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    Reduced volume electrochemical sensor
    1.
    发明授权
    Reduced volume electrochemical sensor 有权
    体积电化学传感器减少

    公开(公告)号：US07462265B2

    公开(公告)日：2008-12-09

    申请号：US10860220

    申请日：2004-06-02

    申请人： Christopher Philip Leach ,  Erica Mary Beck

    发明人： Christopher Philip Leach ,  Erica Mary Beck

    IPC分类号： G01N27/327

    CPC分类号： G01N27/3272

    摘要： An electrochemical glucose sensor comprising a base substrate, a conductive layer disposed on said base substrate, where said conductive layer comprises a reference electrode and at least two working electrodes; an insulation layer disposed on a part of said conductive layer, a reagent layer disposed on said working electrodes and on at least a part of said reference electrode, an adhesive layer disposed on a portion of said reagent layer and conductive layer wherein said adhesive layer substantially defines an area of said reference electrode which can be wetted by a liquid sample and said insulation layer substantially defines an area of said working electrodes which can be wetted by a liquid sample.

    摘要翻译： 一种电化学葡萄糖传感器，包括基底基板，设置在所述基底基板上的导电层，其中所述导电层包括参考电极和至少两个工作电极; 设置在所述导电层的一部分上的绝缘层，设置在所述工作电极上和所述参考电极的至少一部分上的试剂层，设置在所述试剂层和导电层的一部分上的粘合剂层，其中所述粘合剂层基本上 限定可被液体样品润湿的所述参比电极的区域，并且所述绝缘层基本上限定可被液体样品润湿的所述工作电极的区域。

    Method for determining hematocrit corrected analyte concentrations
    3.
    发明授权
    Method for determining hematocrit corrected analyte concentrations 有权
    确定血细胞比容校正分析物浓度的方法

    公开(公告)号：US08388821B2

    公开(公告)日：2013-03-05

    申请号：US12305363

    申请日：2007-10-05

    申请人： Stephen Patrick Blythe ,  Marco F. Cardosi ,  Andrew Gill ,  Leanne Mills ,  Christopher Philip Leach

    发明人： Stephen Patrick Blythe ,  Marco F. Cardosi ,  Andrew Gill ,  Leanne Mills ,  Christopher Philip Leach

    IPC分类号： G01N27/327

    CPC分类号： C12Q1/006 ,  G01N27/3271

    摘要： Description is provided herein for an embodiment of a method determining a hematocrit-corrected glucose concentration. The exemplary method includes providing a test strip having a reference electrode and a working electrode, wherein the working electrode includes a plurality of microelectrodes and is coated with at least an enzyme and a mediator. The method can be achieved by: providing a test strip comprising a reference electrode and a working electrode formed with a plurality of microelectrodes and coated with a reagent layer; applying a fluid sample to the test strip for a reaction period; applying a test voltage between the reference electrode and the working electrode; measuring a test current as a function of time; measuring a steady state current value when the test current has reached an equilibrium; calculating a ratio of the test current to the steady state current value; plotting the ratio of the test current to the steady state current value as a function of the inverse square root of time; calculating an effective diffusion coefficient from the slope of the linearly regressed plot of the ratio of the test current to the steady state current value as a function of the inverse square root of time; and calculating a hematocrit-corrected concentration of analyte.

    摘要翻译： 本文提供了确定血细胞比容校正葡萄糖浓度的方法的实施方案的描述。 该示例性方法包括提供具有参考电极和工作电极的测试条，其中工作电极包括多个微电极并且至少涂覆有酶和介体。 该方法可以通过以下方式实现：提供包括参考电极和形成有多个微电极并涂覆有试剂层的工作电极的测试条; 将流体样品施加到测试条上一段反应期; 在参考电极和工作电极之间施加测试电压; 测量作为时间的函数的测试电流; 当测试电流达到平衡时测量稳态电流值; 计算测试电流与稳态电流值的比值; 将测试电流与稳态电流值的比率绘制为时间的逆平方根的函数; 根据测试电流与稳态电流值的比值的线性回归曲线的斜率计算有效扩散系数作为时间的平方根的函数; 并计算分析物的血细胞比容校正浓度。

    Dual chamber, multi-analyte test strip with opposing electrodes
    4.
    发明授权
    Dual chamber, multi-analyte test strip with opposing electrodes 有权
    具有相对电极的双室多分析物测试条

