公开(公告)号：US5883284A

公开(公告)日：1999-03-16

申请号：US98538

申请日：1998-06-17

申请人： Takayuki Suzuki ,  Yutaka Honda ,  Kunisuke Izawa

发明人： Takayuki Suzuki ,  Yutaka Honda ,  Kunisuke Izawa

IPC分类号： C07C317/28 ,  C07C323/29 ,  C07C327/30 ,  C07C323/43 ,  C07C323/25 ,  C07C323/41

CPC分类号： C07C323/29 ,  C07C317/28 ,  C07C327/30

摘要： The present invention provides a simple and inexpensive method for producing .alpha.-hydroxy-.beta.-aminocarboxylic acids and their esters.An ester of an N-protected .alpha.-amino acid ester is converted into a .beta.-ketosulfoxide, which is then processed with an acid to give an .alpha.-ketohemimercaptal. Next, this is acylated and then processed with a base to obtain an N-protected .alpha.-acyloxy-.beta.-amino-thioester, which is then saponified to obtain an intended compound. According to the method of the present invention, it is possible to produce .alpha.-hydroxy-.beta.-aminocarboxylic acid derivatives, which are intermediates in producing various HIV protease inhibitors, renin inhibitors and carcinostatics, from a-amino acids. The method comprises reduced reaction steps, the selectivity in the method to give the intended product is high, and the yield of the product obtained is high.

摘要翻译： 本发明提供了用于生产α-羟基-β-氨基羧酸及其酯的简单和便宜的方法。 将N-保护的α-氨基酸酯的酯转化成β-酮亚砜，然后用酸处理，得到α-酮基二巯基。 接下来，将其进行酰化，然后用碱处理，得到N-保护的α-酰氧基-β-氨基 - 硫代酯，然后皂化，得到目标化合物。 根据本发明的方法，可以生产α-羟基-β-氨基羧酸衍生物，它们是从α-氨基酸生产各种HIV蛋白酶抑制剂，肾素抑制剂和制癌剂的中间体。 该方法包括减少反应步骤，得到所需产物的方法中的选择性高，所得产物的产率高。

公开(公告)号：US5466793A

公开(公告)日：1995-11-14

申请号：US860605

申请日：1992-03-30

申请人： Yutaka Honda ,  Hiroshi Shiragami ,  Hisao Iwagami ,  Masayuki Arai

发明人： Yutaka Honda ,  Hiroshi Shiragami ,  Hisao Iwagami ,  Masayuki Arai

IPC分类号： C07H19/04 ,  C07H19/06 ,  C07H19/16 ,  C07H19/173 ,  C07H19/073

CPC分类号： C07H19/04 ,  C07H19/06 ,  C07H19/16 ,  Y02P20/55

摘要： A process for preparing 2',3'-dideoxyinosine comprising reducing a nucleoside of the formula IIIa or IIIb ##STR1## wherein R.sup.2 is hydrogen, C.sub.1-12 acyl, C.sub.1-12 alkyl, C.sub.7-8 aralkyl or a silyl protecting group; X is Cl, Br, or I; R.sub.5 is C.sub.1-12 acyl; H.sub.x is hypoxanthine; with hydrogen in the presence of a palladium catalyst; wherein said reduction is conducted in a solvent containing a base of pH 9-11 and wherein the solvent is acetonitrile, aqueous acetonitrile, aqueous ethyl acetate, or aqueous methanol.

摘要翻译： 制备2'，3'-二脱氧肌苷的方法，包括还原式IIIa或IIIb的核苷（IIIa）（IIIb）其中R2是氢，C1-12酰基，C1-12烷基，C7- 8芳烷基或甲硅烷基保护基; X是Cl，Br或I; R5是C1-12酰基; Hx是次黄嘌呤; 在钯催化剂存在下用氢气; 其中所述还原在含有pH9-11的碱的溶剂中进行，其中溶剂是乙腈，乙腈水溶液，乙酸乙酯水溶液或甲醇水溶液。

