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31.发明申请Process for the preparation of the amorphous form of atorvastatin calcium salt 审中-公开制备无定型阿托伐他汀钙盐的方法公开(公告)号：US20060128971A1
公开(公告)日：2006-06-15
申请号：US10512895
申请日：2003-04-25
IPC分类号： A61K31/401 , C07D207/333
CPC分类号： C07D207/34
摘要： Process for preparing atorvastatin calcium salt in amorphous form comprising: a) dissolving the atorvastatin calcium salt in an organic solvent miscible with water, b) gradually adding said solution to water while stirring, c) filtering and vacuum drying the solid obtained. Formula
摘要翻译： 制备无定形形式的阿托伐他汀钙盐的方法，包括：a）将阿托伐他汀钙盐溶解在与水混溶的有机溶剂中，b）在搅拌下逐渐加入所述溶液，c）过滤并真空干燥得到的固体。 式
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32.发明申请Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propaneamine 失效制备N，N-二异丙基-3-（2-羟基-5-甲基苯基）-3-苯基 - 丙胺的方法公开(公告)号：US20060079716A1
公开(公告)日：2006-04-13
申请号：US11244396
申请日：2005-10-06
IPC分类号： C07C209/18
CPC分类号： C07C215/54 , C07C303/28 , Y02P20/542 , C07C309/73
摘要： A process is described for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propaneamine comprising substitution of the sulfonyloxy group of the compound of the formula in which the substituents R and R″ have the meanings stated in the description, in a solvent comprising an ionic liquid, to yield the tertiary amine of the formula and the subsequent deprotection thereof.
摘要翻译： 描述了制备N，N-二异丙基-3-（2-羟基-5-甲基苯基）-3-苯基 - 丙胺的方法，其包括将下式化合物的磺酰氧基取代，其中取代基R和R “具有说明书中所述的含义，在含有离子液体的溶剂中，得到下式的叔胺，随后将其脱保护。
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33.发明申请Process for the preparation of sulphinyl derivatives by oxidation of the corresponding sulfides 失效通过氧化相应硫化物制备亚磺酰基衍生物的方法公开(公告)号：US20060014798A1
公开(公告)日：2006-01-19
申请号：US11149544
申请日：2005-06-10
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D401/12
摘要： The present invention relates to a mild and industrially applicable process for preparing sulfinyl derivatives of Formula (II), useful as inhibitors of gastric acid secretion, comprising the selective oxidation of the corresponding sulfides of Formula (I), as represented in scheme (I) and (II) in which said oxidation is performed with hydrogen peroxide in the presence of low amounts of a rhenium compound as catalyst, at a temperature from 0° C. to room temperature.
摘要翻译： 本发明涉及用于制备式（II）的亚磺酰基衍生物的温和和工业上适用的方法，其可用作胃酸分泌的抑制剂，其包括如方案（I）所示的相应的式（I）硫化物的选择性氧化， 和（II），其中在少量的铼化合物作为催化剂的存在下，在0℃至室温的温度下，用过氧化氢进行所述氧化。
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公开(公告)号：USRE43764E1
公开(公告)日：2012-10-23
申请号：US13167785
申请日：2011-06-24
申请人： Lorenzo De Ferra , Pietro Massardo
发明人： Lorenzo De Ferra , Pietro Massardo
IPC分类号： C12P13/06
CPC分类号： C07F9/103
摘要： The present invention relates to a purifying process for phosphatidylserine, the latter being prepared by trans-phosphatidylation of phosphatidylcholine with serine in presence of the enzyme D-phospholipase and containing as impurities hydrophilic compounds, proteins and inorganic salts.
摘要翻译： 本发明涉及一种磷脂酰丝氨酸的纯化方法，后者是通过在酶D-磷脂酶存在下用丝氨酸反磷脂酰化制备的，并含有杂质亲水性化合物，蛋白质和无机盐。
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公开(公告)号：US5315023A
公开(公告)日：1994-05-24
申请号：US27946
申请日：1993-03-08
CPC分类号： C07F9/091
摘要： A process for the preparation of highly pure deacylated glycerophosphorylcholine, glycerophosphorylethanolamine and glicerophosphorylserine starting from mixtures of the corresponding acylated derivatives.The process according to the invention is characterized in that the deacylation reaction, by means of alcoholysis, and the fractionation are carried out in a single step in a reactor containing a basic ion-exchange resin.
