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公开(公告)号：US07875660B2
公开(公告)日：2011-01-25
申请号：US12725975
申请日：2010-03-17
IPC分类号： G02C7/04
摘要： Biomedical devices, such as ophthalmic lenses, and methods of making such devices having a surface coating including at least one polyionic layer. A preferred method involves spray coating a polycationic material onto a core lens, rinsing and drying the lens, followed by spray coating a polyanionic material, rinsing and drying. The coating process may be applied a plurality of times to achieve a multi-layer coating on the lens surface. A particularly preferred embodiment is a contact lens comprising a highly oxygen permeable hydrophobic core coated with a 5 to 20 bilayers of hydrophilic polyionic materials.
摘要翻译： 生物医学装置，如眼科镜片，以及制造具有包括至少一个聚离子层的表面涂层的装置的方法。 优选的方法包括将聚阳离子材料喷涂到芯晶片上，漂洗和干燥晶状体，然后喷涂聚阴离子材料，冲洗和干燥。 涂覆过程可以多次施加以在透镜表面上实现多层涂层。 特别优选的实施方案是包含涂覆有5至20双亲水性聚离子材料的高透氧性疏水核心的隐形眼镜。
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公开(公告)号：US07297725B2
公开(公告)日：2007-11-20
申请号：US10202758
申请日：2002-07-24
IPC分类号： G02C7/04
摘要： Biomedical devices, such as ophthalmic lenses, and methods of making such devices having a surface coating including at least one polyionic layer. A preferred method involves spray coating a polycationic material onto a core lens, rinsing and drying the lens, followed by spray coating a polyanionic material, rinsing and drying. The coating process may be applied a plurality of times to achieve a multi-layer coating on the lens surface. A particularly preferred embodiment is a contact lens comprising a highly oxygen permeable hydrophobic core coated with a 5 to 20 bilayers of hydrophilic polyionic materials.
摘要翻译： 生物医学装置，如眼科镜片，以及制造具有包括至少一个聚离子层的表面涂层的装置的方法。 优选的方法包括将聚阳离子材料喷涂到芯晶片上，漂洗和干燥晶状体，然后喷涂聚阴离子材料，冲洗和干燥。 涂覆过程可以多次施加以在透镜表面上实现多层涂层。 特别优选的实施方案是包含涂覆有5至20双亲水性聚离子材料的高透氧性疏水核心的隐形眼镜。
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公开(公告)号：US07165839B2
公开(公告)日：2007-01-23
申请号：US11007442
申请日：2004-12-08
IPC分类号： G02C7/04
CPC分类号： B29D11/00317
摘要： The invention provides a method of producing a full-body tinted contact lens. The method of the invention comprises the steps of: preconditioning particles of a pigments; dispersing the preconditioned pigment particles in a polymerizable fluid composition to obtain a pigment-containing polymerizable dispersion; introducing an amount of the pigment-containing polymerizable dispersion in a mold for making a contact lens; polymerizing the polymerizable dispersion in the mold to form a full-body tinted contact lens with the particles of the pigment entrapped and distributed therein. In addition, the invention provides a method for preparing preconditioned pigment particles and full-body tinted contact lenses produced according the method of the invention.
摘要翻译： 本发明提供一种制造全身有色隐形眼镜的方法。 本发明的方法包括以下步骤：预处理颜料颗粒; 将预处理的颜料颗粒分散在可聚合流体组合物中以获得含颜料的可聚合分散体; 将一定量的含颜料的可聚合分散体引入用于制造隐形眼镜的模具中; 将可聚合分散体聚合在模具中以形成全身有色隐形眼镜，其中包含并分布在其中的颜料颗粒。 此外，本发明提供了一种根据本发明的方法制备预处理的颜料颗粒和全身有色隐形眼镜的方法。
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公开(公告)号：US06451871B1
公开(公告)日：2002-09-17
申请号：US09559945
申请日：2000-04-27
IPC分类号： G02C704
摘要： Biomedical devices, such as ophthalmic lenses, and methods of making such devices having a surface coating including at least one polyionic layer. A preferred method involves spray coating a polycationic material onto a core lens, rinsing and drying the lens, followed by spray coating a polyanionic material, rinsing and drying. The coating process may be applied a plurality of times to achieve a multi-layer coating on the lens surface. A particularly preferred embodiment is a contact lens comprising a highly oxygen permeable hydrophobic core coated with a 5 to 20 bilayers of hydrophilic polyionic materials.
