公开(公告)号：US20180055891A1

公开(公告)日：2018-03-01

申请号：US15688464

申请日：2017-08-28

申请人： Yong Zhao

发明人： Yong Zhao

IPC分类号： A61K35/51 ,  A61K38/18 ,  A61L27/36 ,  A61K38/30 ,  C12N5/00

摘要： The described invention provides a method of functionally reprogramming adult cells to an immature cell type that expresses one or more embryonic biomarkers. The reprogramming is accomplished by contacting the adult cells with a platelet rich fraction comprising platelet-like cells from umbilical cord blood or peripheral blood, and expanding the immature cell type in vitro under culture conditions to generate an insulin-producing cell population that expresses human beta-cell specific transcription factors and is functionally equivalent to human pancreatic beta-cells. Without being limited by theory, platelet-like cells and their released mitochondria display immune tolerance-associated markers that may modulate the function and differentiation of immune cells. The described invention further provides a pharmaceutical composition comprising a cell product containing a therapeutic amount of an insulin-producing cell population derived from functionally reprogrammed adult cells, wherein the insulin-producing cell population expresses human beta-cell specific transcription factors and is functionally equivalent to human pancreatic beta-cells.

公开(公告)号：US09758932B2

公开(公告)日：2017-09-12

申请号：US14342242

申请日：2012-08-28

申请人： Chunfang Lu ,  Youming Zhao ,  Cheng Jiang ,  Jijun Wang ,  Meng Wang ,  Yong Zhao ,  Weibin Liu ,  Ziqing Jiang ,  Ruilin You ,  Xianggang Du ,  Jia Fan

发明人： Chunfang Lu ,  Youming Zhao ,  Cheng Jiang ,  Jijun Wang ,  Meng Wang ,  Yong Zhao ,  Weibin Liu ,  Ziqing Jiang ,  Ruilin You ,  Xianggang Du ,  Jia Fan

IPC分类号： E01B1/00 ,  E01B3/40

CPC分类号： E01B1/007 ,  E01B1/002 ,  E01B1/004 ,  E01B3/40

摘要： A ballastless track system comprises a base; a track slab arranged above the base; a poured-field layer arranged between the base and the track slab, the poured-field layer being formed by filling self-compacting concrete, emulsified asphalt cement mortar or resin mortar, and the inside of the poured-field layer being of a steel bar structure; a connecting piece, the first end of the connecting piece extending into the track slab, and the second end of the connecting piece extending into the poured-field layer; and two rows of rail-seat arranged on the track slab in parallel; and rails arranged on the rail-seat. The ballastless track system is high in reliability, good in durability, and easy in construction and maintenance.

公开(公告)号：US09388382B2

公开(公告)日：2016-07-12

申请号：US12099054

申请日：2008-04-07

申请人： Yong Zhao ,  Theodore Mazzone

发明人： Yong Zhao ,  Theodore Mazzone

IPC分类号： C12N5/00 ,  C12N5/074 ,  A61K35/12

CPC分类号： C12N5/0607 ,  A61K2035/122

摘要： The present invention is related generally to embryonic-like stem cells isolated from human umbilical cord blood, designated herein as cord blood-stem cells (CB-SC's), which display the characteristics of embryonic stem cells and hematopoietic cells. These cells have the capability of proliferation and are able to differentiate to multiple types of cells. In addition, the CB-SC display low immunogenicity and immune regulation. These cells are, therefore, suitable for use in stem cell-based therapies for the treatment of diseases such as Parkinson's disease, diabetes, spinal cord damage, multiple sclerosis, cardiovascular disease, stroke and birth defects, and for preventing, treating and/or reducing an autoimmune disease in a mammalian subject.

摘要翻译： 本发明一般涉及从人脐带血分离的胚胎样干细胞，本文称为脐带血干细胞（CB-SC），其显示胚胎干细胞和造血细胞的特征。 这些细胞具有增殖能力，能够分化成多种类型的细胞。 此外，CB-SC显示低免疫原性和免疫调节。 因此，这些细胞适合用于治疗诸如帕金森病，糖尿病，脊髓损伤，多发性硬化，心血管疾病，中风和出生缺陷的疾病的基于干细胞的疗法，以及用于预防，治疗和/ 减少哺乳动物受试者的自身免疫性疾病。

公开(公告)号：US08818333B2

公开(公告)日：2014-08-26

申请号：US12155764

申请日：2008-06-10

申请人： Lu Tian ,  Yong Zhao

发明人： Lu Tian ,  Yong Zhao

IPC分类号： H04M1/66

CPC分类号： H04W48/04 ,  H04W60/04

摘要： As a mobile device moves from one location area to another, the mobile device detects the different location identifiers broadcast by the wireless network(s) in those locations areas. The mobile device stores the location identifier for the last location area in which the mobile device was located. By comparing a received location identifier to the stored location identifier, the mobile device determines if the mobile device has entered a new location area. If so, the mobile device sends a location update request. In one embodiment, if the location update request is for a location area to which access by the mobile device is restricted, the network sends a communication to the mobile device that triggers the mobile device to update a location identifier stored at the mobile device to the location identifier for the restricted location area so that the mobile can update the network after entering/selecting a different location area.

