公开(公告)号：US08618187B2

公开(公告)日：2013-12-31

申请号：US13433329

申请日：2012-03-29

申请人： Bernhard Seiferling ,  Thomas Schmidt ,  Jürgen Vogt

发明人： Bernhard Seiferling ,  Thomas Schmidt ,  Jürgen Vogt

IPC分类号： G02B1/04 ,  C08F20/56 ,  C09K3/00 ,  C08F2/50

CPC分类号： G02B1/043 ,  C08F20/56 ,  C08L101/14 ,  C08L33/26 ,  C08L33/10 ,  C08L83/04

摘要： There is described a composition for forming an contact lens, in particular for forming a silicone hydrogel contact lens, comprising at least one first vinylic monomer or macromer having one first ethylenically unsaturated group and at least one second vinylic monomer or macromer having one second ethylenically unsaturated group, wherein the first and second ethylenically unsaturated groups are different from each other and wherein the composition further comprises a crosslinker with at least two ethylenically unsaturated (polymerizable) groups with a selected kinetic copolymerization parameter r1 of less than 1.0 relative to one of the first and second ethylenically unsaturated (polymerizable) groups as defined above.

摘要翻译： 描述了用于形成隐形眼镜的组合物，特别是用于形成硅氧水凝胶隐形眼镜的组合物，其包含至少一种具有一个第一烯属不饱和基团的至少一种第一乙烯基单体或大分子单体和至少一种具有一个第二烯属不饱和基团的第二乙烯基单体或大分子单体 基团，其中所述第一和第二烯属不饱和基团彼此不同，并且其中所述组合物还包含具有至少两个烯键式不饱和（可聚合）基团的交联剂，其中选择的动力学共聚参数r1相对于所述第一 和第二烯属不饱和（可聚合）基团。

公开(公告)号：US07143990B2

公开(公告)日：2006-12-05

申请号：US10106739

申请日：2002-03-26

申请人： Yasuo Matsuzawa ,  Harald Bothe ,  Bernhard Seiferling

发明人： Yasuo Matsuzawa ,  Harald Bothe ,  Bernhard Seiferling

IPC分类号： B29D11/00

CPC分类号： B29D11/00548 ,  B29C33/40 ,  B29C33/56 ,  B29D11/00432 ,  B29L2011/0016 ,  Y10S425/808

摘要： An apparatus and method for the production of ophthalmic lenses, and particularly contact lenses, which minimizes damage of the lens in removal from the mold. The ophthalmic lens is produced in a mold having a male part and a female part that are placed in proximate relation to each other to create a lens-forming cavity. At least the female surface of the female part mold is preferably coated with plasma and is irradiated for a predetermined time such that the female surface and/or surface coating is at least partially cured. Once the female surface, and alternately the male surface and other surfaces of the mold, is at least partially cured, a curable lens-forming material is placed into the lens-forming cavity and cured to form an ophthalmic lens.

公开(公告)号：US06884283B2

公开(公告)日：2005-04-26

申请号：US10318622

申请日：2002-12-13

申请人： Bernhard Seiferling ,  Achim Müller ,  Iris Jlona Leder-Brück ,  Mark Hülsebusch

发明人： Bernhard Seiferling ,  Achim Müller ,  Iris Jlona Leder-Brück ,  Mark Hülsebusch

IPC分类号： C08J3/02 ,  B29B13/00 ,  B01D19/00

CPC分类号： B29B13/00 ,  B29L2011/0016

摘要： In a process for removing bubbles from viscous polymer solutions (P) in which the content of dissolved gases lies below the saturation limit, the viscous polymer solution (P) is subjected to a superatmospheric pressure. The superatmospheric pressure is such that the gases contained in the bubbles of the polymer solution (P) dissolve.

摘要翻译： 在从溶解气体含量低于饱和极限的粘性聚合物溶液（P）中除去气泡的过程中，粘性聚合物溶液（P）经受超大气压力。 超大气压使聚合物溶液（P）的气泡中所含的气体溶解。

公开(公告)号：US06849210B2

公开(公告)日：2005-02-01

申请号：US10091820

申请日：2002-03-06

申请人： Harald Bothe ,  Achim Müller ,  Bernhard Seiferling

发明人： Harald Bothe ,  Achim Müller ,  Bernhard Seiferling

IPC分类号： G02C7/04 ,  A61F2/16 ,  B29C39/02 ,  B29D11/00 ,  B29K29/00 ,  B29L11/00 ,  C08F8/28 ,  C08F299/00 ,  C08L29/04 ,  C08L29/14 ,  C08L33/26 ,  C08L71/02 ,  G02B1/04 ,  C08J3/28

CPC分类号： C08L29/14 ,  C08L33/26 ,  C08L71/02 ,  G02B1/043 ,  C08L29/00 ,  C08L2666/04 ,  C08L2666/14

摘要： The invention relates to a process for the manufacture of a molding comprising the steps of a) preparing an aqueous solution comprising a water-soluble prepolymer having crosslinkable groups and a further polymer which is devoid of crosslinkable groups, b) introducing the solution obtained into a mold, c) triggering the crosslinking, and d) opening the mold such that the molding can be removed from the mold. According to the process of the invention moldings such as contact lenses may be manufactured with an improved quality and an improved overall yield.

