公开(公告)号：US09707175B2

公开(公告)日：2017-07-18

申请号：US13996877

申请日：2010-12-21

Applicant: Bruno Provstgaard Nielsen

Inventor： Bruno Provstgaard Nielsen

IPC: A61K9/68 ,  A23G4/06 ,  A23G4/08 ,  A61K31/465 ,  A61K47/32 ,  A61K47/48

CPC classification number: A61K9/0058 ,  A23G4/06 ,  A23G4/08 ,  A61K31/465 ,  A61K47/32 ,  A61K47/585

Abstract: The present invention provides a chewing gum composition comprising a gum base matrix and a bulk portion, wherein the chewing gum composition comprises nicotine and includes a cross-linked polyacrylic acid, such as a carbomer, added in an amount of 0.1 to 5.0% by weight of the chewing gum composition. The invention may be used to enhance the release of nicotine in a nicotine chewing gum.

公开(公告)号：US09420806B2

公开(公告)日：2016-08-23

申请号：US13330452

申请日：2011-12-19

Applicant: Carsten Andersen ,  Gitte Lorenzen ,  Nicolai Arent ,  Bitten Thorengaard ,  Helle Wittorff

Inventor： Carsten Andersen ,  Gitte Lorenzen ,  Nicolai Arent ,  Bitten Thorengaard ,  Helle Wittorff

IPC: A61K9/68 ,  A61K9/00 ,  A61K9/22 ,  A61K31/465 ,  A61P25/34 ,  A23G4/06 ,  A23G4/08 ,  A23G4/12 ,  A23G4/20

CPC classification number: A23G4/064 ,  A23G4/06 ,  A23G4/08 ,  A23G4/126 ,  A23G4/20 ,  A61K9/0058

Abstract: A chewing gum composition with high pH-release includes an insoluble gum base matrix and a soluble bulk portion, wherein the gum base matrix and the bulk portion is mixed and extruded to form a final chewing gum core, and wherein the gum base matrix is buffered before mixing with the bulk portion. Furthermore, a method of producing a chewing gum core, wherein a gum base matrix and a bulk portion is mixed and extruded to form a final chewing gum core, and wherein the gum base matrix is buffered before mixing with the bulk portion, and the gum base matrix includes a first amount of buffer from 2 to 20 percent by weight of the gum base matrix before mixing with the bulk portion.

Abstract translation: 具有高pH释放的口香糖组合物包括不溶性胶基基质和可溶性本体部分，其中将胶基基质和本体部分混合并挤出以形成最终的口香糖芯，并且其中胶基基质被缓冲 在与本体部分混合之前。 此外，制备口香糖芯的方法，其中将胶基基体和本体部分混合并挤出以形成最终的口香糖芯，并且其中胶基基质在与本体部分混合之前被缓冲，而胶基 基础基质包括在与本体部分混合之前的胶基基质的2至20重量％的第一量缓冲剂。

公开(公告)号：US09028803B2

公开(公告)日：2015-05-12

申请号：US14109127

申请日：2013-12-17

Applicant: Fertin Pharma A/S

Inventor： Bruno Provstgaard Nielsen ,  Jesper Neergard

IPC: A61K9/68 ,  A61K31/465 ,  A61K31/787 ,  A23G4/06 ,  A23G4/12

CPC classification number: A61K31/465 ,  A23G4/066 ,  A23G4/12 ,  A61K9/0058 ,  A61K31/787

Abstract: The present invention relates to a chewing gum having a high Surface Area to Volume ratio (SAV ratio), wherein said chewing gum comprises a water insoluble gum base matrix, a water soluble bulk portion and nicotine, wherein the gum base matrix, nicotine and the bulk portion are mixed and extruded to form a final extruded chewing gum product having a SAV ratio above 0.7, and wherein sustained release of nicotine is facilitated by adding 0.1-10% of C8-C10 triglycerides by weight of the chewing gum.