摘要翻译： 随着移动设备从一个位置区域移动到另一个位置区域，移动设备检测由那些位置区域中的无线网络广播的不同位置标识符。 移动设备存储移动设备所在的最后位置区域的位置标识符。 通过将接收到的位置标识符与存储的位置标识符进行比较，移动设备确定移动设备是否已经进入新的位置区域。 如果是，则移动设备发送位置更新请求。 在一个实施例中，如果所述位置更新请求是针对所述移动设备的访问被限制的位置区域，则所述网络向所述移动设备发送触发所述移动设备的通信，以将存储在所述移动设备处的位置标识符更新为 用于受限位置区域的位置标识符，使得移动台可以在进入/选择不同位置区域之后更新网络。

公开(公告)号：US08698979B2

公开(公告)日：2014-04-15

申请号：US12413096

申请日：2009-03-27

申请人： Yong Zhao ,  Christopher James Newton Fryer ,  Richard Guy Blakesley ,  Christopher Miles Evans ,  William Frank Tyldesley

发明人： Yong Zhao ,  Christopher James Newton Fryer ,  Richard Guy Blakesley ,  Christopher Miles Evans ,  William Frank Tyldesley

IPC分类号： G02F1/1335

CPC分类号： G02F1/133602 ,  G02F1/1334 ,  G02F2201/44

摘要： A display including an electroluminescent layer, a liquid crystal layer, a barrier layer arranged between the electroluminescent layer and the liquid crystal layer to restrict migration of liquid crystal from the liquid crystal layer to the electroluminescent layer, and a first electrode and a second electrode arranged such that the electroluminescent layer and the liquid crystal layer are disposed between the first and second electrodes and arranged to apply an electric field across both the electroluminescent layer and the liquid crystal layer.

公开(公告)号：US20130129696A1

公开(公告)日：2013-05-23

申请号：US13662012

申请日：2012-10-26

申请人： Eliezer Huberman ,  Yong Zhao

发明人： Eliezer Huberman ,  Yong Zhao

IPC分类号： C12N5/0781

CPC分类号： C12N5/0635 ,  A61K35/12 ,  A61K2035/124 ,  C12N5/0607 ,  C12N5/0619 ,  C12N5/0636 ,  C12N5/0645 ,  C12N5/067 ,  C12N5/069 ,  C12N2501/11 ,  C12N2501/12 ,  C12N2501/13 ,  C12N2501/165 ,  C12N2501/22 ,  C12N2501/2306 ,  C12N2501/235 ,  C12N2501/52 ,  C12N2501/599 ,  C12N2503/02 ,  C12N2506/03 ,  C12N2506/115 ,  G01N33/5073 ,  Y02A50/401 ,  Y02A50/57

摘要： Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals is provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof The uses of these biological materials include methods of treating disorders or diseases, as well as methods of ameliorating a symptom associated with any such disorder or disease.

摘要翻译： 提供从哺乳动物的外周血分离的单核细胞来源的成体干细胞（MDSC），以及含有MDSC的药物组合物，含有药物组合物的试剂盒，以及制备，增殖和使用MDSC或其衍生物的方法。 包括治疗疾病或疾病的方法，以及改善与任何此类疾病或疾病相关的症状的方法。

公开(公告)号：US20120323544A1

公开(公告)日：2012-12-20

申请号：US13437342

申请日：2012-04-02

申请人： Yong Zhao ,  Martin Mlacnik

发明人： Yong Zhao ,  Martin Mlacnik

IPC分类号： G06G7/48

CPC分类号： E21B49/00

摘要： A method is described for producing an amended realization of a geostatistical model of a hydrocarbon reservoir using the Karhunen-Loève (KL) expansion. The KL expansion may be used to produce amended realizations for history matching and is widely used. However, it is necessary in order to use the KL expansion to perform singular value decomposition of the covariance matrix of the model to provide eigenvectors and eigen values for use in the expansion. In a typical geostatistical model, the covariance matrix is too large for singular value decomposition to be performed. Prior solutions to this problem involved reducing the resolution of the model so as to reduce the size of the covariance matrix. In the method described, a plurality of random realizations are generated and an approximation of the covariance matrix is constructed from the realizations, the approximation matrix having smaller dimensions than the true covariance matrix.