摘要翻译： 本发明涉及一种用于制造模制品的方法，包括以下步骤：a）制备包含具有可交联基团的水溶性预聚物的水溶液和不具有可交联基团的另外的聚合物，b）将获得的溶液引入模具 ，c）触发交联，和d）打开模具，使模制品可以从模具中取出。 根据本发明的方法，可以制造具有改善的质量和改进的总产率的模制品，例如隐形眼镜。

公开(公告)号：US6162844A

公开(公告)日：2000-12-19

申请号：US469680

申请日：1999-12-22

申请人： John Martin Lally ,  Deborah Jean Mulcahy ,  Achim Muller ,  Beat Muller ,  Bernhard Seiferling ,  Friedrich Stockinger

发明人： John Martin Lally ,  Deborah Jean Mulcahy ,  Achim Muller ,  Beat Muller ,  Bernhard Seiferling ,  Friedrich Stockinger

IPC分类号： G02C7/04 ,  B29C39/02 ,  B29C39/24 ,  C08F2/44 ,  G02B1/04 ,  G02B1/10 ,  C08L29/04 ,  C09B62/00 ,  D06P3/58

CPC分类号： C08F2/44 ,  G02B1/043 ,  Y10S525/937

摘要： A method of incorporating radiation-absorbing agents (i.e., dyes) into polymeric materials. A preferred method involves crosslinking or polymerizing a polymerizable or crosslinkable material in the presence of a polymeric dye. A preferred product is a tinted contact lens comprising poly(vinyl alcohol). The methods offer advantages in reduced fabrication cycles, reduced extractables, elimination of post-polymerization activation steps, elimination of post-polymerization extraction steps and reduced scrap and costs associated with lens handling.

摘要翻译： 将辐射吸收剂（即染料）掺入聚合材料中的方法。 优选的方法包括在聚合染料存在下交联或聚合可聚合的或可交联的材料。 优选的产品是包含聚（乙烯醇）的着色隐形眼镜。 该方法在减少制造周期，降低的可萃取物，消除后聚合活化步骤，消除后聚合萃取步骤以及降低的废料和与透镜处理相关的成本方面具有优势。

公开(公告)号：US5712356A

公开(公告)日：1998-01-27

申请号：US339384

申请日：1994-11-14

申请人： Harald Bothe ,  Achim Muller ,  Bernhard Seiferling ,  Sharla Borghorst ,  John Golby ,  Peter Hagmann ,  Peter Herbrechtsmeier ,  Otto Kretzschmar

发明人： Harald Bothe ,  Achim Muller ,  Bernhard Seiferling ,  Sharla Borghorst ,  John Golby ,  Peter Hagmann ,  Peter Herbrechtsmeier ,  Otto Kretzschmar

IPC分类号： G02C7/04 ,  C08F8/00 ,  C08F16/08 ,  C08F16/14 ,  C08F20/26 ,  C08F20/52 ,  C08F26/00 ,  C08F216/08 ,  C08F216/14 ,  C08F218/02 ,  C08F218/04 ,  C08F220/04 ,  C08F220/06 ,  C08F220/28 ,  C08F220/56 ,  C08F226/06 ,  C08F226/10 ,  C08F246/00 ,  C08F293/00 ,  C08F299/00 ,  G02B1/04 ,  C08F220/18 ,  C08F224/00 ,  C08F226/02 ,  C08F228/02

CPC分类号： C08F226/06 ,  C08F293/005 ,  C08F8/14 ,  G02B1/043 ,  C08F226/10 ,  C08F2800/10 ,  C08F2800/20 ,  C08F2810/20 ,  C08F2810/50

摘要： The present invention describes novel statistical copolymers and the preparation and possible uses thereof. Copolymers are described that are water-soluble and cross-linkable and that comprise the copolymerisation product of a monomer mixture consisting substantially of a vinyl lactam (a) and at least one further vinyl monomer (b) of a different type selected from the group consisting of hydrophobic, hydrophilic and functional vinyl monomers, wherein the monomers are present in the copolymer in the form of statistically distributed building blocks, and, if a functional vinyl monomer is present as a building block in the copolymer, that building block is, where appropriate, modified with a reactive vinyl monomer (c), the reactive vinyl monomer (c) being linked to a building block of a functional vinyl monomer with retention of its vinylic group and with the formation of a covalent bond.