摘要翻译： 从相应的酰化衍生物的混合物开始制备高纯度脱酰基甘油磷酰胆碱，甘油磷酸乙醇胺和起始磷酸丝氨酸的方法。 根据本发明的方法的特征在于通过醇解和脱分解反应在单一步骤中在含有碱性离子交换树脂的反应器中进行。
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公开(公告)号：US4968847A
公开(公告)日：1990-11-06
申请号：US495417
申请日：1990-03-19
申请人： Pietro Massardo , Franco Bettarini , Paolo Piccardi , Franco Rama
发明人： Pietro Massardo , Franco Bettarini , Paolo Piccardi , Franco Rama
IPC分类号： C07C29/64 , C07C43/23 , C07C45/68 , C07C47/195 , C07C47/56 , C07C205/26 , C07D213/30 , C07D307/42 , C07D333/16
CPC分类号： C07D213/30 , C07C205/26 , C07C29/64 , C07C43/23 , C07C45/68 , C07C47/195 , C07C47/56 , C07D307/42 , C07D333/16
摘要： There is disclosed a process for preparing polyhalogenated carbinols having formula: ##STR1## by reacting a compound having formula: ##STR2## with a system consisting of a compound having formula: ##STR3## and of a divalent metal or of a metal salt, in protic dipolar solvents, in which formulaeR=H, an alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkadienyl, phenyl, naphthyl, anthracyl group, a heterocyclic radical, optionally substituted;R'=H, a haloalkyl, --CN, --COOR" group with R" equal to H or to an alkyl group;X.sup.1 =Cl, Br; .dbd.X.sup.2 =F, Cl, Br;X.sup.3 =Cl, Br, CF.sub.3, CCl.sub.3 ; Y=Br or Cl when X.sup.1, X.sup.2 and X.sup.3 are different from Br.
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37.发明授权Method for combatting infestations of insects and acari, and compositions for use in said method 失效防治昆虫和螨虫侵袭的方法，以及用于所述方法的组合物
公开(公告)号：US4540711A
公开(公告)日：1985-09-10
申请号：US482261
申请日：1983-04-05
IPC分类号： A01N31/16 , C07C43/225 , C07C43/23 , A01N31/14
CPC分类号： C07C43/225 , A01N31/16 , C07C43/23
摘要： There is disclosed a method for fighting infestations of acari or noxious insects including ants, more particularly "fire-ants", by treating the insect, its habitat, or its food with a hydroquinone diether having at least one acetylenic and halogen-substituted chain and selected from 1-[(5-chloro-pent-4-inyl)-oxy]-4-phenoxybenzene of formula ##STR1## and 1,4-di-(5-chloro-4-pentinyloxy)-benzene of formula ##STR2## The disclosure comprises a method for fighting ants using the diether of formula (I) either as such or as an active ingredient of suitable formulations or poisoned baits.
摘要翻译： 公开了一种通过用具有至少一个炔属和卤素取代的链的对苯二酚二醚处理昆虫，其栖息地或其食物来对抗包括蚂蚁，特别是“火蚁”的蜱虫或有害昆虫的侵染的方法，以及 选自式（I）的1 - [（5-氯 - 戊-4-烯基） - 氧基] -4-苯氧基苯和1,4-二 - （5-氯-4-戊烯氧基） - 苯， （II）本公开内容包括使用式（I）的二醚作为合适制剂或中毒诱饵的活性成分的方法。
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公开(公告)号：US4503042A
公开(公告)日：1985-03-05
申请号：US413830
申请日：1982-09-01
CPC分类号： A01N59/20
摘要： Acaricide mixtures obtained from the synergistic coupling of an acaricide belonging to the class of the hydroquinone diethers with metallic copper or copper compounds and the use of said mixtures in suitable compositions in the treatment of mite infestations on useful plants are disclosed.
摘要翻译： 公开了由属于对苯二酚二醚类的杀螨剂与金属铜或铜化合物的协同偶联获得的杀螨剂混合物，以及在合适的组合物中使用所述混合物来治疗有用植物上的螨虫侵袭。
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公开(公告)号：US4334104A
公开(公告)日：1982-06-08
申请号：US198489
申请日：1980-10-20
IPC分类号： A01N31/16 , C07C43/225 , C07C43/23 , C07C43/205
CPC分类号： C07C43/225 , A01N31/16 , C07C43/23
摘要： A hydroquinone diether having two 5,5-dichloro-4-pentenyl side chains and possessing improved acaricidal and juvenile hormonal activity is disclosed.
摘要翻译： 公开了具有两个5,5-二氯-4-戊烯基侧链并且具有改善的杀螨和少年激素活性的氢醌二醚。
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公开(公告)号：US06645742B2
公开(公告)日：2003-11-11
申请号：US09982468
申请日：2001-10-18
申请人： Lorenzo De Ferra , Pietro Massardo
发明人： Lorenzo De Ferra , Pietro Massardo
IPC分类号： C12P1306
CPC分类号： C07F9/103
摘要： The present invention relates to a purifying process for phosphatidylserine, the latter being prepared by trans-phosphatidylation of phosphatidylcholine with serine in presence of the enzyme D-phospholipase and containing as impurities hydrophilic compounds, proteins and inorganic salts.
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