公开(公告)号：US08137623B2

公开(公告)日：2012-03-20

申请号：US11808046

申请日：2007-06-06

申请人： Yosuke Iwata ,  Tsuyoshi Kobayashi

发明人： Yosuke Iwata ,  Tsuyoshi Kobayashi

IPC分类号： G01N15/06

CPC分类号： G01N21/33 ,  Y10T436/117497 ,  Y10T436/118339

摘要： The present invention provides an apparatus for analyzing easily not only the overall taste of a sample but also what kind of components, synergetic effects and diminishing effects contribute to the taste. A sample to be analyzed is injected into a mobile phase by a liquid sending pump, and the sample is sent to a taste detector by way of a blending means and valves. Then, detection signals are obtained by taste sensors on the taste detector. The sample sent through the taste detector is introduced into a column by way of a 6-port-2-position valve, temporally separated into components and eluted from the column. After each component is detected by a UV detector, the eluted liquid is sent to the taste detector once more, and detection signals which reflect the tastes of each sample component. When analyzing how the taste changes by an additive, send the additive to the blending means and blend it with the sample.

摘要翻译： 本发明提供了一种用于不仅容易分析样品的整体味道的装置，而且还分析了哪种成分，协同作用和递减效果有助于味道的装置。 将待分析的样品通过送液泵注入流动相中，并通过混合装置和阀门将样品送至味觉检测器。 然后，通过味觉检测器上的味道传感器获得检测信号。 通过味道检测器发送的样品通过6端口2-位置阀引入柱中，时间上分离成组分并从柱上洗脱。 每个成分被紫外检测器检测到后，洗脱液再次送到味觉检测器，反映出每个样品成分的味道的检测信号。 当分析添加剂的味道如何变化时，将添加剂发送到混合装置并将其与样品混合。

公开(公告)号：US20100000301A1

公开(公告)日：2010-01-07

申请号：US12492054

申请日：2009-06-25

申请人： Yosuke Iwata

发明人： Yosuke Iwata

IPC分类号： G01N30/04

CPC分类号： G01N30/463 ,  G01N30/466 ,  G01N30/468 ,  G01N30/84 ,  G01N2030/8411

摘要： Disclosed herein is a liquid chromatograph in which a fractionation flow path, a non-fractionation flow path, a concentration flow path, and a secondary analysis flow path can be provided by operating flow path switching valves and flow path selecting valves. The concentration flow path and either one of the fractionation flow path and the non-fractionation flow path can be provided at the same time, and the secondary analysis flow path and either one of the fractionation flow path and the non-fractiontation flow path can also be provided at the same time.

摘要翻译： 本文公开了一种液相色谱仪，其中可以通过操作流路切换阀和流路选择阀来提供分馏流路，非分馏流路，浓缩流路和二次分析流路。 可以同时提供浓缩流路和分馏流路和非分馏流路之一，二次分析流路和分馏流路和非分馏流路之一也可以 同时提供。

公开(公告)号：US20080245715A1

公开(公告)日：2008-10-09

申请号：US12061610

申请日：2008-04-02

申请人： Yosuke Iwata

发明人： Yosuke Iwata

IPC分类号： B01D15/08

CPC分类号： B01D15/166 ,  G01N30/08 ,  G01N30/468 ,  G01N2030/027 ,  G01N2030/085

摘要： A liquid chromatograph having a flow passage switching mechanism for switching among a normal analysis flow passage formed by connecting a mobile-phase-sending-unit, a second mixer having a large capacity, a sample injection portion, an analysis column and a detector in this order, a concentration flow passage formed by connecting a concentration liquid sending unit for sending a liquid for transferring a sample to be concentrated, the second mixer, the sample injection portion and a trapping column in this order, and a concentration analysis flow passage formed by connecting the mobile-phase-sending-unit, a first mixer having a smaller capacity than the second mixer, the trapping column, the analysis column and the detector in this order so that any one of the three flow passages is selectively formed, The mobile-phase-sending-unit is set so that the flow rate of a mobile phase becomes smaller when the concentration analysis flow passage is selected than when the normal analysis flow passage is selected.