公开(公告)号：US08491163B2

公开(公告)日：2013-07-23

申请号：US12885030

申请日：2010-09-17

申请人： Kazunari Higuchi ,  Takayoshi Moriyama ,  Yutaka Honda ,  Kenji Nezu ,  Shinichi Kumashiro

发明人： Kazunari Higuchi ,  Takayoshi Moriyama ,  Yutaka Honda ,  Kenji Nezu ,  Shinichi Kumashiro

IPC分类号： F21V29/00

CPC分类号： F21S8/026 ,  F21V17/162 ,  F21V21/04 ,  F21Y2105/10 ,  F21Y2115/10

摘要： According to one embodiment, a lighting apparatus includes a main body including a flat thermal conduction surface. The thermal conduction surface contacts a back surface of a board. Light-emitting devices are mounted on a front surface of the board. An optical member is opposed to a peripheral part of the board on the front surface side of the board. The optical member is fastened to the main body by fastening members, to push the peripheral part of the board against the heat conduction surface of the main body.

摘要翻译： 根据一个实施例，照明装置包括主体，其包括平坦的热传导表面。 导热表面接触板的背面。 发光装置安装在板的前表面上。 光学构件与板的前表面侧上的板的周边部分相对。 光学构件通过紧固构件紧固到主体，以将板的周边部分推靠在主体的导热表面上。

公开(公告)号：US20110075427A1

公开(公告)日：2011-03-31

申请号：US12885030

申请日：2010-09-17

申请人： Kazunari Higuchi ,  Takayoshi Moriyama ,  Yutaka Honda ,  Kenji Nezu ,  Shinichi Kumashiro

发明人： Kazunari Higuchi ,  Takayoshi Moriyama ,  Yutaka Honda ,  Kenji Nezu ,  Shinichi Kumashiro

IPC分类号： F21V29/00

CPC分类号： F21S8/026 ,  F21V17/162 ,  F21V21/04 ,  F21Y2105/10 ,  F21Y2115/10

摘要： According to one embodiment, a lighting apparatus includes a main body including a flat thermal conduction surface. The thermal conduction surface contacts a back surface of a board. Light-emitting devices are mounted on a front surface of the board. An optical member is opposed to a peripheral part of the board on the front surface side of the board. The optical member is fastened to the main body by fastening members, to push the peripheral part of the board against the heat conduction surface of the main body.

摘要翻译： 根据一个实施例，照明装置包括主体，其包括平坦的热传导表面。 导热表面接触板的背面。 发光装置安装在板的前表面上。 光学构件与板的前表面侧上的板的周边部分相对。 光学构件通过紧固构件紧固到主体，以将板的周边部分推靠在主体的导热表面上。

公开(公告)号：US20100038657A1

公开(公告)日：2010-02-18

申请号：US12582721

申请日：2009-10-21

申请人： Kazunari HIGUCHI ,  Takayoshi Moriyama ,  Sumio Hashimoto ,  Shinichi Kumashiro ,  Yutaka Honda ,  Kenji Nezu

发明人： Kazunari HIGUCHI ,  Takayoshi Moriyama ,  Sumio Hashimoto ,  Shinichi Kumashiro ,  Yutaka Honda ,  Kenji Nezu

IPC分类号： H01L33/00

CPC分类号： F21S8/02 ,  F21S8/026 ,  F21V7/0083 ,  F21V21/04 ,  F21V23/026 ,  F21V29/507 ,  F21V29/75 ,  F21V29/76 ,  F21V29/77 ,  F21Y2115/10

摘要： A lighting apparatus is provided with a plurality of light-emitting devices, a substrate, a blind member, and a reflector. The reflector is formed with a plurality of reflective surfaces corresponding to the light-emitting devices, individually. The shielding angle at which light emitted from that one of the light-emitting devices which is located on the outermost periphery is intercepted by the reflective surface corresponding to the outermost light-emitting device is greater than shielding angles at which light emitted from the light-emitting devices located inside the outermost light-emitting device is intercepted by the reflective surfaces corresponding to the inside light-emitting devices.