Abstract translation: 本发明涉及具有高表面积/体积比（SAV比）的口香糖，其中所述口香糖包括水不溶性胶基基质，水溶性本体部分和尼古丁，其中胶基基质，尼古丁和 将本体部分混合并挤出以形成具有高于0.7的SAV比率的最终挤出的口香糖产品，并且其中通过加入0.1-10％的口香糖重量的C8-C10甘油三酯来促进尼古丁的持续释放。

公开(公告)号：US08623331B2

公开(公告)日：2014-01-07

申请号：US12819932

申请日：2010-06-21

Applicant: Carsten Andersen ,  Gitte Lorenzen ,  Nicolai Arent ,  Bitten Thorengaard ,  Helle Wittorff

Inventor： Carsten Andersen ,  Gitte Lorenzen ,  Nicolai Arent ,  Bitten Thorengaard ,  Helle Wittorff

IPC: A61K9/68 ,  A01N43/40 ,  A61K31/44

CPC classification number: A61K9/2072 ,  A23G4/043 ,  A23G4/12 ,  A23G4/20 ,  A61K9/0058 ,  A61K9/146 ,  A61K9/2077 ,  A61K9/2086 ,  A61K31/465 ,  A61K38/00

Abstract: A compressed chewing gum tablet includes at least a first and a second chewing gum module, the first chewing gum module including a first chewing gum composition including at least a first active ingredient and chewing gum granules containing gum base, the second chewing gum module including a second chewing gum composition including at least a second active ingredient and chewing gum granules containing gum base, wherein the first active ingredient is a pharmaceutically active ingredient, and the second active ingredient is selected from the group consisting of pharmaceutically active ingredients and enhancers, wherein the gum base content of the first and second chewing gum modules is different.

Abstract translation: 压缩口香糖片包括至少第一和第二口香糖组件，所述第一口香糖模块包括包含至少第一活性成分的第一口香糖组合物和含有胶基糖的口香糖颗粒，所述第二口香糖模块包括 第二口香糖组合物，其包含至少第二活性成分和含有胶基的口香糖颗粒，其中所述第一活性成分是药物活性成分，所述第二活性成分选自药物活性成分和增强剂，其中 第一和第二口香糖模块的胶基含量不同。

公开(公告)号：US20130011343A1

公开(公告)日：2013-01-10

申请号：US13360102

申请日：2012-01-27

Applicant: Bruno Provstgaard NIELSEN ,  Jesper NEERGAARD

Inventor： Bruno Provstgaard NIELSEN ,  Jesper NEERGAARD

IPC: A61K9/68 ,  A61K31/787 ,  A61P25/26 ,  A61K31/465

CPC classification number: A61K31/465 ,  A23G4/066 ,  A23G4/12 ,  A61K9/0058 ,  A61K31/787

Abstract: The present invention relates to a chewing gum having a high Surface Area to Volume ratio (SAV ratio), wherein said chewing gum comprises a water insoluble gum base matrix, a water soluble bulk portion and nicotine, wherein the gum base matrix, nicotine and the bulk portion are mixed and extruded to form a final extruded chewing gum product having a SAV ratio above 0.7, and wherein sustained release of nicotine is facilitated by adding 0.1-10% of C8-C10 triglycerides by weight of the chewing gum.

Abstract translation: 本发明涉及具有高表面积/体积比（SAV比）的口香糖，其中所述口香糖包括水不溶性胶基基质，水溶性本体部分和尼古丁，其中胶基基质，尼古丁和 将本体部分混合并挤出以形成具有高于0.7的SAV比率的最终挤出的口香糖产品，并且其中通过加入0.1-10％的口香糖重量的C8-C10甘油三酯来促进尼古丁的持续释放。

公开(公告)号：US20100189768A1

公开(公告)日：2010-07-29

申请号：US12668413

申请日：2008-07-11

Applicant: Carsten Andersen ,  My Ly Lao

Inventor： Carsten Andersen ,  My Ly Lao

IPC: A61K9/68

CPC classification number: A61K31/495 ,  A61K9/0058 ,  A61K9/209 ,  A61K31/496

Abstract: The present invention relates to compressed chewing gum tablets comprising a useful antihistamine. In particular, the present invention is directed to compressed chewing gum tablet, which effectively mask the unpleasant tastes of compound according to formula I, such as cetirizine, contained therein and methods for preparing such compressed chewing gum tablet.

