公开(公告)号：US09274058B2

公开(公告)日：2016-03-01

申请号：US13879245

申请日：2010-10-20

Applicant: Zhiyong Li ,  R. Stanley Williams

Inventor： Zhiyong Li ,  R. Stanley Williams

IPC: G01N21/65 ,  G01N21/64

CPC classification number: G01N21/658 ,  G01N21/648

Abstract: A metallic-nanofinger device for chemical sensing. The device includes a substrate, and a plurality of nanofingers. A nanofinger includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger are to self-arrange into a close-packed configuration with at least one analyte molecule disposed between at least the metallic cap and a second metallic cap of respective nanofinger and second nanofinger. A morphology of the metallic cap is to generate a shifted plasmonic-resonance peak associated with amplified luminescence from the analyte molecule. A coating encapsulating the metallic cap to respond upon exposure to a liquid, and a chemical-sensing chip including the metallic-nanofinger device are also provided.

Abstract translation: 用于化学感应的金属纳米膜装置。 该装置包括基板和多个纳米装置。 纳米针框包括柔性柱和与柔性柱的顶点相连的金属帽。 至少纳米酮和第二纳米酮将自排列成紧密堆积的构型，其中至少一个分析物分子设置在至少金属盖和相应的纳芬酮和第二纳米酮之间的第二金属盖之间。 金属帽的形态是产生与来自分析物分子的放大发光相关的移位等离子体共振峰。 还提供了包封金属盖以在暴露于液体时响应的涂层，以及包括金属纳米酮装置的化学感测芯片。

公开(公告)号：US20140036262A1

公开(公告)日：2014-02-06

申请号：US13562567

申请日：2012-07-31

Applicant: Shih-Yuan Wang ,  Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Huei Pei Kuo ,  Zhang-Lin Zhou ,  R Stanley Williams

Inventor： Shih-Yuan Wang ,  Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Huei Pei Kuo ,  Zhang-Lin Zhou ,  R Stanley Williams

IPC: G01J3/44

CPC classification number: G01N21/658

Abstract: An apparatus for surface enhanced Raman spectroscopy includes a substrate, a nanostructure and a plasmonic material. The nanostructure and the plasmonic material are integrated together to provide electronic and plasmonic enhancement to a Raman signal produced by electromagnetic radiation scattering from an analyte.

Abstract translation: 用于表面增强拉曼光谱的装置包括底物，纳米结构和等离子体激元材料。 将纳米结构和等离子体激元材料集成在一起，以对由分析物的电磁辐射散射产生的拉曼信号提供电子和等离子体增强。

公开(公告)号：US20140029002A1

公开(公告)日：2014-01-30

申请号：US13561561

申请日：2012-07-30

Applicant: Shih-Yuan Wang ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Gary Gibson ,  Huei Pei Kuo ,  Zhang-Lin Zhou ,  Steven J. Barcelo ,  Ansoon Kim ,  R Stanley Williams

Inventor： Shih-Yuan Wang ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Gary Gibson ,  Huei Pei Kuo ,  Zhang-Lin Zhou ,  Steven J. Barcelo ,  Ansoon Kim ,  R Stanley Williams

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B82Y15/00

Abstract: A sensor for surface enhanced Raman spectroscopy (SERS) sensor includes surfaces and an actuator to adjust an intersurface spacing between the surfaces to contain an analyte and allow the analyte to be released from containment.

Abstract translation: 用于表面增强拉曼光谱（SERS）传感器的传感器包括表面和致动器，以调节表面之间的表面间隔，以包含分析物并允许分析物从容纳物释放。

公开(公告)号：US08395768B2

公开(公告)日：2013-03-12

申请号：US12772161

申请日：2010-04-30

Applicant: Zhiyong Li ,  David A. Fattal ,  Jingjing Li ,  R. Stanley Williams

Inventor： Zhiyong Li ,  David A. Fattal ,  Jingjing Li ,  R. Stanley Williams

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/1895 ,  G01N21/658

Abstract: A scattering spectroscopy apparatus, system and method employ guided mode resonance (GMR) and a GMR grating. The apparatus includes a GMR grating having a subwavelength grating, and an optical detector configured to receive a portion of a scattered signal produced by an interaction between an excitation signal and an analyte associated with a surface of the GMR grating. A propagation direction of the received portion of the scattered signal is substantially different from a propagation direction of a GMR-coupled portion of the excitation signal within the GMR grating. The system includes the apparatus and an optical source. The method includes exciting a GMR in a GMR grating, interacting a GMR-coupled portion of the excitation signal with an analyte to produce a scattered signal and detecting a portion of the scattered signal.