    公开(公告)号：US08323467B2

    公开(公告)日：2012-12-04

    申请号：US12606467

    申请日：2009-10-27

    申请人： Gavin MacFie ,  Graeme Webster ,  Marco F. Cardosi ,  Christopher Philip Leach ,  Steven Setford ,  Selwayan Saini

    发明人： Gavin MacFie ,  Graeme Webster ,  Marco F. Cardosi ,  Christopher Philip Leach ,  Steven Setford ,  Selwayan Saini

    IPC分类号： G01N27/327

    CPC分类号： G01N27/3272 ,  G01N2035/00118

    摘要： A dual chamber, multi-analyte test strip has a first insulating layer, a first electrically conductive layer, with a first working electrode, disposed on the first insulating layer and a first patterned spacer layer positioned above the first electrically conductive layer. The first patterned spacer layer has a first sample-receiving chamber, with first and second end openings, defined therein that overlies the first working electrode. The test strip also includes a first counter/reference electrode layer that is exposed to the first sample receiving chamber and is in an opposing relationship to the first working electrode. The test strip further includes a counter/reference insulating layer disposed over the first counter/reference electrode layer and a second counter/reference electrode layer disposed on the counter/reference substrate. Also included in the test strip is a second patterned spacer layer that is positioned above the second counter/reference electrode layer. The second patterned spacer layer has a second sample-receiving chamber, with first and second end openings, defined therein. The test strip additionally has a second electrically conductive layer, with a second working electrode, disposed above the second patterned spacer layer, a second insulating layer disposed above the second electrically conductive layer, a first analyte reagent layer disposed on the first working electrode within the first sample-receiving chamber; and a second analyte reagent layer disposed on the second working electrode within the second sample-receiving chamber. The second counter/reference electrode layer is exposed to the second sample receiving chamber and is in an opposing relationship to the second working electrode.

    摘要翻译： 双室多分析物测试条具有设置在第一绝缘层上的第一绝缘层，第一导电层和第一工作电极，以及位于第一导电层上方的第一图案化间隔层。 第一图案化间隔层具有第一样品接收室，其中限定在其中的第一和第二端部开口覆盖在第一工作电极上。 测试条还包括暴露于第一样品接收室并与第一工作电极相对关系的第一计数器/参考电极层。 测试条还包括设置在第一计数器/参考电极层上的计数器/参考绝缘层和设置在反向/参考基板上的第二计数器/参考电极层。 还包括在测试条中的是位于第二计数器/参考电极层上方的第二图案化间隔层。 第二图案化间隔层具有第二样品接收室，其中限定有第一和第二端部开口。 测试条另外具有第二导电层，第二工作电极设置在第二图案化间隔层上方，设置在第二导电层上方的第二绝缘层，设置在第二工作电极内的第一分析物试剂层， 第一采样室; 以及设置在第二样品接收室内的第二工作电极上的第二分析物试剂层。 第二计数器/参考电极层暴露于第二样品接收室，并且与第二工作电极相对。

    DUAL CHAMBER, MULTI-ANALYTE TEST STRIP WITH OPPOSING ELECTRODES
    5.
    发明申请
    DUAL CHAMBER, MULTI-ANALYTE TEST STRIP WITH OPPOSING ELECTRODES 有权
    双室，多分析测试带与电极

    公开(公告)号：US20110094896A1

    公开(公告)日：2011-04-28

    申请号：US12606467

    申请日：2009-10-27

    申请人： Gavin MACFIE ,  Graeme Webster ,  Marco F. Cardosi ,  Christopher Philip Leach ,  Steven Setford ,  Selwayan Saini

    发明人： Gavin MACFIE ,  Graeme Webster ,  Marco F. Cardosi ,  Christopher Philip Leach ,  Steven Setford ,  Selwayan Saini