Abstract translation: 本发明涉及包含有用的抗组胺剂的压缩口香糖片剂。 特别地，本发明涉及压缩口香糖片剂，其有效地掩盖了包含在其中的根据式I的化合物（例如西替利嗪）的令人不愉快的味道以及制备这种压缩口香糖片剂的方法。

公开(公告)号：US20080038209A1

公开(公告)日：2008-02-14

申请号：US10581628

申请日：2004-12-02

Applicant: Carsten Andersen

Inventor： Carsten Andersen

IPC: A61K9/68 ,  A61K31/4439 ,  A61P25/34

CPC classification number: A24B15/10 ,  A24B15/287 ,  A61K9/0058 ,  A61K31/465 ,  A61K47/10 ,  A61K47/585

Abstract: A nicotine delivery product comprising the reaction product of a nicotine/cation exchange resin complex and an organic polyol; and a method for preparing it comprising (a) mixing an aqueous suspension of a nicotine/cation exchange resin complex with an organic polyol or an aqueous solution thereof, and (b) removing water from the mixture to produce said nicotine delivery product. The nicotine delivery product has a nicotine release rate of at least 80% over a 10 minute period. It is particularly suited for use in smoking substitution devices delivering nicotine such as chewing gum, patches, lozenges, melting tablets and tablets for chewing.

Abstract translation: 尼古丁输送产物，其包含尼古丁/阳离子交换树脂复合物和有机多元醇的反应产物; 及其制备方法，包括（a）将尼古丁/阳离子交换树脂配合物的水悬浮液与有机多元醇或其水溶液混合，和（b）从混合物中除去水以产生所述尼古丁递送产物。 尼古丁递送产品在10分钟内具有至少80％的尼古丁释放率。 它特别适合用于提供尼古丁的吸烟替代装置，例如口香糖，贴剂，锭剂，熔化片和片剂用于咀嚼。

公开(公告)号：US12194149B2

公开(公告)日：2025-01-14

申请号：US18464911

申请日：2023-09-11

Applicant: Fertin Pharma A/S

Inventor： Kent Albin Nielsen ,  Rikke Pranger-Rasmussen ,  Dorthe Schackinger Boesen ,  Heidi Ziegler Bruun ,  Bruno Provstgaard Nielsen

IPC: A61K9/20 ,  A61K31/4439

Abstract: A water-dissolvable nicotine tablet is disclosed, the nicotine tablet comprising at least a first compressed module and a second compressed module, wherein the first compressed module is an FDT-module and comprises nicotine, alkaline pH regulating agent, and disintegrant, and, wherein the second compressed module is a lozenge-module and comprises acidic pH regulating agent. Also, a method of manufacturing a nicotine tablet is disclosed.

公开(公告)号：US20250009651A1

公开(公告)日：2025-01-09

申请号：US18766089

申请日：2024-07-08

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff ,  Bruno Provstgaard Nielsen ,  Helle Martinussen

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/465 ,  A61K47/36

Abstract: A dissolvable orally adhering nicotine tablet for sustained delivery of nicotine is disclosed, the tablet is a multilayer tablet comprising a first layer and a second layer, wherein the first layer is a mucoadhesive layer comprising a mucoadhesive, and wherein the second layer comprises at least one sugar alcohol and nicotine.

公开(公告)号：US20240415853A1

公开(公告)日：2024-12-19

申请号：US18612256

申请日：2024-03-21

Applicant: Fertin Pharma A/S

Inventor： Sanne Skov Jensen ,  Gitte Nykjær Nikolajsen ,  Simon Laursen ,  Dorthe Schackinger Boesen

IPC: A61K31/00 ,  A61K9/00 ,  A61K9/48 ,  A61K47/02 ,  A61K47/14 ,  A61K47/26 ,  A61K47/44

Abstract: An orally dissolvable or chewable tableted powder formulation is presented. The formulation includes one or more carrier systems including one or more liquid or solid self-emulsifying systems loaded with cannabinoids in an amount of at least 10% by weight of the tableted powder formulation. The one or more self-emulsifying systems includes: at least one or more surfactants, one or more lipids and one or more isolated or synthetic cannabinoids when the self-emulsifying system is a liquid self-emulsifying system, and at least one or more surfactants, one or more waxes and one or more isolated or synthetic cannabinoids when the self-emulsifying system is a solid self-emulsifying system. The formulation further includes one or more water-soluble agents in an amount of 20-80% by weight of the tableted powder formulation and one or more flavors.