公开(公告)号：US07521019B2

公开(公告)日：2009-04-21

申请号：US09832663

申请日：2001-04-11

申请人： Anthony J. Polak ,  Ralph Ballerstadt ,  Allyson Beuhler ,  Claudia Gamboa

发明人： Anthony J. Polak ,  Ralph Ballerstadt ,  Allyson Beuhler ,  Claudia Gamboa

IPC分类号： G01N21/01

CPC分类号： B82Y5/00 ,  B82Y10/00 ,  G01N33/54366

摘要： The present invention provides a device and methods for detecting the presence of an analyte in a sample using an encapsulated sensor. Methods for manufacturing the sensor are also disclosed.

公开(公告)号：US20090043177A1

公开(公告)日：2009-02-12

申请号：US11836030

申请日：2007-08-08

申请人： Eric Milledge ,  Mahyar Z. Kermani

发明人： Eric Milledge ,  Mahyar Z. Kermani

IPC分类号： A61B5/145

CPC分类号： A61B5/0215 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/6862 ,  A61B5/6876 ,  A61F2/82 ,  A61F2250/0002

摘要： A method for the integrated facilitization of blood flow and monitoring of blood analyte concentration (for example, blood glucose concentration) includes implanting a stent configured to facilitate blood flow into a cardiovascular system of a user's body with the stent having attached thereto a continuous blood analyte determination module of a blood analyte monitoring system. The method also includes disposing a reader module of the blood analyte monitoring system external to the user's body and in proximity to a portion of the user's skin layer and monitoring blood analyte concentration via (i) emitting an RF carrier signal from the reader module toward the stent; (ii) receiving the RF carrier signal at a reflection antenna of the continuous blood analyte determination module; (iii) reflecting a modulated signal by the reflection antenna with the modulated signal being encoded with a blood analyte concentration determined by a sensor of the continuous blood analyte determination module; (iv) receiving the modulated signal by the reader module; and (v) decoding the analyte concentration from the modulated signal by the reader module.

摘要翻译： 用于综合促进血液流动和监测血液分析物浓度（例如，血糖浓度）的方法包括植入支架，其构造成便于血液流入使用者身体的心血管系统，其中支架具有连续的血液分析物 血液分析物监测系统的测定模块。 该方法还包括将血液分析物监测系统的读取器模块设置在用户身体外部并靠近用户皮肤层的一部分，并且通过（i）从读取器模块朝向所述读取器模块发射RF载波信号来监测血液分析物浓度 支架; （ii）在连续血液分析物确定模块的反射天线处接收RF载波信号; （iii）通过所述反射天线反射调制信号，所述调制信号由所述连续血液分析物确定模块的传感器确定的血液分析物浓度编码; （iv）由读取器模块接收调制信号; 和（v）由读取器模块从调制信号解码分析物浓度。

公开(公告)号：US20090027040A1

公开(公告)日：2009-01-29

申请号：US11782865

申请日：2007-07-25

申请人： Mahyar Z. Kermani ,  Edward Docherty ,  John McInulty

发明人： Mahyar Z. Kermani ,  Edward Docherty ,  John McInulty

IPC分类号： G01R17/02

CPC分类号： G01N27/3273

摘要： System, circuits, and methods to reduce or eliminate uncompensated voltage drop between an electrode of an electrochemical cell usable for analyte measurement. In one example, a system is provided that includes a test strip, a reference voltage circuit, an operational amplifier connected to the reference voltage circuit to provide a predetermined fraction of a reference voltage substantially equal to the test voltage applied to the first line, the operational amplifier having an output configured for one of a connected or disconnected state to the first line, and a processing circuit connected to the output of the operational amplifier and the first line such that, during a disconnected state between the output and the first line, the processing circuit remains in connection with the first line. In another example, a method of measuring an electrochemical reaction of an electrochemical cell is provided that includes applying a test voltage to the first electrode and connecting the second electrode to ground; uncoupling the first electrode from the output of the circuit while allowing electrical communication from the first electrode to the processor; and coupling the first electrode to the output to measure a test current generated in the electrochemical cell without an uncompensated voltage drop.