摘要翻译： 生物医学装置，如眼科镜片，以及制造具有包括至少一个聚离子层的表面涂层的装置的方法。 优选的方法包括将聚阳离子材料喷涂到芯晶片上，漂洗和干燥晶状体，然后喷涂聚阴离子材料，冲洗和干燥。 涂覆过程可以多次施加以在透镜表面上实现多层涂层。 特别优选的实施方案是包含涂覆有5至20双亲水性聚离子材料的高透氧性疏水核心的隐形眼镜。
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公开(公告)号：US08647658B2
公开(公告)日：2014-02-11
申请号：US12229769
申请日：2008-08-27
CPC分类号： G02B1/043 , A61K9/0048 , A61L12/04 , B29D11/00067
摘要： The present invention relates to improved contact lens products which not only have initial insertion comfort but also are comfortable to wear for more than about 6 hours. The invention is achieved by packaging and storing a hydrogel lens with two or more leachable polymeric lubricants incorporated therein in a relatively viscous packaging solution including a relatively low molecular weight polyethylene glycol (PEG) and a viscosity-enhancing hydrophilic polymer. The present invention also provides methods for making contact lens products of the invention.
摘要翻译： 本发明涉及改进的隐形眼镜产品，其不仅具有初始插入舒适性，而且佩戴舒适时间超过约6小时。 本发明通过将包含两种或更多种可浸出的聚合润滑剂的水凝胶透镜包装并储存在包含相对低分子量聚乙二醇（PEG）和增粘亲水性聚合物的相对粘稠的包装溶液中来实现。 本发明还提供了制造本发明隐形眼镜产品的方法。
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公开(公告)号：US08440735B2
公开(公告)日：2013-05-14
申请号：US12834998
申请日：2010-07-13
IPC分类号： C08F2/46 , C08F290/06 , C08J3/28 , G02B1/06 , G02B1/04
摘要： The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a phospholipid into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the phospholipids.
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公开(公告)号：US08415404B2
公开(公告)日：2013-04-09
申请号：US12794333
申请日：2010-06-04
申请人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
发明人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号： G02B1/04
CPC分类号： G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an ophthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.
摘要翻译： 一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。 在一个实施方案中，眼用透镜是至少一种氧精，至少一种离子交换剂和交联剂的共聚产物。 在一个实施方案中，透镜的拉伸模量小于约3.0MPa，而在另一个实施方案中，拉伸模量为约0.5至约1.5MPa。
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公开(公告)号：US20100276823A1
公开(公告)日：2010-11-04
申请号：US12834979
申请日：2010-07-13
IPC分类号： B29D11/00
摘要： The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a phospholipid into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the phospholipids.
摘要翻译： 本发明涉及一种用于制造具有改善的镜片质量和增加的产品产量的隐形眼镜的方法和流体组合物。 本发明的方法包括将磷脂添加到包含透镜形成材料的流体组合物中，其量足以将平均的模具分离力与没有磷脂的模具分离力相比降低至少约40％。
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公开(公告)号：US20100238398A1
公开(公告)日：2010-09-23
申请号：US12794333
申请日：2010-06-04
申请人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jörg Griesser , Arthur Ho , Jens Hõpken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jürgen Vogt , Lynn Cook Winterton
发明人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jörg Griesser , Arthur Ho , Jens Hõpken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jürgen Vogt , Lynn Cook Winterton
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an opthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.
摘要翻译： 一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。 在一个实施方案中，眼用透镜是至少一种氧精，至少一种离子交换剂和交联剂的共聚产物。 在一个实施方案中，透镜的拉伸模量小于约3.0MPa，而在另一个实施方案中，拉伸模量为约0.5至约1.5MPa。
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公开(公告)号：US20090059165A1
公开(公告)日：2009-03-05
申请号：US12229769
申请日：2008-08-27
CPC分类号： G02B1/043 , A61K9/0048 , A61L12/04 , B29D11/00067
摘要： The present invention relates to improved contact lens products which not only have initial insertion comfort but also are comfortable to wear for more than about 6 hours. The invention is achieved by packaging and storing a hydrogel lens with two or more leachable polymeric lubricants incorporated therein in a relatively viscous packaging solution including a relatively low molecular weight polyethylene glycol (PEG) and a viscosity-enhancing hydrophilic polymer. The present invention also provides methods for making contact lens products of the invention.
摘要翻译： 本发明涉及改进的隐形眼镜产品，其不仅具有初始插入舒适性，而且佩戴舒适时间超过约6小时。 本发明通过将包含两种或更多种可浸出的聚合润滑剂的水凝胶透镜包装并储存在包含相对低分子量聚乙二醇（PEG）和增粘亲水性聚合物的相对粘稠的包装溶液中来实现。 本发明还提供了制造本发明隐形眼镜产品的方法。
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