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49 条记录 (耗时 0.033 秒)

    Microprojection apparatus and system with low infection potential
    31.
    发明申请
    Microprojection apparatus and system with low infection potential 审中-公开
    具有低感染潜力的微型投影仪和系统

    公开(公告)号：US20060034902A1

    公开(公告)日：2006-02-16

    申请号：US11201617

    申请日：2005-08-10

    申请人： Michel Cormier ,  Peter Daddona ,  Rolfe Anderson

    发明人： Michel Cormier ,  Peter Daddona ,  Rolfe Anderson

    IPC分类号： A61F13/02 ,  A61L15/16

    CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61K9/06 ,  A61M2037/0023 ,  A61M2037/0046

    摘要： A transdermal agent delivery apparatus and system having a low infection potential comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the microprojection member includes a biocompatible coating having at least one biologically active agent and at least one antimicrobial agent disposed therein. In another embodiment, the microprojection member includes a hydrogel formulation having at least one biologically active agent and at least one antimicrobial agent. In yet another embodiment, the microprojection member includes a hydrogel formulation having at least one antimicrobial agent and a solid film having at least one biologically active agent.

    摘要翻译： 具有低感染潜能的透皮药物递送装置和系统包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或其阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层， 或表皮和真皮层。 在一个实施方案中，微突出物构件包括具有至少一种生物活性剂和设置在其中的至少一种抗微生物剂的生物相容性涂层。 在另一个实施方案中，微突出物构件包括具有至少一种生物活性剂和至少一种抗微生物剂的水凝胶制剂。 在另一个实施方案中，微突出物构件包括具有至少一种抗微生物剂和具有至少一种生物活性剂的固体膜的水凝胶制剂。

    Apparatus and method for transdermal delivery of fentanyl-based agents
    33.
    发明申请
    Apparatus and method for transdermal delivery of fentanyl-based agents 审中-公开
    用于透皮递送芬太尼基药剂的装置和方法

    公开(公告)号：US20050226922A1

    公开(公告)日：2005-10-13

    申请号：US11084636

    申请日：2005-03-18

    申请人： Mahmoud Ameri ,  Michel Cormier ,  Yuh-Fun Maa ,  Peter Daddona

    发明人： Mahmoud Ameri ,  Michel Cormier ,  Yuh-Fun Maa ,  Peter Daddona

    IPC分类号： A61K9/70 ,  A61K31/445 ,  A61M37/00

    CPC分类号： A61K9/0021 ,  A61K31/445 ,  A61M37/0015 ,  A61M2037/0023

    摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the fentanyl-based agent is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having a fentanyl-based agent-containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the fentanyl-based agent is contained in both the coating and the hydrogel formulation.

    摘要翻译： 一种用于透皮递送生物活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或 表皮和真皮层。 在一个实施方案中，基于芬太尼的药剂包含在施加到微突出物构件的生物相容性涂层中。 在另一个实施方案中，递送系统包括具有含有基于芬太尼的药剂的水凝胶制剂的凝胶包，其在施用到患者皮肤之后设置在微突出物构件上。 在替代实施方案中，基于芬太尼的药剂包含在包衣和水凝胶制剂中。

    Peptidically buffered formulations for electrotransport applications and methods of making
    35.
    发明申请
    Peptidically buffered formulations for electrotransport applications and methods of making 审中-公开
    用于电转运应用的肽缓冲制剂和制备方法

    公开(公告)号：US20050142531A1

    公开(公告)日：2005-06-30

    申请号：US10993649

    申请日：2004-11-19

    申请人： David Rauser ,  Rama Padmanabhan ,  Joseph Phipps ,  Michel Cormier

    发明人： David Rauser ,  Rama Padmanabhan ,  Joseph Phipps ,  Michel Cormier

    IPC分类号： A01N1/00 ,  A61K9/00 ,  A61K31/74 ,  A61N1/30

    CPC分类号： A61N1/0448 ,  A61K9/0095 ,  A61N1/0412

    摘要： Methods for preparing compositions for use in electrotransport delivery systems. The method includes providing a drug solution comprising drug ions and associated counterions; adjusting the pH of the drug solution by contacting the drug solution with a ion exchange material first; separating the ion exchange material from the pH-adjusted drug solution; and buffering the pH-adjusted drug solution with a buffer. A peptidic buffer is preferably used. The methods result in compositions suitable for use in electrotransport delivery systems.

    摘要翻译： 制备用于电转运系统的组合物的方法。 该方法包括提供包含药物离子和相关联的抗衡离子的药物溶液; 首先通过使药液与离子交换材料接触来调节药液的pH值; 将离子交换材料与pH调节药液分离; 并用缓冲液缓冲pH调节的药物溶液。 优选使用肽缓冲剂。 该方法导致组合物适用于电转运递送系统。

    Pretreatment method and system for enhancing transdermal drug delivery
    36.
    发明申请
    Pretreatment method and system for enhancing transdermal drug delivery 审中-公开
    增强透皮药物输送的预处理方法和系统

    公开(公告)号：US20050106226A1

    公开(公告)日：2005-05-19

    申请号：US10970901

    申请日：2004-10-21

    申请人： Michel Cormier ,  WeiQi Lin ,  Juanita Johnson ,  Kofi Nyam

    发明人： Michel Cormier ,  WeiQi Lin ,  Juanita Johnson ,  Kofi Nyam

    IPC分类号： A61F13/00 ,  A61K9/00 ,  A61K9/70 ,  A61M20060101 ,  A61M37/00

    CPC分类号： A61K9/7084 ,  A61K9/0021 ,  A61K9/703 ,  A61M37/0015 ,  A61M2037/0023

    摘要： A drug delivery system for delivering a biologically active agent through the skin of a patient comprises (i) a pretreatment patch adapted to be placed on the patient's skin, the pretreatment patch having a backing membrane and a microprojection array, the microprojection array being adhered to the backing membrane, the microprojection array including a plurality of microprojections adapted to pierce the stratum corneum of the patient, the pretreatment patch including a skin template that remains on the patient's skin after the pretreatment patch is applied to and removed from the patient's skin, and (ii) a gel patch having a top and bottom surface, the gel patch including a reservoir containing a hydrogel formulation, the gel patch having a skin contact area in the range of approximately 0.5-30 cm2.

    摘要翻译： 用于递送生物活性剂通过患者皮肤的药物递送系统包括（i）适于放置在患者皮肤上的预处理贴剂，所述预处理贴片具有背衬膜和微突出物阵列，所述微突出物阵列粘附到 所述背衬膜，所述微突出物阵列包括适于刺穿所述患者角质层的多个微突出物，所述预处理贴片包括在将所述预处理贴片施加到患者皮肤并从患者皮肤移除之后残留在患者皮肤上的皮肤模板，以及 （ii）具有顶部和底部表面的凝胶贴片，所述凝胶贴片包括含有水凝胶制剂的储存器，所述凝胶贴片具有在约0.5-30cm 2范围内的皮肤接触面积。