公开(公告)号：US20210052598A1

公开(公告)日：2021-02-25

申请号：US16977375

申请日：2019-03-06

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： Wenyi Wei

IPC分类号： A61K31/551 ,  A61K31/4353 ,  G01N33/574

摘要： The present disclosure features compositions and methods of treating a cancer in a subject by administering to the subject a Skp2 inhibitor and an inhibitor of glycolytic metabolism (e.g., PKM2 inhibitor).

公开(公告)号：US20200377599A1

公开(公告)日：2020-12-03

申请号：US16767487

申请日：2018-11-28

申请人： BETH ISRAEL DEACONESS MEDICAL CENTER, INC.

发明人： WENYI WEI

IPC分类号： C07K16/28 ,  C07K16/40 ,  A61P35/00

摘要： Provided are compositions and methods of treating subjects having cancer which involve administering to the subject an anti-PD-L1 or an anti-PD-1 antibody and an inhibitor of cyclin D kinase (CDK)4/6 to treat the cancer. Combining CDK4/6 inhibitor treatment with anti-PD-L1 or anti-PD-1 immunotherapy enhanced tumor regression and dramatically improved overall survival rates in tumor models.

公开(公告)号：US10806890B2

公开(公告)日：2020-10-20

申请号：US15736555

申请日：2016-06-17

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： Rami Burstein

IPC分类号： A61M21/02 ,  G02C7/10 ,  A61B3/00 ,  F21V9/30 ,  F21S6/00 ,  F21S8/04 ,  F21V9/08 ,  F21V23/02 ,  F21V8/00 ,  F21Y115/30 ,  F21Y115/10 ,  A61M21/00 ,  A61N5/06 ,  A61N5/067 ,  F21V3/04 ,  F21V5/04

摘要： Apparatus and methods for producing narrow-band radiation in the green region of the visible spectrum are described. The narrow-band radiation may be used to aid subjects experiencing photophobia. In some cases, subjects may experience a reduction in pain (e.g., migraine photophobia) when using the narrow-band radiation.

公开(公告)号：US20200230592A1

公开(公告)日：2020-07-23

申请号：US16486114

申请日：2018-02-14

申请人： FRAUNHOFER USA, INC. ,  THE CHILDREN'S MEDICAL CENTER CORPORATION ,  BETH ISRAEL DEACONESS MEDICAL CENTER, INC.

发明人： Alexis Sauer-Budge ,  Holger Wirz ,  Samuel J. Brookfield ,  Nira Pollock ,  Ronald Janzen

IPC分类号： B01L3/02 ,  F04B13/00 ,  F04B9/14 ,  F04B53/10

摘要： A pipetting device includes a housing, a valve assembly, and an actuator assembly. The housing includes a tip for receiving a capillary tube. The valve assembly includes a shuttle valve having a filling position and a dispensing position and a valve rod. The actuator assembly includes an actuator, a valve trigger, a piston mount, and an indexing mechanism. The actuator extends from the housing and has a push button coupled to a push rod. The valve trigger being configured to engage the valve assembly and includes an aperture configured to receive the piston mount therein. The indexing mechanism is configured to index a rotated position of the push button to a predefined volume of dispensed fluid.

公开(公告)号：US10718841B2

公开(公告)日：2020-07-21

申请号：US16069245

申请日：2017-01-17

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： David Alsop ,  Gopal Varma

IPC分类号： G01R33/56

摘要： A system and methods for improved homogeneous and inhomegeneous magnetic transfer imaging are provided. In some aspects, a plurality of gradient coils and an RF system of a magnetic resonance imaging (“MRI”) system are controlled, using a computer, to perform, at least one pulse sequence that includes a preparation module followed by an imaging module, wherein the preparation module comprises a plurality of radio frequency (“RF”) saturation pulses applied according to a concentrated pulse cycle to manipulate exchangeable magnetization from protons in the subject, and the imaging module is configured to acquire image data. The computer is also configured to analyze the image data acquired to generate frequency information indicative of the exchangeable magnetization from protons in the subject, and generate a report, using the frequency information, pertaining to inhomogeneous or homogeneous magnetization transfer occurring in the subject.

