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公开(公告)号：US08211867B2
公开(公告)日：2012-07-03
申请号：US12740211
申请日：2008-10-29
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , A61K31/407 , A61K31/44 , A61K31/4745 , A61K31/513 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K31/7088 , A61K31/7105 , A61K45/06 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12N2310/3525
摘要： Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.
摘要翻译： 本文提供了用于治疗肝癌的方法。 这些方法包括施用包含修饰的寡核苷酸的化合物，其中修饰的寡核苷酸靶向于miRNA。 本文还提供了用于治疗肝癌的组合物。 这样的组合物包括包含修饰的寡核苷酸的化合物，其中修饰的寡核苷酸靶向于miRNA。 某些miRNA已被鉴定为在肝癌中过度表达，例如肝细胞癌，因此被选择用修饰的寡核苷酸靶向。 此外，某些miRNA已被鉴定为在暴露于二恶英的肝细胞癌细胞中过表达，因此被选择用修饰的寡核苷酸靶向。 已经发现某些这些miRNA的反义抑制抑制细胞增殖并诱导细胞凋亡。
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公开(公告)号：US20100267814A1
公开(公告)日：2010-10-21
申请号：US12740211
申请日：2008-10-29
IPC分类号： A61K31/7125 , A61K31/7088 , A61K31/712 , A61K31/7115 , A61P35/00
CPC分类号： C12N15/113 , A61K31/407 , A61K31/44 , A61K31/4745 , A61K31/513 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K31/7088 , A61K31/7105 , A61K45/06 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12N2310/3525
摘要： Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.
摘要翻译： 本文提供了用于治疗肝癌的方法。 这些方法包括施用包含修饰的寡核苷酸的化合物，其中修饰的寡核苷酸靶向于miRNA。 本文还提供了用于治疗肝癌的组合物。 这样的组合物包括包含修饰的寡核苷酸的化合物，其中修饰的寡核苷酸靶向于miRNA。 某些miRNA已被鉴定为在肝癌中过度表达，例如肝细胞癌，因此被选择用修饰的寡核苷酸靶向。 此外，某些miRNA已被鉴定为在暴露于二恶英的肝细胞癌细胞中过表达，因此被选择用修饰的寡核苷酸靶向。 已经发现某些这些miRNA的反义抑制抑制细胞增殖并诱导细胞凋亡。
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公开(公告)号：US06204055B1
公开(公告)日：2001-03-20
申请号：US09290640
申请日：1999-04-12
IPC分类号： C07H2104
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for inhibiting Fas mediated signaling. The compositions comprise antisense compounds targeted to nucleic acids encoding Fas, FasL and Fap-1. Methods of using these antisense compounds for inhibition of Fas, FasL and Fap-1 expression and for treatment of diseases, particularly autoimmune and inflammatory diseases and cancers, associated with overexpression or constitutive activation of Fas, FasL or Fap-1 are provided.
摘要翻译： 提供化合物，组合物和方法用于抑制Fas介导的信号传导。 组合物包含靶向编码Fas，FasL和Fap-1的核酸的反义化合物。 提供了使用这些反义化合物抑制Fas，FasL和Fap-1表达以及治疗与Fas，FasL或Fap-1的过度表达或组成型激活相关的疾病，特别是自身免疫性和炎性疾病和癌症的方法。
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34.发明授权Identification of novel pathways, genes and promoter motifs regulating adipogenesis 失效鉴定调节脂肪形成的新途径，基因和启动子基序公开(公告)号：US07759318B1
公开(公告)日：2010-07-20
申请号：US11140437
申请日：2005-05-27
IPC分类号： A61K48/00
CPC分类号： C07K14/70567 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： The present invention provides compounds, compositions, and methods for identification of motifs within regulatory regions of genes involved in adipogenesis and adipocyte differentiation. Compounds and compositions are provided for modulating expression of nuclear receptor/transcription factor-regulated genes. Methods for modulating the function of PPAR-γ as well as PPAR-γ-regulated gene promoters, and methods of using oligomeric compounds for diagnosis and treatment of diseases such as obesity and diabetes are also provided.