摘要翻译： 一种液相色谱仪，其具有流路切换机构，用于在通过连接流动相发送单元，具有大容量的第二混合器，样品注入部分，分析柱和检测器形成的正常分析流路之间切换 通过将浓缩液送出单元依次连接用于送出用于转移待浓缩样品的液体，第二混合器，样品注入部分和捕集柱而形成的浓缩流路，以及浓度分析流路 连接移动相位发送单元，具有比第二混频器小的容量的第一混频器，捕集列，分析列和检测器，以便选择性地形成三个流动通道中的任何一个。移动 相位发送单元被设定为使得当选择浓度分析流路时流动相的流量变得比在正常分析流程 选择通道。

公开(公告)号：US07394544B2

公开(公告)日：2008-07-01

申请号：US11389714

申请日：2006-03-27

申请人： Yosuke Iwata ,  Motoaki Mori ,  Naoki Asakawa

发明人： Yosuke Iwata ,  Motoaki Mori ,  Naoki Asakawa

IPC分类号： G01N21/00

CPC分类号： G01N21/31 ,  G01N30/74 ,  G01N33/15 ,  G01N2013/006

摘要： An elution test method measures the elution process of a specific component in a process where a preparation containing at least the specific component subject to a change with time in chemical properties after elution and an impurity component not subject to a change with time in chemical properties after elution is eluted into a test liquid. The method obtains a ratio of absorbance k of the impurity component and a ratio of absorbance k′ of the specific component at two isosbestic point wavelengths λ1, λ2 in a spectrum including the specific component and its decomposed matter, and calculates at least one of the absorbances A1(t), A2(t) of said specific component by using k×C2(t)−C1(t)=k×A2(t)−A1(t) and A1(t)/A2(t)=k′ from the absorbance C1(t), C2(t) at said two isosbestic point wavelengths λ1, λ2 measured at the plural time points t in the elution process of said preparation, and converts the result to an elution concentration.

摘要翻译： 洗脱试验方法测定特定成分的洗脱过程，其中至少含有洗脱后化学性质随时间变化的特定成分的制剂和化学性质随时间变化的杂质成分 洗脱液洗脱到测试液体中。 该方法获得杂质成分的吸光度k与包含特定成分的光谱中的两个等腰波长λ1，λ2的特定成分的吸光度k'的比率及其分解物质，并计算出 通过使用kxC 2（t）-C 1（t）= k×A 2（t）-A 1（t）和A 1（t）/ A，所述特定分量的吸光度A 1（t），A 2（t） 在所述制剂的洗脱过程中在多个时间点t测量的所述两个等腰波长λ1，λ2处的吸光度C 1（t），C 2（t）的2（t）= k' 洗脱浓度。

公开(公告)号：US07347936B2

公开(公告)日：2008-03-25

申请号：US11034638

申请日：2005-01-13

申请人： Yosuke Iwata

发明人： Yosuke Iwata

IPC分类号： B01D15/08

CPC分类号： G01N30/468 ,  G01N30/08 ,  G01N2030/085

摘要： A liquid chromatograph has switching valves as a flow passage switching mechanism and an automatic sampler as an injection section. The liquid chromatograph can switch, by switching the switching valves between a concentration flow passage for concentrating the sample injected by the automatic sample via a flow passage which connects the automatic sampler to the trapping column; a concentration analysis flow passage for separating and analyzing the concentrated sample on a per-composition basis which connects the trapping column to the analysis column; and a direct analysis flow passage by separating the sample on a per-composition basis which connects the automatic sampler to the analysis column.