公开(公告)号：US10531812B2

公开(公告)日：2020-01-14

申请号：US13742620

申请日：2013-01-16

申请人： Sebastian Weingärtner ,  Mehmet Akçakaya ,  Warren J. Manning ,  Reza Nezafat

发明人： Sebastian Weingärtner ,  Mehmet Akçakaya ,  Warren J. Manning ,  Reza Nezafat

IPC分类号： A61B5/055 ,  G01R33/56 ,  A61B5/00 ,  G01R33/50 ,  G01R33/567

摘要： A system and method for controlling a magnetic resonance imaging (MRI) system to acquire images of a subject having inconsistencies in a cardiac cycle of the subject. The process includes receiving an identification of a predetermined point in a cardiac cycle of the subject and, thereupon, performing a saturation module configured to dephase magnetization within a region of interest (ROI) from before the predetermined point. The process also includes performing an inversion module configured to invert spins within the ROI and acquiring medical imaging data from the subject. A delay is inserted between the performance of the saturation module and the performance of the inversion module, wherein a duration of the delay is configured, with the saturation module, to control evidence in the medical imaging data of inconsistencies in the cardiac cycle of the subject by controlling a magnetization history of tissue in the ROI.

公开(公告)号：US10517494B2

公开(公告)日：2019-12-31

申请号：US15522615

申请日：2015-11-13

申请人： Beth Israel Deaconess Medical Center, Inc. ,  Johns Hopkins University ,  Oregon Health and Science University

发明人： Larisa G. Tereshchenko ,  Mark E. Josephson

IPC分类号： A61B5/04 ,  A61B5/0464 ,  A61B5/00 ,  A61N1/362 ,  G16H50/30 ,  G06K9/00

摘要： A method and system for determining a patient's risk of ventricular tachycardia are disclosed. The method includes receiving ECG signals from a patient and filtering the collected ECG signals to generate filtered ECG signals. The method further includes identifying a heart vector from the filtered ECG signals, and measuring a velocity of the heart vector movement. A change in curvature of the identified heart vector movement is quantified and a risk of ventricular tachycardia is determined based at least on the measured velocity and the quantified change in curvature of the identified heart vector movement.

公开(公告)号：US10463729B2

公开(公告)日：2019-11-05

申请号：US16385438

申请日：2019-04-16

申请人： Beth Israel Deaconess Medical Center, Inc. ,  Children's Medical Center Corporation

发明人： Stephen C. Harrison ,  Bing Chen ,  Dan H. Barouch ,  Joseph P. Nkolola ,  Michael Scott Seaman

IPC分类号： A61K39/21 ,  C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  C12N7/00

摘要： Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided.

公开(公告)号：US10426831B2

公开(公告)日：2019-10-01

申请号：US15489220

申请日：2017-04-17

申请人： Beth Israel Deaconess Medical Center, Inc. ,  Triad National Security, LLC

发明人： Dan H. Barouch ,  Bette T. Korber ,  William M. Fischer

IPC分类号： A61K39/21 ,  C07K14/005 ,  A61K39/12 ,  A61K39/235 ,  A61K39/275 ,  C12N7/00 ,  A61K39/00

摘要： The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.

公开(公告)号：US10413548B2

公开(公告)日：2019-09-17

申请号：US15645683

申请日：2017-07-10

申请人： Beth Israel Deaconess Medical Center, Inc. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Kun Ping Lu ,  Matthew Brian Boxer ,  Mindy Irene Emily Davis ,  Rajan Pragani ,  Min Shen ,  Anton Momtchilov Simeonov ,  Shuo Wei ,  Xiao Zhen Zhou

IPC分类号： A61K31/5377 ,  A61K31/473 ,  A61K45/06 ,  A61K31/185 ,  A61K31/341 ,  A61K31/357 ,  A61K31/365 ,  A61K31/381 ,  A61K31/382 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/405 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4704 ,  A61K31/496

摘要： The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.