摘要翻译： 本发明描述了新的统计共聚物及其制备及其可能用途。 描述了共聚物是水溶性和可交联的，并且包含基本上由乙烯基内酰胺（a）和至少一种另外的不同类型的乙烯基单体（b）组成的单体混合物的共聚产物，所述另外的乙烯基单体（b）选自 的疏水性，亲水性和功能性的乙烯基单体，其中单体以统计分布的结构单元的形式存在于共聚物中，并且如果官能的乙烯基单体作为共聚物中的结构单元存在，则该结构单元在适当的情况下 ，用反应性乙烯基单体（c）改性，反应性乙烯基单体（c）与保持其乙烯基基团并形成共价键的官能乙烯基单体的结构单元连接。

公开(公告)号：US5609246A

公开(公告)日：1997-03-11

申请号：US434088

申请日：1995-05-03

申请人： Sharla Borghorst ,  Erich Baumann ,  John Golby ,  Peter Hagmann ,  Peter Herbrechtsmeier ,  Otto Kretzschmar ,  Bernhard Seiferling ,  Michele De Lucchi ,  Torsten Fritze ,  Masahiko Cubo

发明人： Sharla Borghorst ,  Erich Baumann ,  John Golby ,  Peter Hagmann ,  Peter Herbrechtsmeier ,  Otto Kretzschmar ,  Bernhard Seiferling ,  Michele De Lucchi ,  Torsten Fritze ,  Masahiko Cubo

IPC分类号： A45C11/04 ,  A61F2/16 ,  B65D1/30 ,  B65D1/36 ,  B65D75/36 ,  B65D77/20 ,  B65D81/24

CPC分类号： B65D77/2036 ,  A61F2/1691 ,  B65D1/30 ,  B65D2585/545 ,  Y10S134/901

摘要： The blister pack comprises a base portion and a cover layer. The base portion comprises a hollow chamber that contains a soft hydrophilic contact lens and a sterile aqueous preserving solution, and a substantially flat flange that extends right round the outside of the hollow chamber. The cover layer is releasably sealed to the flange in a sealing zone that extends right round the circumference of the hollow chamber. The flange comprises a grip region that extends from one side of the hollow chamber beyond the sealing zone and is covered by a corresponding grip region of the cover layer but is not sealed thereto. The hollow chamber comprises a dish-shaped main chamber and, adjoining the side of that main chamber, a secondary chamber in the shape of a channel tapering on all sides away from the main chamber, the main chamber making a smooth transition into the secondary chamber, and the main chamber and the secondary chamber together having a drop-shaped contour in the plane of the flange, the tip of which contour is directed towards the grip region of the flange. Provided in the grip region of the flange is an oval opening by means of which the overlying grip region of the cover layer can be lifted from the flange. A support element that is angled with respect to the plane of the flange is arranged in the grip region of the flange. An angled grip element or facilitating the handling of the blister pack is arranged at the edge of the flange on both sides of the hollow chamber. The base portion is so shaped that the blister packs can be nested in pairs with their undersides one inside the other, in each case the hollow chamber of one blister pack lying in the region of the grip region of the other blister pack. The blister pack is extremely handy, space-saving and stable, requires only an extremely small amount of preserving solution and enables the contact lens it contains to be removed especially easily.

摘要翻译： 泡罩包装包括基部和覆盖层。 底座部分包括一个包含柔软的亲水性隐形眼镜和无菌水性保存液的中空腔，以及在中空腔外侧向外延伸的基本平坦的凸缘。 覆盖层在密封区域中可释放地密封到凸缘上，密封区域在中空室的圆周的右侧延伸。 凸缘包括从中空室的一侧延伸超过密封区并被覆盖层的相应夹持区域覆盖但不被密封的手柄区域。 中空室包括碟形主室，并且邻近该主室的一侧，具有在远离主室的所有侧面上渐缩的通道形式的第二室，主室平滑地过渡到次室 ，并且主室和副室一起在凸缘的平面中具有液滴形轮廓，其顶端的轮廓指向凸缘的把手区域。 在凸缘的把手区域中设置有椭圆形的开口，通过该椭圆形开口可以覆盖层的覆盖夹持区域从凸缘提升。 相对于凸缘的平面成角度的支撑元件布置在凸缘的把手区域中。 倾斜的夹紧元件或便于处理泡罩包装被布置在中空室两侧的凸缘的边缘处。 底部部分是这样成形的，使得泡罩包装件可以与它们的下侧成对嵌套，一个在另一个内部，在每种情况下，一个泡罩包装袋的中空室位于另一个泡罩包装的抓握区域的区域中。 泡罩包装非常方便，节省空间并且稳定，只需要极少量的保存溶液，并且使其包含的隐形眼镜被特别容易地去除。