Abstract translation: 散射光谱装置，系统和方法采用导模共振（GMR）和GMR光栅。 该装置包括具有亚波长光栅的GMR光栅和配置成接收由激发信号与与GMR光栅的表面相关联的分析物之间的相互作用产生的散射信号的一部分的光学检测器。 散射信号的接收部分的传播方向与GMR光栅内的激励信号的GMR耦合部分的传播方向基本上不同。 该系统包括该装置和光源。 该方法包括激励GMR光栅中的GMR，将激发信号的GMR耦合部分与分析物相互作用以产生散射信号并检测散射信号的一部分。

公开(公告)号：US08390805B2

公开(公告)日：2013-03-05

申请号：US12846524

申请日：2010-07-29

Applicant: Huei Pei Kuo ,  Zhiyong Li ,  R. Stanley Williams

Inventor： Huei Pei Kuo ,  Zhiyong Li ,  R. Stanley Williams

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/0227 ,  G01J3/26 ,  G01J3/36 ,  G01N21/658

Abstract: A surface enhanced Raman spectroscopy system includes a surface enhanced Raman spectroscopy substrate and a laser source configured to emit light within a spectrum of wavelengths toward a predetermined species on or near the surface enhanced Raman spectroscopy substrate. The system further includes a set of filters positioned to be in optical communication with light scattered after the laser light interacts with the predetermined species. Each of the filters in the set is respectively configured to pass scattered light within a different predetermined narrow band of wavelengths. The system also includes a plurality of photodetectors, where each photodetector is positioned adjacent to a respective one of the filters in the set and is configured to output a signal if the scattered light passes through the respective one of the filters. The set of filters is targeted for detection of characteristic peaks of the predetermined species.

Abstract translation: 表面增强拉曼光谱系统包括表面增强拉曼光谱基板和激光源，该激光源被配置为向表面增强拉曼光谱基板上或附近的预定物质发射波长光谱的光。 该系统还包括一组滤光器，其被定位成在激光与预定物质相互作用之后与散射的光光通信。 集合中的每个滤光器分别被配置成使不同预定的窄波段内的散射光通过。 该系统还包括多个光电检测器，其中每个光电检测器被定位成与集合中的相应一个滤光器相邻，并且被配置为如果散射光通过相应的一个滤光器则输出信号。 该组滤波器用于检测预定种类的特征峰。

公开(公告)号：US07780841B2

公开(公告)日：2010-08-24

申请号：US11059258

申请日：2005-02-15

Applicant: Sean Xiao-An Zhang ,  Zhiyong Li ,  Zhang-Lin Zhou ,  William M. Tong ,  R. Stanley Williams ,  Yong Chen

Inventor： Sean Xiao-An Zhang ,  Zhiyong Li ,  Zhang-Lin Zhou ,  William M. Tong ,  R. Stanley Williams ,  Yong Chen

IPC: G01N27/327

CPC classification number: G01N33/5308 ,  G01N33/5438 ,  G01N2430/00

Abstract: A sensor array for sensing at least one of chemical moieties and biological moieties is provided. The sensor array comprises a plurality of working electrodes electrically associated with a reference electrode, each working electrode in combination with the reference electrode forming a transducer. Each working electrode is provided with a coating of a sensing element comprised of an ionizable moiety and a functional group sensitive to one of the chemical and/or biological moieties.

Abstract translation: 提供了用于感测化学部分和生物部分中的至少一个的传感器阵列。 传感器阵列包括与参考电极电连接的多个工作电极，每个工作电极与参考电极组合形成换能器。 每个工作电极设置有由可电离部分和对化学和/或生物部分之一敏感的官能团组成的感测元件的涂层。

公开(公告)号：US07763552B2

公开(公告)日：2010-07-27

申请号：US11413476

申请日：2006-04-28

Applicant: William M. Tong ,  Duncan Stewart ,  R. Stanley Williams ,  Manish Sharma ,  Zhiyong Li ,  Gary A. Gibson

Inventor： William M. Tong ,  Duncan Stewart ,  R. Stanley Williams ,  Manish Sharma ,  Zhiyong Li ,  Gary A. Gibson

IPC: H01L21/768 ,  H01L21/62

CPC classification number: H01L21/76892 ,  H01L21/76823 ,  H01L23/5254 ,  H01L27/1052 ,  H01L2924/0002 ,  H01L2924/12044 ,  H01L2924/3011 ,  H01L2924/00

Abstract: A method of forming an electrical interconnect, which includes a first electrode, an interlayer of a programmable material disposed over at least a portion of the first electrode, and a second electrode disposed over the programmable material at a non-zero angle relative to the first electrode. The interlayer includes a modified region having differing electrical properties than the rest of the interlayer, sandwiched at the junction of the first electrode and the second electrode. The interlayer may be exposed to a focused beam to form the modified region.

Abstract translation: 一种形成电互连的方法，包括第一电极，设置在第一电极的至少一部分上的可编程材料的中间层，以及设置在可编程材料上的第二电极，相对于第一电极以非零角度 电极。 中间层包括夹在第一电极和第二电极的接合处的与中间层的其余部分不同的电特性的改性区域。 中间层可以暴露于聚焦光束以形成改质区域。

公开(公告)号：US20080270042A1

公开(公告)日：2008-10-30

申请号：US11796455

申请日：2007-04-26

Applicant: Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Zhaoning Yu ,  R. Stanley Williams

Inventor： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Zhaoning Yu ,  R. Stanley Williams

IPC: G01J3/44

CPC classification number: G01N21/658

Abstract: An apparatus and related methods for facilitating surface-enhanced Raman spectroscopy (SERS) is described. A SERS-active structure near which a plurality of analyte molecules is disposed is periodically deformed at an actuation frequency. A synchronous measuring device synchronized with the actuation frequency receives Raman radiation scattered from the analyte molecules and generates therefrom at least one Raman signal measurement.