    IPC分类号： G01N27/26

    CPC分类号： G01N27/3272 ,  G01N2035/00118

    摘要： A dual chamber, multi-analyte test strip has a first insulating layer, a first electrically conductive layer, with a first working electrode, disposed on the first insulating layer and a first patterned spacer layer positioned above the first electrically conductive layer. The first patterned spacer layer has a first sample-receiving chamber, with first and second end openings, defined therein that overlies the first working electrode. The test strip also includes a first counter/reference electrode layer that is exposed to the first sample receiving chamber and is in an opposing relationship to the first working electrode. The test strip further includes a counter/reference insulating layer disposed over the first counter/reference electrode layer and a second counter/reference electrode layer disposed on the counter/reference substrate. Also included in the test strip is a second patterned spacer layer that is positioned above the second counter/reference electrode layer. The second patterned spacer layer has a second sample-receiving chamber, with first and second end openings, defined therein. The test strip additionally has a second electrically conductive layer, with a second working electrode, disposed above the second patterned spacer layer, a second insulating layer disposed above the second electrically conductive layer, a first analyte reagent layer disposed on the first working electrode within the first sample-receiving chamber; and a second analyte reagent layer disposed on the second working electrode within the second sample-receiving chamber. The second counter/reference electrode layer is exposed to the second sample receiving chamber and is in an opposing relationship to the second working electrode.

    摘要翻译： 双室多分析物测试条具有设置在第一绝缘层上的第一绝缘层，第一导电层和第一工作电极，以及位于第一导电层上方的第一图案化间隔层。 第一图案化间隔层具有第一样品接收室，其中限定在其中的第一和第二端部开口覆盖在第一工作电极上。 测试条还包括暴露于第一样品接收室并与第一工作电极相对关系的第一计数器/参考电极层。 测试条还包括设置在第一计数器/参考电极层上的计数器/参考绝缘层和设置在反向/参考基板上的第二计数器/参考电极层。 还包括在测试条中的是位于第二计数器/参考电极层上方的第二图案化间隔层。 第二图案化间隔层具有第二样品接收室，其中限定有第一和第二端部开口。 测试条另外具有第二导电层，第二工作电极设置在第二图案化间隔层上方，设置在第二导电层上方的第二绝缘层，设置在第二工作电极内的第一分析物试剂层， 第一采样室; 以及设置在第二样品接收室内的第二工作电极上的第二分析物试剂层。 第二计数器/参考电极层暴露于第二样品接收室，并且与第二工作电极相对。

    Test meter for use with a dual chamber, multi-analyte test strip with opposing electrodes
    6.
    发明授权
    Test meter for use with a dual chamber, multi-analyte test strip with opposing electrodes 有权
    用于具有相对电极的双室多分析物测试条的测试仪

    公开(公告)号：US08632664B2

    公开(公告)日：2014-01-21

    申请号：US12606496

    申请日：2009-10-27

    申请人： Gavin Macfie ,  Graeme Webster ,  Marco F. Cardosi ,  Christopher Philip Leach ,  Steven Setford ,  Selwayan Saini

    发明人： Gavin Macfie ,  Graeme Webster ,  Marco F. Cardosi ,  Christopher Philip Leach ,  Steven Setford ,  Selwayan Saini

    IPC分类号： G01N27/327

    CPC分类号： G01N27/3272 ,  G01N2035/00118

    摘要： A test meter for use with a dual-chamber, multi-analyte test strip includes a test strip receiving module and a signal processing module. The test strip receiving module has a first electrical connector configured for contacting a first analyte contact pad of a first working electrode of the test strip; a second electrical connector configured for contacting a second analyte contact pad of a second working electrode of the test strip, a third electrical connector configured for contacting a first counter/reference contact pad of a first counter/reference electrode layer of the test strip, and a fourth electrical connector configured for contacting a second counter/reference contact pad of a second counter/reference electrode layer of the test strip. The signal processing module is configured to receive a first signal via the first electrical connector and the third electrical connector and employ the first signal for the determination of a first analyte (such as glucose) in a bodily fluid sample (for example, whole blood sample) applied to the dual-chamber, multi-analyte test strip. Moreover, the signal processing module is also configured to receive a second signal via the second electrical connector and fourth electrical connector and employ the second signal for the determination of a second analyte (e.g., a ketone analyte) in the bodily fluid sample applied to the dual-chamber, multi-analyte test strip. Furthermore, the third and fourth electrical contacts provide contact in an opposing manner.

