉的手术后疼痛的方法和组合公开(公告)号：US20090264472A1
公开(公告)日：2009-10-22
申请号：US12420177
申请日：2009-04-08
申请人： Amira Wohabrebbi , William F. McKay , Vanja Margareta King , Danielle L. Biggs , Katara Shaw , Christopher M. Hobot , Phillip Edward McDonald
发明人： Amira Wohabrebbi , William F. McKay , Vanja Margareta King , Danielle L. Biggs , Katara Shaw , Christopher M. Hobot , Phillip Edward McDonald
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , A61K9/0024 , A61K9/146 , A61K9/1647 , A61K9/7007 , A61K31/4458
摘要： The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a polymer and a therapeutically effective amount of a local anesthetic or pharmaceutically acceptable salt thereof, wherein the drug depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the drug depot is capable of releasing (i) a bolus dose of the local anesthetic or pharmaceutically acceptable salt thereof at a site beneath the skin and (ii) a sustained release dose of an effective amount of the local anesthetic or pharmaceutically acceptable salt thereof over a period of at least 4 days.
摘要翻译： 本发明涉及可用于减少，预防或治疗需要这种治疗的患者的手术后疼痛的可植入药物储存库，所述可植入药物储库包含聚合物和治疗有效量的局部麻醉剂或药学上可接受的盐 其中所述药物储存库可植入皮肤下面的部位以减少，预防或治疗手术后疼痛，并且所述药物储库能够释放（i）所述局部麻醉剂或其药学上可接受的盐的推注剂量 （ii）持续释放剂量的有效量的局部麻醉剂或其药学上可接受的盐在至少4天的时间内。
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9.发明申请ALPHA ADRENERGIC RECEPTOR AGONISTS FOR TREATMENT OF INFLAMMATORY DISEASES 有权治疗炎症性疾病的ALPHA ADRENERGIC RECEPTOR AGONISTS公开(公告)号：US20090263450A1
公开(公告)日：2009-10-22
申请号：US12422624
申请日：2009-04-13
申请人： John Myers ZANELLA , William F. McKay , Vanja Margareta King , Christopher M. Hobot , Keith R. Hildebrand
发明人： John Myers ZANELLA , William F. McKay , Vanja Margareta King , Christopher M. Hobot , Keith R. Hildebrand
IPC分类号： A61K31/4168 , A61F2/00 , A61P25/00 , A61P29/00
CPC分类号： A61K31/137 , A61K9/0024 , A61K9/14 , A61K31/415 , A61K31/4162
摘要： Effective treatments of pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease are provided. Through the administration of an effective amount of at least one alpha adrenergic agonist at or near a target site, one can reduce, prevent or treat pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease.
摘要翻译： 提供了对肌腱炎，腕管综合征，t疮综合征，骨关节炎，滑囊炎和/或口腔面部疾病的疼痛和/或炎症的有效治疗。 通过在目标部位处或附近施用有效量的至少一种α肾上腺素能激动剂，可以减少，预防或治疗由腱炎，腕管综合征，t疮综合征，骨关节炎，滑囊炎和/或 口腔疾病。
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10.发明申请Medical Devices and Methods Including Polymers Having Biologically Active Agents Therein 有权包括其中具有生物活性剂的聚合物的医疗设备和方法公开(公告)号：US20090081273A1
公开(公告)日：2009-03-26
申请号：US12234011
申请日：2008-09-19
CPC分类号： A61K38/1875 , A61L27/34 , A61L27/54 , A61L2300/252 , A61L2300/45 , A61L2300/602
摘要： Medical devices and methods including polymers having biologically active agents therein are disclosed. The medical devices can be useful as implantable devices such as orthopedic implants.
摘要翻译： 公开了包括其中具有生物活性剂的聚合物的医疗装置和方法。 医疗设备可用作诸如矫形植入物之类的可植入装置。
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