摘要翻译： 液相色谱仪具有作为流路切换机构的切换阀和作为注射部的自动取样器。 液相色谱仪可以通过在通过将自动取样器连接到捕集柱的流动通道将由自动样品注入的样品集中的浓缩流路之间切换切换阀; 浓度分析流程，用于在将捕集柱连接到分析柱的基础上分离和分析浓缩样品; 以及通过将自动采样器连接到分析柱的基于每个组成的分离样品的直接分析流程。

公开(公告)号：US20070288117A1

公开(公告)日：2007-12-13

申请号：US11808046

申请日：2007-06-06

申请人： Yosuke Iwata ,  Tsuyoshi Kobayashi

发明人： Yosuke Iwata ,  Tsuyoshi Kobayashi

IPC分类号： G06F19/00

CPC分类号： G01N21/33 ,  Y10T436/117497 ,  Y10T436/118339

摘要： The present invention provides an apparatus for analyzing easily not only the overall taste of a sample but also what kind of components, synergetic effects and diminishing effects contribute to the taste. A sample to be analyzed is injected into a mobile phase by a liquid sending pump, and the sample is sent to a taste detector by way of a blending means and valves. Then, detection signals are obtained by taste sensors on the taste detector. The sample sent through the taste detector is introduced into a column by way of a 6-port-2-position valve, temporally separated into components and eluted from the column. After each component is detected by a UV detector, the eluted liquid is sent to the taste detector once more, and detection signals which reflect the tastes of each sample component. When analyzing how the taste changes by an additive, send the additive to the blending means and blend it with the sample.

摘要翻译： 本发明提供了一种用于不仅容易分析样品的整体味道的装置，而且还分析了哪种成分，协同作用和递减效果有助于味道的装置。 将待分析的样品通过送液泵注入流动相中，并通过混合装置和阀门将样品送至味觉检测器。 然后，通过味觉检测器上的味道传感器获得检测信号。 通过味道检测器发送的样品通过6端口2-位置阀引入柱中，时间上分离成组分并从柱上洗脱。 每个成分被紫外检测器检测到后，洗脱液再次送到味觉检测器，反映出每个样品成分的味道的检测信号。 当分析添加剂的味道如何变化时，将添加剂发送到混合装置并将其与样品混合。

公开(公告)号：US20060213838A1

公开(公告)日：2006-09-28

申请号：US11389714

申请日：2006-03-27

申请人： Yosuke Iwata ,  Motoaki Mori ,  Naoki Asakawa

发明人： Yosuke Iwata ,  Motoaki Mori ,  Naoki Asakawa

IPC分类号： B01D15/08 ,  G01N1/00

CPC分类号： G01N21/31 ,  G01N30/74 ,  G01N33/15 ,  G01N2013/006

摘要： An elution test method measures the elution process of a specific component in a process where a preparation containing at least the specific component subject to a change with time in chemical properties after elution and an impurity component not subject to a change with time in chemical properties after elution is eluted into a test liquid. The method obtains a ratio of absorbance k of the impurity component and a ratio of absorbance k′ of the specific component at two isosbestic point wavelengths λ1, λ2 in a spectrum including the specific component and its decomposed matter, and calculates at least one of the absorbances A1(t), A2(t) of said specific component by using k×C2(t)−C1(t)=k×A2(t)−A1(t) and A1(t)/A2(t)=k′ from the absorbance C1(t), C2(t) at said two isosbestic point wavelengths λ1, λ2 measured at the plural time points t in the elution process of said preparation, and converts the result to an elution concentration.

摘要翻译： 洗脱试验方法测定特定成分的洗脱过程，其中至少含有洗脱后化学性质随时间变化的特定成分的制剂和化学性质随时间变化的杂质成分 洗脱液洗脱到测试液体中。 该方法获得杂质成分的吸光度k与特定成分的特​​征成分的吸光度k'在包含特定成分及其分解物质的光谱中的两个同位素波长λ1，λ2的比例，并计算出 通过使用kxC2（t）-C1（t）= k×A2（t）-A1（t）和A1（t）/ A2（t）= k'从所述特定分量的吸光度A1（t），A2（t） 在所述制剂的洗脱过程中在多个时间点t测量的所述两个等腰波长λ1，λ2处的吸光度C1（t），C2（t），并将结果转换为洗脱浓度。