    摘要翻译： 用于双腔多分析物测试条的测试仪包括测试条接收模块和信号处理模块。 测试条接收模块具有第一电连接器，其被配置用于接触测试条的第一工作电极的第一分析物接触焊盘; 第二电连接器，其被配置用于接触测试条的第二工作电极的第二分析物接触焊盘;第三电连接器，其被配置用于接触测试条的第一计数器/参考电极层的第一计数器/参考接触焊盘，以及 第四电连接器，其被配置为接触测试条的第二计数器/参考电极层的第二计数器/参考接触焊盘。 信号处理模块被配置为经由第一电连接器和第三电连接器接收第一信号，并且采用第一信号来确定体液样品中的第一分析物（例如葡萄糖）（例如，全血样品 ）应用于双室多分析物测试条。 此外，信号处理模块还被配置为经由第二电连接器和第四电连接器接收第二信号，并且使用第二信号来确定施加到所述第二电连接器和第四电连接器的体液样品中的第二分析物（例如，酮分析物） 双室多分析物测试条。 此外，第三和第四电触点以相反的方式提供接触。

    ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH DIFFUSION-CONTROLLING LAYER AND METHOD FOR DETERMINING AN ANALYTE USING SUCH AN TEST STRIP
    9.
    发明申请
    ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH DIFFUSION-CONTROLLING LAYER AND METHOD FOR DETERMINING AN ANALYTE USING SUCH AN TEST STRIP 审中-公开
    具有扩散控制层的基于电化学的分析测试条和使用这种测试条来确定分析仪的方法

    公开(公告)号：US20120199497A1

    公开(公告)日：2012-08-09

    申请号：US13021956

    申请日：2011-02-07

    申请人： Zuifang Liu ,  Marco F. Cardosi ,  Christopher Philip Leach ,  Scott Sloss

    发明人： Zuifang Liu ,  Marco F. Cardosi ,  Christopher Philip Leach ,  Scott Sloss

    IPC分类号： G01N27/26

    CPC分类号： G01N27/3272 ,  C12Q1/003 ,  C12Q1/006

    摘要： An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (e.g., a whole blood sample) includes a substrate, at least one working electrode disposed on the substrate, a sample-soluble enzymatic reagent layer disposed above the working electrode, a diffusion-controlling layer (DCL) disposed between the at least one working electrode and the sample-soluble enzymatic reagent layer; and a sample-receiving chamber. In addition, the sample-soluble enzymatic reagent layer is configured and constituted for operable solubility in a bodily fluid sample applied to the electrochemical-based analytical test strip and received in the sample-receiving chamber and for electrochemical enzymatic reaction with an analyte in the bodily fluid sample. Moreover, the DCL is configured and constituted to provide a predetermined diffusion rate for a component (for example a mediator) of the electrochemical enzymatic reaction through the DCL that is less than the diffusion rate of the component through the bodily fluid sample and for operable hydration by the bodily fluid sample. A method for determining an analyte in a bodily fluid sample includes applying a bodily fluid sample to an electrochemical-based analytical test strip that includes a substrate, at least one working electrode disposed on the substrate, a sample-soluble enzymatic reagent layer disposed above the working electrode, a DCL disposed between the at least one working electrode and the sample-soluble enzymatic reagent layer; and a sample-receiving chamber defined in the electrochemical-based analytical test strip.

    摘要翻译： 用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的基于电化学的分析测试条包括底物，设置在基底上的至少一个工作电极，样品可溶性酶 设置在所述工作电极上方的试剂层，设置在所述至少一个工作电极和所述样品可溶性酶试剂层之间的扩散控制层（DCL） 和样品接收室。 此外，样品可溶性酶试剂层被构造和构造成用于在施加到基于电化学的分析测试条上的体液样品中的可操作溶解度并且被接收在样品接收室中并且用于与身体中的分析物的电化学酶反应 流体样品。 此外，DCL被配置和构造成通过小于通过体液样品的组分的扩散速率的DCL为电化学酶反应的组分（例如介体）提供预定的扩散速率，并且为了可操作的水合 通过体液样品。 一种用于测定体液样品中的分析物的方法包括将体液样品施加到基于电化学的分析测试条，所述分析测试条包括基底，设置在基底上的至少一个工作电极，设置在基底上的样品可溶性酶试剂层 工作电极，设置在所述至少一个工作电极和所述样品可溶性酶试剂层之间的DCL; 以及在基于电化学的分析测试条中限定的样品接收室。