摘要翻译： 用于减少或消除可用于分析物测量的电化学电池的电极之间的未补偿的电压降的系统，电路和方法。 在一个示例中，提供了一种系统，其包括测试条，参考电压电路，连接到参考电压电路的运算放大器，以提供基本上等于施加到第一线的测试电压的参考电压的预定分数， 运算放大器，具有被配置为与第一线路连接或断开状态之一的输出，以及连接到运算放大器和第一线路的输出的处理电路，使得在输出和第一线路之间的断开状态期间， 处理电路与第一行保持连接。 在另一个实例中，提供了一种测量电化学电池的电化学反应的方法，其包括向第一电极施加测试电压并将第二电极连接到地; 使第一电极与电路的输出端分离，同时允许从第一电极到处理器的电连通; 以及将所述第一电极耦合到所述输出端以测量在所述电化学电池中产生的测试电流，而没有未补偿的电压降。

公开(公告)号：US07462265B2

公开(公告)日：2008-12-09

申请号：US10860220

申请日：2004-06-02

申请人： Christopher Philip Leach ,  Erica Mary Beck

发明人： Christopher Philip Leach ,  Erica Mary Beck

IPC分类号： G01N27/327

CPC分类号： G01N27/3272

摘要： An electrochemical glucose sensor comprising a base substrate, a conductive layer disposed on said base substrate, where said conductive layer comprises a reference electrode and at least two working electrodes; an insulation layer disposed on a part of said conductive layer, a reagent layer disposed on said working electrodes and on at least a part of said reference electrode, an adhesive layer disposed on a portion of said reagent layer and conductive layer wherein said adhesive layer substantially defines an area of said reference electrode which can be wetted by a liquid sample and said insulation layer substantially defines an area of said working electrodes which can be wetted by a liquid sample.

摘要翻译： 一种电化学葡萄糖传感器，包括基底基板，设置在所述基底基板上的导电层，其中所述导电层包括参考电极和至少两个工作电极; 设置在所述导电层的一部分上的绝缘层，设置在所述工作电极上和所述参考电极的至少一部分上的试剂层，设置在所述试剂层和导电层的一部分上的粘合剂层，其中所述粘合剂层基本上 限定可被液体样品润湿的所述参比电极的区域，并且所述绝缘层基本上限定可被液体样品润湿的所述工作电极的区域。

公开(公告)号：US20080208026A1

公开(公告)日：2008-08-28

申请号：US11928560

申请日：2007-10-30

申请人： Sharbel E. NOUJAIM ,  David Horwitz ,  Manoj Sharma ,  Joseph Marhoul

发明人： Sharbel E. NOUJAIM ,  David Horwitz ,  Manoj Sharma ,  Joseph Marhoul

IPC分类号： A61B5/157

CPC分类号： A61B5/14532 ,  A61B5/746 ,  G06F19/00

摘要： The present invention is directed to a method of reducing false readings in a hypoglycemic detector that includes establishing a predetermined hypoglycemic threshold, a predetermined critical threshold, a predetermined rate of change in glucose concentration where the predetermined critical threshold is below the predetermined hypoglycemic threshold. A first sampling rate is then calculated based upon said predetermined hypoglycemic threshold, said predetermined critical threshold, and said predetermined rate of change in glucose concentration.