Abstract translation: 描述了用于促进表面增强拉曼光谱（SERS）的装置和相关方法。 多个分析物分子附近的SERS-活性结构以致动频率周期性地变形。 与致动频率同步的同步测量装置接收从分析物分子散射的拉曼辐射，并由此产生至少一个拉曼信号测量。

公开(公告)号：US07359048B2

公开(公告)日：2008-04-15

申请号：US11413910

申请日：2006-04-28

Applicant: Shih-Yuan Wang ,  R. Stanley Williams ,  Raymond G. Beausoleil ,  Theodore I. Kamins ,  Zhiyong Li ,  Wei Wu

Inventor： Shih-Yuan Wang ,  R. Stanley Williams ,  Raymond G. Beausoleil ,  Theodore I. Kamins ,  Zhiyong Li ,  Wei Wu

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658 ,  G01J3/44

Abstract: Raman systems include a radiation source, a radiation detector, and a Raman device or signal-enhancing structure. Raman devices include a tunable resonant cavity and a Raman signal-enhancing structure coupled to the cavity. The cavity includes a first reflective member, a second reflective member, and an electro-optic material disposed between the reflective members. The electro-optic material exhibits a refractive index that varies in response to an applied electrical field. Raman signal-enhancing structures include a substantially planar layer of Raman signal-enhancing material having a major surface, a support structure extending from the major surface, and a substantially planar member comprising a Raman signal-enhancing material disposed on an end of the support structure opposite the layer of Raman signal-enhancing material. The support structure separates at least a portion of the planar member from the layer of Raman signal-enhancing material by a selected distance of less than about fifty nanometers.

Abstract translation: 拉曼系统包括辐射源，辐射检测器和拉曼器件或信号增强结构。 拉曼器件包括耦合到空腔的可调谐谐振腔和拉曼信号增强结构。 空腔包括第一反射构件，第二反射构件和设置在反射构件之间的电光材料。 电光材料表现出响应于所施加的电场而变化的折射率。 拉曼信号增强结构包括具有主表面的基本平坦的拉曼信号增强材料层，从主表面延伸的支撑结构和包括设置在支撑结构的端部上的拉曼信号增强材料的基本上平面的构件 与拉曼信号增强材料层相对。 支撑结构将平面构件的至少一部分与拉曼信号增强材料层分开小于约五十纳米的选定距离。

公开(公告)号：US07342656B2

公开(公告)日：2008-03-11

申请号：US11252134

申请日：2005-10-17

Applicant: M. Saif Islam ,  Shih-Yuan Wang ,  R. Stanley Williams ,  Philip J. Kuekes ,  Wei Wu ,  Zhiyong Li

Inventor： M. Saif Islam ,  Shih-Yuan Wang ,  R. Stanley Williams ,  Philip J. Kuekes ,  Wei Wu ,  Zhiyong Li

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: A NERS-active structure includes a deformable, active nanoparticle support structure for supporting a first nanoparticle and a second nanoparticle that is disposed proximate the first nanoparticle. The nanoparticles each comprise a NERS-active material. The deformable, active nanoparticle support structure is configured to vary the distance between the first nanoparticle and the second nanoparticle while performing NERS. Various active nanoparticle support structures are disclosed. A NERS system includes such a NERS-active structure, a radiation source for generating radiation scatterable by an analyte located proximate the NERS-active structure, and a radiation detector for detecting Raman scattered radiation scattered by the analyte. A method for performing NERS includes providing such a NERS-active structure, providing an analyte at a location proximate the NERS-active structure, irradiating the NERS-active structure and the analyte with radiation, varying the distance between the nanoparticles, and detecting Raman scattered radiation scattered by the analyte.

Abstract translation: NERS活性结构包括用于支撑第一纳米颗粒的可变形的活性纳米颗粒支撑结构和邻近第一纳米颗粒设置的第二纳米颗粒。 纳米颗粒各自包含NERS-活性材料。 可变形的活性纳米颗粒支撑结构被配置为在执行NERS的同时改变第一纳米颗粒和第二纳米颗粒之间的距离。 公开了各种活性纳米颗粒载体结构。 NERS系统包括这样的NERS-活性结构，用于产生由位于NERS-活性结构附近的分析物可散射的辐射的辐射源，以及用于检测被分析物散射的拉曼散射辐射的辐射检测器。 执行NERS的方法包括提供这样的NERS活性结构，在靠近NERS-活性结构的位置提供分析物，用辐射照射NERS-活性结构和分析物，改变纳米颗粒之间的距离并检测拉曼散射 被分析物散射的辐射。