摘要翻译： 描述了一种使用Karhunen-Loève（KL）扩建来生成油气藏地质统计模型的修正实现的方法。 KL扩展可用于产生历史匹配的修改实现，并被广泛使用。 然而，为了使用KL扩展来执行模型的协方差矩阵的奇异值分解以提供用于扩展的特征向量和特征值是必要的。 在典型的地统计模型中，协方差矩阵太大，无法进行奇异值分解。 此问题的先前解决方案涉及降低模型的分辨率，以减小协方差矩阵的大小。 在所描述的方法中，生成多个随机实现，并且从实现构造协方差矩阵的近似，该逼近矩阵具有比真实协方差矩阵小的维度。

公开(公告)号：US08035331B2

公开(公告)日：2011-10-11

申请号：US12542752

申请日：2009-08-18

申请人： Yong Zhao ,  Junqiang Zhang ,  Dawei Liu ,  Songfa Tang

发明人： Yong Zhao ,  Junqiang Zhang ,  Dawei Liu ,  Songfa Tang

IPC分类号： H02M7/04 ,  H02P1/00

CPC分类号： H02M7/06 ,  H02M1/10

摘要： An AC/DC converting circuit, has a full-bridge rectifier having two input terminals and two output terminals, a first capacitor, a second capacitor, an electronic switch having a control terminal, a trigger circuit having an input terminal and an output terminal, and a detecting circuit having an input terminal and an output terminal. The first capacitor and the second capacitor are serially connected between the output terminals of the full-bridge rectifier, the input terminals of the full-bridge rectifier are connected to an AC input, one end of the electronic switch is connected between the first capacitor and the second capacitor, the other end of the electronic switch is connected to one of the output terminals of the full-bridge rectifier, the input terminal and the output terminal of the detecting circuit are connected to the output terminals of the full-bridge rectifier, the output terminal of the detecting circuit is connected to an input terminal of the trigger circuit, and the output terminal of the trigger circuit is connected to the control terminal of the electronic switch.

摘要翻译： AC / DC转换电路具有全桥整流器，具有两个输入端和两个输出端，第一电容，第二电容，具有控制端的电子开关，具有输入端和触发电路的触发电路， 以及具有输入端子和输出端子的检测电路。 第一电容器和第二电容器串联连接在全桥整流器的输出端子之间，全桥整流器的输入端子连接到AC输入端，电子开关的一端连接在第一电容器和 第二电容器，电子开关的另一端连接到全桥整流器的输出端之一，检测电路的输入端和输出端连接到全桥整流器的输出端， 检测电路的输出端子与触发电路的输入端子连接，触发电路的输出端子与电子开关的控制端子连接。

公开(公告)号：US07962480B1

公开(公告)日：2011-06-14

申请号：US11831841

申请日：2007-07-31

申请人： Li Zhang ,  Yuhong Xiong ,  Shicong Feng ,  Yong Zhao

发明人： Li Zhang ,  Yuhong Xiong ,  Shicong Feng ,  Yong Zhao

IPC分类号： G06F7/04 ,  G06F17/21

CPC分类号： G06F17/30616

摘要： The relevance of documents is automatically determined based upon a weighted tree. Terms considered to be relevant are assigned to the leaf nodes of a tree data structure. A location can also be specified in a leaf node, indicating where in a document the term must appear to be considered relevant. Internal nodes of the tree are assigned operators (e.g., add, maximum or minimum). The connections between nodes are assigned weights. A relevance value for a given document is calculated as a function of occurrence in the document of terms assigned to leaves, operators assigned to internal nodes, and weights assigned to the associated node connections. Weighted trees can be used to process search queries. Documents with high relevance scores calculated against the tree can be returned to a user as the results to a query.

摘要翻译： 文档的相关性是根据加权树自动确定的。 被认为相关的术语被分配给树状数据结构的叶节点。 也可以在叶节点中指定位置，指示文档中的哪个字词必须看起来被认为是相关的。 树的内部节点被分配运算符（例如，添加，最大或最小）。 节点之间的连接被分配权重。 给定文档的相关性值作为分配给叶子的文档的文档，分配给内部节点的运营商以及分配给关联节点连接的权重的函数计算。 加权树可以用于处理搜索查询。 根据树计算的具有高相关性分数的文档可以作为查询的结果返回给用户。

公开(公告)号：US20110087992A1

公开(公告)日：2011-04-14

申请号：US12578493

申请日：2009-10-13

申请人： Xuanran Wang ,  Ron Dun ,  Yong Zhao

发明人： Xuanran Wang ,  Ron Dun ,  Yong Zhao

IPC分类号： G06F3/048

CPC分类号： G06F3/04883 ,  G06F3/04845

摘要： Thumbnail image substitution is described. In embodiments, a navigation input is received that is effective to move from a first view of a media content page to a second view of the media content page. The second view includes a region of the media content page that is not included in the first view of the media content page. A thumbnail image is displayed in the region of the media content page that is not included in the first view and that will display the media content. The thumbnail image is replaced to display the media content in the region of the media content page that corresponds to the second view of the media content page.

摘要翻译： 描述缩略图图像替换。 在实施例中，接收有效地从媒体内容页面的第一视图移动到媒体内容页面的第二视图的导航输入。 第二视图包括不包括在媒体内容页面的第一视图中的媒体内容页面的区域。 在不包括在第一视图中并且将显示媒体内容的媒体内容页面的区域中显示缩略图。 缩略图被替换以在与媒体内容页面的第二视图对应的媒体内容页面的区域中显示媒体内容。