摘要翻译： 本发明涉及减少低血糖检测器中的错误读数的方法，其包括建立预定的低血糖阈值，预定临界阈值，预定临界阈值低于预定低血糖阈值的葡萄糖浓度的预定变化率。 然后基于所述预定的低血糖阈值，所述预定临界阈值和所述预定的葡萄糖浓度变化率来计算第一采样率。

公开(公告)号：US20080154513A1

公开(公告)日：2008-06-26

申请号：US11943226

申请日：2007-11-20

申请人： Boris P. Kovatchev ,  David Price ,  Erik Otto ,  Alan Coulson

发明人： Boris P. Kovatchev ,  David Price ,  Erik Otto ,  Alan Coulson

IPC分类号： G06F17/18 ,  G01N33/48

CPC分类号： G06F19/3456 ,  G16H15/00 ,  G16H50/20

摘要： A method, system, and computer program product related to the maintenance of optimal control of diabetes, and is directed to predicting patterns of hypoglycemia, hyperglycemia, increased glucose variability, and insufficient or excessive testing for the upcoming period of time, based on blood glucose readings collected by a self-monitoring blood glucose device. The method, system, and computer program product pertain directly to the enhancement of existing home blood glucose monitoring devices, by introducing an intelligent data interpretation component capable of predicting and alerting the user to periods of increased risk for hyperglycemia, hypoglycemia, increased glucose variability, and ineffective testing, and to the enhancement of emerging self-monitoring blood glucose devices by the same features. With these predictions the diabetic can take steps to prevent the adverse consequences associated with hyperglycemia, hypoglycemia, and increased glucose variability.

摘要翻译： 与维持糖尿病最佳控制相关的方法，系统和计算机程序产品，旨在预测低血糖，高血糖，葡萄糖变异性增加，以及基于血糖的即将到来时间的不足或过量测试 通过自我监测血糖仪收集的数据。 该方法，系统和计算机程序产品直接关系到现有家用血糖监测装置的增强，引入了智能数据解释组件，能够将用户预测和警告高血糖，低血糖，增加的葡萄糖变异性风险增加的时期， 和无效的测试，以及通过相同的特征增强新兴的自我监测血糖仪。 通过这些预测，糖尿病患者可以采取措施来预防与高血糖，低血糖和葡萄糖变异性增加相关的不良后果。

公开(公告)号：US07361307B2

公开(公告)日：2008-04-22

申请号：US10886789

申请日：2004-07-07

申请人： Robert Shartle ,  Koon-wah Leong ,  Ernest J. Kiser

发明人： Robert Shartle ,  Koon-wah Leong ,  Ernest J. Kiser

IPC分类号： G01N33/48

CPC分类号： A61B5/1486 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150984 ,  A61B5/15142 ,  A61B5/15186 ,  A61B5/157 ,  A61B2562/0295 ,  Y10T436/144444

摘要： A device for accessing biological fluid, sampling biological fluid constituents and determining the concentration of at least one target constituent within the accessed biological fluid is provided. The device has at least one micro-piercing member used to penetrate the skin to a selected depth and to access biological fluid, a constituent sampling means and a constituent measuring means. The constituent sampling means comprises a constituent transfer medium, such as a hydrophilic gel material, by which sampled constituents are transferred from the micro-piercing member to the measuring means. The measuring means includes an electrochemical cell having at least one porous electrode through which at least one sampled constituent is caused to enter into the electrochemical cell. Methods of sampling constituents within the skin and measuring the sampled constituents, as well as kits for practicing the invention are provided.

摘要翻译： 提供了用于访问生物流体的装置，取样生物流体成分并确定所访问的生物流体中至少一种目标成分的浓度。 该装置具有至少一个微穿刺构件，用于将皮肤穿透到选定的深度并且访问生物流体，构成采样装置和构成测量装置。 组分采样装置包括诸如亲水性凝胶材料的组成转印介质，通过该组分转移介质将取样的组分从微穿孔构件转移到测量装置。 测量装置包括具有至少一个多孔电极的电化学电池，使至少一个采样成分进入电化学电池。 提供了对皮肤内的成分进行取样并测量取样成分的方法，以及用于实施本发明的试剂盒。