公开(公告)号：US20050006291A1

公开(公告)日：2005-01-13

申请号：US10881099

申请日：2004-06-29

申请人： Yosuke Iwata ,  Shuzo Maruyama

发明人： Yosuke Iwata ,  Shuzo Maruyama

IPC分类号： G01N30/80 ,  G01N30/72 ,  G01N30/84 ,  B01D15/08

CPC分类号： G01N30/84 ,  G01N30/72 ,  G01N2030/8417 ,  G01N2030/8429

摘要： A distal end portion of a probe has a multi-pipe structure, in which an effluent solution from a high speed liquid chromatography passes through an innermost flow passage, a matrix solution through an outer flow passage, and the air through an outermost flow passage. A distal end of the outermost pipe extends 1.2 mm longer than the distal end of the inner duplex tube to form a liquid reservoir. When dropping a liquid droplet from the distal end of the probe, the air is blown out to expel the liquid gathered in the liquid reservoir to be dropped.

摘要翻译： 探针的远端部分具有多管结构，其中来自高速液相色谱的流出液通过最内流道，通过外流动通道的基质溶液和通过最外流动通道的空气。 最外面的管的远端比内部双管的远端延伸1.2mm以形成液体储存器。 当从探针的远端滴下液滴时，空气被吹出以排出聚集在液体储存器中的液体以便掉落。

公开(公告)号：US06485642B2

公开(公告)日：2002-11-26

申请号：US09873411

申请日：2001-06-05

申请人： Katsuaki Kaito ,  Yosuke Iwata ,  Kaoru Murata ,  Naoki Asakawa

发明人： Katsuaki Kaito ,  Yosuke Iwata ,  Kaoru Murata ,  Naoki Asakawa

IPC分类号： B01D1508

CPC分类号： G01N30/34 ,  G01N2030/085

摘要： A sample solution is sent into a concentration column through a three-way joint and a three-way switching valve to trap and concentrate the sample components on the concentration column, followed by injecting the sample solution into an injector by operating a first dilution solvent pump. When a large volume of the sample solution is to be sent or when the sample solution has a high solvent strength, trapping and concentration on the concentration column may be facilitated by replacing the sample solvent with a second dilution solvent by allowing the second dilution solvent to flow into the three-way joint after setting the flow rate of the second dilution solvent from a second dilution solvent vessel to a prescribed flow rate using a second dilution solvent pump.

摘要翻译： 将样品溶液通过三通接头和三通切换阀送入浓缩柱，以将样品组分捕集并浓缩在浓缩柱上，然后通过操作第一稀释溶剂泵将样品溶液注入注射器 。 当要发送大量的样品溶液时或当样品溶液具有高溶剂强度时，可以通过用第二稀释溶剂将第二稀释溶剂替换为样品溶剂来容易地浓缩在浓缩柱上的捕获和浓缩 在使用第二稀释溶剂泵将第二稀释溶剂的流量从第二稀释溶剂容器设定为规定流量后，流入三通接头。

公开(公告)号：US06456078B1

公开(公告)日：2002-09-24

申请号：US09978584

申请日：2001-10-18

申请人： Yosuke Iwata

发明人： Yosuke Iwata

IPC分类号： G01V300

CPC分类号： G01R33/307

摘要： An NMR device includes an NMR coil, and a sample flow path connected to a sample supply source and passing through the NMR coil. The NMR device can carry out an on-line measurement so that a portion passing through the NMR coil of the sample flow path functions as an NMR probe for measurement. A filler for absorbing a sample is provided at a position of the NMR probe in the sample flow path, and the NMR measurement is carried out in a state where the sample is absorbed by the filler. Thus, when the measurement is carried out, the sample is retained accurately at the NMR coil position while a very small quantity of sample is being concentrated.

摘要翻译： NMR装置包括NMR线圈和连接到样品供应源并通过NMR线圈的样品流路。 NMR装置可以进行在线测量，使得通过样品流路的NMR线圈的部分用作用于测量的NMR探针。 在样品流路中的NMR探针的位置处设置用于吸收样品的填充物，并且在样品被填充物吸收的状态下进行NMR测量。 因此，当进行测量时，样品被精确地保留在NMR线圈位置，同时非常少量的样品被浓缩。