摘要翻译： 照明装置设置有多个发光装置，基板，遮光部件和反射板。 反射器分别形成有与发光装置对应的多个反射面。 从位于最外侧的发光装置的一个发光装置发出的光被与最外侧的发光装置对应的反射面截取的遮蔽角度大于从发光装置发出的光的遮蔽角度， 位于最外侧的发光装置内的发光装置被对应于内部发光装置的反射面截取。

公开(公告)号：US20050228175A1

公开(公告)日：2005-10-13

申请号：US11076877

申请日：2005-03-11

申请人： Sachiko Oka ,  Yutaka Honda ,  Kunisuke Izawa

发明人： Sachiko Oka ,  Yutaka Honda ,  Kunisuke Izawa

IPC分类号： C07D317/22 ,  C07H1/00

CPC分类号： C07H15/04 ,  C07D317/22 ,  C07H1/00 ,  C07H3/02 ,  Y02P20/55

摘要： 2-Deoxy-L-ribose may be prepared by reacting a compound represented by formula (1) with an organometallic compound represented by formula (2) to give a compound represented by formula (3), which is then subjected to deprotection of a hydroxyl group and production of aldehyde by acid hydrolysis: wherein R1 and R2 are each independently a hydroxyl-protecting group or R1 and R2 in combination form a hydroxyl-protecting group, R3 and R4 are each independently an alkyl group, an aralkyl group, an aryl group or a silyl group or R3 and R4 in combination form an alkylene group.

摘要翻译： 2-脱氧-L-核糖可以通过使由式（1）表示的化合物与由式（2）表示的有机金属化合物反应得到由式（3）表示的化合物，然后将其脱羟基 通过酸水解组合和生产醛：其中R 1和R 2各自独立地是羟基保护基或R 1和R 2， SUP> 2组合形成羟基保护基，R 3和R 4各自独立地为烷基，芳烷基，芳基或 甲硅烷基或R 3和R 4组合形成亚烷基。

公开(公告)号：US6051722A

公开(公告)日：2000-04-18

申请号：US110368

申请日：1998-07-06

申请人： Yutaka Honda ,  Iwao Fukuchi ,  Kwan-Yue Alex Jen

发明人： Yutaka Honda ,  Iwao Fukuchi ,  Kwan-Yue Alex Jen

IPC分类号： C07D491/052 ,  C07D311/58 ,  C07D405/06 ,  C07D409/14 ,  C07D493/04 ,  C07D495/04 ,  G02F1/35 ,  G02F1/355 ,  G02F1/361 ,  C07D311/76

CPC分类号： G02F1/3617 ,  C07D311/58 ,  G02F1/3611

摘要： The present invention provides, as heteroaromatic compounds made functional so as to be used for nonlinear optical materials, compounds represented by the following general formula (1), and also provides polymers obtained from these and nonlinear optical parts comprising such polymers. In the formula, Ar.sup.1 and Ar.sup.2 each represents a divalent aromatic group; R.sup.1, R.sup.2 and R.sup.3 each represents an atom or a group independently selected from a hydrogen atom or an alkyl group and an aromatic group; X.sup.1 represents a monovalent organic group; n represents an integer of 2 to 12; and Z.sup.1 and Z.sup.2 each represents a group independently selected from electron attractive functional groups. ##STR1##

摘要翻译： 本发明提供作为用于非线性光学材料的功能性的杂芳族化合物，由以下通式（1）表示的化合物，还提供由这些聚合物和包含这些聚合物的非线性光学部件获得的聚合物。 式中，Ar 1和Ar 2分别表示二价芳香族基团。 R1，R2和R3各自表示独立地选自氢原子或烷基和芳族基团的原子或基团; X1表示一价有机基团; n表示2〜12的整数， Z1和Z2各自表示独立地选自吸电子官能团的基团。