公开(公告)号：US07335292B2

公开(公告)日：2008-02-26

申请号：US10630441

申请日：2003-07-29

申请人： Alastair McIndoe Hodges ,  Ronald Chatelier

发明人： Alastair McIndoe Hodges ,  Ronald Chatelier

IPC分类号： G01N27/30

CPC分类号： A61N1/0492 ,  A61B5/14539 ,  A61B5/1486 ,  A61N1/0476 ,  A61N1/05 ,  G01N27/30 ,  G01N27/3271

摘要： The present invention provides a metal electrode stabilized by a coating, the coating comprising a sulfur containing moiety in its molecular structure. The coating may also include a hydrophilic group and a spacer between the sulfur containing moiety and the hydrophilic group. Preferably, the sulphur-containing moiety is selected from the group comprising thiol, disulphide and SOx, and the hydrophilic group is selected from the group comprising hydroxyl, amine, carboxyl, carbonyl, oligo (ethylene oxide) chain, and zwitterionic species. Compounds useful in the present invention include 2-mercaptoethanol, 2-mercaptoethylamine, 3-mercaptopropionic acid, thiophene, 4-carboxythiophene, cysteine, homocysteine, and cystine.

摘要翻译： 本发明提供了通过涂层稳定的金属电极，该涂层包含其分子结构中的含硫部分。 涂层还可以包括亲水基团和含硫部分和亲水基团之间的间隔基。 优选地，含硫部分选自硫醇，二硫化物和SO x，亲水基团选自羟基，胺，羧基，羰基，低聚（环氧乙烷）链和两性离子物质。 可用于本发明的化合物包括2-巯基乙醇，2-巯基乙胺，3-巯基丙酸，噻吩，4-羧基噻吩，半胱氨酸，高半胱氨酸和胱氨酸。

公开(公告)号：US20070276197A1

公开(公告)日：2007-11-29

申请号：US11440341

申请日：2006-05-24

申请人： Kirk C. Harmon

发明人： Kirk C. Harmon

IPC分类号： A61B5/00

CPC分类号： G16H50/20 ,  G16H50/70

摘要： Systems and methods of individualized disease management are provided and use patient-specific, physician-defined rules to assist a patient in the management of their disease. The set of physician-defined rules for a patient can be maintained within the patient's blood glucose metering system and activated when a lifestyle event or blood glucose result is expected or recorded. Pattern analysis can be performed in real-time to provide physician-generated suggestions to a patient to positively influence their behavior toward managing their disease.

摘要翻译： 提供个性化疾病管理的系统和方法，并使用患者特定的医师定义的规则来帮助患者管理其疾病。 可以在患者的血糖计量系统内维持患者的医师定义的规则，并且当预期或记录生活方式事件或血糖结果时被激活。 可以实时进行模式分析，以向患者提供医师产生的建议，以积极地影响他们管理其疾病的行为。

公开(公告)号：US20070205103A1

公开(公告)日：2007-09-06

申请号：US11284136

申请日：2005-11-21

申请人： Alastair Hodges ,  Jerry Pugh ,  Garry Chambers

发明人： Alastair Hodges ,  Jerry Pugh ,  Garry Chambers

IPC分类号： G01N33/487

CPC分类号： G01N27/3272

摘要： Electrochemical sensors for investigating a physiological sample and methods of manufacture are disclosed. The sensor includes an electrochemical reaction cell, having electrodes and a reagent, and laterally spaced electrical contact points for electrically communication with a meter. Further described herein is a multi-chambered sensor having an electrochemical reaction cell and an immunological cell. The multi-chambered cell can also include a pre-chamber.

摘要翻译： 公开了用于研究生理样品的电化学传感器和制造方法。 传感器包括具有电极和试剂的电化学反应池，以及用于与仪表电连通的横向间隔的电接触点。 本文进一步描述的是具有电化学反应池和免疫细胞的多室传感器。 多室单元还可以包括预制室。