摘要翻译： 本发明提供用于鉴定参与脂肪形成和脂肪细胞分化的基因调节区内的基序的化合物，组合物和方法。 提供化合物和组合物用于调节核受体/转录因子调节基因的表达。 还提供了调节PPAR-γ的功能以及PPAR-γ调节的基因启动子的方法，以及使用低聚化合物诊断和治疗诸如肥胖和糖尿病等疾病的方法。
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公开(公告)号：US6001992A
公开(公告)日：1999-12-14
申请号：US226568
申请日：1999-01-07
IPC分类号： C12N15/09 , A61K31/7105 , A61K31/711 , A61K31/712 , A61K31/7125 , A61K33/24 , A61K45/00 , A61K48/00 , A61P35/00 , C12N5/10 , C12N15/113 , C07H21/04 , C07H21/02 , C12N15/63 , C12Q1/68
CPC分类号： C12N15/1135 , C12N15/113 , C12N2310/315 , C12N2310/318 , C12N2310/3181 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , Y02P20/582
摘要： Compositions and methods are provided for modulating the expression of novel anti-apoptotic bcl-2-related proteins. Antisense oligonucleotides targeted to nucleic acids encoding the human novel anti-apoptotic bcl-2-related proteins A1 and mcl-1 are preferred. Methods of using these compounds for modulation of novel anti-apoptotic bcl-2-related protein expression and for treatment of diseases associated with expression of novel anti-apoptotic bcl-2-related proteins are also provided. Also provided are methods of using these compounds for promoting apoptosis and for treatment of diseases for which promotion of apoptosis is desired.
摘要翻译： 提供组合物和方法用于调节新型抗凋亡性bcl-2相关蛋白的表达。 靶向编码人类新型抗凋亡性bcl-2相关蛋白A1和mcl-1的核酸的反义寡核苷酸是优选的。 还提供了使用这些化合物调节新型抗凋亡性bcl-2相关蛋白表达和治疗与抗细胞凋亡性bcl-2相关蛋白表达相关的疾病的方法。 还提供了使用这些化合物促进细胞凋亡和治疗需要促进细胞凋亡的疾病的方法。
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公开(公告)号：US20120295962A1
公开(公告)日：2012-11-22
申请号：US13481105
申请日：2012-05-25
IPC分类号： A61K31/7088 , A61P35/00 , A61K31/7115 , A61K31/7125 , A61K31/712
CPC分类号： C12N15/113 , A61K31/407 , A61K31/44 , A61K31/4745 , A61K31/513 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K31/7088 , A61K31/7105 , A61K45/06 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12N2310/3525
摘要： Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.
摘要翻译： 本文提供了用于治疗肝癌的方法。 这些方法包括施用包含修饰的寡核苷酸的化合物，其中修饰的寡核苷酸靶向于miRNA。 本文还提供了用于治疗肝癌的组合物。 这样的组合物包括包含修饰的寡核苷酸的化合物，其中修饰的寡核苷酸靶向于miRNA。 某些miRNA已被鉴定为在肝癌中过度表达，例如肝细胞癌，因此被选择用修饰的寡核苷酸靶向。 此外，某些miRNA已被鉴定为在暴露于二恶英的肝细胞癌细胞中过表达，因此被选择用修饰的寡核苷酸靶向。 已经发现某些这些miRNA的反义抑制抑制细胞增殖并诱导细胞凋亡。
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公开(公告)号：US07618947B2
公开(公告)日：2009-11-17
申请号：US11213593
申请日：2005-08-25
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1-beta. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1-beta. Methods of using these compounds for modulation of HIF1-beta expression and for diagnosis and treatment of diseases and conditions associated with expression of HIF1-beta are provided.
摘要翻译： 提供化合物，组合物和方法用于调节HIF1-β的表达。 组合物包含靶向编码HIF1-β的核酸的寡核苷酸。 提供了使用这些化合物调节HIF1-β表达和用于诊断和治疗与HIF1-β表达相关的疾病和病症的方法。
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公开(公告)号：US20100317718A1
公开(公告)日：2010-12-16
申请号：US12846746
申请日：2010-07-29
申请人： Eric G. Marcusson , Scott Henry , Youngsoo Kim , Kenneth W. Dobie
发明人： Eric G. Marcusson , Scott Henry , Youngsoo Kim , Kenneth W. Dobie
IPC分类号： A61K31/7125 , C07H21/00 , A61K31/712 , A61K31/7115 , A61P35/00 , A61P27/02
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1-beta. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1-beta. Methods of using these compounds for modulation of HIF1-beta expression and for diagnosis and treatment of diseases and conditions associated with expression of HIF1-beta are provided.
摘要翻译： 提供化合物，组合物和方法用于调节HIF1-β的表达。 组合物包含靶向编码HIF1-β的核酸的寡核苷酸。 提供了使用这些化合物调节HIF1-β表达和用于诊断和治疗与HIF1-β表达相关的疾病和病症的方法。
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公开(公告)号：US06653133B1
公开(公告)日：2003-11-25
申请号：US09665615
申请日：2000-09-18
IPC分类号： C07H2104
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for inhibiting Fas mediated signaling. The compositions comprise antisense compounds targeted to nucleic acids encoding Fas, FasL and Fap-1. Methods of using these antisense compounds for inhibition of Fas, FasL and Fap-1 expression and for treatment of diseases, particularly autoimmune and inflammatory diseases and cancers, associated with overexpression or constitutive activation of Fas, FasL or Fap-1 are provided.
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