公开(公告)号：US5817859A

公开(公告)日：1998-10-06

申请号：US878079

申请日：1997-06-18

申请人： Takayuki Suzuki ,  Yutaka Honda ,  Kunisuke Izawa

发明人： Takayuki Suzuki ,  Yutaka Honda ,  Kunisuke Izawa

IPC分类号： C07C317/28 ,  C07C323/29 ,  C07C327/30 ,  C07C327/22

CPC分类号： C07C323/29 ,  C07C317/28 ,  C07C327/30

摘要： The present invention provides a simple and inexpensive method for producing a-hydroxy-.beta.-aminocarboxylic acids and their esters. An ester of an N-protected .alpha.-amino acid ester is converted into a .beta.-ketosulfoxide, which is then processed with an acid to give an .alpha.-ketohemimercaptal. Next, this is acylated and then processed with a base to obtain an N-protected .alpha.-acyloxy-.beta.-amino-thioester, which is then saponified to obtain an intended compound. According to the method of the present invention, it is possible to produce .alpha.-hydroxy-.beta.-aminocarboxylic acid derivatives, which are intermediates in producing various HIV protease inhibitors, renin inhibitors and carcinostatics, from a-amino acids. The method comprises reduced reaction steps, the selectivity in the method to give the intended product is high, and the yield of the product obtained is high.

摘要翻译： 本发明提供了一种简单且廉价的α-羟基-β-氨基羧酸及其酯的制备方法。 将N-保护的α-氨基酸酯的酯转化成β-酮亚砜，然后用酸处理，得到α-酮基二巯基。 接下来，将其进行酰化，然后用碱处理，得到N-保护的α-酰氧基-β-氨基 - 硫代酯，然后皂化，得到目标化合物。 根据本发明的方法，可以生产α-羟基-β-氨基羧酸衍生物，它们是从α-氨基酸生产各种HIV蛋白酶抑制剂，肾素抑制剂和制癌剂的中间体。 该方法包括减少反应步骤，得到所需产物的方法中的选择性高，所得产物的产率高。

公开(公告)号：US5705671A

公开(公告)日：1998-01-06

申请号：US725714

申请日：1996-10-04

申请人： Takayuki Suzuki ,  Yutaka Honda ,  Kunisuke Izawa

发明人： Takayuki Suzuki ,  Yutaka Honda ,  Kunisuke Izawa

IPC分类号： C07C317/28 ,  C07C323/29 ,  C07C327/30 ,  C07C327/22

CPC分类号： C07C323/29 ,  C07C317/28 ,  C07C327/30

摘要： The present invention provides a simple and inexpensive method for producing .alpha.-hydroxy-.beta.-aminocarboxylic acids and their esters. An ester of an N-protected .alpha.-amino acid ester is converted into a .beta.-ketosulfoxide, which is then processed with an acid to give an .alpha.-ketohemimercaptal. Next, this is acylated and then processed with a base to obtain an N-protected .alpha.-acyloxy-.beta.-amino-thioester, which is then saponified to obtain an intended compound. According to the method of the present invention, it is possible to produce .alpha.-hydroxy-.beta.-aminocarboxylic acid derivatives, which are intermediates in producing various HIV protease inhibitors, renin inhibitors and carcinostatics, from a-amino acids. The method comprises reduced reaction steps, the selectivity in the method to give the intended product is high, and the yield of the product obtained is high.

公开(公告)号：US5688546A

公开(公告)日：1997-11-18

申请号：US504136

申请日：1995-07-19

申请人： Keigo Shima ,  Tsutomu Harada ,  Eiichiro Suzuki ,  Yutaka Honda

发明人： Keigo Shima ,  Tsutomu Harada ,  Eiichiro Suzuki ,  Yutaka Honda

IPC分类号： A23L27/00 ,  A23L27/10 ,  A23L27/20 ,  A23L27/21 ,  A23L27/22 ,  C07C229/16 ,  C07C279/14 ,  C07D233/88 ,  A23L1/22

CPC分类号： C07D233/88 ,  A23L27/2054 ,  A23L27/21 ,  A23L27/82 ,  C07C279/14

摘要： A seasoning composition containing food and an amino acid derivative that imparts a "thick, sour taste" to the food.

摘要翻译： 含有食物和氨基酸衍生物的调味料组合物，赋予食物“浓酸味”。