公开(公告)号：US08440735B2

公开(公告)日：2013-05-14

申请号：US12834998

申请日：2010-07-13

申请人： John Dallas Pruitt ,  Lynn Cook Winterton ,  Bernhard Seiferling ,  Jüergen Vogt ,  Harald Bothe

发明人： John Dallas Pruitt ,  Lynn Cook Winterton ,  Bernhard Seiferling ,  Jüergen Vogt ,  Harald Bothe

IPC分类号： C08F2/46 ,  C08F290/06 ,  C08J3/28 ,  G02B1/06 ,  G02B1/04

CPC分类号： G02B1/043 ,  B29C33/60

摘要： The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a phospholipid into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the phospholipids.

公开(公告)号：US20110147959A1

公开(公告)日：2011-06-23

申请号：US12969689

申请日：2010-12-16

申请人： Axel Heinrich ,  Bernhard Seiferling ,  Peter Hagmann

发明人： Axel Heinrich ,  Bernhard Seiferling ,  Peter Hagmann

IPC分类号： B29D11/00 ,  B29C45/24

CPC分类号： B29D11/00413 ,  B29C33/00 ,  B29C37/02 ,  B29C71/0009 ,  B29C2071/0027 ,  B29C2071/0045 ,  B29D11/00125 ,  B29D11/00586 ,  B29L2011/0041

摘要： There is described a method of separating excess lens forming material from a molded ophthalmic lens, in particular a contact lens. After polymerization and/or cross-linking of a lens forming material (P) within a mold cavity (4) of a mold (1) comprising female and male mold halves (2, 3) to form an ophthalmic lens non-polymerized and/or non-cross-linked lens forming material is flushed away from the mold halves (2, 3) with a jet of a fluid flushing medium, such as, e.g., water or a solvent or an inert gas. Subsequently the molded lens is dried. In accordance with the invention the flushing is accomplished with the mold halves (2, 3) still in the closed position. There is also described an apparatus for carrying out the method.

摘要翻译： 描述了从模制的眼科镜片，特别是隐形眼镜分离多余的透镜形成材料的方法。 在透镜形成材料（P）在包含阴模和阴半模（2,3）的模具（1）的模腔（4）内聚合和/或交联以形成未聚合的眼科镜片和/ 或非交联透镜形成材料用流体冲洗介质（例如水或溶剂或惰性气体）的射流冲洗离开半模（2,3）。 随后将模制的透镜干燥。 根据本发明，冲洗是通过半模（2,3）仍处于关闭位置来完成的。 还描述了一种用于执行该方法的装置。

公开(公告)号：US20100296049A1

公开(公告)日：2010-11-25

申请号：US12783591

申请日：2010-05-20

申请人： Justyna Justynska ,  Bernhard Seiferling

发明人： Justyna Justynska ,  Bernhard Seiferling

IPC分类号： C07F7/10 ,  B29D11/00 ,  G02C7/04

CPC分类号： C08F283/124 ,  B29D11/00038 ,  C08F290/068 ,  G02B1/043 ,  C08L83/04 ,  C08L51/085 ,  C08F220/56 ,  C08F220/20

摘要： The invention provide a class of actinically-crosslinkable silicone-containing prepolymers which comprise dangling polysiloxane chains each having a terminal ethylenically-unsaturated group and are obtained in a one-step of RAFT polymerization of a reactive mixture comprising a polysiloxane crosslinker, a hydrophilic vinylic monomer, a RAFT agent, and a free-radical initiator. The present invention is also related to silicone hydrogel contact lenses made from a prepolymer of the invention and methods for making the contact lenses in a cost-effective way and with high consistency and high fidelity to the original lens design.

摘要翻译： 本发明提供一类具有光聚合性的含硅氧烷的预聚物，其包含悬链聚硅氧烷链，每个聚硅氧烷链均具有末端烯键式不饱和基团，并且在包括聚硅氧烷交联剂，亲水性乙烯基单体的反应性混合物的一步RAFT聚合反应中获得 ，RAFT试剂和自由基引发剂。 本发明还涉及由本发明的预聚物制成的硅酮水凝胶隐形眼镜以及以成本有效的方式制造隐形眼镜并以与原始透镜设计的高一致性和高保真度的方法。